{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:47:30Z","timestamp":1778546850559,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annales d'Endocrinologie"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.ando.2016.02.006","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T16:26:29Z","timestamp":1466007989000},"page":"214-219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["SFE\/SFHTA\/AFCE consensus on primary aldosteronism, part 5: Genetic diagnosis of primary aldosteronism"],"prefix":"10.1016","volume":"77","author":[{"given":"Maria-Christina","family":"Zennaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Jeunemaitre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ando.2016.02.006_bib0005","doi-asserted-by":"crossref","first-page":"R63","DOI":"10.1530\/JOE-14-0597","article-title":"An update on novel mechanisms of primary aldosteronism","volume":"224","author":"Zennaro","year":"2015","journal-title":"J Endocrinol"},{"key":"10.1016\/j.ando.2016.02.006_bib0010","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/HYPERTENSIONAHA.114.03419","article-title":"Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma","volume":"64","author":"Fernandes-Rosa","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.ando.2016.02.006_bib0015","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nrendo.2012.230","article-title":"Role of KCNJ5 in familial and sporadic primary aldosteronism","volume":"9","author":"Mulatero","year":"2013","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.ando.2016.02.006_bib0020","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1530\/EJE-12-0813","article-title":"Genetics of mineralocorticoid excess: an update for clinicians","volume":"169","author":"Zennaro","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ando.2016.02.006_bib0025","doi-asserted-by":"crossref","first-page":"e06315","DOI":"10.7554\/eLife.06315","article-title":"Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism","volume":"4","author":"Scholl","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.ando.2016.02.006_bib0030","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/ng.2695","article-title":"Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism","volume":"45","author":"Scholl","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.ando.2016.02.006_bib0035","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0003-4266(05)81756-1","article-title":"Familial aspect of primary hyperaldosteronism: analysis of families compatible with primary hyperaldosteronism type 2","volume":"66","author":"Medeau","year":"2005","journal-title":"Ann Endocrinol"},{"key":"10.1016\/j.ando.2016.02.006_bib0040","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1161\/HYPERTENSIONAHA.111.175083","article-title":"Prevalence and characteristics of familial hyperaldosteronism: the PATOGEN study (Primary Aldosteronism in TOrino-GENetic forms)","volume":"58","author":"Mulatero","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.ando.2016.02.006_bib0045","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1055\/s-0031-1299730","article-title":"The prevalence of familial hyperaldosteronism in apparently sporadic primary aldosteronism in Germany: a single center experience","volume":"44","author":"Pallauf","year":"2012","journal-title":"Hormone Metab Res"},{"key":"10.1016\/j.ando.2016.02.006_bib0050","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0960-0760(01)00097-8","article-title":"Familial hyperaldosteronism","volume":"78","author":"Stowasser","year":"2001","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.ando.2016.02.006_bib0055","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1161\/HYPERTENSIONAHA.110.168740","article-title":"Frequency of familial hyperaldosteronism type 1 in a hypertensive pediatric population: clinical and biochemical presentation","volume":"57","author":"Aglony","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.ando.2016.02.006_bib0060","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/355262a0","article-title":"A chimaeric 11beta-hydroxylase aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension","volume":"355","author":"Lifton","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.ando.2016.02.006_bib0065","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1172\/JCI118279","article-title":"Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree","volume":"96","author":"Pascoe","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ando.2016.02.006_bib0070","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1210\/jc.2008-0104","article-title":"Case detection, diagnosis, and treatment of patients with primary aldosteronism: an Endocrine Society clinical practice guideline","volume":"93","author":"Funder","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2016.02.006_bib0075","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1210\/jcem.85.9.6834","article-title":"Treatment of familial hyperaldosteronism type I: only partial suppression of adrenocorticotropin required to correct hypertension","volume":"85","author":"Stowasser","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2016.02.006_bib0080","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1161\/01.HYP.31.1.445","article-title":"Intracranial aneurysm and hemorrhagic stroke in glucocorticoid-remediable aldosteronism","volume":"31","author":"Litchfield","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.ando.2016.02.006_bib0085","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1210\/jc.2005-0681","article-title":"Evidence for abnormal left ventricular structure and function in normotensive individuals with familial hyperaldosteronism type I","volume":"90","author":"Stowasser","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2016.02.006_bib0090","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1210\/jc.2008-0594","article-title":"A novel form of human Mendelian hypertension featuring nonglucocorticoid-remediable aldosteronism","volume":"93","author":"Geller","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2016.02.006_bib0095","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1198785","article-title":"K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension","volume":"331","author":"Choi","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ando.2016.02.006_bib0100","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1073\/pnas.1121407109","article-title":"Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5","volume":"109","author":"Scholl","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ando.2016.02.006_bib0105","doi-asserted-by":"crossref","first-page":"E1532","DOI":"10.1210\/jc.2012-1334","article-title":"A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension","volume":"97","author":"Charmandari","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2016.02.006_bib0110","doi-asserted-by":"crossref","first-page":"E114","DOI":"10.1210\/jc.2014-3636","article-title":"A case of severe hyperaldosteronism caused by a de novo mutation affecting a critical \u2018salt bridge\u2019 Kir3.4 residue","volume":"100","author":"Monticone","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2016.02.006_bib0115","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1161\/HYPERTENSIONAHA.111.183996","article-title":"KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism","volume":"59","author":"Mulatero","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.ando.2016.02.006_bib0120","doi-asserted-by":"crossref","first-page":"E1861","DOI":"10.1210\/jc.2013-2428","article-title":"a Novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III","volume":"98","author":"Monticone","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2016.02.006_bib0125","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1210\/en.2011-1733","article-title":"Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis","volume":"153","author":"Oki","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.ando.2016.02.006_bib0130","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1097\/01.hjh.0000174299.66369.26","article-title":"Familial hyperaldosteronism type II is linked to the chromosome 7p22 region but also shows predicted heterogeneity","volume":"23","author":"So","year":"2005","journal-title":"J Hypertension"},{"key":"10.1016\/j.ando.2016.02.006_bib0135","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1530\/EJE-11-0679","article-title":"Adrenal involvement in MEN1. Analysis of 715 cases from the Groupe d\u2019etude des Tumeurs Endocrines database","volume":"166","author":"Gatta-Cherifi","year":"2012","journal-title":"Eur J Endocrinol"}],"container-title":["Annales d'Endocrinologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000342661630021X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000342661630021X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T22:48:52Z","timestamp":1757717332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000342661630021X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S000342661630021X"],"URL":"https:\/\/doi.org\/10.1016\/j.ando.2016.02.006","relation":{},"ISSN":["0003-4266"],"issn-type":[{"value":"0003-4266","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SFE\/SFHTA\/AFCE consensus on primary aldosteronism, part 5: Genetic diagnosis of primary aldosteronism","name":"articletitle","label":"Article Title"},{"value":"Annales d'Endocrinologie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ando.2016.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}