{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T19:49:09Z","timestamp":1793821749141,"version":"4.6.1"},"reference-count":153,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI175556"],"award-info":[{"award-number":["AI175556"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.anai.2025.11.005","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T08:38:27Z","timestamp":1763627907000},"page":"149-157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Basophils in atopic dermatitis"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9932-9548","authenticated-orcid":false,"given":"Mrinmoy","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raif S.","family":"Geha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-018-0001-z","article-title":"Atopic dermatitis","volume":"4","author":"Weidinger","year":"2018","journal-title":"Nat Rev Dis Primer"},{"key":"10.1016\/j.anai.2025.11.005_bib0002","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-031-54513-9_3","article-title":"Atopic dermatitis: pathophysiology","volume":"1447","author":"Boothe","year":"2024","journal-title":"Adv Exp Med Biol"},{"issue":"10023","key":"10.1016\/j.anai.2025.11.005_bib0003","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0140-6736(15)00149-X","article-title":"Atopic dermatitis","volume":"387","author":"Weidinger","year":"2016","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.anai.2025.11.005_bib0004","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.anai.2023.11.009","article-title":"Atopic dermatitis (eczema) guidelines: 2023 American Academy of Allergy, Asthma and Immunology\/American College of Allergy, Asthma and Immunology Joint Task Force on Practice Parameters GRADE\u2013 and Institute of Medicine\u2013based recommendations","volume":"132","author":"Chu","year":"2024","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"12","key":"10.1016\/j.anai.2025.11.005_bib0005","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra2023911","article-title":"Atopic dermatitis","volume":"384","author":"St\u00e4nder","year":"2021","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.anai.2025.11.005_bib0006","doi-asserted-by":"crossref","DOI":"10.5070\/D3258045124","article-title":"The prevalence of atopic dermatitis in adults: systematic review on population studies","volume":"25","author":"Mathiesen","year":"2019","journal-title":"Dermatol Online J"},{"issue":"suppl 1","key":"10.1016\/j.anai.2025.11.005_bib0007","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000370220","article-title":"Atopic dermatitis: global epidemiology and risk factors","volume":"66","author":"Nutten","year":"2015","journal-title":"Ann Nutr Metab"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0008","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.clindermatol.2011.11.004","article-title":"Psychosomatic factors in pruritus","volume":"31","author":"Tey","year":"2013","journal-title":"Clin Dermatol"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0009","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s40272-022-00499-x","article-title":"Recent developments and advances in atopic dermatitis: a focus on epidemiology, pathophysiology, and treatment in the pediatric setting","volume":"24","author":"Eichenfield","year":"2022","journal-title":"Paediatr Drugs"},{"key":"10.1016\/j.anai.2025.11.005_bib0010","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2147\/JAA.S404350","article-title":"Implications of atopic dermatitis on the quality of life of 6-11 years old children and caregivers (PEDI-BURDEN)","volume":"16","author":"Neri","year":"2023","journal-title":"J Asthma Allergy"},{"issue":"5","key":"10.1016\/j.anai.2025.11.005_bib0011","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.anai.2025.02.017","article-title":"Depression and anxiety in patients with atopic dermatitis: recognizing and addressing mental health burden","volume":"134","author":"LeBovidge","year":"2025","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.1016\/j.anai.2025.11.005_bib0012","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4168\/aair.2011.3.2.67","article-title":"The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma","volume":"3","author":"Zheng","year":"2011","journal-title":"Allergy Asthma Immunol Res"},{"issue":"10","key":"10.1016\/j.anai.2025.11.005_bib0013","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1111\/all.16247","article-title":"Navigating the evolving landscape of atopic dermatitis: challenges and future opportunities: the 4th Davos declaration","volume":"79","author":"Traidl-Hoffmann","year":"2024","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.anai.2025.11.005_bib0014","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.anai.2017.10.037","article-title":"The atopic march: critical evidence and clinical relevance","volume":"120","author":"Hill","year":"2018","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0015","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jaci.2025.02.029","article-title":"Endotypes of atopic dermatitis","volume":"156","author":"Fyhrquist","year":"2025","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.anai.2025.11.005_bib0016","first-page":"51","article-title":"An overview of atopic dermatitis disease burden, pathogenesis, and the current treatment landscape: recommendations for appropriate utilization of systemic therapies","volume":"18","author":"Martin","year":"2025","journal-title":"J Clin Aesthetic Dermatol"},{"issue":"8","key":"10.1016\/j.anai.2025.11.005_bib0017","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1080\/1744666X.2021.1940962","article-title":"The IL-4, IL-13 and IL-31 pathways in atopic dermatitis","volume":"17","author":"Dubin","year":"2021","journal-title":"Expert Rev Clin Immunol"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0018","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.iac.2025.06.006","article-title":"The mechanisms of immunoglobulin E sensitizations in atopic dermatitis","volume":"45","author":"Mukherjee","year":"2025","journal-title":"Immunol Allergy Clin North Am"},{"issue":"3","key":"10.1016\/j.anai.2025.11.005_bib0019","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41423-025-01261-2","article-title":"Type 2 immunity in allergic diseases","volume":"22","author":"Ogulur","year":"2025","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.anai.2025.11.005_bib0020","article-title":"Interplay of cytokines in the pathophysiology of atopic dermatitis: insights from Murin models and human","volume":"11","author":"Yamamura","year":"2024","journal-title":"Front Med (Lausanne)"},{"issue":"3","key":"10.1016\/j.anai.2025.11.005_bib0021","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/all.15591","article-title":"Dupilumab has a profound effect on specific-IgE levels of several food allergens in atopic dermatitis patients","volume":"78","author":"Spekhorst","year":"2023","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0022","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jaci.2018.08.022","article-title":"Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis","volume":"143","author":"Guttman-Yassky","year":"2019","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.anai.2025.11.005_bib0023","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1056\/NEJMoa1314768","article-title":"Dupilumab treatment in adults with moderate-to-severe atopic dermatitis","volume":"371","author":"Beck","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.anai.2025.11.005_bib0024","series-title":"StatPearls","article-title":"Dupilumab","author":"Gade","year":"2025"},{"issue":"6","key":"10.1016\/j.anai.2025.11.005_bib0025","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.jaip.2017.08.005","article-title":"Expert perspectives on management of moderate-to-severe atopic dermatitis: a multidisciplinary consensus addressing current and emerging therapies","volume":"5","author":"Boguniewicz","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.anai.2025.11.005_bib0026","doi-asserted-by":"crossref","first-page":"595","DOI":"10.2147\/JAA.S287638","article-title":"Current perspectives on the systemic management of atopic dermatitis","volume":"14","author":"Davari","year":"2021","journal-title":"J Asthma Allergy"},{"issue":"3","key":"10.1016\/j.anai.2025.11.005_bib0027","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/cei.13575","article-title":"Keratinocytes: innate immune cells in atopic dermatitis","volume":"204","author":"Chieosilapatham","year":"2021","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"10.1016\/j.anai.2025.11.005_bib0028","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1016\/j.jaci.2020.11.036","article-title":"Mast cell\u2013derived IL-13 downregulates IL-12 production by skin dendritic cells to inhibit the TH1 cell response to cutaneous antigen exposure","volume":"147","author":"Leyva-Castillo","year":"2021","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.anai.2025.11.005_bib0029","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.jaci.2023.01.011","article-title":"The IL-4R\u03b1 Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice","volume":"151","author":"Yang","year":"2023","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.anai.2025.11.005_bib0030","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1111\/all.14662","article-title":"Basophils and their effector molecules in allergic disorders","volume":"76","author":"Miyake","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2025.11.005_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1213138","article-title":"Basophils in pruritic skin diseases","volume":"14","author":"Wiebe","year":"2023","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.anai.2025.11.005_bib0032","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jaci.2024.01.022","article-title":"Basophils are important for development of allergic skin inflammation","volume":"153","author":"Leyva-Castillo","year":"2024","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.anai.2025.11.005_bib0033","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jaci.2017.10.042","article-title":"Multifaceted roles of basophils in health and disease","volume":"142","author":"Karasuyama","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2025.11.005_bib0034","doi-asserted-by":"crossref","first-page":"675","DOI":"10.2147\/JAA.S522343","article-title":"The role of basophils in atopic dermatitis, from pathogenesis to therapeutic perspectives","volume":"18","author":"Wang","year":"2025","journal-title":"J Asthma Allergy"},{"issue":"5","key":"10.1016\/j.anai.2025.11.005_bib0035","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.jid.2022.12.005","article-title":"Recent advances of basophils in pruritic skin diseases","volume":"143","author":"Liu","year":"2023","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.anai.2025.11.005_bib0036","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-immunol-031210-101257","article-title":"Nonredundant roles of basophils in immunity","volume":"29","author":"Karasuyama","year":"2011","journal-title":"Annu Rev Immunol"},{"issue":"12","key":"10.1016\/j.anai.2025.11.005_bib0037","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/intimm\/dxab021","article-title":"Basophils, a neglected minority in the immune system, have come into the limelight at last","volume":"33","author":"Karasuyama","year":"2021","journal-title":"Int Immunol"},{"issue":"7","key":"10.1016\/j.anai.2025.11.005_bib0038","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.it.2024.05.009","article-title":"Basophil differentiation, heterogeneity, and functional implications","volume":"45","author":"Chen","year":"2024","journal-title":"Trends Immunol"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0039","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1172\/JCI124609","article-title":"Neuro-immune crosstalk and allergic inflammation","volume":"129","author":"Kabata","year":"2019","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.anai.2025.11.005_bib0040","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.cell.2020.12.033","article-title":"A basophil-neuronal axis promotes itch","volume":"184","author":"Wang","year":"2021","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.anai.2025.11.005_bib0041","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.jaci.2021.06.010","article-title":"Basophil: the cell that itches","volume":"148","author":"Das","year":"2021","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"10.1016\/j.anai.2025.11.005_bib0042","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/exd.13705","article-title":"Possible roles of basophils in chronic itch","volume":"28","author":"Hashimoto","year":"2019","journal-title":"Exp Dermatol"},{"issue":"2","key":"10.1016\/j.anai.2025.11.005_bib0043","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.cell.2020.12.035","article-title":"Basophils add fuel to the flame of eczema itch","volume":"184","author":"Mali","year":"2021","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.anai.2025.11.005_bib0044","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9123942","article-title":"Investigation of basophil activation test for diagnosing milk and egg allergy in younger children","volume":"9","author":"Kim","year":"2020","journal-title":"J Clin Med"},{"issue":"3","key":"10.1016\/j.anai.2025.11.005_bib0045","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.alit.2021.01.005","article-title":"Activated steady status and distinctive Fc\u03b5RI-mediated responsiveness in basophils of atopic dermatitis","volume":"70","author":"Imamura","year":"2021","journal-title":"Allergol Int"},{"key":"10.1016\/j.anai.2025.11.005_bib0046","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.3389\/fimmu.2020.01815","article-title":"Basophil activation as marker of clinically relevant allergy and therapy outcome","volume":"11","author":"Eberlein","year":"2020","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.anai.2025.11.005_bib0047","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1111\/all.14747","article-title":"Basophil activation test: mechanisms and considerations for use in clinical trials and clinical practice","volume":"76","author":"Santos","year":"2021","journal-title":"Allergy"},{"issue":"12","key":"10.1016\/j.anai.2025.11.005_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2024.100998","article-title":"Applications of basophil activation test in paediatric allergic diseases","volume":"17","author":"Giulia","year":"2024","journal-title":"World Allergy Organ J"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0049","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1080\/21645515.2017.1417711","article-title":"The role of basophils as innate immune regulatory cells in allergy and immunotherapy","volume":"14","author":"Chirumbolo","year":"2018","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.anai.2025.11.005_bib0050","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000358734","article-title":"Basophils: historical reflections and perspectives","volume":"100","author":"Marone","year":"2014","journal-title":"Chem Immunol Allergy"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0051","doi-asserted-by":"crossref","first-page":"kyae003","DOI":"10.1093\/discim\/kyae003","article-title":"The ontogenesis and heterogeneity of basophils","volume":"3","author":"Park","year":"2024","journal-title":"Discov Immunol"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0052","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12627","article-title":"Human mast cells and basophils-How are they similar how are they different?","volume":"282","author":"Varricchi","year":"2018","journal-title":"Immunol Rev"},{"issue":"6","key":"10.1016\/j.anai.2025.11.005_bib0053","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0952-7915(00)00154-0","article-title":"Roles of mast cells and basophils in innate and acquired immunity","volume":"12","author":"Wedemeyer","year":"2000","journal-title":"Curr Opin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0054","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1038\/s41467-023-38356-1","article-title":"Single cell transcriptomics clarifies the basophil differentiation trajectory and identifies pre-basophils upstream of mature basophils","volume":"14","author":"Miyake","year":"2023","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.anai.2025.11.005_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126435","article-title":"Expression profiling of human basophils: modulation by cytokines and secretagogues","volume":"10","author":"MacGlashan","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.anai.2025.11.005_bib0056","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1111\/all.14633","article-title":"Single-cell molecular profiling provides a high-resolution map of basophil and mast cell development","volume":"76","author":"Hamey","year":"2021","journal-title":"Allergy"},{"issue":"3","key":"10.1016\/j.anai.2025.11.005_bib0057","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1365-2567.2011.03530.x","article-title":"Understanding the roles of basophils: breaking dawn","volume":"135","author":"Min","year":"2012","journal-title":"Immunology"},{"key":"10.1016\/j.anai.2025.11.005_bib0058","doi-asserted-by":"crossref","DOI":"10.3389\/falgy.2023.1133378","article-title":"Towards standardizing basophil identification by flow cytometry","volume":"4","author":"Sonder","year":"2023","journal-title":"Front Allergy"},{"issue":"21","key":"10.1016\/j.anai.2025.11.005_bib0059","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1101\/gad.1493506","article-title":"The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages","volume":"20","author":"Iwasaki","year":"2006","journal-title":"Genes Dev"},{"issue":"5","key":"10.1016\/j.anai.2025.11.005_bib0060","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nri3427","article-title":"Protective and pathological roles of mast cells and basophils","volume":"13","author":"Voehringer","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"50","key":"10.1016\/j.anai.2025.11.005_bib0061","doi-asserted-by":"crossref","first-page":"18105","DOI":"10.1073\/pnas.0509148102","article-title":"Developmental checkpoints of the basophil\/mast cell lineages in adult murine hematopoiesis","volume":"102","author":"Arinobu","year":"2005","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.anai.2025.11.005_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2021.101510","article-title":"IL-3 in the development and function of basophils","volume":"54","author":"Varricchi","year":"2021","journal-title":"Semin Immunol"},{"issue":"5","key":"10.1016\/j.anai.2025.11.005_bib0063","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00281-016-0567-z","article-title":"New insights into basophil heterogeneity","volume":"38","author":"Oetjen","year":"2016","journal-title":"Semin Immunopathol"},{"issue":"2","key":"10.1016\/j.anai.2025.11.005_bib0064","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.immuni.2005.06.011","article-title":"Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells","volume":"23","author":"Mukai","year":"2005","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.anai.2025.11.005_bib0065","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jaci.2004.10.018","article-title":"Toll-like receptor 2 ligands activate human basophils for both IgE-dependent and IgE-independent secretion","volume":"115","author":"Bieneman","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2025.11.005_bib0066","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1749-6632.2010.05918.x","article-title":"New insights into basophil biology: initiators, regulators and effectors of type 2 inflammation","volume":"1217","author":"Siracusa","year":"2011","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0067","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/MOH.0b013e3282f13ce8","article-title":"Basophils and TYPE 2 immunity","volume":"15","author":"Min","year":"2008","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.anai.2025.11.005_bib0068","unstructured":"Annual Reviews. Regulatory T cells and human disease. Accessed August 30, 2025. Available at: https:\/\/www.annualreviews.org\/content\/journals\/10.1146\/annurev-immunol-042718-041717"},{"issue":"23","key":"10.1016\/j.anai.2025.11.005_bib0069","doi-asserted-by":"crossref","first-page":"eaan0829","DOI":"10.1126\/sciimmunol.aan0829","article-title":"Regulatory T cells induce activation rather than suppression of human basophils","volume":"3","author":"Sharma","year":"2018","journal-title":"Sci Immunol"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0070","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2020.1773193","article-title":"Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms","volume":"9","author":"Das","year":"2020","journal-title":"Oncoimmunology"},{"issue":"8","key":"10.1016\/j.anai.2025.11.005_bib0071","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1111\/j.1365-2222.2010.03542.x","article-title":"Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation","volume":"40","author":"Wang","year":"2010","journal-title":"Clin Exp Allergy"},{"issue":"9","key":"10.1016\/j.anai.2025.11.005_bib0072","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.4049\/jimmunol.181.9.5981","article-title":"An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor","volume":"181","author":"Suzukawa","year":"2008","journal-title":"J Immunol"},{"issue":"7363","key":"10.1016\/j.anai.2025.11.005_bib0073","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nature10329","article-title":"TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation","volume":"477","author":"Siracusa","year":"2011","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0074","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.jaci.2017.11.012","article-title":"Thymic stromal lymphopoietin does not activate human basophils","volume":"141","author":"Salabert-Le Guen","year":"2018","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"10.1016\/j.anai.2025.11.005_bib0075","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/ni.1738","article-title":"Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response","volume":"10","author":"Sokol","year":"2009","journal-title":"Nat Immunol"},{"issue":"6","key":"10.1016\/j.anai.2025.11.005_bib0076","doi-asserted-by":"crossref","first-page":"e233","DOI":"10.3324\/haematol.2016.163451","article-title":"Demystification of enigma on antigen-presenting cell features of human basophils: data from secondary lymphoid organs","volume":"102","author":"Stephen-Victor","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.anai.2025.11.005_bib0077","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/srep01188","article-title":"Circulating human basophils lack the features of professional antigen presenting cells","volume":"3","author":"Sharma","year":"2013","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0078","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.4049\/jimmunol.132.4.1943","article-title":"Biochemical and functional characterization of proteoglycans isolated from basophils of patients with chronic myelogenous leukemia","volume":"132","author":"Metcalfe","year":"1984","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0079","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0952-3278(93)90026-S","article-title":"Purification of human blood basophils and leukotriene C4 generation following calcium ionophore stimulation","volume":"49","author":"Mita","year":"1993","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"2","key":"10.1016\/j.anai.2025.11.005_bib0080","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0091-6749(95)70319-5","article-title":"Histamine release from human basophils induced by platelet activating factor: the role of extracellular calcium, interleukin-3, and granulocyte-macrophage colony-stimulating factor","volume":"95","author":"Columbo","year":"1995","journal-title":"J Allergy Clin Immunol"},{"issue":"11","key":"10.1016\/j.anai.2025.11.005_bib0081","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.4049\/jimmunol.145.11.3855","article-title":"The mechanism of mediator release from human basophils induced by platelet-activating factor","volume":"145","author":"Columbo","year":"1990","journal-title":"J Immunol"},{"issue":"6 Pt 2","key":"10.1016\/j.anai.2025.11.005_bib0082","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/0091-6749(94)90331-X","article-title":"Cytokine generation by human basophils","volume":"94","author":"Schroeder","year":"1994","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.anai.2025.11.005_bib0083","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.immuni.2014.04.013","article-title":"Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation","volume":"40","author":"Motomura","year":"2014","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0084","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/cea.12875","article-title":"Human basophils are a source of - and are differentially activated by - il-31","volume":"47","author":"Raap","year":"2017","journal-title":"Clin Exp Allergy"},{"issue":"3","key":"10.1016\/j.anai.2025.11.005_bib0085","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jaci.2021.02.018","article-title":"Basophils promote barrier dysfunction and resolution in the atopic skin","volume":"148","author":"Pellefigues","year":"2021","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.anai.2025.11.005_bib0086","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1158\/0008-5472.CAN-16-0993","article-title":"Basophils promote tumor rejection via chemotaxis and infiltration of CD8+ T cells","volume":"77","author":"Sektioglu","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.anai.2025.11.005_bib0087","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2019.154934","article-title":"Interleukin 2 regulates the activation of human basophils","volume":"127","author":"Zhao","year":"2020","journal-title":"Cytokine"},{"issue":"10","key":"10.1016\/j.anai.2025.11.005_bib0088","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1002\/eji.1830261033","article-title":"Purified human peripheral blood basophils release interleukin-13 and preformed interleukin-4 following immunological activation","volume":"26","author":"Gibbs","year":"1996","journal-title":"Eur J Immunol"},{"issue":"8","key":"10.1016\/j.anai.2025.11.005_bib0089","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1182\/blood.V88.8.3028.bloodjournal8883028","article-title":"Human blood basophils produce interleukin-13 in response to IgE-receptor-dependent and -independent activation","volume":"88","author":"Ochensberger","year":"1996","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0090","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/1346-8138.16987","article-title":"Cutaneous basophil infiltration in atopic dermatitis is associated with abundant epidermal infiltration of helper T cells: a preliminary retrospective study","volume":"51","author":"Nagashima","year":"2023","journal-title":"J Dermatol"},{"issue":"6","key":"10.1016\/j.anai.2025.11.005_bib0091","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.jaci.2024.06.021","article-title":"IL-4 acts on skin-derived dendritic cells to promote the TH2 response to cutaneous sensitization and the development of allergic skin inflammation","volume":"154","author":"Leyva-Castillo","year":"2024","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0092","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1189\/jlb.70.1.113","article-title":"Chemokine receptors in human basophils: inducible expression of functional CXCR4","volume":"70","author":"Iikura","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.anai.2025.11.005_bib0093","article-title":"IL-3 produced by T cells is crucial for basophil extravasation in hapten-induced allergic contact dermatitis","volume":"14","author":"Hachem","year":"2023","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0094","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.4049\/jimmunol.148.4.1086","article-title":"IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1","volume":"148","author":"Schleimer","year":"1992","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0095","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1172\/JCI124606","article-title":"Epithelial cell\u2013derived cytokines: more than just signaling the alarm","volume":"129","author":"Roan","year":"2019","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0096","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/cmi.2015.77","article-title":"NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammation","volume":"13","author":"Jiao","year":"2016","journal-title":"Cell Mol Immunol"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0097","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3390\/cells10040895","article-title":"Basophils orchestrating eosinophils\u2019 chemotaxis and function in allergic inflammation","volume":"10","author":"Iype","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0098","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/imr.12635","article-title":"Role of mast cells and basophils in pruritus","volume":"282","author":"Steinhoff","year":"2018","journal-title":"Immunol Rev"},{"issue":"12","key":"10.1016\/j.anai.2025.11.005_bib0099","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.it.2018.10.001","article-title":"The itch\u2013scratch cycle: a neuroimmune perspective","volume":"39","author":"Mack","year":"2018","journal-title":"Trends Immunol"},{"issue":"21","key":"10.1016\/j.anai.2025.11.005_bib0100","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.149953","article-title":"Basophil-derived IL-4 promotes cutaneous Staphylococcus aureus infection","volume":"6","author":"Leyva-Castillo","year":"2021","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.anai.2025.11.005_bib0101","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/JLB.3MR0921-030RRR","article-title":"A review of the mechanisms of keratinocytes damage caused by Staphylococcus aureus infection in patients with atopic dermatitis","volume":"110","author":"Tian","year":"2021","journal-title":"J Leukoc Biol"},{"issue":"7","key":"10.1016\/j.anai.2025.11.005_bib0102","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3390\/toxins14070464","article-title":"Exploring the role of Staphylococcus aureus in inflammatory diseases","volume":"14","author":"Chen","year":"2022","journal-title":"Toxins (Basel)"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0103","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/cea.13772","article-title":"Basophil activation test for Staphylococcus aureus enterotoxins in severe asthmatic patients","volume":"51","author":"Flora","year":"2021","journal-title":"Clin Exp Allergy"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0104","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/bjd.14566","article-title":"Prevalence and odds of Staphylococcus aureus carriage in atopic dermatitis: a systematic review and meta-analysis","volume":"175","author":"Tott\u00e9","year":"2016","journal-title":"Br J Dermatol"},{"issue":"5","key":"10.1016\/j.anai.2025.11.005_bib0105","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4168\/aair.2019.11.5.593","article-title":"Interactions between atopic dermatitis and Staphylococcus aureus infection: clinical implications","volume":"11","author":"Kim","year":"2019","journal-title":"Allergy Asthma Immunol Res"},{"issue":"7","key":"10.1016\/j.anai.2025.11.005_bib0106","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1046\/j.1365-2222.2000.00848.x","article-title":"Colonization with superantigen-producing Staphylococcus aureus is associated with increased severity of atopic dermatitis","volume":"30","author":"Zollner","year":"2000","journal-title":"Clin Exp Allergy"},{"issue":"10","key":"10.1016\/j.anai.2025.11.005_bib0107","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.jid.2018.03.1517","article-title":"patients with atopic dermatitis colonized with Staphylococcus aureus have a distinct phenotype and endotype","volume":"138","author":"Simpson","year":"2018","journal-title":"J Invest Dermatol"},{"issue":"10","key":"10.1016\/j.anai.2025.11.005_bib0108","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1111\/exd.14435","article-title":"Updated understanding of Staphylococcus aureus in atopic dermatitis: from virulence factors to commensals and clonal complexes","volume":"30","author":"Hwang","year":"2021","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.anai.2025.11.005_bib0109","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.567090","article-title":"Colonization with Staphylococcus aureus in atopic dermatitis patients: attempts to reveal the unknown","volume":"11","author":"Ogonowska","year":"2021","journal-title":"Front Microbiol"},{"issue":"12","key":"10.1016\/j.anai.2025.11.005_bib0110","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1016\/j.jid.2017.07.834","article-title":"Skin colonization by Staphylococcus aureus precedes the clinical diagnosis of atopic dermatitis in infancy","volume":"137","author":"Meylan","year":"2017","journal-title":"J Invest Dermatol"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0111","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1164\/rccm.201710-2112OC","article-title":"Staphylococcus aureus induces a mucosal Type 2 immune response via epithelial cell\u2013derived cytokines","volume":"198","author":"Lan","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2025.11.005_bib0112","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.902494","article-title":"Role of basophils in a broad spectrum of disorders","volume":"13","author":"Miyake","year":"2022","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.anai.2025.11.005_bib0113","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20240103","article-title":"Interleukin-33\u2013activated basophils promote asthma by regulating Th2 cell entry into lung tissue","volume":"221","author":"Schuijs","year":"2024","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0114","doi-asserted-by":"crossref","DOI":"10.1111\/imr.70024","article-title":"IgE-mediated activation of mast cells and basophils in health and disease","volume":"331","author":"Charles","year":"2025","journal-title":"Immunol Rev"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0115","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jaci.2017.02.035","article-title":"Basophil-derived IL-4 promotes epicutaneous antigen sensitization concomitant with the development of food allergy","volume":"141","author":"Hussain","year":"2018","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0116","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2013.07.046","article-title":"Basophils and allergic inflammation","volume":"132","author":"Siracusa","year":"2013","journal-title":"J Allergy Clin Immunol"},{"issue":"11","key":"10.1016\/j.anai.2025.11.005_bib0117","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/all.12698","article-title":"The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease","volume":"70","author":"Hoffmann","year":"2015","journal-title":"Allergy"},{"issue":"12","key":"10.1016\/j.anai.2025.11.005_bib0118","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1111\/all.15089","article-title":"Advances and highlights in biomarkers of allergic diseases","volume":"76","author":"Ogulur","year":"2021","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.anai.2025.11.005_bib0119","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/0091-6749(93)90318-A","article-title":"Patients with severe atopic dermatitis have activated circulating basophils","volume":"91","author":"James","year":"1993","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0120","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1038\/s41467-024-47691-w","article-title":"PD-L1\u2212 and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus","volume":"15","author":"Tchen","year":"2024","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.anai.2025.11.005_bib0121","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1080\/1744666X.2020.1816825","article-title":"Atopic phenotypes and their implication in the atopic march","volume":"16","author":"Custovic","year":"2020","journal-title":"Expert Rev Clin Immunol"},{"issue":"11","key":"10.1016\/j.anai.2025.11.005_bib0122","doi-asserted-by":"crossref","first-page":"P2769","DOI":"10.1016\/j.immuni.2025.09.001","article-title":"S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis","volume":"58","author":"Das","year":"2025","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.anai.2025.11.005_bib0123","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/all.16420","article-title":"Dupilumab as an adjunct to oral immunotherapy in pediatric patients with peanut allergy","volume":"80","author":"Chinthrajah","year":"2025","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0124","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.anai.2022.10.026","article-title":"Breaking down the complex pathophysiology of eosinophilic esophagitis","volume":"130","author":"Underwood","year":"2023","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2025.11.005_bib0125","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.2147\/JAA.S237759","article-title":"The basophil activation test for clinical management of food allergies: recent advances and future directions","volume":"14","author":"Briceno Noriega","year":"2021","journal-title":"J Asthma Allergy"},{"issue":"suppl 2","key":"10.1016\/j.anai.2025.11.005_bib0126","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/2047-783X-15-S2-21","article-title":"Basophil activation test based on the expression of CD203c in the diagnostics of cow milk allergy in children","volume":"15","author":"Ciepiela","year":"2010","journal-title":"Eur J Med Res"},{"issue":"5","key":"10.1016\/j.anai.2025.11.005_bib0127","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s13555-023-00922-2","article-title":"The association between eosinophils (CD16+ eosinophils), basophils (CD203+ basophils), and CD23 B lymphocytes in patients with atopic dermatitis on dupilumab therapy: pilot study","volume":"13","author":"\u010celakovsk\u00e1","year":"2023","journal-title":"Dermatol Ther (Heidelb)"},{"issue":"9","key":"10.1016\/j.anai.2025.11.005_bib0128","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2019.100060","article-title":"Increased expression levels of CD300c on basophils from allergic individuals","volume":"12","author":"Vitall\u00e9","year":"2019","journal-title":"World Allergy Organ J"},{"issue":"11","key":"10.1016\/j.anai.2025.11.005_bib0129","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1182\/blood-2012-09-435057","article-title":"The CD300 molecules: an emerging family of regulators of the immune system","volume":"121","author":"Borrego","year":"2013","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.anai.2025.11.005_bib0130","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/cyto.b.21003","article-title":"CD300a is expressed on human basophils and seems to inhibit IgE\/Fc\u03b5RI-dependent anaphylactic degranulation","volume":"82","author":"Sabato","year":"2012","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.anai.2025.11.005_bib0131","article-title":"The efficacy and safety of IL-13 inhibitors in atopic dermatitis: a systematic review and meta-analysis","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.anai.2025.11.005_bib0132","doi-asserted-by":"crossref","DOI":"10.7573\/dic.2021-1-7","article-title":"Selective IL-13 inhibitors for the treatment of atopic dermatitis","volume":"10","author":"Gon\u00e7alves","year":"2021","journal-title":"Drugs Context"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0133","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/14712598.2024.2435427","article-title":"Lebrikizumab: a new anti-IL-13 agent for treating moderate-to-severe atopic dermatitis","volume":"25","author":"Stingeni","year":"2025","journal-title":"Expert Opin Biol Ther"},{"issue":"2","key":"10.1016\/j.anai.2025.11.005_bib0134","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s40257-024-00913-9","article-title":"Biomarkers in atopic dermatitis: a review of the role of IL-13 and the impact of tralokinumab treatment","volume":"26","author":"Gorelick","year":"2025","journal-title":"Am J Clin Dermatol"},{"issue":"14-15","key":"10.1016\/j.anai.2025.11.005_bib0135","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1080\/1750743X.2024.2383554","article-title":"The role of nemolizumab in the treatment of atopic dermatitis for the adult population","volume":"16","author":"Prajapati","year":"2024","journal-title":"Immunotherapy"},{"issue":"2","key":"10.1016\/j.anai.2025.11.005_bib0136","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1056\/NEJMoa1917006","article-title":"Trial of nemolizumab and topical agents for atopic dermatitis with pruritus","volume":"383","author":"Kabashima","year":"2020","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0137","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jaad.2005.12.045","article-title":"Efficacy of anti-IgE therapy in patients with atopic dermatitis","volume":"55","author":"Vigo","year":"2006","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0138","doi-asserted-by":"crossref","first-page":"381","DOI":"10.4103\/0019-5154.160490","article-title":"Omalizumab\u2014a review","volume":"60","author":"Godse","year":"2015","journal-title":"Indian J Dermatol"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0139","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1159\/000518541","article-title":"Efficacy and safety of Janus kinase inhibitors for the treatment of atopic dermatitis: a systematic review and meta-analysis","volume":"238","author":"Li","year":"2022","journal-title":"Dermatology"},{"issue":"5","key":"10.1016\/j.anai.2025.11.005_bib0140","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.anai.2023.01.020","article-title":"Oral Janus kinase inhibitors for atopic dermatitis","volume":"130","author":"Mikhaylov","year":"2023","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2025.11.005_bib0141","article-title":"Application of JAK inhibitors in paradoxical reaction through immune-related dermatoses","volume":"15","author":"Zhang","year":"2024","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.anai.2025.11.005_bib0142","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jdermsci.2023.04.007","article-title":"PDE4 inhibition by difamilast regulates filaggrin and loricrin expression via keratinocyte proline-rich protein in human keratinocytes","volume":"110","author":"Tsuji","year":"2023","journal-title":"J Dermatol Sci"},{"issue":"5","key":"10.1016\/j.anai.2025.11.005_bib0143","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.jid.2023.12.025","article-title":"Phosphodiesterase 4 inhibitors, basophils, and atopic dermatitis","volume":"144","author":"Das","year":"2024","journal-title":"J Invest Dermatol"},{"issue":"6","key":"10.1016\/j.anai.2025.11.005_bib0144","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1074\/jbc.M410326200","article-title":"Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells","volume":"280","author":"Simon","year":"2005","journal-title":"J Biol Chem"},{"issue":"7011","key":"10.1016\/j.anai.2025.11.005_bib0145","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/nature02991","article-title":"Essential role for the p110delta phosphoinositide 3-kinase in the allergic response","volume":"431","author":"Ali","year":"2004","journal-title":"Nature"},{"issue":"42","key":"10.1016\/j.anai.2025.11.005_bib0146","doi-asserted-by":"crossref","first-page":"E9859","DOI":"10.1073\/pnas.1805474115","article-title":"Raf kinase inhibitor protein negatively regulates Fc\u03b5RI-mediated mast cell activation and allergic response","volume":"115","author":"Lin","year":"2018","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.anai.2025.11.005_bib0147","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1038\/ncomms2740","article-title":"Basophils are required for the induction of Th2 immunity to haptens and peptide antigens","volume":"4","author":"Otsuka","year":"2013","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0148","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.coi.2010.01.012","article-title":"Role of basophils in the initiation of Th2 responses","volume":"22","author":"Sokol","year":"2010","journal-title":"Curr Opin Immunol"},{"issue":"5","key":"10.1016\/j.anai.2025.11.005_bib0149","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1398-9995.2012.02792.x","article-title":"Basophils are not the key antigen-presenting cells in allergic patients","volume":"67","author":"Eckl-Dorna","year":"2012","journal-title":"Allergy"},{"issue":"5","key":"10.1016\/j.anai.2025.11.005_bib0150","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1398-9995.2011.02764.x","article-title":"Human blood basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1","volume":"67","author":"Kitzm\u00fcller","year":"2012","journal-title":"Allergy"},{"issue":"4","key":"10.1016\/j.anai.2025.11.005_bib0151","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nm.2663","article-title":"Basophils from humans with systemic lupus erythematosus do not express MHC-II","volume":"18","author":"Dijkstra","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.anai.2025.11.005_bib0152","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1059098","article-title":"Skin-homing basophils and beyond","volume":"13","author":"Shibuya","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.anai.2025.11.005_bib0153","doi-asserted-by":"crossref","first-page":"ltab008","DOI":"10.1093\/immadv\/ltab008","article-title":"Behind the scenes with basophils: an emerging therapeutic target","volume":"1","author":"Shah","year":"2021","journal-title":"Immunother Adv"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120625013420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120625013420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:07:14Z","timestamp":1773932834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120625013420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":153,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1081120625013420"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2025.11.005","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Basophils in atopic dermatitis","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2025.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American College of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}