{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:53:46Z","timestamp":1793307226698,"version":"4.5.0"},"reference-count":133,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.anai.2025.09.014","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:29:51Z","timestamp":1759541391000},"page":"131-140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Basic mechanisms of itch and advances in clinical management"],"prefix":"10.1016","volume":"136","author":[{"given":"Giulia","family":"Coscarella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Yosipovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2025.09.014_bib0001","doi-asserted-by":"crossref","unstructured":"St\u00e4nder S, Schmelz M, Lerner E, Murota H, Nattkemper L, Reich A, et al. A multidisciplinary Delphi consensus on the modern definition of pruritus: sensation and disease [e-pub ahead of print]. J Eur Acad Dermatol Venereol. https:\/\/doi.org\/10.1111\/jdv.20851. Accessed July 22, 2025.","DOI":"10.1111\/jdv.20851"},{"issue":"3","key":"10.1016\/j.anai.2025.09.014_bib0002","doi-asserted-by":"crossref","first-page":"xv","DOI":"10.1016\/j.det.2018.02.017","article-title":"Chronic itch: a disease in its own right","volume":"36","author":"Yosipovitch","year":"2018","journal-title":"Dermatol Clin"},{"issue":"2","key":"10.1016\/j.anai.2025.09.014_bib0003","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jaci.2019.04.005","article-title":"Itching as a systemic disease","volume":"144","author":"Hashimoto","year":"2019","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.anai.2025.09.014_bib0004","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/bjd\/ljae260","article-title":"International study on prevalence of itch: examining the role of itch as a major global public health problem","volume":"191","author":"Yosipovitch","year":"2024","journal-title":"Br J Dermatol"},{"issue":"5","key":"10.1016\/j.anai.2025.09.014_bib0005","doi-asserted-by":"crossref","first-page":"532","DOI":"10.2340\/00015555-1572","article-title":"Incidence and determinants of chronic pruritus: a population-based cohort study","volume":"93","author":"Matterne","year":"2013","journal-title":"Acta Derm Venereol"},{"issue":"6","key":"10.1016\/j.anai.2025.09.014_bib0006","doi-asserted-by":"crossref","first-page":"674","DOI":"10.2340\/00015555-1159","article-title":"Prevalence, correlates and characteristics of chronic pruritus: a population-based cross-sectional study","volume":"91","author":"Matterne","year":"2011","journal-title":"Acta Derm Venereol"},{"issue":"24","key":"10.1016\/j.anai.2025.09.014_bib0007","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1001\/jama.2024.4899","article-title":"Chronic pruritus: a review","volume":"331","author":"Butler","year":"2024","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2021.07.076","article-title":"Itch: epidemiology, clinical presentation, and diagnostic workup","volume":"86","author":"Roh","year":"2022","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.anai.2025.09.014_bib0009","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/ijd.14125","article-title":"Chronic generalized pruritus without primary skin lesions: a longitudinal prospective observational study","volume":"58","author":"Alizadeh","year":"2019","journal-title":"Int J Dermatol"},{"issue":"16","key":"10.1016\/j.anai.2025.09.014_bib0010","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3630","article-title":"Chronic pruritus in the absence of skin disease: a retrospective study of 197 French inpatients","volume":"100","author":"Robert","year":"2020","journal-title":"Acta Derm Venereol"},{"issue":"4","key":"10.1016\/j.anai.2025.09.014_bib0011","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2340\/00015555-0305","article-title":"Clinical classification of itch: a position paper of the International Forum for the Study of Itch","volume":"87","author":"St\u00e4nder","year":"2007","journal-title":"Acta Derm Venereol"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0012","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jaci.2023.05.004","article-title":"Basic mechanisms of itch","volume":"152","author":"Misery","year":"2023","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0013","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jaad.2021.07.078","article-title":"Itch: pathogenesis and treatment","volume":"86","author":"Sutaria","year":"2022","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"10.1016\/j.anai.2025.09.014_bib0014","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.mcna.2021.04.007","article-title":"Approach to the patient with chronic pruritus","volume":"105","author":"Lipman","year":"2021","journal-title":"Med Clin North Am"},{"issue":"6","key":"10.1016\/j.anai.2025.09.014_bib0015","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.clindermatol.2019.07.031","article-title":"Pruritus as a sign of systemic disease","volume":"37","author":"Welz-Kubiak","year":"2019","journal-title":"Clin Dermatol"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0016","first-page":"55","article-title":"Pruritus: diagnosis and management","volume":"105","author":"Rupert","year":"2022","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.anai.2025.09.014_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1272230","article-title":"Itch: from the skin to the brain - peripheral and central neural sensitization in chronic itch","volume":"16","author":"Mahmoud","year":"2023","journal-title":"Front Mol Neurosci"},{"issue":"5","key":"10.1016\/j.anai.2025.09.014_bib0018","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jaci.2018.09.005","article-title":"Itch: from mechanism to (novel) therapeutic approaches","volume":"142","author":"Yosipovitch","year":"2018","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"10.1016\/j.anai.2025.09.014_bib0019","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1136\/gutjnl-2013-305870","article-title":"Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity","volume":"63","author":"Deiteren","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.anai.2025.09.014_bib0020","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroscience.2011.06.002","article-title":"Histamine H1, H3 and H4 receptors are involved in pruritus","volume":"190","author":"Rossbach","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.anai.2025.09.014_bib0021","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuroscience.2019.04.039","article-title":"Allergen-induced histaminergic and non-histaminergic activation of itch C-fiber nerve terminals in mouse skin","volume":"410","author":"Jurcakova","year":"2019","journal-title":"Neuroscience"},{"issue":"1-3","key":"10.1016\/j.anai.2025.09.014_bib0022","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neulet.2004.01.019","article-title":"Histamine-induced Ca(2+) influx via the PLA(2)\/lipoxygenase\/TRPV1 pathway in rat sensory neurons","volume":"361","author":"Kim","year":"2004","journal-title":"Neurosci Lett"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0023","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.neuroscience.2009.12.001","article-title":"Histamine potentiates acid-induced responses mediating transient receptor potential V1 in mouse primary sensory neurons","volume":"166","author":"Kajihara","year":"2010","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.anai.2025.09.014_bib0024","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra2023911","article-title":"Atopic dermatitis","volume":"384","author":"St\u00e4nder","year":"2021","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.anai.2025.09.014_bib0025","doi-asserted-by":"crossref","first-page":"6579","DOI":"10.3390\/ijms23126579","article-title":"Pharmacotherapy of itch-antihistamines and histamine receptors as G protein-coupled receptors","volume":"23","author":"Fukasawa","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.anai.2025.09.014_bib0026","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jdermsci.2019.06.007","article-title":"Physiological and pathological roles of kallikrein-related peptidases in the epidermis","volume":"95","author":"Kishibe","year":"2019","journal-title":"J Dermatol Sci"},{"issue":"6","key":"10.1016\/j.anai.2025.09.014_bib0027","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.jid.2019.10.022","article-title":"Kallikrein 7 promotes atopic dermatitis-associated itch independently of skin inflammation","volume":"140","author":"Guo","year":"2020","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.anai.2025.09.014_bib0028","doi-asserted-by":"crossref","first-page":"7864","DOI":"10.1038\/ncomms8864","article-title":"Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs","volume":"6","author":"Reddy","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.anai.2025.09.014_bib0029","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/978-3-662-44605-8_13","article-title":"Protease-activated receptors and itch","volume":"226","author":"Akiyama","year":"2015","journal-title":"Handb Exp Pharmacol"},{"issue":"5","key":"10.1016\/j.anai.2025.09.014_bib0030","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.immuni.2019.03.013","article-title":"Activation of mast-cell-expressed mas-related G-protein-coupled receptors drives non-histaminergic itch","volume":"50","author":"Meixiong","year":"2019","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.anai.2025.09.014_bib0031","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nn.2789","article-title":"TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch","volume":"14","author":"Wilson","year":"2011","journal-title":"Nat Neurosci"},{"issue":"12","key":"10.1016\/j.anai.2025.09.014_bib0032","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/s41583-021-00526-9","article-title":"A neuropeptide code for itch","volume":"22","author":"Chen","year":"2021","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0033","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/imr.12635","article-title":"Role of mast cells and basophils in pruritus","volume":"282","author":"Steinhoff","year":"2018","journal-title":"Immunol Rev"},{"issue":"3","key":"10.1016\/j.anai.2025.09.014_bib0034","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1152\/jn.00539.2012","article-title":"Roles for substance P and gastrin-releasing peptide as neurotransmitters released by primary afferent pruriceptors","volume":"109","author":"Akiyama","year":"2013","journal-title":"J Neurophysiol"},{"issue":"6","key":"10.1016\/j.anai.2025.09.014_bib0035","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/j.jaci.2022.02.021","article-title":"Mast cells, cortistatin, and its receptor, MRGPRX2, are linked to the pathogenesis of chronic prurigo","volume":"149","author":"Kolkhir","year":"2022","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.anai.2025.09.014_bib0036","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jaci.2016.12.980","article-title":"Substance P activates Mas-related G protein-coupled receptors to induce itch","volume":"140","author":"Azimi","year":"2017","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"10.1016\/j.anai.2025.09.014_bib0037","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.3390\/ph16121707","article-title":"Targeting transient receptor potential (TRP) channels, mas-related G-protein-coupled receptors (Mrgprs), and protease-activated receptors (PARs) to relieve itch","volume":"16","author":"Tsagareli","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0038","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pain.2013.09.011","article-title":"Roles of glutamate, substance P, and gastrin-releasing peptide as spinal neurotransmitters of histaminergic and nonhistaminergic itch","volume":"155","author":"Akiyama","year":"2014","journal-title":"Pain"},{"issue":"8","key":"10.1016\/j.anai.2025.09.014_bib0039","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1080\/13543784.2019.1638910","article-title":"The NK1 receptor antagonist serlopitant for treatment of chronic pruritus","volume":"28","author":"St\u00e4nder","year":"2019","journal-title":"Expert Opin Investig Drugs"},{"issue":"5","key":"10.1016\/j.anai.2025.09.014_bib0040","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jaad.2018.02.030","article-title":"Serlopitant for the treatment of chronic pruritus: results of a randomized, multicenter, placebo-controlled phase 2 clinical trial","volume":"78","author":"Yosipovitch","year":"2018","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"10.1016\/j.anai.2025.09.014_bib0041","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.anai.2019.01.016","article-title":"Chronic itch management: therapies beyond those targeting the immune system","volume":"123","author":"Fowler","year":"2019","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"5","key":"10.1016\/j.anai.2025.09.014_bib0042","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/bjd.18025","article-title":"Substance P and neurokinin 1 receptor are new targets for the treatment of chronic pruritus","volume":"181","author":"St\u00e4nder","year":"2019","journal-title":"Br J Dermatol"},{"issue":"6","key":"10.1016\/j.anai.2025.09.014_bib0043","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s40265-021-01478-1","article-title":"Neurokinin 1 receptor antagonists for pruritus","volume":"81","author":"Alam","year":"2021","journal-title":"Drugs"},{"issue":"10","key":"10.1016\/j.anai.2025.09.014_bib0044","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1111\/jdv.20807","article-title":"Systemic neurokinin-1 receptor antagonists mitigate chronic pruritus: a systematic review and meta-analysis","volume":"39","author":"Ho","year":"2025","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"4","key":"10.1016\/j.anai.2025.09.014_bib0045","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jaci.2022.12.805","article-title":"Novel small molecule MRGPRX2 antagonists inhibit a murine model of allergic reaction","volume":"151","author":"Kumar","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2025.09.014_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118371","article-title":"Identification of KMH-45, a novel MRGPRX2 inhibitor with enhanced anti-pruritic properties","volume":"190","author":"Sanjel","year":"2025","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.anai.2025.09.014_bib0047","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1433982","article-title":"Pharmacological blockade of the mast cell MRGPRX2 receptor supports investigation of its relevance in skin disorders","volume":"15","author":"Macphee","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.anai.2025.09.014_bib0048","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1033794","article-title":"Inhibition of MRGPRX2 but not Fc\u03b5RI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist","volume":"13","author":"Bawazir","year":"2022","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.anai.2025.09.014_bib0049","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jaci.2024.07.002","article-title":"Inhibition of mast cell degranulation by novel small molecule MRGPRX2 antagonists","volume":"154","author":"Wollam","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2025.09.014_bib0050","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuroscience.2020.09.048","article-title":"Thermal hyperalgesia and mechanical allodynia elicited by histamine and non-histaminergic itch mediators: respective involvement of TRPV1 and TRPA1","volume":"449","author":"Tsagareli","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.anai.2025.09.014_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115392","article-title":"Transient receptor potential ankyrin 1 (TRPA1) modulators: recent update and future perspective","volume":"257","author":"Hu","year":"2023","journal-title":"Eur J Med Chem"},{"issue":"42","key":"10.1016\/j.anai.2025.09.014_bib0052","doi-asserted-by":"crossref","first-page":"14055","DOI":"10.1523\/JNEUROSCI.1722-14.2014","article-title":"Multimodal use of calcitonin gene-related peptide and substance P in itch and acute pain uncovered by the elimination of vesicular glutamate transporter 2 from transient receptor potential cation channel subfamily V member 1 neurons","volume":"34","author":"Rogoz","year":"2014","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0053","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/biom14010107","article-title":"Site-specific transient receptor potential channel mechanisms and their characteristics for targeted chronic itch treatment","volume":"14","author":"Go","year":"2024","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0054","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3390\/ijms24010420","article-title":"Transient receptor potential channels and itch","volume":"24","author":"Mahmoud","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.anai.2025.09.014_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108355","article-title":"How to get rid of itching","volume":"243","author":"Vander Does","year":"2023","journal-title":"Pharmacol Ther"},{"issue":"10","key":"10.1016\/j.anai.2025.09.014_bib0056","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/j.jid.2024.02.026","article-title":"Increased systemic levels of centrally acting B-type natriuretic peptide are associated with chronic itch of different types","volume":"144","author":"Nattkemper","year":"2024","journal-title":"J Invest Dermatol"},{"issue":"3","key":"10.1016\/j.anai.2025.09.014_bib0057","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1124\/jpet.115.229997","article-title":"Spinal functions of B-type natriuretic peptide, gastrin-releasing peptide, and their cognate receptors for regulating itch in mice","volume":"356","author":"Kiguchi","year":"2016","journal-title":"J Pharmacol Exp Ther"},{"issue":"6135","key":"10.1016\/j.anai.2025.09.014_bib0058","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.1233765","article-title":"The cells and circuitry for itch responses in mice","volume":"340","author":"Mishra","year":"2013","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.anai.2025.09.014_bib0059","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1523\/JNEUROSCI.2559-18.2019","article-title":"Dorsal horn gastrin-releasing peptide expressing neurons transmit spinal itch but not pain signals","volume":"39","author":"Albisetti","year":"2019","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0060","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/s41467-020-15230-y","article-title":"Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors","volume":"11","author":"Barry","year":"2020","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.anai.2025.09.014_bib0061","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1111\/all.15699","article-title":"Microglia-neuron interactions promote chronic itch via the NLRP3-IL-1\u03b2-GRPR axis","volume":"78","author":"Liu","year":"2023","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.anai.2025.09.014_bib0062","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2216230120","article-title":"Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy","volume":"120","author":"Peng","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.anai.2025.09.014_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108259","article-title":"MAS-related G protein-coupled receptors X (MRGPRX): orphan GPCRs with potential as targets for future drugs","volume":"238","author":"Al Hamwi","year":"2022","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.anai.2025.09.014_bib0064","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cytogfr.2017.09.002","article-title":"Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases","volume":"38","author":"Verma","year":"2017","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0065","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1038\/s41467-025-62382-w","article-title":"Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord","volume":"16","author":"Zeng","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.anai.2025.09.014_bib0066","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.86633","article-title":"Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling","volume":"12","author":"Boyle","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.anai.2025.09.014_bib0067","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2025.106806","article-title":"Downregulation of the NPY-Y1R system in Grpr neurons results in mechanical and chemical hyperknesis in chronic itch","volume":"206","author":"Dai","year":"2025","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.anai.2025.09.014_bib0068","doi-asserted-by":"crossref","DOI":"10.1177\/17448069241242982","article-title":"Mechanical and chemical itch regulated by neuropeptide Y-Y1 signaling","volume":"20","author":"Chen","year":"2024","journal-title":"Mol Pain"},{"key":"10.1016\/j.anai.2025.09.014_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2019.101976","article-title":"Neuropeptide Y in itch regulation","volume":"78","author":"Jakobsson","year":"2019","journal-title":"Neuropeptides"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0070","doi-asserted-by":"crossref","first-page":"363","DOI":"10.7150\/thno.89433","article-title":"The plasticity of neuropeptide Y-Y1 receptor system on Tac2 neurons contributes to mechanical hyperknesis during chronic itch","volume":"14","author":"Dai","year":"2024","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.anai.2025.09.014_bib0071","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1016\/j.jid.2018.05.008","article-title":"The neuropeptide Y system regulates both mechanical and histaminergic itch","volume":"138","author":"Gao","year":"2018","journal-title":"J Invest Dermatol"},{"issue":"4","key":"10.1016\/j.anai.2025.09.014_bib0072","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.jaci.2025.05.011","article-title":"Type 2 cytokines pleiotropically modulate sensory nerve architecture and neuroimmune interactions to mediate itch","volume":"156","author":"Jha","year":"2025","journal-title":"J Allergy Clin Immunol"},{"issue":"15","key":"10.1016\/j.anai.2025.09.014_bib0073","doi-asserted-by":"crossref","first-page":"8445","DOI":"10.3390\/ijms25158445","article-title":"Interleukin profiling in atopic dermatitis and chronic nodular prurigo","volume":"25","author":"Wiegmann","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10.1016\/j.anai.2025.09.014_bib0074","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.4049\/jimmunol.1300300","article-title":"TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis","volume":"191","author":"Oh","year":"2013","journal-title":"J Immunol"},{"issue":"12","key":"10.1016\/j.anai.2025.09.014_bib0075","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1097\/j.pain.0000000000001678","article-title":"Itch sensitization? A systematic review of studies using quantitative sensory testing in patients with chronic itch","volume":"160","author":"van Laarhoven","year":"2019","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.anai.2025.09.014_bib0076","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/1346-8138.12317","article-title":"Itch and nerve fibers with special reference to atopic dermatitis: therapeutic implications","volume":"41","author":"Tominaga","year":"2014","journal-title":"J Dermatol"},{"issue":"12","key":"10.1016\/j.anai.2025.09.014_bib0077","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/exd.14034","article-title":"Interleukin-4 and interleukin-13 evoke scratching behaviour in mice","volume":"28","author":"Campion","year":"2019","journal-title":"Exp Dermatol"},{"issue":"3","key":"10.1016\/j.anai.2025.09.014_bib0078","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jaci.2022.11.009","article-title":"IL-31-generating network in atopic dermatitis comprising macrophages, basophils, thymic stromal lymphopoietin, and periostin","volume":"151","author":"Hashimoto","year":"2023","journal-title":"J Allergy Clin Immunol"},{"issue":"10","key":"10.1016\/j.anai.2025.09.014_bib0079","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1111\/all.14791","article-title":"Interleukin-31: the \u201citchy\u201d cytokine in inflammation and therapy","volume":"76","author":"Datsi","year":"2021","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.anai.2025.09.014_bib0080","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaci.2013.10.048","article-title":"A sensory neuron\u2013expressed IL-31 receptor mediates T helper cell\u2013dependent itch: involvement of TRPV1 and TRPA1","volume":"133","author":"Cevikbas","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0081","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/all.13239","article-title":"Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis","volume":"73","author":"Furue","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2025.09.014_bib0082","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-3-030-55617-4_8","article-title":"Interleukin-31, a potent pruritus-inducing cytokine and its role in inflammatory disease and in the tumor microenvironment","volume":"1290","author":"Rook","year":"2021","journal-title":"Adv Exp Med Biol"},{"issue":"17","key":"10.1016\/j.anai.2025.09.014_bib0083","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1056\/NEJMoa2301333","article-title":"Phase 3 trial of nemolizumab in patients with prurigo nodularis","volume":"389","author":"Kwatra","year":"2023","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.anai.2025.09.014_bib0084","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/1744666X.2024.2306225","article-title":"A critical evaluation of nemolizumab for prurigo nodularis","volume":"20","author":"Brooks","year":"2024","journal-title":"Expert Rev Clin Immunol"},{"issue":"suppl 2","key":"10.1016\/j.anai.2025.09.014_bib0085","article-title":"672 - Nemolizumab monotherapy improves itch, sleep disturbance, and skin lesions in patients with moderate-to-severe prurigo nodularis: pooled analyses from OLYMPIA 1 and OLYMPIA 2 phase 3 studies","volume":"191","author":"Yosipovitch","year":"2024","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.anai.2025.09.014_bib0086","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-3-662-44605-8_10","article-title":"Interactions between keratinocytes and somatosensory neurons in itch","volume":"226","author":"Schwendinger-Schreck","year":"2015","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.anai.2025.09.014_bib0087","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115143","article-title":"IL-33\/ST2 signaling in pain and itch: cellular and molecular mechanisms and therapeutic potentials","volume":"165","author":"Li","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.anai.2025.09.014_bib0088","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.621956","article-title":"Major role of the IL17\/23 axis in psoriasis supports the development of new targeted therapies","volume":"12","author":"Bugaut","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.anai.2025.09.014_bib0089","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.594735","article-title":"The IL-23\/IL-17 pathway in inflammatory skin diseases: from bench to bedside","volume":"11","author":"Liu","year":"2020","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.anai.2025.09.014_bib0090","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jid.2017.12.029","article-title":"The genetics of chronic itch: gene expression in the skin of patients with atopic dermatitis and psoriasis with severe itch","volume":"138","author":"Nattkemper","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.anai.2025.09.014_bib0091","doi-asserted-by":"crossref","unstructured":"Zhang Q, Jang M, Dias FC, Zeng Q, Wang P, Tai H, et al. Neuronal mechanisms of psoriatic itch: role of IL-17R\/ERK\/TRPV4 signaling pathway [e-pub ahead of print]. J Invest Dermatol. https:\/\/doi.org\/10.1016\/j.jid.2025.03.037. Accessed July 22, 2025.","DOI":"10.1016\/j.jid.2025.03.037"},{"issue":"10","key":"10.1016\/j.anai.2025.09.014_bib0092","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1016\/j.jid.2021.03.009","article-title":"an emerging player in itch sensation","volume":"141","author":"Hashimoto","year":"2021","journal-title":"J Invest Dermatol"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0093","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3702","article-title":"Dermal periostin: a new player in itch of prurigo nodularis","volume":"101","author":"Hashimoto","year":"2021","journal-title":"Acta Derm Venereol"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0094","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.036","article-title":"Periostin activation of integrin receptors on sensory neurons induces allergic itch","volume":"31","author":"Mishra","year":"2020","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111933","article-title":"Periostin activates distinct modules of inflammation and itching downstream of the type 2 inflammation pathway","volume":"42","author":"Nunomura","year":"2023","journal-title":"Cell Rep"},{"issue":"6","key":"10.1016\/j.anai.2025.09.014_bib0096","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1172\/JCI67323","article-title":"Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1\u2013induced pruritus","volume":"124","author":"Kido-Nakahara","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.anai.2025.09.014_bib0097","article-title":"Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates","volume":"5","author":"Lee","year":"2015","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.anai.2025.09.014_bib0098","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1111\/exd.14669","article-title":"Role of kappa-opioid and mu-opioid receptors in pruritus: peripheral and central itch circuits","volume":"31","author":"Kim","year":"2022","journal-title":"Exp Dermatol"},{"issue":"8","key":"10.1016\/j.anai.2025.09.014_bib0099","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1038\/jid.2015.137","article-title":"Differential changes in the peptidergic and the non-peptidergic skin innervation in rat models for inflammation, dry skin itch, and dermatitis","volume":"135","author":"Sch\u00fcttenhelm","year":"2015","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.anai.2025.09.014_bib0100","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71689","article-title":"BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk","volume":"10","author":"Meng","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.anai.2025.09.014_bib0101","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000446011","article-title":"Central mechanisms of itch","volume":"50","author":"Carstens","year":"2016","journal-title":"Curr Probl Dermatol"},{"issue":"15","key":"10.1016\/j.anai.2025.09.014_bib0102","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1523\/JNEUROSCI.23-15-06176.2003","article-title":"Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin","volume":"23","author":"Steinhoff","year":"2003","journal-title":"J Neurosci"},{"issue":"5","key":"10.1016\/j.anai.2025.09.014_bib0103","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0092-8674(01)00483-4","article-title":"A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons","volume":"106","author":"Dong","year":"2001","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.anai.2025.09.014_bib0104","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1124\/pr.113.008136","article-title":"MAS and its related G protein-coupled receptors, Mrgprs","volume":"66","author":"Bader","year":"2014","journal-title":"Pharmacol Rev"},{"issue":"3","key":"10.1016\/j.anai.2025.09.014_bib0105","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.neuron.2019.01.012","article-title":"A mast-cell-specific receptor mediates neurogenic inflammation and pain","volume":"101","author":"Green","year":"2019","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/j.anai.2025.09.014_bib0106","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1111\/exd.14014","article-title":"Interaction of peripheral nerves and mast cells, eosinophils, and basophils in the development of pruritus","volume":"28","author":"Nakashima","year":"2019","journal-title":"Exp Dermatol"},{"issue":"2","key":"10.1016\/j.anai.2025.09.014_bib0107","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/jdv.15973","article-title":"Neuroimmune interactions in chronic itch of atopic dermatitis","volume":"34","author":"Yosipovitch","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"2","key":"10.1016\/j.anai.2025.09.014_bib0108","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/1346-8138.17565","article-title":"Practical guide for the diagnosis and treatment of localized and generalized cutaneous pruritus (chronic itch with no underlying pruritic dermatosis)","volume":"52","author":"Hashimoto","year":"2025","journal-title":"J Dermatol"},{"issue":"3","key":"10.1016\/j.anai.2025.09.014_bib0109","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.det.2018.02.005","article-title":"Diagnosis and management of neuropathic itch","volume":"36","author":"Rosen","year":"2018","journal-title":"Dermatol Clin"},{"issue":"3","key":"10.1016\/j.anai.2025.09.014_bib0110","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/bjd.20414","article-title":"Immunological eruptions of ageing: reframing chronic pruritic rashes in older adults","volume":"185","author":"Abel","year":"2021","journal-title":"Br J Dermatol"},{"issue":"5","key":"10.1016\/j.anai.2025.09.014_bib0111","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2340\/00015555-3164","article-title":"European S2k guideline on chronic pruritus","volume":"99","author":"Weisshaar","year":"2019","journal-title":"Acta Derm Venereol"},{"issue":"11","key":"10.1016\/j.anai.2025.09.014_bib0112","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1111\/all.15811","article-title":"Tralokinumab therapy for moderate-to-severe atopic dermatitis: clinical outcomes with targeted IL-13 inhibition","volume":"78","author":"Simpson","year":"2023","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.anai.2025.09.014_bib0113","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2147\/tcrm.2006.2.2.213","article-title":"Treatment of pruritic diseases with topical calcineurin inhibitors","volume":"2","author":"St\u00e4nder","year":"2006","journal-title":"Ther Clin Risk Manag"},{"issue":"2","key":"10.1016\/j.anai.2025.09.014_bib0114","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jaad.2023.04.057","article-title":"Emerging treatments for itch in atopic dermatitis: a review","volume":"89","author":"Labib","year":"2023","journal-title":"J Am Acad Dermatol"},{"issue":"12","key":"10.1016\/j.anai.2025.09.014_bib0115","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1056\/NEJMoa2206714","article-title":"Two Phase 3 trials of lebrikizumab for moderate-to-severe atopic dermatitis","volume":"388","author":"Silverberg","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.anai.2025.09.014_bib0116","doi-asserted-by":"crossref","DOI":"10.2340\/actadv.v103.5346","article-title":"Itch and Janus kinase inhibitors","volume":"103","author":"Han","year":"2023","journal-title":"Acta Derm Venereol"},{"issue":"3","key":"10.1016\/j.anai.2025.09.014_bib0117","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s13555-023-00892-5","article-title":"A review on the safety of using JAK inhibitors in dermatology: clinical and laboratory monitoring","volume":"13","author":"Samuel","year":"2023","journal-title":"Dermatol Ther (Heidelb)"},{"issue":"2","key":"10.1016\/j.anai.2025.09.014_bib0118","doi-asserted-by":"crossref","first-page":"AB176","DOI":"10.1016\/j.jaci.2024.12.556","article-title":"The impact of remibrutinib on urticaria control in patients with chronic spontaneous urticaria: long-term results from the REMIX-1\/-2 phase 3 trials","volume":"155","author":"Metz","year":"2025","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2025.09.014_bib0119","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jdin.2024.03.025","article-title":"Dupilumab improves pruritus and skin lesions in patients with prurigo nodularis: pooled results from 2 phase 3 trials (LIBERTY-PN PRIME and PRIME2)","volume":"16","author":"Yosipovitch","year":"2024","journal-title":"JAAD Int"},{"issue":"10","key":"10.1016\/j.anai.2025.09.014_bib0120","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1056\/NEJMoa2408792","article-title":"Remibrutinib in chronic spontaneous urticaria","volume":"392","author":"Metz","year":"2025","journal-title":"N Engl J Med"},{"issue":"10246","key":"10.1016\/j.anai.2025.09.014_bib0121","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0140-6736(20)30732-7","article-title":"Efficacy and safety of abrocitinib in adults and adolescents with moderate-to-severe atopic dermatitis (JADE MONO-1): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial","volume":"396","author":"Simpson","year":"2020","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.anai.2025.09.014_bib0122","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jaci.2023.10.007","article-title":"Remibrutinib demonstrates favorable safety profile and sustained efficacy in chronic spontaneous urticaria over 52 weeks","volume":"153","author":"Jain","year":"2024","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.anai.2025.09.014_bib0123","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/bjd\/ljaf156","article-title":"Efficacy and safety of rilzabrutinib in patients with moderate-to-severe atopic dermatitis: 16-week results from a proof-of-concept phase II clinical trial","volume":"193","author":"Kircik","year":"2025","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.anai.2025.09.014_bib0124","doi-asserted-by":"crossref","unstructured":"Metz M, St\u00e4nder S, Moiin A, Nattkemper L, Bloom B, Alvarado D, et al. Safety and efficacy of barzolvolimab, an anti-KIT monoclonal antibody, in adults with moderate-to-severe prurigo nodularis: a randomized phase 1b intravenous single-dose study [e-pub ahead of print]. J Am Acad Dermatol. https:\/\/doi.org\/10.1016\/j.jaad.2025.08.022. Accessed August 22, 2025.","DOI":"10.1016\/j.jaad.2025.08.022"},{"issue":"8","key":"10.1016\/j.anai.2025.09.014_bib0125","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1111\/all.16598","article-title":"Anti-KIT barzolvolimab for chronic spontaneous urticaria","volume":"80","author":"Maurer","year":"2025","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.anai.2025.09.014_bib0126","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1093\/bjd\/ljae052","article-title":"Prurigo nodularis: new insights into pathogenesis and novel therapeutics","volume":"190","author":"Liao","year":"2024","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.anai.2025.09.014_bib0127","unstructured":"ClincalTrials.gov. A study of barzolvolimab in patients with atopic dermatitis. Accessed September 1, 2025. Available at: https:\/\/clinicaltrials.gov\/study\/NCT06727552"},{"issue":"5","key":"10.1016\/j.anai.2025.09.014_bib0128","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1517\/14656566.2016.1127355","article-title":"Advances in therapeutic strategies for the treatment of pruritus","volume":"17","author":"Stull","year":"2016","journal-title":"Expert Opin Pharmacother"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0129","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.det.2019.08.008","article-title":"Phototherapy for itch","volume":"38","author":"Zhong","year":"2020","journal-title":"Dermatol Clin"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0130","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/1744666X.2023.2272048","article-title":"Intravenous difelikefalin for the treatment of hemodialysis pruritus","volume":"20","author":"Mahmoud","year":"2024","journal-title":"Expert Rev Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2025.09.014_bib0131","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s40257-024-00898-5","article-title":"From compression to itch: exploring the link between nerve compression and neuropathic pruritus","volume":"26","author":"Mashoudy","year":"2025","journal-title":"Am J Clin Dermatol"},{"issue":"18","key":"10.1016\/j.anai.2025.09.014_bib0132","doi-asserted-by":"crossref","first-page":"5368","DOI":"10.3390\/jcm13185368","article-title":"Integrative treatment approaches with mind-body therapies in the management of atopic dermatitis","volume":"13","author":"Yosipovitch","year":"2024","journal-title":"J Clin Med"},{"issue":"22","key":"10.1016\/j.anai.2025.09.014_bib0133","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.3390\/jcm13226854","article-title":"A narrative review on stress and itch: what we know and what we would like to know","volume":"13","author":"Khalil","year":"2024","journal-title":"J Clin Med"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120625012001?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120625012001?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:42:33Z","timestamp":1773387753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120625012001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":133,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1081120625012001"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2025.09.014","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Basic mechanisms of itch and advances in clinical management","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2025.09.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}