{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:23:42Z","timestamp":1793489022872,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.anai.2023.08.021","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T01:54:37Z","timestamp":1693014877000},"page":"42-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry"],"prefix":"10.1016","volume":"132","author":[{"given":"Ghislaine","family":"Scelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Torres-Duque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Maspero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trung N.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"Menzies-Gow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C.","family":"Christoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todor A.","family":"Popov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9anne","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Bergeron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delbert","family":"Dorscheid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Mark","family":"FitzGerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis Philippe","family":"Boulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Bhutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Sadatsafavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libardo","family":"Jim\u00e9nez-Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Duran-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bellanid","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Andres","family":"Celis-Preciado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Jimena","family":"Cano-Rosales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Solarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jose","family":"Fernandez-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Parada-Tovar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"von B\u00fclow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Sofie","family":"Bjerrum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte S.","family":"Ulrik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin Dahl","family":"Assing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda Makowska","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Altraja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Bourdin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Taille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Charriot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Roche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriana I.","family":"Papaioannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kostikas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos G.","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundeep","family":"Salvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Costello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Sirena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Cardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Heffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Puggioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio Walter","family":"Canonica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Guida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Iwanaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Al-Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9sir\u00e9e Larenas","family":"Linnemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulises","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Kuna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o A.","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyad","family":"Al-Lehebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko Siyue","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin Kook","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja G.","family":"Cosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Perez","family":"de Llano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diahn-Warng","family":"Perng (Steve)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick Wan-Chun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Chien","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Ju","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam","family":"Mahboub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila Ibraheem Jaber","family":"Salameh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Busby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam G.","family":"Heaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Pfeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Grippen","family":"Goddard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Hoyte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Wechsler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Katial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakmini","family":"Bulathsinhala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neva","family":"Eleangovan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Con","family":"Ariti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9728-9992","authenticated-orcid":false,"given":"David B.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Porsbjerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2023.08.021_bib0001","unstructured":"Global Initiative for Asthma. Global strategy for asthma management and prevention. 2023. Available at: https:\/\/ginasthma.org\/wp-content\/uploads\/2023\/05\/GINA-2023-Full-Report-2023-WMS.pdf. Accessed September 22, 2023."},{"key":"10.1016\/j.anai.2023.08.021_bib0002","unstructured":"Global Initiative for Asthma. Global strategy for asthma management and prevention. Revised 2014. Available at: https:\/\/ginasthma.org\/wp-content\/uploads\/2019\/01\/2014-GINA.pdf. Accessed September 22, 2023."},{"issue":"1","key":"10.1016\/j.anai.2023.08.021_bib0003","first-page":"5","article-title":"Comorbidities associated with severe asthma","volume":"2","author":"Patel","year":"2019","journal-title":"J Precis Respir Med"},{"issue":"4","key":"10.1016\/j.anai.2023.08.021_bib0004","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02114-2017","article-title":"Multimorbidity medications and poor asthma prognosis","volume":"51","author":"Chanoine","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.anai.2023.08.021_bib0005","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2147\/JAA.S321212","article-title":"Association between a type 2 inflammatory disease burden score and outcomes among patients with asthma","volume":"14","author":"Price","year":"2021","journal-title":"J Asthma Allergy"},{"issue":"1","key":"10.1016\/j.anai.2023.08.021_bib0006","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12931-016-0421-9","article-title":"The impact of comorbidities on productivity loss in asthma patients","volume":"17","author":"Ehteshami-Afshar","year":"2016","journal-title":"Respir Res"},{"issue":"6","key":"10.1016\/j.anai.2023.08.021_bib0007","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1183\/13993003.01141-2016","article-title":"Excess medical costs in patients with asthma and the role of comorbidity","volume":"48","author":"Chen","year":"2016","journal-title":"Eur Respir J"},{"issue":"7","key":"10.1016\/j.anai.2023.08.021_bib0008","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s40265-014-0213-9","article-title":"Defining phenotypes in asthma: a step towards personalized medicine","volume":"74","author":"Chung","year":"2014","journal-title":"Drugs"},{"issue":"4","key":"10.1016\/j.anai.2023.08.021_bib0009","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/resp.13026","article-title":"Co-morbidities in severe asthma: clinical impact and management","volume":"22","author":"Porsbjerg","year":"2017","journal-title":"Respirology"},{"key":"10.1016\/j.anai.2023.08.021_bib0010","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2147\/JAA.S176026","article-title":"Adverse outcomes from initiation of systemic corticosteroids for asthma: long-term observational study","volume":"11","author":"Price","year":"2018","journal-title":"J Asthma Allergy"},{"issue":"4","key":"10.1016\/j.anai.2023.08.021_bib0011","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/thoraxjnl-2015-207630","article-title":"Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry","volume":"71","author":"Sweeney","year":"2016","journal-title":"Thorax"},{"issue":"10","key":"10.1016\/j.anai.2023.08.021_bib0012","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.rmed.2005.03.003","article-title":"Are psychiatric disorders associated with worse asthma control and quality of life in asthma patients?","volume":"99","author":"Lavoie","year":"2005","journal-title":"Respir Med"},{"issue":"159","key":"10.1016\/j.anai.2023.08.021_bib0013","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0185-2019","article-title":"Asthma-COPD overlap: current understanding and the utility of experimental models","volume":"30","author":"Tu","year":"2021","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.anai.2023.08.021_bib0014","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.rmed.2017.03.005","article-title":"Comparative prevalence of co-morbidities in smoking and non-smoking asthma patients with incomplete reversibility of airway obstruction, non-smoking asthma patients with complete reversibility of airway obstruction and COPD patients","volume":"125","author":"Nadeau","year":"2017","journal-title":"Respir Med"},{"key":"10.1016\/j.anai.2023.08.021_bib0015","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/819194","article-title":"Chronic comorbidities contribute to the burden and costs of persistent asthma","volume":"2015","author":"Kauppi","year":"2015","journal-title":"Mediators Inflamm"},{"issue":"8","key":"10.1016\/j.anai.2023.08.021_bib0016","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1590\/S1807-59322009000800010","article-title":"Comorbidities in severe asthma: frequency of rhinitis, nasal polyposis, gastroesophageal reflux disease, vocal cord dysfunction and bronchiectasis","volume":"64","author":"Bisaccioni","year":"2009","journal-title":"Clinics (S Paulo)"},{"issue":"2","key":"10.1016\/j.anai.2023.08.021_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaip.2018.08.016","article-title":"Development of the International Severe Asthma Registry (ISAR): a modified Delphi study","volume":"7","author":"Bulathsinhala","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"4","key":"10.1016\/j.anai.2023.08.021_bib0018","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.chest.2019.10.051","article-title":"International Severe Asthma Registry (ISAR): mission statement","volume":"157","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.anai.2023.08.021_bib0019","unstructured":"International Severe Asthma Registry (ISAR). Available at: https:\/\/isaregistries.org\/. Accessed September 22, 2023."},{"issue":"1","key":"10.1016\/j.anai.2023.08.021_bib0020","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12874-020-01065-0","article-title":"International Severe Asthma Registry (ISAR): protocol for a global registry","volume":"20","author":"FitzGerald","year":"2020","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.anai.2023.08.021_bib0021","unstructured":"Global Initiative for Asthma. Global strategy for asthma management and prevention. 2018. Available at: https:\/\/ginasthma.org\/wp-content\/uploads\/2019\/01\/2018-GINA.pdf. Accessed September 22, 2023."},{"key":"10.1016\/j.anai.2023.08.021_bib0022","article-title":"Adult severe asthma registries: a global and growing inventory","author":"Cushen","year":"2023","journal-title":"Prag Obs Res"},{"issue":"suppl 16","key":"10.1016\/j.anai.2023.08.021_bib0023","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1183\/09041950.005s1693","article-title":"Lung volumes and forced ventilatory flows","volume":"6","author":"Quanjer","year":"1993","journal-title":"Eur Respir J"},{"key":"10.1016\/j.anai.2023.08.021_bib0024","unstructured":"R Core Team. A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing. Available at: https:\/\/www.R-project.org\/. Accessed September 22, 2023."},{"issue":"4","key":"10.1016\/j.anai.2023.08.021_bib0025","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.chest.2019.10.053","article-title":"Characterization of severe asthma worldwide: data from the International Severe Asthma Registry (ISAR)","volume":"157","author":"Wang","year":"2020","journal-title":"Chest"},{"issue":"12","key":"10.1016\/j.anai.2023.08.021_bib0026","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1080\/02770903.2018.1539100","article-title":"A systematic review of the adverse events and economic impact associated with oral corticosteroids in asthma","volume":"56","author":"Al Efraij","year":"2019","journal-title":"J Asthma"},{"issue":"2","key":"10.1016\/j.anai.2023.08.021_bib0027","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/joim.13273","article-title":"Long-term corticosteroid use, adrenal insufficiency and the need for steroid-sparing treatment in adult severe asthma","volume":"290","author":"Gurnell","year":"2021","journal-title":"J Intern Med"},{"issue":"2","key":"10.1016\/j.anai.2023.08.021_bib0028","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4104\/pcrj.2012.00035","article-title":"Poor asthma control?\u2013then look up the nose. The importance of co-morbid rhinitis in patients with asthma","volume":"21","author":"Scadding","year":"2012","journal-title":"Prim Care Respir J"},{"issue":"4","key":"10.1016\/j.anai.2023.08.021_bib0029","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4104\/pcrj.2009.00037","article-title":"The value of self-report assessment of adherence, rhinitis and smoking in relation to asthma control","volume":"18","author":"Clatworthy","year":"2009","journal-title":"Prim Care Respir J"},{"key":"10.1016\/j.anai.2023.08.021_bib0030","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1471-2466-13-46","article-title":"Major comorbid conditions in asthma and association with asthma-related hospitalizations and emergency department admissions in adults: results from the German National Health Telephone Interview Survey (GEDA) 2010","volume":"13","author":"Steppuhn","year":"2013","journal-title":"BMC Pulm Med"},{"issue":"2","key":"10.1016\/j.anai.2023.08.021_bib0031","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01927-2017","article-title":"Prevalence, characteristics and management of frequently exacerbating asthma patients: an observational study in Sweden (PACEHR)","volume":"52","author":"Janson","year":"2018","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.anai.2023.08.021_bib0032","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00408-023-00603-z","article-title":"Prevalence and severity distribution of type 2 inflammation-related comorbidities among patients with asthma, chronic rhinosinusitis with nasal polyps, and atopic dermatitis","volume":"201","author":"Khan","year":"2023","journal-title":"Lung"},{"issue":"1","key":"10.1016\/j.anai.2023.08.021_bib0033","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S2213-2600(17)30424-1","article-title":"Fractional exhaled nitric oxide as a predictor of response to inhaled corticosteroids in patients with non-specific respiratory symptoms and insignificant bronchodilator reversibility: a randomised controlled trial","volume":"6","author":"Price","year":"2018","journal-title":"Lancet Respir Med"},{"issue":"7","key":"10.1016\/j.anai.2023.08.021_bib0034","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/thorax-2021-217032","article-title":"Asthma exacerbations are associated with a decline in lung function: a longitudinal population-based study","volume":"78","author":"Soremekun","year":"2023","journal-title":"Thorax"},{"issue":"3","key":"10.1016\/j.anai.2023.08.021_bib0035","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1164\/rccm.201904-0903SO","article-title":"Systematic literature review of systemic corticosteroid use for asthma management","volume":"201","author":"Bleecker","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2023.08.021_bib0036","first-page":"1","article-title":"Predicting frequent asthma exacerbations using blood eosinophil count and other patient data routinely available in clinical practice","volume":"9","author":"Price","year":"2016","journal-title":"J Asthma Allergy"},{"issue":"1","key":"10.1016\/j.anai.2023.08.021_bib0037","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.2500\/aap.2021.42.200098","article-title":"Obstructive sleep apnea is a determinant of asthma control independent of smoking, reflux, and rhinitis","volume":"42","author":"\u00d6zden Mat","year":"2021","journal-title":"Allergy Asthma Proc"},{"issue":"12","key":"10.1016\/j.anai.2023.08.021_bib0038","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1111\/resp.14147","article-title":"Oral corticosteroids stewardship for asthma in adults and adolescents: a position paper from the Thoracic Society of Australia and New Zealand","volume":"26","author":"Blakey","year":"2021","journal-title":"Respirology"},{"issue":"7","key":"10.1016\/j.anai.2023.08.021_bib0039","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1164\/rccm.202007-2721OC","article-title":"Expert consensus on the tapering of oral corticosteroids for the treatment of asthma. A Delphi study","volume":"203","author":"Suehs","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"10.1016\/j.anai.2023.08.021_bib0040","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1442-2050.2012.01399.x","article-title":"Association of gastroesophageal reflux disease with asthma control","volume":"26","author":"Liang","year":"2013","journal-title":"Dis Esophagus"},{"issue":"3","key":"10.1016\/j.anai.2023.08.021_bib0041","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1164\/rccm.201602-0419OC","article-title":"Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations","volume":"195","author":"Denlinger","year":"2017","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120623006300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120623006300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:32:56Z","timestamp":1761053576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120623006300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S1081120623006300"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2023.08.021","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2023.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}