{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:33:06Z","timestamp":1786984386334,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["T32 AR059039"],"award-info":[{"award-number":["T32 AR059039"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011395","name":"Massachusetts Medical Society","doi-asserted-by":"publisher","award":["T32 AR059039"],"award-info":[{"award-number":["T32 AR059039"]}],"id":[{"id":"10.13039\/100011395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011395","name":"Massachusetts Medical Society","doi-asserted-by":"publisher","award":["U01 AI155299"],"award-info":[{"award-number":["U01 AI155299"]}],"id":[{"id":"10.13039\/100011395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011395","name":"Massachusetts Medical Society","doi-asserted-by":"publisher","award":["K12 HD043483"],"award-info":[{"award-number":["K12 HD043483"]}],"id":[{"id":"10.13039\/100011395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011395","name":"Massachusetts Medical Society","doi-asserted-by":"publisher","award":["K23 AI118804"],"award-info":[{"award-number":["K23 AI118804"]}],"id":[{"id":"10.13039\/100011395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01 AI155299"],"award-info":[{"award-number":["U01 AI155299"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["17SFRN33520017"],"award-info":[{"award-number":["17SFRN33520017"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["K12 HD043483"],"award-info":[{"award-number":["K12 HD043483"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["K23 AI118804"],"award-info":[{"award-number":["K23 AI118804"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013017","name":"Vanderbilt University Medical Center","doi-asserted-by":"publisher","award":["UL1TR000445"],"award-info":[{"award-number":["UL1TR000445"]}],"id":[{"id":"10.13039\/100013017","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","annallergy.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.anai.2024.09.005","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T17:32:50Z","timestamp":1726594370000},"page":"660-666.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of metabolic and weight components on incident asthma using a real-world cohort"],"prefix":"10.1016","volume":"133","author":[{"given":"Melissa H.","family":"Bloodworth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Staso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Farber-Eger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Niswender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Frank E.","family":"Harrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinn S.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard B.","family":"Bacharier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Shuey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8549-1835","authenticated-orcid":false,"given":"Katherine N.","family":"Cahill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.anai.2024.09.005_bib0001","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.jaci.2013.10.006","article-title":"Phenotypes determined by cluster analysis in severe or difficult-to-treat asthma","volume":"133","author":"Schatz","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"239","key":"10.1016\/j.anai.2024.09.005_bib0002","first-page":"1","article-title":"Current asthma prevalence by weight status among adults: United States, 2001-2014","author":"Akinbami","year":"2016","journal-title":"NCHS Data Brief"},{"issue":"25","key":"10.1016\/j.anai.2024.09.005_bib0003","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1056\/NEJMsa1909301","article-title":"Projected U.S. State-Level prevalence of adult obesity and severe obesity","volume":"381","author":"Ward","year":"2019","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.anai.2024.09.005_bib0004","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1164\/rccm.200611-1717OC","article-title":"Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies","volume":"175","author":"Beuther","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.anai.2024.09.005_bib0005","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.jaci.2011.03.036","article-title":"Obesity and asthma: an association modified by age of asthma onset","volume":"127","author":"Holguin","year":"2011","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.anai.2024.09.005_bib0006","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.jaci.2009.04.005","article-title":"National heart L, blood institute's Asthma Clinical Research N. Body mass index and phenotype in subjects with mild-to-moderate persistent asthma","volume":"123","author":"Sutherland","year":"2009","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.anai.2024.09.005_bib0007","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/oby.2007.75","article-title":"BMI vs. waist circumference for identifying vascular risk","volume":"16","author":"Freiberg","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.anai.2024.09.005_bib0008","first-page":"46","article-title":"Effect of diuretic use on the development of diabetes mellitus. The Framingham study","volume":"22","author":"Donahue","year":"1990","journal-title":"Horm Metab Res Suppl"},{"issue":"6","key":"10.1016\/j.anai.2024.09.005_bib0009","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/j.jaip.2019.02.029","article-title":"Association between prediabetes\/diabetes and asthma exacerbations in a claims-based obese asthma cohort","volume":"7","author":"Wu","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"2","key":"10.1016\/j.anai.2024.09.005_bib0010","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1164\/rccm.201409-1587OC","article-title":"Inflammation, metabolic dysregulation, and pulmonary function among obese urban adolescents with asthma","volume":"191","author":"Rastogi","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2024.09.005_bib0011","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.rmed.2017.03.003","article-title":"Association of systemic inflammation, adiposity, and metabolic dysregulation with asthma burden among Hispanic adults","volume":"125","author":"Rastogi","year":"2017","journal-title":"Respir Med"},{"issue":"5","key":"10.1016\/j.anai.2024.09.005_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2009.08.005","article-title":"Novel relationship of serum cholesterol with asthma and wheeze in the United States","volume":"124","author":"Fessler","year":"2009","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2024.09.005_bib0013","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ccm.2018.10.007","article-title":"Diet and metabolism in the evolution of asthma and obesity","volume":"40","author":"Dixon","year":"2019","journal-title":"Clin Chest Med"},{"issue":"4","key":"10.1016\/j.anai.2024.09.005_bib0014","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jaci.2020.08.011","article-title":"Obesity and asthma","volume":"146","author":"Miethe","year":"2020","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.anai.2024.09.005_bib0015","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1183\/09031936.00046013","article-title":"Metabolic syndrome and incidence of asthma in adults: the HUNT study","volume":"42","author":"Brumpton","year":"2013","journal-title":"Eur Respir J"},{"issue":"3","key":"10.1016\/j.anai.2024.09.005_bib0016","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1164\/rccm.201303-0457OC","article-title":"Body mass index is a stronger predictor than the metabolic syndrome for future asthma in women. The longitudinal CARDIA study","volume":"188","author":"Assad","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2024.09.005_bib0017","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jbi.2014.02.003","article-title":"Secondary use of clinical data: the Vanderbilt approach","volume":"52","author":"Danciu","year":"2014","journal-title":"J Biomed Inform"},{"issue":"3","key":"10.1016\/j.anai.2024.09.005_bib0018","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/clpt.2008.89","article-title":"Development of a large scale de-identified DNA biobank to enable personalized medicine","volume":"84","author":"Roden","year":"2008","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.anai.2024.09.005_bib0019","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/osp4.543","article-title":"Exploration of an alternative to body mass index to characterize the relationship between height and weight for prediction of metabolic phenotypes and cardiovascular outcomes","volume":"8","author":"Shuey","year":"2022","journal-title":"Obes Sci Pract"},{"issue":"1","key":"10.1016\/j.anai.2024.09.005_bib0020","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13073-020-00820-8","article-title":"Clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of complex disease","volume":"13","author":"Dennis","year":"2021","journal-title":"Genome Med"},{"key":"10.1016\/j.anai.2024.09.005_bib0021","first-page":"112","article-title":"Creation and validation of an EMR-based algorithm for identifying major adverse cardiac events while on statins","volume":"2014","author":"Wei","year":"2014","journal-title":"AMIA Jt Summits Transl Sci Proc"},{"key":"10.1016\/j.anai.2024.09.005_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104674","article-title":"A genetically supported drug repurposing pipeline for diabetes treatment using electronic health records","volume":"94","author":"Shuey","year":"2023","journal-title":"EBiomedicine"},{"issue":"19","key":"10.1016\/j.anai.2024.09.005_bib0023","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1001\/jama.2013.280521","article-title":"Effect of weight reduction and cardiometabolic risk factor management on symptom burden and severity in patients with atrial fibrillation: a randomized clinical trial","volume":"310","author":"Abed","year":"2013","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.anai.2024.09.005_bib0024","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1183\/13993003.00246-2016","article-title":"Insulin resistance modifies the association between obesity and current asthma in adults","volume":"48","author":"Cardet","year":"2016","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.anai.2024.09.005_bib0025","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/crj.13011","article-title":"The impact of therapy on the risk of asthma in type 2 diabetes","volume":"13","author":"Rayner","year":"2019","journal-title":"Clin Respir J"},{"issue":"13","key":"10.1016\/j.anai.2024.09.005_bib0026","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.3390\/ijerph19138211","article-title":"Metformin and the development of asthma in patients with type 2 diabetes","volume":"19","author":"Yen","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"7","key":"10.1016\/j.anai.2024.09.005_bib0027","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/resp.12818","article-title":"Metformin use and asthma outcomes among patients with concurrent asthma and diabetes","volume":"21","author":"Li","year":"2016","journal-title":"Respirology"},{"issue":"1","key":"10.1016\/j.anai.2024.09.005_bib0028","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12931-021-01658-3","article-title":"Metformin use and respiratory outcomes in asthma-COPD overlap","volume":"22","author":"Wu","year":"2021","journal-title":"Respir Res"},{"issue":"12","key":"10.1016\/j.anai.2024.09.005_bib0029","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1513\/AnnalsATS.201812-897OC","article-title":"Association of metformin initiation and risk of asthma exacerbation. A claims-based cohort study","volume":"16","author":"Wu","year":"2019","journal-title":"Ann Am Thorac Soc"},{"issue":"7","key":"10.1016\/j.anai.2024.09.005_bib0030","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/resp.13486","article-title":"Reduced mortality from lower respiratory tract disease in adult diabetic patients treated with metformin","volume":"24","author":"Mendy","year":"2019","journal-title":"Respirology"},{"issue":"3","key":"10.1016\/j.anai.2024.09.005_bib0031","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1183\/09031936.00073312","article-title":"Smoking and asthma: dangerous liaisons","volume":"41","author":"Polosa","year":"2013","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.anai.2024.09.005_bib0032","article-title":"Association between tobacco product use and asthma among US adults from the Population Assessment of Tobacco and Health (PATH) Study waves 2-4","volume":"10","author":"Brunette","year":"2023","journal-title":"BMJ Open Respir Res"},{"issue":"1","key":"10.1016\/j.anai.2024.09.005_bib0033","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/amiajnl-2014-002649","article-title":"Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality","volume":"22","author":"Xu","year":"2015","journal-title":"J Am Med Inform Assoc"},{"issue":"3","key":"10.1016\/j.anai.2024.09.005_bib0034","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1001\/jama.2016.19627","article-title":"Reevaluation of diagnosis in adults with physician-diagnosed asthma","volume":"317","author":"Aaron","year":"2017","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.anai.2024.09.005_bib0035","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1503\/cmaj.081332","article-title":"Overdiagnosis of asthma in obese and nonobese adults","volume":"179","author":"Aaron","year":"2008","journal-title":"CMAJ"},{"issue":"2","key":"10.1016\/j.anai.2024.09.005_bib0036","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.chest.2020.03.052","article-title":"Performance characteristics of spirometry with negative bronchodilator response and methacholine challenge testing and implications for asthma diagnosis","volume":"158","author":"Selvanathan","year":"2020","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.anai.2024.09.005_bib0037","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0002-9343(03)00007-X","article-title":"Attitudes of physicians toward objective measures of airway function in asthma","volume":"114","author":"O'Dowd","year":"2003","journal-title":"Am J Med"},{"issue":"650","key":"10.1016\/j.anai.2024.09.005_bib0038","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3399\/bjgp16X686953","article-title":"Is spirometry essential in diagnosing asthma? Yes","volume":"66","author":"Akker","year":"2016","journal-title":"Br J Gen Pract"},{"issue":"650","key":"10.1016\/j.anai.2024.09.005_bib0039","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3399\/bjgp16X686965","article-title":"Is spirometry essential in diagnosing asthma? No","volume":"66","author":"Levy","year":"2016","journal-title":"Br J Gen Pract"},{"issue":"6","key":"10.1016\/j.anai.2024.09.005_bib0040","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.anai.2022.03.025","article-title":"Comparison and validation of algorithms for asthma diagnosis in an electronic medical record system","volume":"128","author":"Howell","year":"2022","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"4","key":"10.1016\/j.anai.2024.09.005_bib0041","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1161\/01.CIR.0000136587.68725.8E","article-title":"Association of atrial fibrillation and obstructive sleep apnea","volume":"110","author":"Gami","year":"2004","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.anai.2024.09.005_bib0042","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/CIRCOUTCOMES.110.957951","article-title":"Landmark analysis at the 25-year landmark point","volume":"4","author":"Dafni","year":"2011","journal-title":"Circ Cardiovasc Qual Outcomes"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120624015096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120624015096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:58:27Z","timestamp":1733054307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120624015096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S1081120624015096"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2024.09.005","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of metabolic and weight components on incident asthma using a real-world cohort","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2024.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}