{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:21:08Z","timestamp":1793834468825,"version":"4.6.1"},"reference-count":99,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["U01AI147462"],"award-info":[{"award-number":["U01AI147462"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"NIEHS","doi-asserted-by":"publisher","award":["R01ES032253"],"award-info":[{"award-number":["R01ES032253"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["5P01HL152953"],"award-info":[{"award-number":["5P01HL152953"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","annallergy.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.anai.2024.01.017","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T07:24:17Z","timestamp":1705821857000},"page":"426-432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Effect of air pollution on asthma"],"prefix":"10.1016","volume":"132","author":[{"given":"Xiaoying","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanitha","family":"Sampath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-2955","authenticated-orcid":false,"given":"Kari C.","family":"Nadeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2024.01.017_bib0001","unstructured":"EPA. NAAQS table. Available at: https:\/\/www.epa.gov\/criteria-air-pollutants\/naaqs-table. Accessed January 8, 2024."},{"key":"10.1016\/j.anai.2024.01.017_bib0002","unstructured":"WHO. Ambient (outdoor) air pollution. Available at:https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ambient-(outdoor)-air-quality-and-health. Accessed January 8, 2024."},{"key":"10.1016\/j.anai.2024.01.017_bib0003","unstructured":"WHO. Air pollution. Available at: https:\/\/www.who.int\/health-topics\/air-pollution#tab=tab_1. Accessed January 8, 2024."},{"key":"10.1016\/j.anai.2024.01.017_bib0004","unstructured":"National Heart, Lung, and Blood Institute. Expert panel report 3 (EPR3): guidelines for the diagnosis and management of asthma. Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK7232\/. Accessed January 8, 2024."},{"issue":"12","key":"10.1016\/j.anai.2024.01.017_bib0005","article-title":"Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity","volume":"2","author":"Tsuo","year":"2022","journal-title":"Cell Genom"},{"issue":"1","key":"10.1016\/j.anai.2024.01.017_bib0006","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1038\/s41467-020-15649-3","article-title":"Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma","volume":"11","author":"Han","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.anai.2024.01.017_bib0007","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13073-021-00967-y","article-title":"Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus","volume":"13","author":"Soliai","year":"2021","journal-title":"Genome Med"},{"issue":"2","key":"10.1016\/j.anai.2024.01.017_bib0008","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4168\/aair.2019.11.2.170","article-title":"Lessons learned from GWAS of asthma","volume":"11","author":"Kim","year":"2019","journal-title":"Allergy Asthma Immunol Res"},{"issue":"1","key":"10.1016\/j.anai.2024.01.017_bib0009","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13148-021-01049-x","article-title":"A review of epigenetic changes in asthma: methylation and acetylation","volume":"13","author":"Sheikhpour","year":"2021","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.anai.2024.01.017_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.532849","article-title":"Long noncoding RNAs in the regulation of asthma: current research and clinical implications","volume":"11","author":"Zhu","year":"2020","journal-title":"Front Pharmacol"},{"issue":"4","key":"10.1016\/j.anai.2024.01.017_bib0011","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/all.15666","article-title":"Decoding the genetic and epigenetic basis of asthma","volume":"78","author":"Stikker","year":"2023","journal-title":"Allergy"},{"issue":"17","key":"10.1016\/j.anai.2024.01.017_bib0012","doi-asserted-by":"crossref","first-page":"6212","DOI":"10.3390\/ijerph17176212","article-title":"Impact of air pollution on asthma outcomes","volume":"17","author":"Tiotiu","year":"2020","journal-title":"Int J Environ Res Public Health"},{"issue":"6","key":"10.1016\/j.anai.2024.01.017_bib0013","doi-asserted-by":"crossref","first-page":"6374","DOI":"10.1007\/s11356-020-12051-w","article-title":"Airway hyperresponsiveness development and the toxicity of PM2.5","volume":"28","author":"Lu","year":"2021","journal-title":"Environ Sci Pollut Res Int"},{"issue":"12","key":"10.1016\/j.anai.2024.01.017_bib0014","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.3390\/ijerph19127511","article-title":"Recent insights into particulate matter (PM2.5)-mediated toxicity in humans: an overview","volume":"19","author":"Thangavel","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"5","key":"10.1016\/j.anai.2024.01.017_bib0015","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1007\/s10753-020-01269-y","article-title":"PM2.5 exposure induces inflammatory response in macrophages via the TLR4\/COX-2\/NF-\u03baB pathway","volume":"43","author":"Fu","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.anai.2024.01.017_bib0016","doi-asserted-by":"crossref","first-page":"44256","DOI":"10.1038\/srep44256","article-title":"The acute airway inflammation induced by PM2.5 exposure and the treatment of essential oils in BALB\/c mice","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.anai.2024.01.017_bib0017","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/all.15630","article-title":"How does particulate air pollution affect barrier functions and inflammatory activity of lung vascular endothelium?","volume":"78","author":"Olesiejuk","year":"2023","journal-title":"Allergy"},{"issue":"679","key":"10.1016\/j.anai.2024.01.017_bib0018","doi-asserted-by":"crossref","first-page":"eadd2563","DOI":"10.1126\/scitranslmed.add2563","article-title":"Allergy: mechanistic insights into new methods of prevention and therapy","volume":"15","author":"Akdis","year":"2023","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.anai.2024.01.017_bib0019","unstructured":"EPA. Health effects of ozone in patients with asthma and other chronic respiratory disease. Available at:https:\/\/www.epa.gov\/ozone-pollution-and-your-patients-health\/health-effects-ozone-patients-asthma-and-other-chronic. Accessed January 8, 2024."},{"issue":"4","key":"10.1016\/j.anai.2024.01.017_bib0020","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/all.15079","article-title":"Climate change: a call to action for the United Nations","volume":"77","author":"Nadeau","year":"2022","journal-title":"Allergy"},{"issue":"11","key":"10.1016\/j.anai.2024.01.017_bib0021","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41577-022-00776-3","article-title":"Human and planetary health on fire","volume":"22","author":"Akdis","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.anai.2024.01.017_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2023.101765","article-title":"Mechanisms of climate change and related air pollution on the immune system leading to allergic disease and asthma","volume":"67","author":"Sampath","year":"2023","journal-title":"Semin Immunol"},{"key":"10.1016\/j.anai.2024.01.017_bib0023","doi-asserted-by":"crossref","unstructured":"Gould CF, Heft-Neal S, Prunicki M, Aguilera J, Burke M, Nadeau K. Health effects of wildfire smoke exposure [e-pub ahead of print]. Annu Rev Med. https:\/\/doi.10.1146\/annurev-med-052422-020909, accessed January 8, 2024.","DOI":"10.1146\/annurev-med-052422-020909"},{"key":"10.1016\/j.anai.2024.01.017_bib0024","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.envpol.2017.08.072","article-title":"The effects of PM2.5 on asthmatic and allergic diseases or symptoms in preschool children of six Chinese cities, based on China, Children, Homes and Health (CCHH) project","volume":"232","author":"Chen","year":"2018","journal-title":"Environ Pollut"},{"issue":"4","key":"10.1016\/j.anai.2024.01.017_bib0025","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/oem.2010.055152","article-title":"Traffic-related air pollution and incident asthma in a high-risk birth cohort","volume":"68","author":"Carlsten","year":"2011","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.anai.2024.01.017_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106486","article-title":"Fine particulate matter concentration and composition and the incidence of childhood asthma","volume":"152","author":"Lavigne","year":"2021","journal-title":"Environ Int"},{"key":"10.1016\/j.anai.2024.01.017_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107297","article-title":"Early-life exposure to PM2.5 constituents and childhood asthma and wheezing: findings from China, Children, Homes, Health study","volume":"165","author":"Zhang","year":"2022","journal-title":"Environ Int"},{"key":"10.1016\/j.anai.2024.01.017_bib0028","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.envint.2017.04.006","article-title":"Concentration-response of short-term ozone exposure and hospital admissions for asthma in Texas","volume":"104","author":"Zu","year":"2017","journal-title":"Environ Int"},{"issue":"3","key":"10.1016\/j.anai.2024.01.017_bib0029","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174050","article-title":"Effect of outdoor air pollution on asthma exacerbations in children and adults: systematic review and multilevel meta-analysis","volume":"12","author":"Orellano","year":"2017","journal-title":"PLoS One"},{"issue":"9928","key":"10.1016\/j.anai.2024.01.017_bib0030","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/S0140-6736(14)60617-6","article-title":"Outdoor air pollution and asthma","volume":"383","author":"Guarnieri","year":"2014","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.anai.2024.01.017_bib0031","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s11356-015-5321-x","article-title":"The impact of PM2.5 on asthma emergency department visits: a systematic review and meta-analysis","volume":"23","author":"Fan","year":"2016","journal-title":"Environ Sci Pollut Res Int"},{"issue":"9","key":"10.1016\/j.anai.2024.01.017_bib0032","doi-asserted-by":"crossref","first-page":"690","DOI":"10.4103\/ija.IJA_490_19","article-title":"Cardiovascular and respiratory physiology in children","volume":"63","author":"Saikia","year":"2019","journal-title":"Indian J Anaesth"},{"key":"10.1016\/j.anai.2024.01.017_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.115687","article-title":"A life course approach to asthma and wheezing among young children caused by ozone: a prospective birth cohort in northern China","volume":"226","author":"Bai","year":"2023","journal-title":"Environ Res"},{"issue":"8","key":"10.1016\/j.anai.2024.01.017_bib0034","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/15287394.2013.875497","article-title":"Cumulative PM(2.5) exposure and telomere length in workers exposed to welding fumes","volume":"77","author":"Wong","year":"2014","journal-title":"J Toxicol Environ Health A"},{"issue":"7","key":"10.1016\/j.anai.2024.01.017_bib0035","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1289\/ehp.1509728","article-title":"Biomolecular markers within the core axis of aging and particulate air pollution exposure in the elderly: a cross-sectional study","volume":"124","author":"Pieters","year":"2016","journal-title":"Environ Health Perspect"},{"issue":"5","key":"10.1016\/j.anai.2024.01.017_bib0036","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1289\/ehp.1002486","article-title":"Effects of short-term exposure to inhalable particulate matter on telomere length, telomerase expression, and telomerase methylation in steel workers","volume":"119","author":"Dioni","year":"2011","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.anai.2024.01.017_bib0037","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.envint.2012.06.020","article-title":"Air pollution exposure and telomere length in highly exposed subjects in Beijing, China: a repeated-measure study","volume":"48","author":"Hou","year":"2012","journal-title":"Environ Int"},{"key":"10.1016\/j.anai.2024.01.017_bib0038","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.envpol.2018.09.130","article-title":"Air pollution and telomere length in adults: a systematic review and meta-analysis of observational studies","volume":"244","author":"Miri","year":"2019","journal-title":"Environ Pollut"},{"issue":"1","key":"10.1016\/j.anai.2024.01.017_bib0039","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1083\/jcb.201708092","article-title":"Senescence and aging: causes, consequences, and therapeutic avenues","volume":"217","author":"McHugh","year":"2018","journal-title":"J Cell Biol"},{"key":"10.1016\/j.anai.2024.01.017_bib0040","article-title":"Telomere length as a marker of biological age: state-of-the-art, open issues, and future perspectives","volume":"11","author":"Vaiserman","year":"2020","journal-title":"Front Genet"},{"issue":"3","key":"10.1016\/j.anai.2024.01.017_bib0041","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3390\/cancers12030558","article-title":"Telomeres and telomere length: a general overview","volume":"12","author":"Srinivas","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"6265","key":"10.1016\/j.anai.2024.01.017_bib0042","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1126\/science.aab3389","article-title":"Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection","volume":"350","author":"Blackburn","year":"2015","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.anai.2024.01.017_bib0043","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1513\/AnnalsATS.201212-115OC","article-title":"Adult-onset asthma becomes the dominant phenotype among women by age 40 years. the longitudinal CARDIA study","volume":"10","author":"Sood","year":"2013","journal-title":"Ann Am Thorac Soc"},{"issue":"1","key":"10.1016\/j.anai.2024.01.017_bib0044","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12890-019-1040-2","article-title":"Age-specific incidence of allergic and non-allergic asthma","volume":"20","author":"Pakkasela","year":"2020","journal-title":"BMC Pulm Med"},{"issue":"7","key":"10.1016\/j.anai.2024.01.017_bib0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133490","article-title":"Asthma is more severe in older adults","volume":"10","author":"Zein","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.anai.2024.01.017_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108550","article-title":"Association between long-term air pollution exposure and DNA methylation: the REGICOR study","volume":"176","author":"Sayols-Baixeras","year":"2019","journal-title":"Environ Res"},{"key":"10.1016\/j.anai.2024.01.017_bib0047","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fgene.2020.00171","article-title":"DNA methylation biomarkers in aging and age-related diseases","volume":"11","author":"Salameh","year":"2020","journal-title":"Front Genet"},{"issue":"2","key":"10.1016\/j.anai.2024.01.017_bib0048","doi-asserted-by":"crossref","DOI":"10.1093\/eep\/dvw006","article-title":"Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study","volume":"2","author":"Nwanaji-Enwerem","year":"2016","journal-title":"Environ Epigenet"},{"issue":"46","key":"10.1016\/j.anai.2024.01.017_bib0049","doi-asserted-by":"crossref","first-page":"74510","DOI":"10.18632\/oncotarget.12903","article-title":"Long-term exposure to air pollution is associated with biological aging","volume":"7","author":"Ward-Caviness","year":"2016","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/j.anai.2024.01.017_bib0050","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol"},{"key":"10.1016\/j.anai.2024.01.017_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107501","article-title":"Life-course exposure to air pollution and biological ageing in the Lothian Birth Cohort 1936","volume":"169","author":"Baranyi","year":"2022","journal-title":"Environ Int"},{"issue":"2","key":"10.1016\/j.anai.2024.01.017_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.opresp.2022.100229","article-title":"Impact of air pollution on asthma: a scoping review","volume":"5","author":"Bronte-Moreno","year":"2023","journal-title":"Open Respir Arch"},{"issue":"2","key":"10.1016\/j.anai.2024.01.017_bib0053","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/cea.12880","article-title":"Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications","volume":"47","author":"Robinson","year":"2017","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"10.1016\/j.anai.2024.01.017_bib0054","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nri3786","article-title":"Type 2 inflammation in asthma\u2013present in most, absent in many","volume":"15","author":"Fahy","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.anai.2024.01.017_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116452","article-title":"BC and 1,4NQ-BC up-regulate the cytokines and enhance IL-33 expression in LPS pretreatment of human bronchial epithelial cells\u2606","volume":"273","author":"Ge","year":"2021","journal-title":"Environ Pollut"},{"issue":"12","key":"10.1016\/j.anai.2024.01.017_bib0056","first-page":"2907","article-title":"Effect of PM2.5 mediated oxidative stress on the innate immune cellular response of Der p1 treated human bronchial epithelial cells","volume":"21","author":"Bao","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.anai.2024.01.017_bib0057","article-title":"IL-33 upregulate myeloid DC maturation induced by diesel-exhaust particle treated human bronchial epithelial cells","volume":"183","author":"Bleck","year":"2011","journal-title":"Am J Respir Crit Care"},{"issue":"2","key":"10.1016\/j.anai.2024.01.017_bib0058","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10875-007-9149-0","article-title":"Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation and polarization via thymic stromal lymphopoietin","volume":"28","author":"Bleck","year":"2008","journal-title":"J Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2024.01.017_bib0059","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jaci.2021.05.033","article-title":"TSLP disease-associated genetic variants combined with airway TSLP expression influence asthma risk","volume":"149","author":"Murrison","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2024.01.017_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107847","article-title":"The central role of IL-33\/IL-1RL1 pathway in asthma: from pathogenesis to intervention","volume":"225","author":"Saikumar Jayalatha","year":"2021","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.anai.2024.01.017_bib0061","doi-asserted-by":"crossref","DOI":"10.3389\/falgy.2021.738741","article-title":"Translational analysis of moderate to severe asthma GWAS signals into candidate causal genes and their functional, tissue-dependent and disease-related associations","volume":"2","author":"Portelli","year":"2021","journal-title":"Front Allergy"},{"issue":"1","key":"10.1016\/j.anai.2024.01.017_bib0062","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13601-020-00347-6","article-title":"Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa","volume":"10","author":"Laulajainen-Hongisto","year":"2020","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.anai.2024.01.017_bib0063","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.2147\/COPD.S270762","article-title":"PM2.5 induces the expression of inflammatory cytokines via the Wnt5a\/Ror2 pathway in human bronchial epithelial cells","volume":"15","author":"Zou","year":"2020","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"6","key":"10.1016\/j.anai.2024.01.017_bib0064","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3390\/antiox12061189","article-title":"Exogenous 8-hydroxydeoxyguanosine attenuates PM2.5-induced inflammation in human bronchial epithelial cells by decreasing NLRP3 inflammasome activation","volume":"12","author":"Bang","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"8","key":"10.1016\/j.anai.2024.01.017_bib0065","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/tox.22102","article-title":"Pro-inflammatory response and oxidative stress induced by specific components in ambient particulate matter in human bronchial epithelial cells","volume":"31","author":"Yang","year":"2016","journal-title":"Environ Toxicol"},{"issue":"8","key":"10.1016\/j.anai.2024.01.017_bib0066","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1084\/jem.20112691","article-title":"Interleukin-1\u03b1 controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33","volume":"209","author":"Willart","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.anai.2024.01.017_bib0067","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/567351","article-title":"Type I IL-1 receptor (IL-1RI) as potential new therapeutic target for bronchial asthma","volume":"2010","author":"Lee","year":"2010","journal-title":"Mediators Inflamm"},{"issue":"5","key":"10.1016\/j.anai.2024.01.017_bib0068","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"Schmitz","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.anai.2024.01.017_bib0069","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/487074","article-title":"Oxidative stress and air pollution exposure","volume":"2011","author":"Lodovici","year":"2011","journal-title":"J Toxicol"},{"issue":"10","key":"10.1016\/j.anai.2024.01.017_bib0070","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1111\/all.13158","article-title":"Oxidative stress serves as a key checkpoint for IL-33 release by airway epithelium","volume":"72","author":"Uchida","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2024.01.017_bib0071","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct Target Ther"},{"issue":"11","key":"10.1016\/j.anai.2024.01.017_bib0072","doi-asserted-by":"crossref","first-page":"4398","DOI":"10.21037\/jtd.2017.09.135","article-title":"Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-\u03baB signaling pathway","volume":"9","author":"Wang","year":"2017","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.anai.2024.01.017_bib0073","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.coi.2020.10.002","article-title":"Mechanisms of non-type 2 asthma","volume":"66","author":"Hudey","year":"2020","journal-title":"Curr Opin Immunol"},{"issue":"8","key":"10.1016\/j.anai.2024.01.017_bib0074","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1172\/JCI80911","article-title":"High IFN-\u03b3 and low SLPI mark severe asthma in mice and humans","volume":"125","author":"Raundhal","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/j.anai.2024.01.017_bib0075","doi-asserted-by":"crossref","first-page":"18680","DOI":"10.1038\/srep18680","article-title":"Ozone-induced IL-17A and neutrophilic airway inflammation is orchestrated by the caspase-1-IL-1 cascade","volume":"6","author":"Che","year":"2016","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/j.anai.2024.01.017_bib0076","first-page":"5808","article-title":"Antagonism of interleukin 17 protects chronic obstructive pulmonary disease rat lungs from adverse effects of environmental PM2.5","volume":"12","author":"Li","year":"2020","journal-title":"Am J Transl Res"},{"issue":"15","key":"10.1016\/j.anai.2024.01.017_bib0077","doi-asserted-by":"crossref","first-page":"8532","DOI":"10.1111\/jcmm.15475","article-title":"IL-17A-producing T cells exacerbate fine particulate matter-induced lung inflammation and fibrosis by inhibiting PI3K\/Akt\/mTOR-mediated autophagy","volume":"24","author":"Cong","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.anai.2024.01.017_bib0078","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110254","article-title":"PM2.5 exposure regulates Th1\/Th2\/Th17 cytokine production through NF-\u03baB signaling in combined allergic rhinitis and asthma syndrome","volume":"119","author":"Piao","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.anai.2024.01.017_bib0079","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13148-017-0433-4","article-title":"Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma","volume":"10","author":"Prunicki","year":"2018","journal-title":"Clin Epigenetics"},{"issue":"1","key":"10.1016\/j.anai.2024.01.017_bib0080","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jaci.2019.10.008","article-title":"Particulate matter of 2.5 \u03bcm or less in diameter disturbs the balance of TH17\/regulatory T cells by targeting glutamate oxaloacetate transaminase 1 and hypoxia-inducible factor 1\u03b1 in an asthma model","volume":"145","author":"Sun","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2024.01.017_bib0081","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107788","article-title":"Traffic-related PM2.5 and diverse constituents disturb the balance of Th17\/Treg cells by STAT3\/ROR\u03b3t-STAT5\/Foxp3 signaling pathway in a rat model of asthma","volume":"96","author":"Wang","year":"2021","journal-title":"Int Immunopharmacol"},{"issue":"Pt B","key":"10.1016\/j.anai.2024.01.017_bib0082","article-title":"Integrated analysis of ATAC-seq and RNA-seq unveils the role of ferroptosis in PM2.5-induced asthma exacerbation","volume":"125","author":"Zhang","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.anai.2024.01.017_bib0083","article-title":"Ferroptosis: a critical moderator in the life cycle of immune cells","volume":"13","author":"Wang","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.anai.2024.01.017_bib0084","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.alit.2017.08.011","article-title":"Role of airway epithelial barrier dysfunction in pathogenesis of asthma","volume":"67","author":"Gon","year":"2018","journal-title":"Allergol Int"},{"issue":"11","key":"10.1016\/j.anai.2024.01.017_bib0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206251","article-title":"Role of truncated oxidized phospholipids in acute endothelial barrier dysfunction caused by particulate matter","volume":"13","author":"Karki","year":"2018","journal-title":"PLoS One"},{"issue":"7152","key":"10.1016\/j.anai.2024.01.017_bib0086","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature06014","article-title":"Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma","volume":"448","author":"Moffatt","year":"2007","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.anai.2024.01.017_bib0087","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","article-title":"A large-scale, consortium-based genomewide association study of asthma","volume":"363","author":"Moffatt","year":"2010","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.anai.2024.01.017_bib0088","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ejhg.2010.191","article-title":"Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia","volume":"19","author":"Ferreira","year":"2011","journal-title":"Eur J Hum Genet"},{"issue":"8","key":"10.1016\/j.anai.2024.01.017_bib0089","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.4049\/jimmunol.1303047","article-title":"ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma","volume":"192","author":"Miller","year":"2014","journal-title":"J Immunol"},{"issue":"10","key":"10.1016\/j.anai.2024.01.017_bib0090","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1164\/rccm.200810-1621OC","article-title":"Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness","volume":"180","author":"Koppelman","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.anai.2024.01.017_bib0091","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/ng.2830","article-title":"A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations","volume":"46","author":"B\u00f8nnelykke","year":"2014","journal-title":"Nat Genet"},{"issue":"10","key":"10.1016\/j.anai.2024.01.017_bib0092","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1111\/all.12683","article-title":"eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes","volume":"70","author":"Li","year":"2015","journal-title":"Allergy"},{"issue":"4","key":"10.1016\/j.anai.2024.01.017_bib0093","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1165\/rcmb.2018-0220OC","article-title":"CDHR3 asthma-risk genotype affects susceptibility of airway epithelium to rhinovirus C infections","volume":"61","author":"Basnet","year":"2019","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"6","key":"10.1016\/j.anai.2024.01.017_bib0094","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-6-research0027","article-title":"ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins","volume":"3","author":"Hjelmqvist","year":"2002","journal-title":"Genome Biol"},{"issue":"2","key":"10.1016\/j.anai.2024.01.017_bib0095","first-page":"535","article-title":"Investigating the regulatory role of ORMDL3 in airway barrier dysfunction using in vivo and in vitro models","volume":"44","author":"Yang","year":"2019","journal-title":"Int J Mol Med"},{"issue":"1","key":"10.1016\/j.anai.2024.01.017_bib0096","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1096\/fj.11-185207","article-title":"Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation","volume":"26","author":"Koning","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.anai.2024.01.017_bib0097","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12890-015-0078-z","article-title":"Protocadherin-1 is a glucocorticoid-responsive critical regulator of airway epithelial barrier function","volume":"15","author":"Kozu","year":"2015","journal-title":"BMC Pulm Med"},{"issue":"6","key":"10.1016\/j.anai.2024.01.017_bib0098","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.jaci.2020.04.010","article-title":"Epithelial barriers in allergy and asthma","volume":"145","author":"Hellings","year":"2020","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.anai.2024.01.017_bib0099","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jaci.2019.01.052","article-title":"Functional genomics of CDHR3 confirms its role in HRV-C infection and childhood asthma exacerbations","volume":"144","author":"Everman","year":"2019","journal-title":"J Allergy Clin Immunol"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120624000188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120624000188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T03:46:30Z","timestamp":1729050390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120624000188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":99,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1081120624000188"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2024.01.017","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of air pollution on asthma","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2024.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}