{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:20:15Z","timestamp":1792686015236,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U24AI86837"],"award-info":[{"award-number":["U24AI86837"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.anai.2026.08.019","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:56:59Z","timestamp":1787669819000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical characteristics of IgE deficiency among patients with primary immunodeficiencies"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3790-3951","authenticated-orcid":false,"given":"Dorde","family":"Jevtic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Jakubowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisa","family":"Ferastraoaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2026.08.019_bib0001","series-title":"StatPearls [Internet]","article-title":"Immunoglobulin E","author":"Hostoffer","year":"2023"},{"issue":"3","key":"10.1016\/j.anai.2026.08.019_bib0002","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.anai.2017.07.006","article-title":"Increased malignancy incidence in IgE deficient patients not due to concomitant common variable immunodeficiency","volume":"119","author":"Ferastraoaru","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"10.1016\/j.anai.2026.08.019_bib0003","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1038\/s41467-025-57870-y","article-title":"Hyperinflammatory repolarisation of ovarian cancer patient macrophages by anti-tumour IgE antibody, MOv18, restricts an immunosuppressive macrophage:Treg cell interaction","volume":"16","author":"Osborn","year":"2025","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.anai.2026.08.019_bib0004","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.2500\/aap.2014.35.3734","article-title":"Selective IgE deficiency, immune dysregulation, and autoimmunity","volume":"35","author":"Magen","year":"2014","journal-title":"Allergy Asthma Proc"},{"issue":"8","key":"10.1016\/j.anai.2026.08.019_bib0005","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s10875-021-01127-y","article-title":"Is there a clinical significance of very low serum immunoglobulin E level?","volume":"41","author":"Al","year":"2021","journal-title":"J Clin Immunol"},{"issue":"3","key":"10.1016\/j.anai.2026.08.019_bib0006","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s10875-022-01401-7","article-title":"Increased hazard risk of first malignancy in adults with undetectable serum IgE: a retrospective cohort study","volume":"43","author":"Weller","year":"2023","journal-title":"J Clin Immunol"},{"issue":"4","key":"10.1016\/j.anai.2026.08.019_bib0007","doi-asserted-by":"crossref","DOI":"10.1111\/pai.70092","article-title":"IgE deficiency (<2.5 IU\/mL) in children: clinical insights from a population-based study of 123,393 subjects","volume":"36","author":"Nemet","year":"2025","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.anai.2026.08.019_bib0008","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13601-020-00335-w","article-title":"AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer\u2014a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)","volume":"10","author":"Ferastraoaru","year":"2020","journal-title":"Clin Transl Allergy"},{"issue":"3","key":"10.1016\/j.anai.2026.08.019_bib0009","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1081-1206(10)63188-2","article-title":"Clinical manifestations of IgE hypogammaglobulinemia","volume":"78","author":"Smith","year":"1997","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2026.08.019_bib0010","first-page":"192","article-title":"IgE deficiency: a forgotten disease?","volume":"56","author":"Garc\u00eda Pav\u00f3n Osorio","year":"2009","journal-title":"Rev Alerg Mex"},{"issue":"3","key":"10.1016\/j.anai.2026.08.019_bib0011","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10875-018-0476-0","article-title":"Low serum IgE is a sensitive and specific marker for common variable immunodeficiency (CVID)","volume":"38","author":"Lawrence","year":"2018","journal-title":"J Clin Immunol"},{"issue":"5","key":"10.1016\/j.anai.2026.08.019_bib0012","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.anai.2018.07.036","article-title":"IgE deficiency and prior diagnosis of malignancy: results of the 2005-2006 National Health and Nutrition Examination Survey","volume":"121","author":"Ferastraoaru","year":"2018","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"3","key":"10.1016\/j.anai.2026.08.019_bib0013","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/cei.12885","article-title":"Low immunoglobulin E flags two distinct types of immune dysregulation","volume":"187","author":"Elkuch","year":"2017","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"10.1016\/j.anai.2026.08.019_bib0014","first-page":"22","article-title":"Serum IgE levels in patients with selective IgA deficiency","volume":"41","author":"Kanok","year":"1978","journal-title":"Ann Allergy"},{"issue":"1","key":"10.1016\/j.anai.2026.08.019_bib0015","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.clim.2011.05.007","article-title":"Clinical and immunological manifestations of patients with atypical severe combined immunodeficiency","volume":"141","author":"Felgentreff","year":"2011","journal-title":"Clin Immunol."},{"issue":"10","key":"10.1016\/j.anai.2026.08.019_bib0016","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1080\/1744666X.2019.1658523","article-title":"Malignancy in common variable immunodeficiency: a systematic review and meta-analysis","volume":"15","author":"Kiaee","year":"2019","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.anai.2026.08.019_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1465159","article-title":"The impact of immune dysregulation on the risk of malignancy in common variable immunodeficiency: insights from a multicenter study","volume":"15","author":"Caba\u00f1ero-Navalon","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.anai.2026.08.019_bib0018","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fimmu.2020.00149","article-title":"Non-infectious complications of common variable immunodeficiency: updated clinical spectrum, sequelae, and insights to pathogenesis","volume":"11","author":"Ho","year":"2020","journal-title":"Front Immunol"},{"issue":"18","key":"10.1016\/j.anai.2026.08.019_bib0019","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.3390\/jcm10184160","article-title":"Spectrum of disease manifestations in patients with selective immunoglobulin E deficiency","volume":"10","author":"Picado","year":"2021","journal-title":"J Clin Med"},{"issue":"9","key":"10.1016\/j.anai.2026.08.019_bib0020","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s00262-012-1315-4","article-title":"The nascent field of AllergoOncology","volume":"61","author":"Jensen-Jarolim","year":"2012","journal-title":"Cancer Immunol Immunother"},{"issue":"5","key":"10.1016\/j.anai.2026.08.019_bib0021","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.4049\/jimmunol.179.5.2832","article-title":"IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells","volume":"179","author":"Karagiannis","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.anai.2026.08.019_bib0022","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ebiom.2019.03.080","article-title":"IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states","volume":"43","author":"Pellizzari","year":"2019","journal-title":"EBiomedicine"},{"issue":"2","key":"10.1016\/j.anai.2026.08.019_bib0023","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.anai.2024.04.025","article-title":"IgE deficiency is not associated with hypogammaglobulinemia in a large cohort of military recruits","volume":"133","author":"Makin","year":"2024","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"3","key":"10.1016\/j.anai.2026.08.019_bib0024","first-page":"271","article-title":"Serum immunoglobulin E levels in patients with primary hypogammaglobulinemia - experience from a tertiary hospital in Taiwan","volume":"42","author":"Tsai","year":"2009","journal-title":"J Microbiol Immunol Infect Wei Mian Yu Gan Ran Za Zhi"},{"issue":"3","key":"10.1016\/j.anai.2026.08.019_bib0025","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.anai.2017.07.005","article-title":"Hypogammaglobulinemia E in 216 adults with IgG subclass deficiency and respiratory tract infections","volume":"119","author":"Barton","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.1016\/j.anai.2026.08.019_bib0026","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2141.2010.08077.x","article-title":"Update on the hyper immunoglobulin M syndromes","volume":"149","author":"Davies","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1016\/j.anai.2026.08.019_bib0027","series-title":"GeneReviews\u00ae","article-title":"X-linked agammaglobulinemia","author":"Smith","year":"1993"},{"issue":"16","key":"10.1016\/j.anai.2026.08.019_bib0028","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJMoa073687","article-title":"STAT3 mutations in the hyper-IgE syndrome","volume":"357","author":"Holland","year":"2007","journal-title":"N Engl J Med."},{"issue":"8","key":"10.1016\/j.anai.2026.08.019_bib0029","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1084\/jem.20110958","article-title":"Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis","volume":"208","author":"Liu","year":"2011","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.anai.2026.08.019_bib0030","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/cei.13620","article-title":"Lymphadenopathy at the crossroad between immunodeficiency and autoinflammation: an intriguing challenge","volume":"205","author":"Costagliola","year":"2021","journal-title":"Clin Exp Immunol"},{"issue":"2 suppl 2","key":"10.1016\/j.anai.2026.08.019_bib0031","doi-asserted-by":"crossref","first-page":"S182","DOI":"10.1016\/j.jaci.2009.07.053","article-title":"Primary immunodeficiencies","volume":"125","author":"Notarangelo","year":"2010","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.anai.2026.08.019_bib0032","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/1744666X.2016.1224664","article-title":"Autoimmunity in common variable immunodeficiency: epidemiology, pathophysiology and management","volume":"13","author":"Azizi","year":"2017","journal-title":"Expert Rev Clin Immunol"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108112062600414X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108112062600414X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:24:57Z","timestamp":1790281497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S108112062600414X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":32,"alternative-id":["S108112062600414X"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2026.08.019","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical characteristics of IgE deficiency among patients with primary immunodeficiencies","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2026.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}