{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:29:17Z","timestamp":1791188957624,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annales d'Endocrinologie"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.ando.2011.12.005","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T03:50:10Z","timestamp":1327895410000},"page":"20-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Dehydroepiandrosterone (DHEA) improves pulmonary hypertension in chronic obstructive pulmonary disease (COPD): A pilot study"],"prefix":"10.1016","volume":"73","author":[{"given":"Eric","family":"Dumas de La Roque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Savineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-C\u00e9cile","family":"Metivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Alain","family":"Billes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Kraemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Doutreleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Jougon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Marthan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fayon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9tienne-\u00c9mile","family":"Baulieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Dromer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ando.2011.12.005_bib0005","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1378\/chest.87.4.470","article-title":"Gas exchange alterations in patients with chronic obstructive lung disease","volume":"87","author":"Marthan","year":"1985","journal-title":"Chest"},{"key":"10.1016\/j.ando.2011.12.005_bib0010","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2165\/00003495-200969090-00002","article-title":"Pulmonary hypertension in patients with chronic obstructive pulmonary disease: advances in pathophysiology and management","volume":"69","author":"Barbera","year":"2009","journal-title":"Drugs"},{"key":"10.1016\/j.ando.2011.12.005_bib0015","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1056\/NEJM197204272861703","article-title":"Patterns of cardiovascular dysfunction in chronic obstructive lung disease","volume":"286","author":"Burrows","year":"1972","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ando.2011.12.005_bib0020","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1136\/thx.36.10.752","article-title":"Prognostic value of pulmonary artery pressure in chronic obstructive pulmonary disease","volume":"36","author":"Weitzenblum","year":"1981","journal-title":"Thorax"},{"key":"10.1016\/j.ando.2011.12.005_bib0025","first-page":"895","article-title":"Predictors of mortality in chronic obstructive pulmonary disease. A 15-year follow-up study","volume":"119","author":"Traver","year":"1979","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.ando.2011.12.005_bib0030","first-page":"528","article-title":"Nitric oxide in chronic obstructive pulmonary disease","volume":"51","author":"Barbera","year":"1996","journal-title":"Monaldi Arch Chest Dis"},{"key":"10.1016\/j.ando.2011.12.005_bib0035","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1378\/chest.109.3.750","article-title":"A placebo-controlled trial of prostacyclin in acute respiratory failure in COPD","volume":"109","author":"Archer","year":"1996","journal-title":"Chest"},{"key":"10.1016\/j.ando.2011.12.005_bib0040","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1183\/09031936.00011308","article-title":"A randomised, controlled trial of bosentan in severe COPD","volume":"32","author":"Stolz","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ando.2011.12.005_bib0045","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1164\/rccm.200907-0988OC","article-title":"Hemodynamic and gas exchange effects of sildenafil in patients with chronic obstructive pulmonary disease and pulmonary hypertension","volume":"181","author":"Blanco","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ando.2011.12.005_bib0050","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1378\/chest.113.1.65","article-title":"Effects of long-term oxygen therapy on pulmonary hemodynamics in COPD patients: a 6-year prospective study","volume":"113","author":"Zielinski","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.ando.2011.12.005_bib0055","doi-asserted-by":"crossref","first-page":"519","DOI":"10.7326\/0003-4819-99-4-519","article-title":"Long-term oxygen therapy","volume":"99","author":"Anthonisen","year":"1983","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ando.2011.12.005_bib0060","first-page":"411","article-title":"An adrenal-secreted \u201candrogen\u201d: dehydroisoandrosterone sulfate. Its metabolism and a tentative generalization on the metabolism of other steroid conjugates in man","volume":"21","author":"Baulieu","year":"1965","journal-title":"Recent Prog Horm Res"},{"key":"10.1016\/j.ando.2011.12.005_bib0065","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0303-7207(02)00363-5","article-title":"Androgen biosynthesis from cholesterol to DHEA","volume":"198","author":"Miller","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.ando.2011.12.005_bib0070","first-page":"1086","article-title":"Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men","volume":"79","author":"Belanger","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2011.12.005_bib0075","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1210\/jcem.82.8.4160","article-title":"Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging","volume":"82","author":"Labrie","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2011.12.005_bib0080","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0303-7207(02)00367-2","article-title":"Androgens and aging men","volume":"198","author":"Baulieu","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.ando.2011.12.005_bib0085","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1056\/NEJM198612113152405","article-title":"A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease","volume":"315","author":"Barrett-Connor","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ando.2011.12.005_bib0090","doi-asserted-by":"crossref","first-page":"9488","DOI":"10.1073\/pnas.1633724100","article-title":"Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension","volume":"100","author":"Bonnet","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ando.2011.12.005_bib0095","doi-asserted-by":"crossref","first-page":"40S","DOI":"10.1016\/j.jacc.2004.02.032","article-title":"Diagnosis and differential assessment of pulmonary arterial hypertension","volume":"43","author":"Barst","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ando.2011.12.005_bib0100","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"Standardisation of spirometry","volume":"26","author":"Miller","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ando.2011.12.005_bib0105","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1164\/ajrccm.155.4.9105067","article-title":"Interpreting small differences in functional status: the 6-minute-walk test in chronic lung disease patients","volume":"155","author":"Redelmeier","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ando.2011.12.005_bib0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0954-6111(06)80164-2","article-title":"Measuring functional status in chronic lung disease: conclusions from a randomized control trial","volume":"85 Suppl. B","author":"Guyatt","year":"1991","journal-title":"Respir Med"},{"key":"10.1016\/j.ando.2011.12.005_bib0115","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1056\/NEJMoa012212","article-title":"Bosentan therapy for pulmonary arterial hypertension","volume":"346","author":"Rubin","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ando.2011.12.005_bib0120","doi-asserted-by":"crossref","first-page":"391","DOI":"10.7326\/0003-4819-93-3-391","article-title":"Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial","volume":"93","author":"Nocturnal oxygen therapy trial group","year":"1980","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ando.2011.12.005_bib0125","doi-asserted-by":"crossref","first-page":"29","DOI":"10.7326\/0003-4819-102-1-29","article-title":"Hemodynamic response to oxygen therapy in chronic obstructive pulmonary disease","volume":"102","author":"Timms","year":"1985","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ando.2011.12.005_bib0130","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1002\/art.10615","article-title":"Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus: a multicenter randomized, double-blind, placebo-controlled trial","volume":"46","author":"Chang","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ando.2011.12.005_bib0135","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.pharmthera.2010.02.003","article-title":"Dehydroepiandrosterone: a new treatment for vascular remodeling diseases including pulmonary arterial hypertension","volume":"126","author":"Dumas de la Roque","year":"2010","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.ando.2011.12.005_bib0140","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1210\/jc.2003-031560","article-title":"Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors","volume":"89","author":"Williams","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2011.12.005_bib0145","doi-asserted-by":"crossref","first-page":"L71","DOI":"10.1152\/ajplung.90251.2008","article-title":"Involvement of RhoA\/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone","volume":"295","author":"Homma","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ando.2011.12.005_bib0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jsbmb.2007.12.001","article-title":"DHEA decreases HIF-1alpha accumulation under hypoxia in human pulmonary artery cells: potential role in the treatment of pulmonary arterial hypertension","volume":"109","author":"Dessouroux","year":"2008","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.ando.2011.12.005_bib0155","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1161\/CIRCULATIONAHA.109.848911","article-title":"Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt\/GSK3-{beta}\/NFAT axis","volume":"120","author":"Bonnet","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ando.2011.12.005_bib0160","doi-asserted-by":"crossref","first-page":"343","DOI":"10.7326\/0003-4819-115-5-343","article-title":"Survival in patients with primary pulmonary hypertension. Results from a national prospective registry","volume":"115","author":"D\u2019Alonzo","year":"1991","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ando.2011.12.005_bib0165","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.pupt.2005.09.006","article-title":"Sildenafil improves hemodynamic parameters in COPD\u00a0\u2013\u00a0an investigation of six patients","volume":"19","author":"Alp","year":"2006","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.ando.2011.12.005_bib0170","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.vph.2006.01.013","article-title":"A potential role for sildenafil in the management of pulmonary hypertension in patients with parenchymal lung disease","volume":"44","author":"Madden","year":"2006","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.ando.2011.12.005_bib0175","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1183\/09031936.00114207","article-title":"Sildenafil treatment in COPD does not affect stroke volume or exercise capacity","volume":"31","author":"Rietema","year":"2008","journal-title":"Eur Respir J"}],"container-title":["Annales d'Endocrinologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003426611002101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003426611002101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T22:44:58Z","timestamp":1757717098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003426611002101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0003426611002101"],"URL":"https:\/\/doi.org\/10.1016\/j.ando.2011.12.005","relation":{},"ISSN":["0003-4266"],"issn-type":[{"value":"0003-4266","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dehydroepiandrosterone (DHEA) improves pulmonary hypertension in chronic obstructive pulmonary disease (COPD): A pilot study","name":"articletitle","label":"Article Title"},{"value":"Annales d'Endocrinologie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ando.2011.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}