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Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC). clinicaltrials.gov. Available at: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05263206. Accessed June 6, 2023."},{"issue":"7","key":"10.1016\/j.anai.2023.08.008_bib0060","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1034\/j.1600-0560.2000.027007359.x","article-title":"CGRP-immunoreactive nerves in prurigo nodularis - an exploration of neurogenic inflammation","volume":"27","author":"Liang","year":"2000","journal-title":"J Cutan Pathol"},{"issue":"8","key":"10.1016\/j.anai.2023.08.008_bib0061","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1056\/NEJMoa1908316","article-title":"Trial of nemolizumab in moderate-to-severe prurigo nodularis","volume":"382","author":"St\u00e4nder","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.anai.2023.08.008_bib0062","unstructured":"Galderma. R&D. 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