{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T04:23:48Z","timestamp":1770524628344,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.anai.2025.02.011","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T16:03:48Z","timestamp":1740240228000},"page":"713-718.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Can exclusive breastfeeding in the first 4 months reduce food allergy?"],"prefix":"10.1016","volume":"134","author":[{"given":"Nadira","family":"Musallam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meital","family":"Almog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roni","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa","family":"Epov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vika","family":"Dor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aharon","family":"Kessel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.anai.2025.02.011_bib0001","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1016\/j.jaip.2020.04.020","article-title":"Prevalence of food sensitization and food allergy in children across Europe","volume":"8","author":"Lyons","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"6","key":"10.1016\/j.anai.2025.02.011_bib0002","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2018-1235","article-title":"The public health impact of parent-reported childhood food allergies in the United States","volume":"142","author":"Gupta","year":"2018","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.anai.2025.02.011_bib0003","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jaci.2017.11.003","article-title":"Food allergy: a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management","volume":"141","author":"Sicherer","year":"2018","journal-title":"J Allergy Clin Immunol"},{"issue":"9","key":"10.1016\/j.anai.2025.02.011_bib0004","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1056\/NEJMoa1414850","article-title":"Randomized trial of peanut consumption in infants at risk for peanut allergy","volume":"372","author":"Du Toit","year":"2015","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.anai.2025.02.011_bib0005","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.jaci.2019.06.045","article-title":"Enquiring About Tolerance (EAT) study team. Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy","volume":"144","author":"Perkin","year":"2019","journal-title":"J Allergy Clin Immunol"},{"issue":"10066","key":"10.1016\/j.anai.2025.02.011_bib0006","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0140-6736(16)31418-0","article-title":"Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomized, double-blind, placebo-controlled trial","volume":"389","author":"Natsume","year":"2017","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.anai.2025.02.011_bib0007","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.jaci.2021.10.018","article-title":"Food allergy across the globe","volume":"148","author":"Sampath","year":"2021","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2025.02.011_bib0008","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jaip.2020.11.002","article-title":"A consensus approach to the primary prevention of food allergy through nutrition: guidance from the American Academy of Allergy, Asthma, & Immunology","volume":"9","author":"Fleischer","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"4","key":"10.1016\/j.anai.2025.02.011_bib0009","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jaci.2015.10.049","article-title":"Does atopic dermatitis cause food allergy? A systematic review","volume":"137","author":"Tsakok","year":"2016","journal-title":"J Allergy Clin Immunol"},{"issue":"1-2","key":"10.1016\/j.anai.2025.02.011_bib0010","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/pr.2014.160","article-title":"Breast milk, microbiota, and intestinal immune homeostasis","volume":"77","author":"Walker","year":"2015","journal-title":"Pediatr Res"},{"key":"10.1016\/j.anai.2025.02.011_bib0011","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3389\/fmicb.2017.00356","article-title":"First foods and gut microbes","volume":"8","author":"Laursen","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.anai.2025.02.011_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.770913","article-title":"Association between breastmilk microbiota and food allergy in infants","volume":"11","author":"Wang","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"issue":"5","key":"10.1016\/j.anai.2025.02.011_bib0013","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/all.14625","article-title":"Butyrate as a bioactive human milk protective component against food allergy","volume":"76","author":"Paparo","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2025.02.011_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1154211","article-title":"Breast milk microRNAs: potential players in oral tolerance development","volume":"14","author":"Ahlberg","year":"2023","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.anai.2025.02.011_bib0015","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1007\/s00431-024-05580-w","article-title":"Breastfeeding and risk of food allergy and allergic rhinitis in offspring: a systematic review and meta-analysis of cohort studies","volume":"183","author":"Ding","year":"2024","journal-title":"Eur J Pediatr"},{"issue":"5","key":"10.1016\/j.anai.2025.02.011_bib0016","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/pai.13496","article-title":"EAACIguideline: preventing the development of food allergy in infants and youngchildren (2020 update)","volume":"32","author":"Halken","year":"2021","journal-title":"Pediatr Allergy Immunol"},{"issue":"1","key":"10.1016\/j.anai.2025.02.011_bib0017","article-title":"Section on Breastfeeding\/Policy statement: breastfeeding and the use of human milk","volume":"150","author":"Meek","year":"2022","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.anai.2025.02.011_bib0018","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/MPG.0000000000002234","article-title":"Breastfeeding rates and programs in Europe: a survey of 11 national breastfeeding committees and representatives","volume":"68","author":"Theurich","year":"2019","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.anai.2025.02.011_bib0019","unstructured":"Centers for Disease Control and Prevention. Breastfeeding report card, United States, 2022. Accessed January 2, 2023. Available at: https:\/\/www.cdc.gov\/breastfeeding\/pdf\/2022-breastfeeding-report-card-h.pdf"},{"issue":"1","key":"10.1016\/j.anai.2025.02.011_bib0020","doi-asserted-by":"crossref","DOI":"10.1186\/s12884-023-05382-2","article-title":"Rates of and factors associated with exclusive and any breastfeeding at six months in Canada: an analysis of population-based cross-sectional data","volume":"23","author":"Ricci","year":"2023","journal-title":"BMC Pregnancy Childbirth"},{"issue":"7","key":"10.1016\/j.anai.2025.02.011_bib0021","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nm.4142","article-title":"The microbiome in early life: implications for health outcomes","volume":"22","author":"Tamburini","year":"2016","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.anai.2025.02.011_bib0022","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1542\/peds.72.3.317","article-title":"Development and differences of intestinal flora in the neonatal period in breast-fed and bottle-fed infants","volume":"72","author":"Yoshioka","year":"1983","journal-title":"Pediatrics"},{"issue":"12","key":"10.1016\/j.anai.2025.02.011_bib0023","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1016\/j.celrep.2016.05.047","article-title":"Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways","volume":"15","author":"Tan","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.anai.2025.02.011_bib0024","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.3389\/fimmu.2020.01225","article-title":"Exploring the molecular mechanisms underlying the protective effects of microbial SCFAs on intestinal tolerance and food allergy","volume":"11","author":"Luu","year":"2020","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.anai.2025.02.011_bib0025","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2018.1161","article-title":"Association of exposure to formula in the hospital and subsequent infant feeding practices with gut microbiota and risk of overweight in the first year of life","volume":"172","author":"Forbes","year":"2018","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.anai.2025.02.011_bib0026","article-title":"Characteristics ofexogenous allergen in breast milk and their impact on oral tolerance induction","volume":"10","author":"Kosmeri","year":"2022","journal-title":"Front Pediatr"},{"key":"10.1016\/j.anai.2025.02.011_bib0027","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fimmu.2019.00016","article-title":"Cytokines and soluble receptors in breast milk asenhancers of oral tolerance development","volume":"10","author":"Dawod","year":"2019","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.anai.2025.02.011_bib0028","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/mi.2010.23","article-title":"Breast milk immune complexes are potent inducers of oral tolerance in neonatesand prevent asthma development","volume":"3","author":"Mosconi","year":"2010","journal-title":"Mucosal Immunol"},{"issue":"12","key":"10.1016\/j.anai.2025.02.011_bib0029","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1001\/jamapediatrics.2019.3544","article-title":"Primary prevention of cow's milk sensitization and food allergy by avoiding supplementation with cow's milk formula at birth: a randomized clinical trial","volume":"173","author":"Urashima","year":"2019","journal-title":"JAMA Pediatr"},{"issue":"2","key":"10.1016\/j.anai.2025.02.011_bib0030","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.anai.2022.10.013","article-title":"Early, continuing exposure to cow's milk formula and cow's milk allergy: the COMEET study, a single center, prospective interventional study","volume":"130","author":"Lachover-Roth","year":"2023","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"10.1016\/j.anai.2025.02.011_bib0031","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/cea.12406","article-title":"Which infants with eczema are at risk of food allergy? Results from a population-based cohort","volume":"45","author":"Martin","year":"2015","journal-title":"Clin Exp Allergy"},{"issue":"8","key":"10.1016\/j.anai.2025.02.011_bib0032","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1001\/jamadermatol.2018.1572","article-title":"Association of inadequately controlled disease and disease severity with patient-reported disease burden in adults with atopic dermatitis","volume":"154","author":"Simpson","year":"2018","journal-title":"JAMA Dermatol"},{"issue":"10","key":"10.1016\/j.anai.2025.02.011_bib0033","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/aje\/kwu072","article-title":"Breastfeeding and childhood asthma: systematic review and meta-analysis","volume":"179","author":"Dogaru","year":"2014","journal-title":"Am J Epidemiol"},{"issue":"5","key":"10.1016\/j.anai.2025.02.011_bib0034","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1399-3038.2008.00718.x","article-title":"The importance of early complementary feeding in the development of oral tolerance: concerns and controversies","volume":"19","author":"Prescott","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"issue":"2","key":"10.1016\/j.anai.2025.02.011_bib0035","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.clinthera.2021.11.017","article-title":"Breastfeeding in a global context: epidemiology, impact, and future directions","volume":"44","author":"North","year":"2022","journal-title":"Clin Ther"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120625000894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120625000894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T09:15:16Z","timestamp":1748855716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120625000894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1081120625000894"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2025.02.011","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Can exclusive breastfeeding in the first 4 months reduce food allergy?","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2025.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}