{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T21:21:24Z","timestamp":1778102484703,"version":"3.51.4"},"reference-count":22,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007306","name":"Arizona Department of Health Services","doi-asserted-by":"publisher","award":["RFGA2023-008-27"],"award-info":[{"award-number":["RFGA2023-008-27"]}],"id":[{"id":"10.13039\/100007306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.anai.2025.09.008","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T01:27:59Z","timestamp":1758590879000},"page":"204-212.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk factors and challenge outcomes in trimethoprim-sulfamethoxazole hypersensitivity in HIV-negative patients"],"prefix":"10.1016","volume":"136","author":[{"given":"Susan","family":"Kinate","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo J.","family":"Estrada-Mendizabal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayne","family":"Voelker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine R.F.","family":"Rukasin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saiyara","family":"Shama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebram N.","family":"Labib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Rank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5754-6130","authenticated-orcid":false,"given":"Alexei","family":"Gonzalez-Estrada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2025.09.008_bib0001","doi-asserted-by":"crossref","first-page":"778.e1","DOI":"10.1016\/j.amjmed.2009.01.034","article-title":"Self-reported antibiotic allergy incidence and prevalence: age and sex effects","volume":"122","author":"Macy","year":"2009","journal-title":"Am J Med"},{"issue":"7","key":"10.1016\/j.anai.2025.09.008_bib0002","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/j.jaip.2019.05.034","article-title":"Sulfonamide hypersensitivity: fact and fiction","volume":"7","author":"Khan","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"4","key":"10.1016\/j.anai.2025.09.008_bib0003","doi-asserted-by":"crossref","DOI":"10.1111\/tid.70063","article-title":"Impact of pretransplant antimicrobial sulfonamide allergy label in kidney transplant recipients","volume":"27","author":"Powers","year":"2025","journal-title":"Transpl Infect Dis"},{"issue":"6","key":"10.1016\/j.anai.2025.09.008_bib0004","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.jaci.2022.08.028","article-title":"Drug allergy: a 2022 practice parameter update","volume":"150","author":"Khan","year":"2022","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.anai.2025.09.008_bib0005","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2217\/pgs.09.6","article-title":"TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole","volume":"10","author":"Alfirevic","year":"2009","journal-title":"Pharmacogenomics"},{"issue":"1","key":"10.1016\/j.anai.2025.09.008_bib0006","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1067\/mjd.2002.120468","article-title":"Prospective evaluation of risk factors of cutaneous drug reactions to sulfonamides in patients with AIDS","volume":"47","author":"Eliaszewicz","year":"2002","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"10.1016\/j.anai.2025.09.008_bib0007","doi-asserted-by":"crossref","first-page":"495","DOI":"10.7326\/0003-4819-100-4-495","article-title":"Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome","volume":"100","author":"Gordin","year":"1984","journal-title":"Ann Intern Med"},{"issue":"8359","key":"10.1016\/j.anai.2025.09.008_bib0008","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0140-6736(83)90627-X","article-title":"Complications of co-trimoxazole in treatment of AIDS-associated pneumocystis carinii pneumonia in homosexual men","volume":"2","author":"Jaffe","year":"1983","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.anai.2025.09.008_bib0009","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1177\/009127009903900514","article-title":"The association of opportunistic infections with the occurrence of trimethoprim\/sulfamethoxazole hypersensitivity in patients infected with human immunodeficiency virus","volume":"39","author":"Lehmann","year":"1999","journal-title":"J Clin Pharmacol"},{"issue":"1","key":"10.1016\/j.anai.2025.09.008_bib0010","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.anai.2021.04.001","article-title":"Outcome of trimethoprim-sulfamethoxazole challenge in previously reported patients with sulfa antibiotic allergy","volume":"127","author":"Benesch","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.1016\/j.anai.2025.09.008_bib0011","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jaip.2019.07.003","article-title":"Oral challenge with trimethoprim-sulfamethoxazole in patients with \u201csulfa\u201d antibiotic allergy","volume":"8","author":"Krantz","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"4","key":"10.1016\/j.anai.2025.09.008_bib0012","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.jaip.2021.11.024","article-title":"A single- or two-step challenge versus a six-step challenge in non-HIV-infected patients with a sulfonamide antibiotic allergy label: a retrospective case series","volume":"10","author":"Motoa","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"10","key":"10.1016\/j.anai.2025.09.008_bib0013","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1016\/j.jaip.2021.05.046","article-title":"The safety and efficacy of direct oral challenge in trimethoprim-sulfamethoxazole antibiotic allergy","volume":"9","author":"Rose","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"6","key":"10.1016\/j.anai.2025.09.008_bib0014","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.16776","article-title":"Development and validation of a sulfa antibiotic allergy clinical decision rule","volume":"6","author":"Waldron","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"3","key":"10.1016\/j.anai.2025.09.008_bib0015","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jaip.2016.09.041","article-title":"Identifying allergic drug reactions through placebo-controlled graded challenges","volume":"5","author":"Iammatteo","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"2","key":"10.1016\/j.anai.2025.09.008_bib0016","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.anai.2012.11.007","article-title":"Adverse reactions during drug challenges: a single US institution\u2019s experience","volume":"110","author":"Kao","year":"2013","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"4","key":"10.1016\/j.anai.2025.09.008_bib0017","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4103\/0378-6323.66587","article-title":"Patient-reported multiple drug reactions: clinical profile and results of challenge testing","volume":"76","author":"Ramam","year":"2010","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"6","key":"10.1016\/j.anai.2025.09.008_bib0018","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1056\/NEJMra1907805","article-title":"Placebo and nocebo effects","volume":"382","author":"Colloca","year":"2020","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.anai.2025.09.008_bib0019","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1111\/all.13440","article-title":"Multiple drug intolerance syndrome and multiple drug allergy syndrome: epidemiology and associations with anxiety and depression","volume":"73","author":"Blumenthal","year":"2018","journal-title":"Allergy"},{"issue":"9","key":"10.1016\/j.anai.2025.09.008_bib0020","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1016\/j.jaip.2020.08.033","article-title":"Tackling the patient with multiple drug \u201callergies\u201d: multiple drug intolerance syndrome","volume":"8","author":"Guyer","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"2","key":"10.1016\/j.anai.2025.09.008_bib0021","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.anai.2011.11.006","article-title":"Multiple drug intolerance syndrome: prevalence, clinical characteristics, and management","volume":"108","author":"Macy","year":"2012","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"6","key":"10.1016\/j.anai.2025.09.008_bib0022","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.jaci.2023.08.018","article-title":"United States Drug Allergy Registry (USDAR) grading scale for immediate drug reactions","volume":"152","author":"Khan","year":"2023","journal-title":"J Allergy Clin Immunol"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120625011664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120625011664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:44:08Z","timestamp":1773387848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120625011664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1081120625011664"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2025.09.008","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors and challenge outcomes in trimethoprim-sulfamethoxazole hypersensitivity in HIV-negative patients","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2025.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}