{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:01:21Z","timestamp":1781586081783,"version":"3.54.5"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca PLC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.anai.2025.09.015","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T07:04:48Z","timestamp":1759993488000},"page":"61-65.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of tezepelumab on asthma exacerbations co-occurring with infection-attributed acute respiratory illnesses"],"prefix":"10.1016","volume":"136","author":[{"given":"Wojciech","family":"Feleszko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Caminati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Gern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian L.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Marchese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Ambrose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2670-704X","authenticated-orcid":false,"given":"Andrew W.","family":"Lindsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.anai.2025.09.015_bib0001","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s12016-014-8435-x","article-title":"Infection in severe asthma exacerbations and critical asthma syndrome","volume":"48","author":"Sandrock","year":"2015","journal-title":"Clin Rev Allergy Immunol"},{"issue":"7340","key":"10.1016\/j.anai.2025.09.015_bib0002","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/bmj.324.7340.763","article-title":"Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study","volume":"324","author":"Green","year":"2002","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.anai.2025.09.015_bib0003","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1398-9995.2010.02505.x","article-title":"Viruses and bacteria in acute asthma exacerbations \u2013 a GA\u00b2 LEN-DARE systematic review","volume":"66","author":"Papadopoulos","year":"2011","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.anai.2025.09.015_bib0004","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1183\/09031936.00149009","article-title":"Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers","volume":"36","author":"Xepapadaki","year":"2010","journal-title":"Eur Respir J"},{"issue":"11","key":"10.1016\/j.anai.2025.09.015_bib0005","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.4049\/jimmunol.0901194","article-title":"Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells","volume":"184","author":"Gill","year":"2010","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.anai.2025.09.015_bib0006","first-page":"325","article-title":"Thymic stromal lymphopoietin (TSLP) as a bridge between infection and atopy","volume":"1","author":"Esnault","year":"2008","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"10.1016\/j.anai.2025.09.015_bib0007","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1164\/rccm.202210-2005OC","article-title":"Efficacy of tezepelumab in severe, uncontrolled asthma: pooled analysis of the PATHWAY and NAVIGATOR clinical trials","volume":"208","author":"Corren","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2025.09.015_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/JAA.S286036","article-title":"Tezepelumab reduces exacerbations across all seasons in patients with severe, uncontrolled asthma: a post hoc analysis of the PATHWAY phase 2b study","volume":"14","author":"Corren","year":"2021","journal-title":"J Asthma Allergy"},{"issue":"5","key":"10.1016\/j.anai.2025.09.015_bib0009","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.anai.2023.08.015","article-title":"Tezepelumab reduces exacerbations across all seasons in patients with severe, uncontrolled asthma (NAVIGATOR)","volume":"131","author":"Pavord","year":"2023","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2025.09.015_bib0010","unstructured":"MedDRA. Multiaxiality. Accessed May 8, 2025. Available at: https:\/\/www.meddra.org\/multiaxiality"},{"issue":"3","key":"10.1016\/j.anai.2025.09.015_bib0011","doi-asserted-by":"crossref","first-page":"155","DOI":"10.12793\/tcp.2022.30.e16","article-title":"Implementation of Miettinen-Nurminen score method with or without stratification in R","volume":"30","author":"Lee","year":"2022","journal-title":"Transl Clin Pharmacol"},{"issue":"2","key":"10.1016\/j.anai.2025.09.015_bib0012","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/sim.4780040211","article-title":"Comparative analysis of two rates","volume":"4","author":"Miettinen","year":"1985","journal-title":"Stat Med"},{"issue":"7","key":"10.1016\/j.anai.2025.09.015_bib0013","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1136\/thx.2009.125930","article-title":"Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma","volume":"65","author":"Uller","year":"2010","journal-title":"Thorax"},{"issue":"2","key":"10.1016\/j.anai.2025.09.015_bib0014","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.4049\/jimmunol.179.2.1080","article-title":"TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells","volume":"179","author":"Kato","year":"2007","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.anai.2025.09.015_bib0015","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.jaci.2012.07.031","article-title":"Thymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infection","volume":"130","author":"Lee","year":"2012","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2025.09.015_bib0016","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jaci.2015.05.007","article-title":"Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33","volume":"137","author":"Mehta","year":"2016","journal-title":"J Allergy Clin Immunol"},{"issue":"11","key":"10.1016\/j.anai.2025.09.015_bib0017","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S2213-2600(21)00226-5","article-title":"Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a double-blind, randomised, placebo-controlled, phase 2 trial","volume":"9","author":"Diver","year":"2021","journal-title":"Lancet Respir Med"},{"issue":"7","key":"10.1016\/j.anai.2025.09.015_bib0018","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1007\/s12325-024-02889-8","article-title":"Efficacy of tezepelumab in patients with severe, uncontrolled asthma across multiple clinically relevant subgroups in the NAVIGATOR study","volume":"41","author":"Carr","year":"2024","journal-title":"Adv Ther"},{"issue":"5","key":"10.1016\/j.anai.2025.09.015_bib0019","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1164\/rccm.202201-0129OC","article-title":"Exacerbation profile and risk factors in a type-2-low enriched severe asthma cohort: a clinical trial to assess asthma exacerbation phenotypes","volume":"206","author":"McDowell","year":"2022","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120625012013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120625012013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:52:04Z","timestamp":1773899524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120625012013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1081120625012013"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2025.09.015","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of tezepelumab on asthma exacerbations co-occurring with infection-attributed acute respiratory illnesses","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2025.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}