{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:33:23Z","timestamp":1783506803380,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.anai.2026.04.002","type":"journal-article","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T11:20:31Z","timestamp":1775388031000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["When the eyes and nose collide: The shared pathways of rhinoconjunctivitis"],"prefix":"10.1016","author":[{"given":"Sophie","family":"Spicer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0725-2353","authenticated-orcid":false,"given":"Anne K.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.anai.2026.04.002_bib0001","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13223-025-00975-2","article-title":"Prevalence trends and risk factors for allergic rhinoconjunctivitis, asthma and eczema in the UK","volume":"21","author":"Diwakar","year":"2025","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2026.04.002_bib0002","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13223-020-0403-9","article-title":"A contemporary look at allergic conjunctivitis","volume":"16","author":"Dupuis","year":"2020","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2026.04.002_bib0003","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13223-018-0314-1","article-title":"The complex pathophysiology of AR: scientific rationale for the development of an alternative treatment option","volume":"15","author":"Bjermer","year":"2019","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2026.04.002_bib0004","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1939-4551-4-S1-S1","article-title":"Nasal-ocular reflexes and their role in the management of allergic rhinoconjunctivitis with intranasal steroids","volume":"4","author":"Baroody","year":"2011","journal-title":"World Allergy Organ J"},{"issue":"9","key":"10.1016\/j.anai.2026.04.002_bib0005","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/j.1398-9995.2010.02360.x","article-title":"Conjunctival effects of a selective nasal pollen provocation","volume":"65","author":"Callebaut","year":"2010","journal-title":"Allergy"},{"issue":"3","key":"10.1016\/j.anai.2026.04.002_bib0006","doi-asserted-by":"crossref","first-page":"ar2013","DOI":"10.2500\/ar.2013.4.0067","article-title":"The anatomical and functional relationship between allergic conjunctivitis and allergic rhinitis","volume":"4","author":"Hom","year":"2013","journal-title":"Allergy Rhinol (Providence)"},{"issue":"4","key":"10.1016\/j.anai.2026.04.002_bib0007","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11882-010-0119-x","article-title":"Allergic conjunctivitis and nasal allergy","volume":"10","author":"Pelikan","year":"2010","journal-title":"Curr Allergy Asthma Rep"},{"issue":"3","key":"10.1016\/j.anai.2026.04.002_bib0008","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S1081-1206(10)60442-5","article-title":"Nasal ocular reflexes and eye symptoms in patients with AR","volume":"100","author":"Baroody","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"4","key":"10.1016\/j.anai.2026.04.002_bib0009","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2222.1996.tb00552.x","article-title":"Unilateral nasal allergen challenge leads to bilateral release of prostaglandin D2","volume":"26","author":"Wagenmann","year":"1996","journal-title":"Clin Exp Allergy"},{"issue":"9","key":"10.1016\/j.anai.2026.04.002_bib0010","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1152\/japplphysiol.00547.2013","article-title":"Unilateral nasal allergic reactions increase bilateral sinus eosinophil infiltration","volume":"115","author":"Baroody","year":"2013","journal-title":"J Appl Physiol"},{"issue":"23","key":"10.1016\/j.anai.2026.04.002_bib0011","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222312994","article-title":"The communication between ocular surface and nasal epithelia in 3D cell culture technology for translational research: a narrative review","volume":"22","author":"Aydin","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.anai.2026.04.002_bib0012","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1128\/CVI.00347-09","article-title":"Nasolacrimal Duct Closure Modulates Ocular Mucosal and Systemic CD4+ T-cell Responses Induced following Topical Ocular or intranasal Immunization","volume":"17","author":"Chentoufi","year":"2010","journal-title":"Clin Vaccine Immunol"},{"issue":"1","key":"10.1016\/j.anai.2026.04.002_bib0013","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12865-025-00697-5","article-title":"Advances in the Understanding of ocular and nasal lymphatics","volume":"26","author":"Yan","year":"2025","journal-title":"BMC Immunol"},{"key":"10.1016\/j.anai.2026.04.002_bib0014","series-title":"Morgan & Claypool Life Sciences","article-title":"The ocular circulation [Internet]","author":"Kiel","year":"2010"},{"issue":"3","key":"10.1016\/j.anai.2026.04.002_bib0015","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bjps.2006.01.056","article-title":"The arterial anatomy of the eyelid: importance for reconstructive and aesthetic surgery","volume":"60","author":"Erdogmus","year":"2007","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"1","key":"10.1016\/j.anai.2026.04.002_bib0016","doi-asserted-by":"crossref","first-page":"7","DOI":"10.12701\/yujm.2018.35.1.7","article-title":"Comprehensive understanding of vascular anatomy for endovascular treatment of intractable oronasal bleeding","volume":"35","author":"Moon","year":"2018","journal-title":"Yeungnam Univ J Med"},{"issue":"10","key":"10.1016\/j.anai.2026.04.002_bib0017","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/cea.12148","article-title":"Nasal levels of soluble IL \u221233R ST 2 and il \u221216 in AR: inverse correlation trends with disease severity","volume":"43","author":"Baumann","year":"2013","journal-title":"Clin Exp Allergy"},{"issue":"4","key":"10.1016\/j.anai.2026.04.002_bib0018","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1046\/j.1365-2222.2003.01632.x","article-title":"A single nasal allergen challenge increases induced sputum inflammatory markers in non-asthmatic subjects with seasonal AR: correlation with plasma interleukin-5","volume":"33","author":"Beeh","year":"2003","journal-title":"Clin Exp Allergy"},{"issue":"10","key":"10.1016\/j.anai.2026.04.002_bib0019","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.4049\/jimmunol.1700378","article-title":"Investigating immune gene signatures in peripheral blood from subjects with allergic rhinitis undergoing nasal allergen challenge","volume":"199","author":"Kim","year":"2017","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.anai.2026.04.002_bib0020","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3390\/medicina59030609","article-title":"New insights into the communications of the facial vein with the dural venous sinuses","volume":"59","author":"Siwetz","year":"2023","journal-title":"Medicina"},{"issue":"5","key":"10.1016\/j.anai.2026.04.002_bib0021","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1442-9071.2010.02325.x","article-title":"Ophthalmic and facial veins are not valveless","volume":"38","author":"Zhang","year":"2010","journal-title":"Clin Exper Ophthalmol"},{"issue":"5","key":"10.1016\/j.anai.2026.04.002_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2021.100540","article-title":"Naso-ocular neuropeptide interactions in allergic rhinoconjunctivitis, rhinitis, and conjunctivitis","volume":"14","author":"Meng","year":"2021","journal-title":"World Allergy Organ J"},{"issue":"1","key":"10.1016\/j.anai.2026.04.002_bib0023","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/j.2040-4603.2015.tb00603.x","article-title":"Autonomic control of the eye","volume":"5","author":"McDougal","year":"2015","journal-title":"Compr Physiol"},{"issue":"1","key":"10.1016\/j.anai.2026.04.002_bib0024","first-page":"13","article-title":"The Trigeminal (V) and Facial (VII) Cranial Nerves: Head and Face Sensation and Movement","volume":"7","author":"Sanders","year":"2010","journal-title":"Psychiatry (Edgmont)"},{"issue":"4","key":"10.1016\/j.anai.2026.04.002_bib0025","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s11882-009-0043-0","article-title":"Intranasal corticosteroids: do they improve ocular allergy?","volume":"9","author":"Origlieri","year":"2009","journal-title":"Curr Allergy Asthma Rep"},{"issue":"8","key":"10.1016\/j.anai.2026.04.002_bib0026","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/nn.3144","article-title":"Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology","volume":"15","author":"Chiu","year":"2012","journal-title":"Nat Neurosci"},{"issue":"10","key":"10.1016\/j.anai.2026.04.002_bib0027","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1007\/s10792-018-01066-5","article-title":"Mechanism of interaction between ocular and nasal neurogenic inflammation in allergic rhinoconjunctivitis","volume":"39","author":"Gao","year":"2019","journal-title":"Int Ophthalmol"},{"issue":"3","key":"10.1016\/j.anai.2026.04.002_bib0028","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0091-6749(94)70071-0","article-title":"The effect of terfenadine on unilateral nasal challenge with allergen","volume":"93","author":"Wagenmann","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2026.04.002_bib0029","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.3389\/fimmu.2018.01873","article-title":"The role of histamine and histamine receptors in mast cell-mediated allergy and inflammation: the hunt for new therapeutic targets","volume":"9","author":"Thangam","year":"2018","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.anai.2026.04.002_bib0030","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2500\/ajra.2013.27.3841","article-title":"Effect of intranasal fluticasone furoate and intraocular olopatadine on nasal and ocular allergen-induced symptoms","volume":"27","author":"Baroody","year":"2013","journal-title":"Am J Rhinol Allergy"},{"issue":"11","key":"10.1016\/j.anai.2026.04.002_bib0031","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1007\/s11064-023-03983-z","article-title":"Capsaicin, the vanilloid receptor TRPV1 agonist in neuroprotection: mechanisms involved and significance","volume":"48","author":"Abdel-Salam","year":"2023","journal-title":"Neurochem Res"},{"issue":"6","key":"10.1016\/j.anai.2026.04.002_bib0032","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0091-6749(94)90122-8","article-title":"The human nasal response to capsaicin","volume":"94","author":"Philip","year":"1994","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2026.04.002_bib0033","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s12016-025-09098-3","article-title":"Decoding allergic conjunctivitis: latest perspectives on etiological drivers and immunopathological mechanisms","volume":"68","author":"Bao","year":"2025","journal-title":"Clin Rev Allerg Immunol"},{"key":"10.1016\/j.anai.2026.04.002_bib0034","article-title":"Allergic rhinitis: A clinical and pathophysiological overview","volume":"9","author":"SM","year":"2022","journal-title":"Front Med"},{"issue":"3","key":"10.1016\/j.anai.2026.04.002_bib0035","doi-asserted-by":"crossref","first-page":"157","DOI":"10.5415\/apallergy.2011.1.3.157","article-title":"Overview on the pathomechanisms of AR","volume":"1","author":"Pawankar","year":"2011","journal-title":"Asia Pac Allergy"},{"issue":"1","key":"10.1016\/j.anai.2026.04.002_bib0036","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jaip.2012.07.001","article-title":"Leukotriene receptor antagonists in allergic eye disease: A systematic review and meta-analysis","volume":"1","author":"Gane","year":"2013","journal-title":"J Allergy Clin Immunol: Pract"},{"key":"10.1016\/j.anai.2026.04.002_bib0037","article-title":"Novel insights into the study of goblet cell hypersecretion in AR","volume":"16","author":"Zhu","year":"2025","journal-title":"Front Immunol"},{"issue":"21","key":"10.1016\/j.anai.2026.04.002_bib0038","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.168596","article-title":"A nerve-goblet cell association promotes allergic conjunctivitis through rapid antigen passage","volume":"8","author":"Kimura","year":"2023","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.anai.2026.04.002_bib0039","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/S0091-6749(96)70193-8","article-title":"Evidence that enhanced nasal reactivity to bradykinin in patients with symptomatic allergy is mediated by neural reflexes","volume":"97","author":"Riccio","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2026.04.002_bib0040","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.767967","article-title":"Unilateral corneal insult also alters sensory nerve activity in the contralateral eye","volume":"8","author":"Luna","year":"2021","journal-title":"Front Med"},{"issue":"2","key":"10.1016\/j.anai.2026.04.002_bib0041","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1164\/ajrccm.155.2.9032173","article-title":"Bilateral increases in histamine after unilateral nasal allergen challenge","volume":"155","author":"Wagenmann","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.anai.2026.04.002_bib0042","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.anai.2012.06.008","article-title":"Nasal corticosteroid treatment reduces substance P levels in tear fluid in allergic rhinoconjunctivitis","volume":"109","author":"Callebaut","year":"2012","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.1016\/j.anai.2026.04.002_bib0043","doi-asserted-by":"crossref","first-page":"AB39","DOI":"10.1016\/j.jaci.2009.12.185","article-title":"Comparison of the Effect of Fluticasone Furoate Nasal Spray (FFNS) versus Placebo on Ocular Itching and histamine Levels in the Tears of Subjects with Seasonal Allergic Rhinoconjunctivitis (SARC) due to Tree and\/or Grass Pollen","volume":"125","author":"Lazzaro","year":"2010","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.anai.2026.04.002_bib0044","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1272\/jnms.79.182","article-title":"Mometasone furoate nasal spray relieves the ocular symptoms of seasonal allergic rhinoconjunctivitis","volume":"79","author":"Igarashi","year":"2012","journal-title":"J Nippon Med Sch"},{"issue":"6","key":"10.1016\/j.anai.2026.04.002_bib0045","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.jaci.2009.03.015","article-title":"Fluticasone furoate nasal spray reduces the nasal-ocular reflex: a mechanism for the efficacy of topical steroids in controlling allergic eye symptoms","volume":"123","author":"Baroody","year":"2009","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.anai.2026.04.002_bib0046","first-page":"331","article-title":"The efficacy of intranasal fluticasone propionate in the relief of ocular symptoms associated with seasonal AR","volume":"24","author":"DeWester","year":"2003","journal-title":"Allergy Asthma Proc"},{"issue":"2","key":"10.1016\/j.anai.2026.04.002_bib0047","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jaci.2024.04.016","article-title":"Intranasal antihistamines and corticosteroids in AR: A systematic review and meta-analysis","volume":"154","author":"Sousa-Pinto","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2026.04.002_bib0048","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.2147\/OPTH.S476163","article-title":"Alleviation of allergic rhinoconjunctivitis symptoms in participants treated with a 0.005% tacrolimus eye-drop solution","volume":"18","author":"Sladek","year":"2024","journal-title":"Clin Ophthalmol"},{"issue":"3","key":"10.1016\/j.anai.2026.04.002_bib0049","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2500\/108854189778960135","article-title":"Ocular, nasal and oral cromolyn sodium in the management of non-asthmatic allergic problems","volume":"10","author":"Spector","year":"1989","journal-title":"Allergy Proc"},{"key":"10.1016\/j.anai.2026.04.002_bib0050","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1418897","article-title":"Mast cell stabilizers: from pathogenic roles to targeting therapies","volume":"15","author":"Cao","year":"2024","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.anai.2026.04.002_bib0051","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1080\/14656566.2017.1346085","article-title":"Olopatadine hydrochloride ophthalmic solution for the treatment of allergic conjunctivitis","volume":"18","author":"GonzalezEstrada","year":"2017","journal-title":"Expert Opin Pharmacother"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120626001523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120626001523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:40:53Z","timestamp":1778154053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120626001523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":51,"alternative-id":["S1081120626001523"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2026.04.002","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"When the eyes and nose collide: The shared pathways of rhinoconjunctivitis","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2026.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}