{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:52:30Z","timestamp":1791186750853,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annales d'Endocrinologie"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.ando.2015.03.008","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T09:17:05Z","timestamp":1430212625000},"page":"253-259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["The history of Distilb\u00e8ne\u00ae (Diethylstilbestrol) told to grandchildren\u00a0\u2013\u00a0the transgenerational effect"],"prefix":"10.1016","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0509-175X","authenticated-orcid":false,"given":"Patrick","family":"F\u00e9nichel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Brucker-Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Chevalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ando.2015.03.008_bib0005","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1158\/1055-9965.EPI-06-0109","article-title":"Prenatal diethylstilbestrol exposure and risk of breast cancer","volume":"15","author":"Palmer","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"9312","key":"10.1016\/j.ando.2015.03.008_bib0010","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/S0140-6736(02)08152-7","article-title":"Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study","volume":"359","author":"Klip","year":"2002","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.ando.2015.03.008_bib0015","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/S0002-9378(16)38617-3","article-title":"Does the administration of diethylstilbestrol during pregnancy have therapeutic value?","volume":"66","author":"Dieckmann","year":"1953","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.ando.2015.03.008_bib0020","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/1097-0142(197004)25:4<745::AID-CNCR2820250402>3.0.CO;2-2","article-title":"Adenocarcinoma of the vagina in adolescence. A report of 7 cases including 6 clear-cell carcinomas (so-called mesonephromas)","volume":"25","author":"Herbst","year":"1970","journal-title":"Cancer"},{"issue":"1\u20132","key":"10.1016\/j.ando.2015.03.008_bib0025","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mce.2009.02.024","article-title":"Environmental estrogens and obesity","volume":"304","author":"Newbold","year":"2009","journal-title":"Mol Cell Endocrinol"},{"issue":"8","key":"10.1016\/j.ando.2015.03.008_bib0030","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1023\/A:1025388901248","article-title":"The developmental origins of adult disease","volume":"18","author":"Barker","year":"2003","journal-title":"Eur J Epidemiol"},{"issue":"8","key":"10.1016\/j.ando.2015.03.008_bib0035","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1016\/j.fertnstert.2011.02.047","article-title":"Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study","volume":"95","author":"Kalfa","year":"2011","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.ando.2015.03.008_bib0040","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-2605.2009.01010.x","article-title":"Birth defects in the sons and daughters of women who were exposed in utero to diethylstilbestrol (DES)","volume":"33","author":"Titus-Ernstoff","year":"2010","journal-title":"Int J Androl"},{"issue":"Suppl. 6","key":"10.1016\/j.ando.2015.03.008_bib0045","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1210\/en.2005-1164","article-title":"Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations","volume":"147","author":"Newbold","year":"2006","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.ando.2015.03.008_bib0050","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jmb.2004.05.052","article-title":"A HOXA10 estrogen response element (ERE) is differentially regulated by 17 beta-estradiol and diethylstilbestrol (DES)","volume":"340","author":"Akbas","year":"2004","journal-title":"J Mol Biol"},{"issue":"32","key":"10.1016\/j.ando.2015.03.008_bib0055","doi-asserted-by":"crossref","first-page":"33639","DOI":"10.1074\/jbc.M402195200","article-title":"Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity","volume":"279","author":"Greschik","year":"2004","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.ando.2015.03.008_bib0060","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1172\/JCI38521","article-title":"The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice","volume":"119","author":"Volle","year":"2009","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.ando.2015.03.008_bib0065","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1073\/pnas.94.5.2056","article-title":"Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses","volume":"94","author":"vom Saal","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"10.1016\/j.ando.2015.03.008_bib0070","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1289\/ehp.0800367","article-title":"Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor","volume":"117","author":"Bouskine","year":"2009","journal-title":"Environ Health Perspect"},{"issue":"2","key":"10.1016\/j.ando.2015.03.008_bib0075","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/dbio.1998.8907","article-title":"(AbdB) Hoxa genes: regulation in adult uterus by estrogen and progesterone and repression in mullerian duct by the synthetic estrogen diethylstilbestrol (DES)","volume":"197","author":"Ma","year":"1998","journal-title":"Dev Biol"},{"issue":"19","key":"10.1016\/j.ando.2015.03.008_bib0080","first-page":"4356","article-title":"Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus","volume":"57","author":"Li","year":"1997","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.ando.2015.03.008_bib0085","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/mc.10147","article-title":"Neonatal diethylstilbestrol exposure induces persistent elevation of c-fos expression and hypomethylation in its exon-4 in mouse uterus","volume":"38","author":"Li","year":"2003","journal-title":"Mol Carcinog"},{"issue":"5727","key":"10.1016\/j.ando.2015.03.008_bib0090","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.1108190","article-title":"Epigenetic transgenerational actions of endocrine disruptors and male fertility","volume":"308","author":"Anway","year":"2005","journal-title":"Science"},{"issue":"7092","key":"10.1016\/j.ando.2015.03.008_bib0095","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature04674","article-title":"RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse","volume":"441","author":"Rassoulzadegan","year":"2006","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.ando.2015.03.008_bib0100","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/carcin\/21.7.1355","article-title":"Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol","volume":"21","author":"Newbold","year":"2000","journal-title":"Carcinogenesis"},{"issue":"9","key":"10.1016\/j.ando.2015.03.008_bib0105","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/carcin\/19.9.1655","article-title":"Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol","volume":"19","author":"Newbold","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ando.2015.03.008_bib0110","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/141247b0","article-title":"Oestrogenic activity of certain synthetic compounds","volume":"141","author":"Dodds","year":"1936","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ando.2015.03.008_bib0115","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0002-9378(80)90913-8","article-title":"Upper genital tract changes and pregnancy outcome in offspring exposed in utero to diethylstilbestrol","volume":"137","author":"Kaufman","year":"1980","journal-title":"Am J Obstet Gynecol"},{"issue":"1 Pt 1","key":"10.1016\/j.ando.2015.03.008_bib0120","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0368-2315(05)82668-7","article-title":"[Obstetrical outcome in 454 women exposed to diethylstilbesterol during their fetal life: a case-control analysis]","volume":"34","author":"Papiernik","year":"2005","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"issue":"7","key":"10.1016\/j.ando.2015.03.008_bib0125","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1210\/en.2009-0071","article-title":"Hypermethylation of homeobox A10 by in utero diethylstilbestrol exposure: an epigenetic mechanism for altered developmental programming","volume":"150","author":"Bromer","year":"2009","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.ando.2015.03.008_bib0130","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/ijc.22631","article-title":"Cancer risk in women prenatally exposed to diethylstilbestrol","volume":"121","author":"Troisi","year":"2007","journal-title":"Int J Cancer"},{"issue":"7","key":"10.1016\/j.ando.2015.03.008_bib0135","first-page":"999","article-title":"Cancer risk in DES daughters","volume":"21","author":"Verloop","year":"2010","journal-title":"Cancer Causes Control"},{"issue":"9","key":"10.1016\/j.ando.2015.03.008_bib0140","first-page":"837","article-title":"Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States)","volume":"12","author":"Hatch","year":"2001","journal-title":"Cancer Causes Control"},{"issue":"1","key":"10.1016\/j.ando.2015.03.008_bib0145","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0301-2115(97)00206-6","article-title":"The daughters of diethylstilbestrol. Lessons from an error","volume":"75","author":"Tournaire","year":"1997","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"3","key":"10.1016\/j.ando.2015.03.008_bib0150","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0015-0282(16)47713-7","article-title":"Diethylstilbestrol exposure in utero and endometriosis in infertile females","volume":"41","author":"Stillman","year":"1984","journal-title":"Fertil Steril"},{"issue":"5","key":"10.1016\/j.ando.2015.03.008_bib0155","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1471-0528.1986.tb08661.x","article-title":"Primary infertility in women exposed to diethylstilboestrol in utero","volume":"93","author":"Menczer","year":"1986","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.ando.2015.03.008_bib0160","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1476-069X-8-37","article-title":"Urogenital abnormalities in men exposed to diethylstilbestrol in utero: a cohort study","volume":"8","author":"Palmer","year":"2009","journal-title":"Environ Health"},{"issue":"3","key":"10.1016\/j.ando.2015.03.008_bib0165","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/humrep\/dei398","article-title":"Hypospadias: a transgenerational effect of diethylstilbestrol?","volume":"21","author":"Brouwers","year":"2006","journal-title":"Hum Reprod"},{"issue":"7","key":"10.1016\/j.ando.2015.03.008_bib0170","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/jnci\/93.7.545","article-title":"Cancer risk in men exposed in utero to diethylstilbestrol","volume":"93","author":"Strohsnitter","year":"2001","journal-title":"J Natl Cancer Inst"},{"issue":"7","key":"10.1016\/j.ando.2015.03.008_bib0175","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/aje\/kwm136","article-title":"Time to pregnancy and secondary sex ratio in men exposed prenatally to diethylstilbestrol","volume":"166","author":"Wise","year":"2007","journal-title":"Am J Epidemiol"},{"issue":"21","key":"10.1016\/j.ando.2015.03.008_bib0180","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1056\/NEJM199505253322104","article-title":"Fertility in men exposed prenatally to diethylstilbestrol","volume":"332","author":"Wilcox","year":"1995","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.ando.2015.03.008_bib0185","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/EDE.0b013e318289bdf7","article-title":"Medical conditions among adult offspring prenatally exposed to diethylstilbestrol","volume":"24","author":"Troisi","year":"2013","journal-title":"Epidemiology"},{"issue":"2","key":"10.1016\/j.ando.2015.03.008_bib0190","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1464-410X.2009.08772.x","article-title":"Hypospadias: risk factor patterns and different phenotypes","volume":"105","author":"Brouwers","year":"2010","journal-title":"BJU Int"},{"issue":"4","key":"10.1016\/j.ando.2015.03.008_bib0195","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/01.ede.0000164789.59728.6d","article-title":"Hypospadias in sons of women exposed to diethylstilbestrol in utero","volume":"16","author":"Palmer","year":"2005","journal-title":"Epidemiology"},{"issue":"5","key":"10.1016\/j.ando.2015.03.008_bib0200","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/pd.1136","article-title":"Hypospadias in sons of women exposed to diethylstilbestrol in utero","volume":"25","author":"Pons","year":"2005","journal-title":"Prenatal diagnosis"},{"issue":"9","key":"10.1016\/j.ando.2015.03.008_bib0205","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1371\/journal.pgen.0030151","article-title":"Evidence for transgenerational transmission of epigenetic tumor susceptibility in Drosophila","volume":"3","author":"Xing","year":"2007","journal-title":"PLoS Genet"},{"issue":"12","key":"10.1016\/j.ando.2015.03.008_bib0210","doi-asserted-by":"crossref","first-page":"5617","DOI":"10.1210\/en.2010-0684","article-title":"Transgenerational inheritance of glucose intolerance in a mouse model of neonatal overnutrition","volume":"151","author":"Pentinat","year":"2010","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.ando.2015.03.008_bib0215","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1210\/en.2010-1461","article-title":"Maternal high-fat diet effects on third-generation female body size via the paternal lineage","volume":"152","author":"Dunn","year":"2011","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.ando.2015.03.008_bib0220","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.biopsych.2010.05.036","article-title":"Epigenetic transmission of the impact of early stress across generations","volume":"68","author":"Franklin","year":"2010","journal-title":"Biol Psychiatry"},{"issue":"10","key":"10.1016\/j.ando.2015.03.008_bib0225","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1096\/fj.12-224048","article-title":"Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content","volume":"27","author":"Fullston","year":"2013","journal-title":"FASEB J"},{"issue":"5","key":"10.1016\/j.ando.2015.03.008_bib0230","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nn.3695","article-title":"Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice","volume":"17","author":"Gapp","year":"2014","journal-title":"Nature Neurosci"}],"container-title":["Annales d'Endocrinologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003426615000293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003426615000293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T22:47:21Z","timestamp":1757717241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003426615000293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0003426615000293"],"URL":"https:\/\/doi.org\/10.1016\/j.ando.2015.03.008","relation":{},"ISSN":["0003-4266"],"issn-type":[{"value":"0003-4266","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The history of Distilb\u00e8ne\u00ae (Diethylstilbestrol) told to grandchildren\u00a0\u2013\u00a0the transgenerational effect","name":"articletitle","label":"Article Title"},{"value":"Annales d'Endocrinologie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ando.2015.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}