{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:13:23Z","timestamp":1782512003303,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.anai.2025.09.019","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T06:09:55Z","timestamp":1759298995000},"page":"75-84.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative effectiveness of fixed-dose inhaled corticosteroid\/long-acting beta-agonist therapy in adult patients with asthma"],"prefix":"10.1016","volume":"136","author":[{"given":"Te-Jung","family":"Kung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Fu","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Chieh","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8249-7481","authenticated-orcid":false,"given":"Fang-Ju","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.anai.2025.09.019_bib0001","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jaip.2017.05.001","article-title":"Asthma exacerbations: pathogenesis, prevention, and treatment","volume":"5","author":"Castillo","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.anai.2025.09.019_bib0002","unstructured":"Global Initiative for Asthma. Global strategy for asthma management and prevention. Accessed March 30, 2025. Available at: https:\/\/ginasthma.org\/2024-report\/"},{"issue":"4","key":"10.1016\/j.anai.2025.09.019_bib0003","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005535","article-title":"Long-acting beta2-agonists versus placebo in addition to inhaled corticosteroids in children and adults with chronic asthma","volume":"4","author":"Ni Chroinin","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"10.1016\/j.anai.2025.09.019_bib0004","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1465-9921-8-46","article-title":"Salmeterol\/fluticasone stable-dose treatment compared with formoterol\/budesonide adjustable maintenance dosing: impact on health-related quality of life","volume":"8","author":"Price","year":"2007","journal-title":"Respir Res"},{"issue":"7","key":"10.1016\/j.anai.2025.09.019_bib0005","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2165\/11533420-000000000-00000","volume":"30","author":"Aalbers","year":"2010","journal-title":"Clin Drug Investig"},{"issue":"5","key":"10.1016\/j.anai.2025.09.019_bib0006","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.pupt.2011.05.004","article-title":"Comparison of budesonide\/formoterol Turbuhaler with fluticasone\/salmeterol Diskus for treatment effects on small airway impairment and airway inflammation in patients with asthma","volume":"24","author":"Hozawa","year":"2011","journal-title":"Pulm Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.anai.2025.09.019_bib0007","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2332\/allergolint.13-OA-0590","article-title":"A comparison of long-term anti-inflammatory effect of two ICS\/LABA combination inhalers; fix-dosed maintenance therapy with budesonide\/formoterol and salmeterol\/fluticasone","volume":"63","author":"Hojo","year":"2014","journal-title":"Allergol Int"},{"issue":"4","key":"10.1016\/j.anai.2025.09.019_bib0008","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1183\/09031936.00095906","article-title":"Beclomethasone\/formoterol versus budesonide\/formoterol combination therapy in asthma","volume":"29","author":"Papi","year":"2007","journal-title":"Eur Respir J."},{"key":"10.1016\/j.anai.2025.09.019_bib0009","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pupt.2014.08.007","article-title":"Effects of beclomethason\/formoterol and budesonide\/formoterol fixed combinations on lung function and airway inflammation in patients with mild to moderate asthma \u2013 an exploratory study","volume":"31","author":"Kirsten","year":"2015","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.anai.2025.09.019_bib0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pupt.2016.01.005","article-title":"Comparison of early effects of budesonide\/formoterol maintenance and reliever therapy with fluticasone furoate\/vilanterol for asthma patients requiring step-up from inhaled corticosteroid monotherapy","volume":"37","author":"Hozawa","year":"2016","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.anai.2025.09.019_bib0011","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.rmed.2018.06.009","article-title":"Efficacy and safety of once-daily fluticasone furoate\/vilanterol (FF\/VI) versus twice-daily inhaled corticosteroids\/long-acting \u03b22-agonists (ICS\/LABA) in patients with uncontrolled asthma: an open-label, randomized, controlled trial","volume":"141","author":"Devillier","year":"2018","journal-title":"Respir Med"},{"issue":"4","key":"10.1016\/j.anai.2025.09.019_bib0012","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1378\/chest.13-0178","article-title":"Efficacy and safety of fluticasone furoate\/vilanterol compared with fluticasone propionate\/salmeterol combination in adult and adolescent patients with persistent asthma : a randomized trial","volume":"144","author":"Woodcock","year":"2013","journal-title":"Chest"},{"issue":"9","key":"10.1016\/j.anai.2025.09.019_bib0013","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1080\/02770903.2017.1386214","article-title":"Once-daily fluticasone furoate\/vilanterol versus twice-daily fluticasone propionate\/salmeterol in patients with asthma well controlled on ICS\/LABA","volume":"55","author":"Bernstein","year":"2018","journal-title":"J Asthma"},{"issue":"7","key":"10.1016\/j.anai.2025.09.019_bib0014","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1080\/02770903.2018.1490751","article-title":"Effectiveness of fluticasone furoate\/vilanterol versus fluticasone propionate\/salmeterol on asthma control in the Salford Lung Study","volume":"56","author":"Jacques","year":"2019","journal-title":"J Asthma"},{"issue":"1","key":"10.1016\/j.anai.2025.09.019_bib0015","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1055\/s-0043-118536","article-title":"A comparison of the efficacy of once-daily fluticasone furoate\/vilanterole with twice-daily fluticasone propionate\/salmeterol in elderly asthmatics","volume":"68","author":"Ishiura","year":"2018","journal-title":"Drug Res (Stuttg)"},{"issue":"10","key":"10.1016\/j.anai.2025.09.019_bib0016","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/j.1398-9995.2007.01493.x","article-title":"ICAT SE study group. Beclomethasone\/formoterol vs fluticasone\/salmeterol inhaled combination in moderate to severe asthma","volume":"62","author":"Papi","year":"2007","journal-title":"Allergy"},{"issue":"12","key":"10.1016\/j.anai.2025.09.019_bib0017","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.jfma.2017.12.005","article-title":"Comparative efficacy and tolerability of beclomethasone\/formoterol and fluticasone\/salmeterol fixed combination in Taiwanese asthmatic patients","volume":"117","author":"Hsieh","year":"2018","journal-title":"J Formos Med Assoc"},{"issue":"12","key":"10.1016\/j.anai.2025.09.019_bib0018","article-title":"Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in adults and children","volume":"2011","author":"Lasserson","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"12","key":"10.1016\/j.anai.2025.09.019_bib0019","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1111\/j.1742-1241.2008.01895.x","article-title":"A retrospective database study comparing treatment outcomes and cost associated with choice of fixed-dose inhaled corticosteroid\/long-acting beta-agonists for asthma maintenance treatment in Germany","volume":"62","author":"Aball\u00e9a","year":"2008","journal-title":"Int J Clin Pract"},{"issue":"6","key":"10.1016\/j.anai.2025.09.019_bib0020","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jaip.2014.07.016","article-title":"Comparative effectiveness of budesonide-formoterol combination and fluticasone-salmeterol combination for asthma management: a United States retrospective database analysis","volume":"2","author":"Tunceli","year":"2014","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"7","key":"10.1016\/j.anai.2025.09.019_bib0021","doi-asserted-by":"crossref","first-page":"762","DOI":"10.3109\/02770903.2014.905592","article-title":"Real-world effects of two inhaled corticosteroid\/long-acting \u03b22-agonist combinations in the treatment of asthma","volume":"51","author":"Yatera","year":"2014","journal-title":"J Asthma"},{"issue":"17","key":"10.1016\/j.anai.2025.09.019_bib0022","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.2217\/cer-2021-0142","article-title":"Budesonide\/formoterol versus salmeterol\/fluticasone for asthma in children: an effectiveness and safety analysis","volume":"10","author":"Jiang","year":"2021","journal-title":"J Comp Eff Res"},{"issue":"9","key":"10.1016\/j.anai.2025.09.019_bib0023","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1080\/02770903.2021.1963767","article-title":"Symptom control in patients with asthma using inhaled corticosteroids\/long-acting \u03b22-agonists (fluticasone furoate\/vilanterol or budesonide\/formoterol) in the US: a retrospective matched cohort study","volume":"59","author":"Averell","year":"2021","journal-title":"J Asthma"},{"key":"10.1016\/j.anai.2025.09.019_bib0024","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40248-018-0131-x","article-title":"Fluticasone furoate\/vilanterol 92\/22 \u03bcg once-a-day vs beclomethasone dipropionate\/formoterol 100\/6 \u03bcg b. I.D.: a 12-month comparison of outcomes in mild-to-moderate asthma","volume":"13","author":"Dal Negro","year":"2018","journal-title":"Multidiscip Respir Med"},{"issue":"4","key":"10.1016\/j.anai.2025.09.019_bib0025","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-053964","article-title":"Treatment persistence and exacerbations in patients with asthma initiating treatment with inhaled corticosteroids and beta-adrenergic agonists: retrospective cohort study","volume":"12","author":"Sicras-Mainar","year":"2022","journal-title":"BMJ Open"},{"key":"10.1016\/j.anai.2025.09.019_bib0026","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2147\/CLEP.S196293","article-title":"Taiwan\u2019s National Health Insurance Research Database: past and future","volume":"11","author":"Hsieh","year":"2019","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.anai.2025.09.019_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.pupt.2022.102167","article-title":"May a different kinetic mode explain the high efficacy\/safety profile of inhaled budesonide?","volume":"77","author":"Brattsand","year":"2022","journal-title":"Pulm Pharmacol Ther"},{"issue":"7","key":"10.1016\/j.anai.2025.09.019_bib0028","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1080\/17425255.2016.1192125","article-title":"Pharmacodynamic and pharmacokinetic assessment of fluticasone furoate + vilanterol for the treatment of asthma","volume":"12","author":"Calzetta","year":"2016","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"5","key":"10.1016\/j.anai.2025.09.019_bib0029","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1517\/14656566.2016.1145659","article-title":"Fixed-Dose combination of the inhaled corticosteroid and long-acting beta2-agonist therapy in adults with persistent asthma","volume":"17","author":"Chantaphakul","year":"2016","journal-title":"Expert Opin Pharmacother"},{"issue":"9","key":"10.1016\/j.anai.2025.09.019_bib0030","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1007\/s12325-023-02585-z","article-title":"Assessing the effects of changing patterns of inhaled corticosteroid dosing and adherence with fluticasone furoate and budesonide on asthma management","volume":"40","author":"Daley-Yates","year":"2023","journal-title":"Adv Ther"},{"issue":"suppl 1","key":"10.1016\/j.anai.2025.09.019_bib0031","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/S0954-6111(12)70005-7","article-title":"Inhaled corticosteroid and long-acting \u03b22-agonist pharmacological profiles: effective asthma therapy in practice","volume":"106","author":"Tamm","year":"2012","journal-title":"Respir Med"},{"issue":"5","key":"10.1016\/j.anai.2025.09.019_bib0032","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1586\/17476348.2016.1161508","article-title":"Inhaled beclometasone dipropionate\/formoterol fumarate extrafine fixed combination for the treatment of asthma","volume":"10","author":"Crisafulli","year":"2016","journal-title":"Expert Rev Respir Med"},{"issue":"1","key":"10.1016\/j.anai.2025.09.019_bib0033","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaci.2013.10.040","article-title":"Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine","volume":"133","author":"Ortega","year":"2014","journal-title":"J Allergy Clin Immunol"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120625012050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120625012050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T09:30:31Z","timestamp":1765963831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120625012050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1081120625012050"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2025.09.019","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative effectiveness of fixed-dose inhaled corticosteroid\/long-acting beta-agonist therapy in adult patients with asthma","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2025.09.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}