{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T23:09:39Z","timestamp":1782083379088,"version":"3.54.5"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annales d'Endocrinologie"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.ando.2015.03.005","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T08:51:12Z","timestamp":1428915072000},"page":"134-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["How to manage an isolated elevated PTH?"],"prefix":"10.1016","volume":"76","author":[{"given":"Jean-Claude","family":"Souberbielle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Cavalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Cormier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ando.2015.03.005_bib0215","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1210\/jc.2013-3349","article-title":"Interpretation of plasma PTH concentrations according to 25OHD status, gender, age, weight status, and calcium intake: importance of the reference values","volume":"99","author":"Touvier","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0220","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.archger.2007.12.005","article-title":"Responses of parathyroid hormone to vitamin D supplementation: a systematic review of clinical trials","volume":"48","author":"Bj\u00f6rkman","year":"2009","journal-title":"Arch Gerontol Geriatrics"},{"key":"10.1016\/j.ando.2015.03.005_bib0225","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1210\/jc.2008-1758","article-title":"Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop","volume":"94","author":"Eastell","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0230","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1210\/jc.2014-1413","article-title":"Guidelines for the management of asymptomatic ptrimary hyperparathyroidism: summary statement from the fourth international workshop","volume":"99","author":"Bilezikian","year":"2014","journal-title":"J Clin Endocrinol metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0235","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1093\/clinchem\/33.8.1364","article-title":"Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia","volume":"33","author":"Nussbaum","year":"1987","journal-title":"Clin Chem"},{"key":"10.1016\/j.ando.2015.03.005_bib0240","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1210\/jcem-67-2-353","article-title":"Two-site assay of intact parathyroid hormone in the investigation of primary hyperparathyroidism and other disorders of calcium metabolism compared with a mid-region assay","volume":"67","author":"Blind","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0245","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/clinchem\/37.2.162","article-title":"Immunochemiluminometric and immunoradiometric determinations of intact and total immunoreactive parathyrin: performance in the differential diagnosis of hypercalcemia and hypoparathyroidism","volume":"37","author":"Endres","year":"1991","journal-title":"Clin Chem"},{"key":"10.1016\/j.ando.2015.03.005_bib0250","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1093\/clinchem\/35.9.1957","article-title":"Performance and diagnostic application of a two-site immunometric assay for parathyrin in serum","volume":"35","author":"Ratcliffe","year":"1989","journal-title":"Clin Chem"},{"key":"10.1016\/j.ando.2015.03.005_bib0255","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1359\/jbmr.2001.16.4.605","article-title":"Development of a novel immunoradiometric assay exclusively for biologically active whole parathyroid hormone 1\u201384: implication for improvement of accurate assesment of parathyroid function","volume":"16","author":"Gao","year":"2001","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ando.2015.03.005_bib0260","first-page":"3086","article-title":"Vitamin D status and redefining serum parathyroid hormone reference range","volume":"86","author":"Souberbielle","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0265","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1373\/clinchem.2004.037606","article-title":"Assay-specific decision limits for two new automated parathyroid hormone and 25-hydroxyvitamin D assays","volume":"51","author":"Souberbielle","year":"2005","journal-title":"Clin Chem"},{"key":"10.1016\/j.ando.2015.03.005_bib0270","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1093\/ndt\/gfr535","article-title":"Interpretation of serum PTH concentrations with different kits in dialysis patients according to the KDIGO guidelines: importance of the reference (normal) values","volume":"27","author":"Cavalier","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ando.2015.03.005_bib0275","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00198-014-2623-7","article-title":"Vitamin D status of schoolchildren in Northern Algeria, seasonal variations and determinants of vitamin D deficiency","volume":"25","author":"Djennane","year":"2014","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.ando.2015.03.005_bib0285","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/jc.2010-2704","article-title":"The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know","volume":"96","author":"Ross","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0280","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0290","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/ajcn\/84.3.602","article-title":"Optimal vitamin D status and serum parathyroid hormone concentrations in African American women","volume":"84","author":"Aloia","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ando.2015.03.005_bib0295","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00774-010-0200-5","article-title":"Vitamin D insufficiency defined by serum 25-hydroxyvitamin D and parathyroid hormone before and after oral vitamin D3 supplementation load in Japanese patients","volume":"29","author":"Okazaki","year":"2011","journal-title":"J Bone Miner Metab"},{"issue":"Suppl.\u00a0113","key":"10.1016\/j.ando.2015.03.005_bib0300","first-page":"S1","article-title":"Clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone disorder (CKD-MBD)","volume":"76","author":"KDIGO. Work Group C.-M.","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.ando.2015.03.005_bib0305","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1365-2265.2010.03894.x","article-title":"Determinants of plasma PTH and their implication for defining a reference interval","volume":"74","author":"Rejnmark","year":"2011","journal-title":"Clin Endocrinol (Oxford)"},{"key":"10.1016\/j.ando.2015.03.005_bib0310","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1172\/JCI111995","article-title":"Evidence for alteration of the vitamin D-endocrine system in blacks","volume":"76","author":"Bell","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ando.2015.03.005_bib0315","first-page":"494","article-title":"Influence of vitamin D on parathyroid hormone in the elderly","volume":"75","author":"Quesada","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0320","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1210\/jc.2003-030097","article-title":"The use in clinical practice of parathyroid hormone normative values established in vitamin D-sufficient subjects","volume":"88","author":"Souberbielle","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0325","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1681\/ASN.2007040449","article-title":"Pitfalls of measuring total blood calcium in patients with CKD","volume":"19","author":"Gauci","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ando.2015.03.005_bib0330","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1210\/jc.2012-1429","article-title":"The importance of measuring ionized calcium in characterizing calcium status and diagnosing primary hyperparathyroidism","volume":"97","author":"Ong","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0335","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s001980050110","article-title":"Urinary calcium in perimenopausal women: normative values","volume":"9","author":"Heaney","year":"1999","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.ando.2015.03.005_bib0340","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s00198-009-1052-5","article-title":"Measurement uncertainty of 25-OH vitamin D determination with different commercially available kits: impact on the clinical cut-offs","volume":"21","author":"Cavalier","year":"2010","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.ando.2015.03.005_bib0345","first-page":"S1","article-title":"Clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD)","volume":"79","author":"KDIGO","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.ando.2015.03.005_bib0350","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1007\/s00774-011-0275-7","article-title":"Acute-onset hypomagnesemia-induced hypocalcemia caused by the refractoriness of bones and renal tubules to parathyroid hormone","volume":"29","author":"Yamamoto","year":"2011","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0355","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1210\/jc.2011-1048","article-title":"Pseudohypoparathyroidism: diagnosis and treatment","volume":"96","author":"Mantovani","year":"2011","journal-title":"J Clin Endocrinol metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0360","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jocd.2012.12.001","article-title":"Normocalcemic primary hyperparathyroidism","volume":"16","author":"Cusano","year":"2013","journal-title":"J Clin Densitometry."},{"key":"10.1016\/j.ando.2015.03.005_bib0365","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1210\/jc.2006-2802","article-title":"Normocalcemic primary hyperparathyroidism: further characterization of a new clinical phenotype","volume":"92","author":"Lowe","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0370","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1210\/jc.2002-021404","article-title":"Normocalcemic primary hyperparathyroidism: evidence for a generalized target-tissue resistance to parathyroid hormone","volume":"88","author":"Maruani","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0375","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1007\/s12020-012-9694-z","article-title":"Normocalcemic primary hyperparathyroidism: one year follow-up in one hundred postmenopausal women","volume":"42","author":"Garcia-MartinA","year":"2012","journal-title":"Endocrine"},{"key":"10.1016\/j.ando.2015.03.005_bib0380","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1210\/jc.2013-1300","article-title":"Normocalcemic hyperparathyroidism and hypoparathyroidism in two community-based non-referral populations","volume":"98","author":"Cusano","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0385","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1210\/jc.2013-1518","article-title":"Bone mineral density evolution after successful parathyroidectomy in patients with normocalcemic primary hyperparathyroidism","volume":"98","author":"Koumakis","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2015.03.005_bib0390","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1089\/end.2008.0567","article-title":"Differentiating primary from secondary hyperparathyroidism in stone patients: the \u201cthiazide challenge\u201d","volume":"23","author":"Eisner","year":"2009","journal-title":"J Endourol"},{"key":"10.1016\/j.ando.2015.03.005_bib0395","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1359\/JBMR.051210","article-title":"Dissimilar PTH, gastrinn and calcitonin responses to oral calcium and peptones in hypocalciuric hypercalcemia, primary hyperparathyroidism, and normal subjects: a useful tool for differential diagnosis","volume":"21","author":"Bevilacqua","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ando.2015.03.005_bib0400","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1590\/S0100-879X2004000900013","article-title":"Response to an oral calcium load in nephrolithiasis patients with fluctuating parathyroid hormone and ionized calcium levels","volume":"37","author":"Gomes","year":"2004","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.ando.2015.03.005_bib0405","first-page":"1103","article-title":"Role of the oral calcium-loading test with measurement of intact parathyroid hormone in the diagnosis of symptomatic subtle primary hyperparathyroidism","volume":"112","author":"Monchik","year":"1992","journal-title":"Surgery"},{"key":"10.1016\/j.ando.2015.03.005_bib0410","first-page":"1026","article-title":"Oral calcium load test: diagnostic and physiologic complications in hyperparathyroidism","volume":"108","author":"McHenry","year":"1990","journal-title":"Surgery"},{"key":"10.1016\/j.ando.2015.03.005_bib0415","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/gut.39.2.273","article-title":"Oral calcium tolerance test in the early diagnosis of primary hyperparathyroidism and multiple endocrine neoplasia typ1 in patients with the Zollinger-Ellison syndrome","volume":"39","author":"Cadiot","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.ando.2015.03.005_bib0420","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/clinchem\/38.10.2129","article-title":"Superiority of dynamic over static reference intervals for intac, midmolecule, and C-terminal parathyrin in evaluating calcemic disorders","volume":"38","author":"Lepage","year":"1992","journal-title":"Clin Chem"}],"container-title":["Annales d'Endocrinologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003426615000268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003426615000268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T22:48:28Z","timestamp":1757717308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003426615000268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0003426615000268"],"URL":"https:\/\/doi.org\/10.1016\/j.ando.2015.03.005","relation":{},"ISSN":["0003-4266"],"issn-type":[{"value":"0003-4266","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"How to manage an isolated elevated PTH?","name":"articletitle","label":"Article Title"},{"value":"Annales d'Endocrinologie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ando.2015.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}