{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:16:54Z","timestamp":1791605814517,"version":"4.3.4"},"reference-count":15,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031004","name":"KalVista Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031004","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031825","name":"US Hereditary Angioedema Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.anai.2024.12.012","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T15:00:24Z","timestamp":1734361224000},"page":"570-579.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["On-demand treatment of hereditary angioedema attacks"],"prefix":"10.1016","volume":"134","author":[{"given":"Sandra","family":"Christiansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeve","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristine","family":"Radojicic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. James","family":"Wedner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry","family":"Danese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Ulloa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibha","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Utter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Andriotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Audhya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Busse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.anai.2024.12.012_bib0001","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1808012","article-title":"Hereditary angioedema","volume":"382","author":"Busse","year":"2020","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.anai.2024.12.012_bib0002","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2500\/aap.2015.36.3831","article-title":"Before and after, the impact of available on-demand treatment for HAE","volume":"36","author":"Christiansen","year":"2015","journal-title":"Allergy Asthma Proc"},{"issue":"5","key":"10.1016\/j.anai.2024.12.012_bib0003","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2500\/aap.2010.31.3394","article-title":"The humanistic burden of hereditary angioedema: impact on health-related quality of life, productivity, and depression","volume":"31","author":"Lumry","year":"2010","journal-title":"Allergy Asthma Proc"},{"issue":"4","key":"10.1016\/j.anai.2024.12.012_bib0004","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.anai.2013.05.028","article-title":"Depression and anxiety in patients with hereditary angioedema","volume":"112","author":"Fouche","year":"2014","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"10.1016\/j.anai.2024.12.012_bib0005","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2500\/aap.2013.34.3685","article-title":"The humanistic burden of hereditary angioedema: results from the Burden of Illness Study in Europe","volume":"35","author":"Caballero","year":"2014","journal-title":"Allergy Asthma Proc"},{"issue":"suppl 1","key":"10.1016\/j.anai.2024.12.012_bib0006","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.2500\/aap.2020.41.200066","article-title":"Hereditary angioedema: on-demand treatment of angioedema attacks","volume":"41","author":"Christiansen","year":"2020","journal-title":"Allergy Asthma Proc"},{"issue":"3","key":"10.1016\/j.anai.2024.12.012_bib0007","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.2500\/aap.2021.42.210017","article-title":"Physician and patient perspectives on the management of hereditary angioedema: a survey on treatment burden and needs","volume":"42","author":"Riedl","year":"2021","journal-title":"Allergy Asthma Proc"},{"issue":"3","key":"10.1016\/j.anai.2024.12.012_bib0008","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.2500\/aap.2021.42.210025","article-title":"Patient perspectives on the treatment burden of injectable medication for hereditary angioedema","volume":"42","author":"Radojicic","year":"2021","journal-title":"Allergy Asthma Proc"},{"issue":"1","key":"10.1016\/j.anai.2024.12.012_bib0009","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13223-024-00903-w","article-title":"The complexities of decision-making associated with on-demand treatment of hereditary angioedema (HAE) attacks","volume":"20","author":"Betschel","year":"2024","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2024.12.012_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaip.2020.08.046","article-title":"US HAEA Medical Advisory Board 2020 Guidelines for the management of hereditary angioedema","volume":"9","author":"Busse","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"2","key":"10.1016\/j.anai.2024.12.012_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2022.12.445","article-title":"Patient perspectives on early use of on-demand treatment for hereditary angioedema (HAE) attacks to reduce severity and duration","volume":"151","author":"Radojicic","year":"2023","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"10.1016\/j.anai.2024.12.012_bib0012","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/all.12731","article-title":"Efficacy of on-demand treatment in reducing morbidity in patients with hereditary angioedema due to C1 inhibitor deficiency","volume":"70","author":"Zanichelli","year":"2015","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.anai.2024.12.012_bib0013","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000430864","article-title":"Treatment of HAE attacks in the icatibant outcome survey: an analysis of icatibant self-administration versus administration by health care professionals","volume":"167","author":"de Rojas","year":"2015","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.anai.2024.12.012_bib0014","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13223-019-0376-8","article-title":"The international\/Canadian hereditary angioedema guideline","volume":"15","author":"Betschel","year":"2019","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"7","key":"10.1016\/j.anai.2024.12.012_bib0015","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1111\/all.15214","article-title":"The international WAO\/EAACI guideline for the management of hereditary angioedema -The 2021 revision and update","volume":"77","author":"Maurer","year":"2022","journal-title":"Allergy"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120624017320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120624017320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T17:34:54Z","timestamp":1762364094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120624017320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1081120624017320"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2024.12.012","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"On-demand treatment of hereditary angioedema attacks","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2024.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}