{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:12:37Z","timestamp":1793725957005,"version":"4.6.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100014807","name":"Nagoya University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","annallergy.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.anai.2024.07.001","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T02:31:28Z","timestamp":1720233088000},"page":"550-558.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy of dupilumab for severe chronic rhinosinusitis with nasal polyps and asthma"],"prefix":"10.1016","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4646-5378","authenticated-orcid":false,"given":"Tomoko","family":"Tajiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirono","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keima","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Fukumitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kanemitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotsugu","family":"Ohkubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Takemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Maeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Oguri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Niimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.anai.2024.07.001_bib0001","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.alit.2020.01.002","article-title":"Dupilumab: basic aspects and applications to allergic diseases","volume":"69","author":"Matsunaga","year":"2020","journal-title":"Allergol Int"},{"issue":"10209","key":"10.1016\/j.anai.2024.07.001_bib0002","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0140-6736(19)31881-1","article-title":"Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials","volume":"394","author":"Bachert","year":"2019","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.anai.2024.07.001_bib0003","doi-asserted-by":"crossref","first-page":"E1770","DOI":"10.1002\/lary.29230","article-title":"The effect of dupilumab on intractable chronic rhinosinusitis with nasal polyps in Japan","volume":"131","author":"Fujieda","year":"2021","journal-title":"Laryngoscope"},{"issue":"10","key":"10.1016\/j.anai.2024.07.001_bib0004","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1111\/all.15772","article-title":"Dupilumab in the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP): a multicentric observational Phase IV real-life study (DUPIREAL)","volume":"78","author":"De Corso","year":"2023","journal-title":"Allergy"},{"issue":"9","key":"10.1016\/j.anai.2024.07.001_bib0005","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.3390\/jpm12091526","article-title":"Effectiveness of dupilumab in the treatment of patients with uncontrolled severe CRSwNP: a \u201creal-life\u201d observational study in na\u00efve and post-surgical patients","volume":"12","author":"Ottaviano","year":"2022","journal-title":"J Pers Med"},{"issue":"4","key":"10.1016\/j.anai.2024.07.001_bib0006","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3390\/ph16040630","article-title":"Effectiveness and safety profile of dupilumab in chronic rhinosinusitis with nasal polyps: real-life data in tertiary care","volume":"16","author":"Galletti","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"10.1016\/j.anai.2024.07.001_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjoto.2023.104106","article-title":"Dupilumab in chronic rhinosinusitis with nasal polyps: real life data in a multicentric Sicilian experience","volume":"45","author":"Galletti","year":"2024","journal-title":"Am J Otolaryngol"},{"issue":"2","key":"10.1016\/j.anai.2024.07.001_bib0008","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/all.12778","article-title":"Measurements of nasal airflow and patency: a critical review with emphasis on the use of peak nasal inspiratory flow in daily practice","volume":"71","author":"Ottaviano","year":"2016","journal-title":"Allergy"},{"issue":"5","key":"10.1016\/j.anai.2024.07.001_bib0009","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.anai.2021.01.012","article-title":"Dupilumab improves upper and lower airway disease control in chronic rhinosinusitis with nasal polyps and asthma","volume":"126","author":"Laidlaw","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.1016\/j.anai.2024.07.001_bib0010","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jaip.2019.07.016","article-title":"Dupilumab efficacy in uncontrolled, moderate-to-severe asthma with self-reported chronic rhinosinusitis","volume":"8","author":"Maspero","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"2","key":"10.1016\/j.anai.2024.07.001_bib0011","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.anai.2022.11.006","article-title":"Long-term efficacy of dupilumab in asthma with or without chronic rhinosinusitis and nasal polyps","volume":"130","author":"Berger","year":"2023","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2024.07.001_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/JAA.S420140","article-title":"Dupilumab reduces asthma disease burden and recurrent SCS use in patients with CRSwNP and coexisting asthma","volume":"17","author":"Gurnell","year":"2024","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.anai.2024.07.001_bib0013","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2147\/JAA.S328988","article-title":"Short-term evaluation of dupilumab effects in patients with severe asthma and nasal polyposis","volume":"14","author":"Pelaia","year":"2021","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.anai.2024.07.001_bib0014","doi-asserted-by":"crossref","unstructured":"Garvey E, Naimi B, Duffy A, Kahn C, Farquhar D, Rosen M, et al. Medication utilization for patients with chronic rhinosinusitis with nasal polyposis and asthma in 12 months pre- and post-dupilumab initiation [e-pub ahead of print]. Int Forum Allergy Rhinol. https:\/\/doi.org\/10.1002\/alr.23340, accessed February 26, 2024.","DOI":"10.1002\/alr.23340"},{"issue":"2","key":"10.1016\/j.anai.2024.07.001_bib0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.otc.2023.08.006","article-title":"Current and novel biologic therapies for patients with asthma and nasal polyps","volume":"57","author":"Mandl","year":"2024","journal-title":"Otolaryngol Clin North Am"},{"issue":"suppl S29","key":"10.1016\/j.anai.2024.07.001_bib0016","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"issue":"3","key":"10.1016\/j.anai.2024.07.001_bib0017","first-page":"287","article-title":"EPOS2020\/EUFOREA expert opinion on defining disease states and therapeutic goals in CRSwNP","volume":"62","author":"Fokkens","year":"2024","journal-title":"Rhinology"},{"key":"10.1016\/j.anai.2024.07.001_bib0018","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2147\/JAA.S391896","article-title":"Dupilumab improves outcomes in patients with chronic rhinosinusitis with nasal polyps and coexisting asthma irrespective of baseline asthma characteristics","volume":"16","author":"Busse","year":"2023","journal-title":"J Asthma Allergy"},{"issue":"4","key":"10.1016\/j.anai.2024.07.001_bib0019","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jaip.2021.09.037","article-title":"Olfactory outcomes with dupilumab in chronic rhinosinusitis with nasal polyps","volume":"10","author":"Mullol","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"5","key":"10.1016\/j.anai.2024.07.001_bib0020","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.anl.2019.04.002","article-title":"Clinical practice guidelines for the management of olfactory dysfunction - Secondary publication","volume":"46","author":"Miwa","year":"2019","journal-title":"Auris Nasus Larynx"},{"issue":"1","key":"10.1016\/j.anai.2024.07.001_bib0021","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1164\/rccm.202109-2205PP","article-title":"Global initiative for asthma strategy 2021: executive summary and rationale for key changes","volume":"205","author":"Reddel","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.anai.2024.07.001_bib0022","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.alit.2024.02.002","article-title":"Efficacy of dupilumab for airway hypersecretion and airway wall thickening in patients with moderate-to-severe asthma: a prospective, observational study","volume":"73","author":"Tajiri","year":"2024","journal-title":"Allergol Int"},{"issue":"5","key":"10.1016\/j.anai.2024.07.001_bib0023","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2500\/105065898780182390","article-title":"A study of the relationship between the T&T olfactometer and the University of Pennsylvania Smell Identification Test in a Japanese population","volume":"12","author":"Kondo","year":"1998","journal-title":"Am J Rhinol"},{"issue":"6","key":"10.1016\/j.anai.2024.07.001_bib0024","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1177\/000348941212100609","article-title":"Evaluation of card-type odor identification test for Japanese patients with olfactory disturbance","volume":"121","author":"Fujio","year":"2012","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"4","key":"10.1016\/j.anai.2024.07.001_bib0025","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund","year":"1993","journal-title":"Rhinology"},{"issue":"3","key":"10.1016\/j.anai.2024.07.001_bib0026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0283070","article-title":"The relationship between adherence to continuous positive airway pressure and nasal resistance measured by rhinomanometry in patients with obstructive sleep apnea syndrome","volume":"18","author":"Fujito","year":"2023","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.anai.2024.07.001_bib0027","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1183\/09031936.05.00034505","article-title":"General considerations for lung function testing","volume":"26","author":"Miller","year":"2005","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.anai.2024.07.001_bib0028","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1749-4486.2009.01995.x","article-title":"Psychometric validity of the 22-item sinonasal Outcome Test","volume":"34","author":"Hopkins","year":"2009","journal-title":"Clin Otolaryngol"},{"issue":"5","key":"10.1016\/j.anai.2024.07.001_bib0029","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/lary.29766","article-title":"Development of sinonasal outcome test (SNOT-22) domains in chronic rhinosinusitis with nasal polyps","volume":"132","author":"Khan","year":"2022","journal-title":"Laryngoscope"},{"issue":"4","key":"10.1016\/j.anai.2024.07.001_bib0030","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1034\/j.1399-3003.1999.14d29.x","article-title":"Development and validation of a questionnaire to measure asthma control","volume":"14","author":"Juniper","year":"1999","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1016\/j.anai.2024.07.001_bib0031","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.rmed.2005.08.012","article-title":"Identifying \u2018well-controlled\u2019 and \u2018not well-controlled\u2019 asthma using the Asthma Control Questionnaire","volume":"100","author":"Juniper","year":"2006","journal-title":"Respir Med"},{"issue":"8","key":"10.1016\/j.anai.2024.07.001_bib0032","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3390\/jpm13081241","article-title":"Effectiveness of dupilumab in the treatment of adult and older adult patients with severe, uncontrolled CRSwNP","volume":"13","author":"Ottaviano","year":"2023","journal-title":"J Pers Med"},{"issue":"1","key":"10.1016\/j.anai.2024.07.001_bib0033","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/19458924231204128","article-title":"Long-term efficacy of dupilumab for eosinophilic chronic rhinosinusitis","volume":"38","author":"Tsunemi","year":"2024","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.anai.2024.07.001_bib0034","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1356298","article-title":"The interleukin-4\/interleukin-13 pathway in type 2 inflammation in chronic rhinosinusitis with nasal polyps","volume":"15","author":"Bachert","year":"2024","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.anai.2024.07.001_bib0035","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/lio2.485","article-title":"Olfaction: sensitive indicator of inflammatory burden in chronic rhinosinusitis","volume":"5","author":"Yan","year":"2020","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"3","key":"10.1016\/j.anai.2024.07.001_bib0036","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/all.13559","article-title":"Type 2\/Th2-driven inflammation impairs olfactory sensory neurogenesis in mouse chronic rhinosinusitis model","volume":"74","author":"Rouyar","year":"2019","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.anai.2024.07.001_bib0037","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1177\/0194599817696294","article-title":"Association between nasal obstruction and risk of depression in chronic rhinosinusitis","volume":"157","author":"Phillips","year":"2017","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"3","key":"10.1016\/j.anai.2024.07.001_bib0038","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jaip.2020.09.063","article-title":"Chronic rhinosinusitis with nasal polyps and asthma","volume":"9","author":"Laidlaw","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"10","key":"10.1016\/j.anai.2024.07.001_bib0039","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/alr.21182","article-title":"A systematic review and meta-analysis of asthma outcomes following endoscopic sinus surgery for chronic rhinosinusitis","volume":"3","author":"Vashishta","year":"2013","journal-title":"Int Forum Allergy Rhinol"},{"issue":"2","key":"10.1016\/j.anai.2024.07.001_bib0040","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.alit.2019.12.001","article-title":"Effect of endoscopic sinus surgery for chronic rhinosinusitis on the state of coexisting asthma","volume":"69","author":"Tajiri","year":"2020","journal-title":"Allergol Int"},{"issue":"1","key":"10.1016\/j.anai.2024.07.001_bib0041","article-title":"The effect of biologics in lung function and quality of life of patients with united airways disease: a systematic review","volume":"3","author":"Dom\u00ednguez-Ortega","year":"2024","journal-title":"J Allergy Clin Immunol Glob"},{"issue":"1","key":"10.1016\/j.anai.2024.07.001_bib0042","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaci.2020.11.013","article-title":"EUFOREA expert board meeting on uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) and biologics: definitions and management","volume":"147","author":"Bachert","year":"2021","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2024.07.001_bib0043","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/all.14906","article-title":"Dupilumab efficacy in chronic rhinosinusitis with nasal polyps from SINUS-52 is unaffected by eosinophilic status","volume":"77","author":"Fujieda","year":"2022","journal-title":"Allergy"},{"issue":"4","key":"10.1016\/j.anai.2024.07.001_bib0044","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2500\/aap.2023.44.230015","article-title":"Dupilumab efficacy in patients with chronic rhinosinusitis with nasal polyps with and without allergic rhinitis","volume":"44","author":"Peters","year":"2023","journal-title":"Allergy Asthma Proc"},{"issue":"4","key":"10.1016\/j.anai.2024.07.001_bib0045","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/all.15067","article-title":"Efficacy and safety of dupilumab in patients with uncontrolled severe chronic rhinosinusitis with nasal polyps and a clinical diagnosis of NSAID-ERD: results from two randomized placebo-controlled phase 3 trials","volume":"77","author":"Mullol","year":"2022","journal-title":"Allergy"},{"issue":"3","key":"10.1016\/j.anai.2024.07.001_bib0046","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/alr.23249","article-title":"Prevalence of type 2 inflammatory signatures and efficacy of dupilumab in patients with chronic rhinosinusitis with nasal polyps from two phase 3 clinical trials: SINUS-24 and SINUS-52","volume":"14","author":"Bachert","year":"2024","journal-title":"Int Forum Allergy Rhinol"},{"issue":"4","key":"10.1016\/j.anai.2024.07.001_bib0047","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.4110\/in.2022.22.e35","article-title":"Tobacco smoking could accentuate epithelial-mesenchymal transition and Th2-type response in patients with chronic rhinosinusitis with nasal polyps","volume":"22","author":"Lee","year":"2022","journal-title":"Immune Netw"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120624004228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120624004228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T16:07:05Z","timestamp":1732378025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120624004228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S1081120624004228"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2024.07.001","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of dupilumab for severe chronic rhinosinusitis with nasal polyps and asthma","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2024.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}