{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:05:46Z","timestamp":1790762746199,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008890","name":"University of Dundee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.anai.2026.05.020","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:02:49Z","timestamp":1779145369000},"page":"477-482.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of dupilumab on Sino-Nasal Outcome Test\u201322 (SNOT-22) domains: Focus on the ear"],"prefix":"10.1016","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1426-4544","authenticated-orcid":false,"given":"Philipp","family":"Suter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Greig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Lipworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.anai.2026.05.020_bib0001","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1080\/03007995.2020.1815682","article-title":"Systematic literature review of the epidemiology and clinical burden of chronic rhinosinusitis with nasal polyposis","volume":"36","author":"Chen","year":"2020","journal-title":"Curr Med Res Opin"},{"issue":"5","key":"10.1016\/j.anai.2026.05.020_bib0002","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.jaci.2022.02.016","article-title":"Mechanisms and pathogenesis of chronic rhinosinusitis","volume":"149","author":"Kato","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2026.05.020_bib0003","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2147\/JAA.S290424","article-title":"Burden of disease in chronic rhinosinusitis with nasal polyps","volume":"14","author":"Bachert","year":"2021","journal-title":"J Asthma Allergy"},{"issue":"4","key":"10.1016\/j.anai.2026.05.020_bib0004","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/ohn.627","article-title":"Impact of dupilumab on sinonasal symptoms and outcomes in severe chronic rhinosinusitis with nasal polyps","volume":"170","author":"Hopkins","year":"2024","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"7","key":"10.1016\/j.anai.2026.05.020_bib0005","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/alr.22942","article-title":"Eustachian tube dysfunction (ETD) in chronic rhinosinusitis with comparison to primary ETD: a systematic review and meta-analysis","volume":"12","author":"Chen","year":"2022","journal-title":"Int Forum Allergy Rhinol"},{"issue":"12","key":"10.1016\/j.anai.2026.05.020_bib0006","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/alr.21408","article-title":"SNOT-22 quality of life domains differentially predict treatment modality selection in chronic rhinosinusitis","volume":"4","author":"DeConde","year":"2014","journal-title":"Int Forum Allergy Rhinol"},{"issue":"4","key":"10.1016\/j.anai.2026.05.020_bib0007","article-title":"Impact of chronic rhinosinusitis with nasal polyps on Eustachian tube dysfunction","volume":"76","author":"Garc\u00eda-Callejo","year":"2025","journal-title":"Acta Otorrinolaringol Esp (Engl Educ)"},{"issue":"2","key":"10.1016\/j.anai.2026.05.020_bib0008","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4193\/Rhin17.165","article-title":"Eustachian tube symptoms are frequent in chronic rhinosinusitis and respond well to endoscopic sinus surgery","volume":"56","author":"Maniakas","year":"2018","journal-title":"Rhinology"},{"issue":"4","key":"10.1016\/j.anai.2026.05.020_bib0009","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1017\/S0022215125103861","article-title":"Eustachian tube dysfunction symptoms in chronic rhinosinusitis with nasal polyps","volume":"140","author":"Misirovs","year":"2026","journal-title":"J Laryngol Otol"},{"issue":"5","key":"10.1016\/j.anai.2026.05.020_bib0010","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/coa.12475","article-title":"Eustachian tube dysfunction: consensus statement on definition, types, clinical presentation and diagnosis","volume":"40","author":"Schilder","year":"2015","journal-title":"Clin Otolaryngol"},{"issue":"5","key":"10.1016\/j.anai.2026.05.020_bib0011","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/lary.29766","article-title":"Development of sinonasal outcome test (SNOT-22) domains in chronic rhinosinusitis with nasal polyps","volume":"132","author":"Khan","year":"2022","journal-title":"Laryngoscope"},{"issue":"9","key":"10.1016\/j.anai.2026.05.020_bib0012","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/alr.22967","article-title":"Minimal clinically important difference for subdomains of the 22-item sino-nasal Outcome Test in medically managed chronic rhinosinusitis patients","volume":"12","author":"Singerman","year":"2022","journal-title":"Int Forum Allergy Rhinol"},{"issue":"suppl S29","key":"10.1016\/j.anai.2026.05.020_bib0013","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"issue":"9","key":"10.1016\/j.anai.2026.05.020_bib0014","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.3390\/medicina61091620","article-title":"Recurrence of chronic rhinosinusitis with nasal polyps after surgery: risk factors, predictive models, and treatment approaches with a focus on western and Asian differences","volume":"61","author":"Chen","year":"2025","journal-title":"Medicina (Kaunas)"},{"issue":"11","key":"10.1016\/j.anai.2026.05.020_bib0015","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1017\/S0022215123000853","article-title":"Phenotypic associations of medical polypectomy and revision surgery following endoscopic sinus surgery: a retrospective study of a single-centre experience in Scotland","volume":"137","author":"Misirovs","year":"2023","journal-title":"J Laryngol Otol"},{"issue":"3","key":"10.1016\/j.anai.2026.05.020_bib0016","first-page":"194","article-title":"EPOS\/EUFOREA update on indication and evaluation of biologics in chronic rhinosinusitis with nasal polyps 2023","volume":"61","author":"Fokkens","year":"2023","journal-title":"Rhinology"},{"issue":"8","key":"10.1016\/j.anai.2026.05.020_bib0017","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.jaip.2025.04.043","article-title":"Reappraisal of biologic efficacy from Phase 3 trials in refractory chronic rhinosinusitis and nasal polyps","volume":"13","author":"Lipworth","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"5","key":"10.1016\/j.anai.2026.05.020_bib0018","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.anai.2026.01.011","article-title":"Bucher indirect treatment comparison of phase 3 trials with dupilumab and tezepelumab in chronic rhinosinusitis with nasal polyps","volume":"136","author":"Suter","year":"2026","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.1016\/j.anai.2026.05.020_bib0019","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/lary.29888","article-title":"Estimating clinically meaningful change of efficacy outcomes in inadequately controlled chronic rhinosinusitis with nasal polyposis","volume":"132","author":"Han","year":"2022","journal-title":"Laryngoscope"},{"issue":"5","key":"10.1016\/j.anai.2026.05.020_bib0020","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.jaci.2006.09.005","article-title":"Rhinosinusitis: developing guidance for clinical trials","volume":"118","author":"Meltzer","year":"2006","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2026.05.020_bib0021","first-page":"32","article-title":"Peak nasal inspiratory flow; normal range in adult population","volume":"44","author":"Ottaviano","year":"2006","journal-title":"Rhinology"},{"issue":"4","key":"10.1016\/j.anai.2026.05.020_bib0022","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00965-2016","article-title":"A European Respiratory Society technical standard: exhaled biomarkers in lung disease","volume":"49","author":"Horvath","year":"2017","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1016\/j.anai.2026.05.020_bib0023","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4193\/Rhino15.072","article-title":"Stratification of SNOT-22 scores into mild, moderate or severe and relationship with other subjective instruments","volume":"54","author":"Toma","year":"2016","journal-title":"Rhinology"},{"issue":"2","key":"10.1016\/j.anai.2026.05.020_bib0024","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/194589240501900214","article-title":"The effect of endoscopic sinus surgery on symptoms of eustachian tube dysfunction","volume":"19","author":"Stoikes","year":"2005","journal-title":"Am J Rhinol"},{"issue":"10","key":"10.1016\/j.anai.2026.05.020_bib0025","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1007\/s00405-015-3812-5","article-title":"Middle ear function in sinonasal polyposis","volume":"273","author":"Bakhshaee","year":"2016","journal-title":"Eur Arch Oto-rhino-laryngol"},{"issue":"4","key":"10.1016\/j.anai.2026.05.020_bib0026","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3390\/jcm9040925","article-title":"Associations between the quality of life and nasal polyp size in patients suffering from chronic rhinosinusitis without nasal polyps, with nasal polyps or aspirin-exacerbated respiratory disease","volume":"9","author":"Schneider","year":"2020","journal-title":"J Clin Med"},{"issue":"4","key":"10.1016\/j.anai.2026.05.020_bib0027","first-page":"2985","article-title":"Are objective \u2018findings\u2019 the same as subjective \u2018severity\u2019? A study of the relationship between computed tomography findings and subjective severity in preoperative CRSwNP patients","volume":"20","author":"Lu","year":"2020","journal-title":"Exp Ther Med"},{"issue":"1","key":"10.1016\/j.anai.2026.05.020_bib0028","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00405-024-08973-7","article-title":"Correlation of sino-nasal outcome test and nasal polyp score in dupilumab-treated chronic rhinosinusitis with nasal polyps","volume":"282","author":"Mauthe","year":"2025","journal-title":"Eur Arch Oto-rhino-laryngol"},{"key":"10.1016\/j.anai.2026.05.020_bib0029","doi-asserted-by":"crossref","first-page":"g1647","DOI":"10.1136\/bmj.g1647","article-title":"Eustachian tube dysfunction in adults","volume":"348","author":"Sproat","year":"2014","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.anai.2026.05.020_bib0030","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s43163-025-00919-y","article-title":"Multi-dimensional characterization of eustachian tube function in patients with perforated tympanic membrane","volume":"41","author":"Azmy","year":"2025","journal-title":"Egypt J Otolaryngol"},{"key":"10.1016\/j.anai.2026.05.020_bib0031","doi-asserted-by":"crossref","unstructured":"Fallon K, Remenschneider A. Understanding Eustachian tube dysfunction [e-pub ahead of print]. JAMA Otolaryngol Head Neck Surg. doi:10.1001\/jamaoto.2024.3474, accessed March 29, 2026.","DOI":"10.1001\/jamaoto.2024.3474"},{"issue":"4","key":"10.1016\/j.anai.2026.05.020_bib0032","article-title":"Biologic therapy relieves otologic symptoms and signs in patients with asthma and chronic rhinosinusitis with nasal polyps","volume":"10","author":"Suikkila","year":"2025","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"3","key":"10.1016\/j.anai.2026.05.020_bib0033","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jaip.2020.09.063","article-title":"Chronic rhinosinusitis with nasal polyps and asthma","volume":"9","author":"Laidlaw","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"10","key":"10.1016\/j.anai.2026.05.020_bib0034","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1111\/all.13496","article-title":"Precision medicine in united airways disease: a \u201ctreatable traits\u201d approach","volume":"73","author":"Yii","year":"2018","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.anai.2026.05.020_bib0035","article-title":"Evaluation of the association between allergic rhinitis and middle ear dysfunction: a clinicopathological study","volume":"15","author":"Sidam","year":"2023","journal-title":"Cureus"},{"issue":"5","key":"10.1016\/j.anai.2026.05.020_bib0036","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2298\/VSP0905353A","article-title":"Clinical evaluation of eustachian tube transience and function in patients with different types of increased nasal resistance","volume":"66","author":"Filipovi\u0107","year":"2009","journal-title":"Vojnosanit Pregl"},{"issue":"6","key":"10.1016\/j.anai.2026.05.020_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2020.100131","article-title":"Effect of short-course glucocorticoid application on patients with chronic rhinosinusitis with nasal polyps","volume":"13","author":"Xu","year":"2020","journal-title":"World Allergy Organ J"},{"issue":"1","key":"10.1016\/j.anai.2026.05.020_bib0038","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/lary.27470","article-title":"Does medical therapy improve SinoNasal outcomes Test-22 domain scores? An analysis of clinically important differences","volume":"129","author":"Chowdhury","year":"2019","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1016\/j.anai.2026.05.020_bib0039","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1177\/0194599820917396","article-title":"The effect of endoscopic sinus surgery on Eustachian tube dysfunction symptoms","volume":"163","author":"Chang","year":"2020","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"10.1016\/j.anai.2026.05.020_bib0040","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.wjorl.2017.03.001","article-title":"Impact of endoscopic sinus surgery on otologic symptoms associated with chronic rhinosinusitis","volume":"3","author":"Teo","year":"2017","journal-title":"World J Otorhinolaryngol Head Neck Surg"},{"issue":"3","key":"10.1016\/j.anai.2026.05.020_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2025.101041","article-title":"A real-life evaluation of SNOT-22 domains in a cohort of CRSwNP patients treated with biologic therapies for 12 months","volume":"18","author":"Costanzo","year":"2025","journal-title":"World Allergy Organ J"},{"issue":"1","key":"10.1016\/j.anai.2026.05.020_bib0042","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1038\/s41598-025-33742-9","article-title":"Impact of dupilumab on SNOT-22 domain and individual item scores in chronic rhinosinusitis with nasal polyps","volume":"16","author":"Lang","year":"2025","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.anai.2026.05.020_bib0043","doi-asserted-by":"crossref","first-page":"142","DOI":"10.7874\/jao.2021.00654","article-title":"Association between Eustachian tube dysfunction Questionnaire-7 scores and eustachian tube function test results in symptomatic patients with a normal drum","volume":"26","author":"Moon","year":"2022","journal-title":"J Audiol Otol"},{"issue":"5","key":"10.1016\/j.anai.2026.05.020_bib0044","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/alr.22056","article-title":"The prevalence of Eustachian tube dysfunction symptoms in patients with chronic rhinosinusitis","volume":"8","author":"Tangbumrungtham","year":"2018","journal-title":"Int Forum Allergy Rhinol"},{"issue":"6","key":"10.1016\/j.anai.2026.05.020_bib0045","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00234-016-1663-4","article-title":"Imaging of the Eustachian tube and its function: a systematic review","volume":"58","author":"Smith","year":"2016","journal-title":"Neuroradiology"},{"issue":"1","key":"10.1016\/j.anai.2026.05.020_bib0046","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13601-020-00328-9","article-title":"Eustachian tube dysfunction in patients with house dust mite-allergic rhinitis","volume":"10","author":"Ma","year":"2020","journal-title":"Clin Transl Allergy"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120626002243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120626002243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:44:29Z","timestamp":1790761469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120626002243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1081120626002243"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2026.05.020","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of dupilumab on Sino-Nasal Outcome Test\u201322 (SNOT-22) domains: Focus on the ear","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2026.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}