{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:37:34Z","timestamp":1778895454654,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annales d'Endocrinologie"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.ando.2018.06.001","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:01:20Z","timestamp":1537401680000},"page":"117-121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Expression of \u03b2-endorphin in peripheral tissues after systemic administration of lipopolysaccharide as a model of endotoxic shock in mice"],"prefix":"10.1016","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6382-7000","authenticated-orcid":false,"given":"Kanta","family":"Kido","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Shindo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Toda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ando.2018.06.001_bib0165","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/00024382-200115060-00011","article-title":"Opiate modulation of hemodynamic, hormonal, and cytokine responses to hemorrhage","volume":"15","author":"Molina","year":"2001","journal-title":"Shock"},{"key":"10.1016\/j.ando.2018.06.001_bib0170","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1213\/01.ane.0000287252.39383.17","article-title":"The influence of hemorrhagic shock on the minimum alveolar anesthetic concentration of isoflurane in a swine model","volume":"105","author":"Kurita","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ando.2018.06.001_bib0175","first-page":"S126","article-title":"Endogenous opioid analgesia in hemorrhagic shock","volume":"54","author":"Molina","year":"2003","journal-title":"J Trauma"},{"key":"10.1016\/j.ando.2018.06.001_bib0180","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11373-005-0647-x","article-title":"Effects of naltrexone on lipopolysaccharide-induced sepsis in rats","volume":"12","author":"Lin","year":"2005","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.ando.2018.06.001_bib0185","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.bbi.2003.12.001","article-title":"The opioid antagonist naltrexone blocks acute endotoxic shock by inhibiting tumor necrosis factor-alpha production","volume":"18","author":"Greeneltch","year":"2004","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.ando.2018.06.001_bib0190","first-page":"279","article-title":"Endogenous opioid analgesia in peripheral tissues and the clinical implications for pain control","volume":"1","author":"Kapitzke","year":"2005","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.ando.2018.06.001_bib0195","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0753-3322(93)90080-5","article-title":"Physiology of beta-endorphins. A close-up view and a review of the literature","volume":"47","author":"Dalayeun","year":"1993","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.ando.2018.06.001_bib0200","doi-asserted-by":"crossref","first-page":"552","DOI":"10.4161\/onci.19335","article-title":"beta-endorphin neuron transplantation: A possible novel therapy for cancer prevention","volume":"1","author":"Zhang","year":"2012","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.ando.2018.06.001_bib0205","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1073\/pnas.73.8.2895","article-title":"beta-endorphin is a potent analgesic agent","volume":"73","author":"Loh","year":"1976","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ando.2018.06.001_bib0210","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1046\/j.1440-1681.2002.03638.x","article-title":"Stress-specific opioid modulation of haemodynamic counter-regulation","volume":"29","author":"Molina","year":"2002","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.ando.2018.06.001_bib0215","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/275450a0","article-title":"Naloxone reversal of endotoxin hypotension suggests role of endorphins in shock","volume":"275","author":"Holaday","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.ando.2018.06.001_bib0220","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev.pa.23.040183.002545","article-title":"Cardiovascular effects of endogenous opiate systems","volume":"23","author":"Holaday","year":"1983","journal-title":"Ann Rev Pharmacol Toxicol"},{"key":"10.1016\/j.ando.2018.06.001_bib0225","first-page":"101","article-title":"Reduced microvascular adrenergic receptor activity due to opioids in endotoxin shock","volume":"32","author":"Baker","year":"1990","journal-title":"Circ Shock"},{"key":"10.1016\/j.ando.2018.06.001_bib0230","first-page":"227","article-title":"The effects of naloxone on endotoxic and hemorrhagic shock in horses","volume":"44","author":"Weld","year":"1984","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"10.1016\/j.ando.2018.06.001_bib0235","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/0024-3205(92)90053-R","article-title":"Centrally acting endogenous hypotensive substances in rats subjected to endotoxic shock","volume":"51","author":"Xu","year":"1992","journal-title":"Life Sci"},{"key":"10.1016\/j.ando.2018.06.001_bib0240","doi-asserted-by":"crossref","DOI":"10.2174\/138161212803582513","article-title":"Non-analgesic effects of opioids: Peripheral opioid effects on inflammation and wound healing","author":"Stein","year":"2012","journal-title":"Curr Pharm Des."},{"key":"10.1016\/j.ando.2018.06.001_bib0245","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tips.2010.05.008","article-title":"Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: clinical and therapeutic implications","volume":"31","author":"Hua","year":"2010","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.ando.2018.06.001_bib0250","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nm908","article-title":"Attacking pain at its source: new perspectives on opioids","volume":"9","author":"Stein","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.ando.2018.06.001_bib0255","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.1073\/pnas.87.15.5935","article-title":"Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation","volume":"87","author":"Stein","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ando.2018.06.001_bib0260","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1556\/amicr.61.2014.3.1","article-title":"Hormones in the immune system and their possible role. A critical review","volume":"61","author":"Csaba","year":"2014","journal-title":"Acta Microbiol Immunol Hung"},{"key":"10.1016\/j.ando.2018.06.001_bib0265","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0306-3623(95)02141-8","article-title":"Hypothermia as an indicator of the acute effects of lipopolysaccharides: comparison with serum levels of IL1 beta, IL6 and TNF alpha","volume":"27","author":"Blanque","year":"1996","journal-title":"Gen Pharmacol"},{"key":"10.1016\/j.ando.2018.06.001_bib0270","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.peptides.2015.10.009","article-title":"Endogenous opiates and behavior: 2014","volume":"75","author":"Bodnar","year":"2016","journal-title":"Peptides"},{"key":"10.1016\/j.ando.2018.06.001_bib0275","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.bbi.2009.10.013","article-title":"Opioid receptors and opioid peptide-producing leukocytes in inflammatory pain--basic and therapeutic aspects","volume":"24","author":"Busch-Dienstfertig","year":"2010","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.ando.2018.06.001_bib0280","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJM199506223322506","article-title":"The control of pain in peripheral tissue by opioids","volume":"332","author":"Stein","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ando.2018.06.001_bib0285","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1124\/pr.56.3.2","article-title":"Opioids as modulators of cell death and survival - Unraveling mechanisms and revealing new indications","volume":"56","author":"Tegeder","year":"2004","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.ando.2018.06.001_bib0290","doi-asserted-by":"crossref","first-page":"772","DOI":"10.2174\/092986708783955518","article-title":"The other side of the opioid story: modulation of cell growth and survival signaling","volume":"15","author":"Chen","year":"2008","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.ando.2018.06.001_bib0295","first-page":"337","article-title":"Sites of action of clonidine: centrally mediated increase in vagal tone, centrally mediated hypotensive and sympatho-inhibitory effects, Prog Brain Res","volume":"47","author":"Laubie","year":"1977"},{"key":"10.1016\/j.ando.2018.06.001_bib0300","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1476-4431.2010.00561.x","article-title":"Immunomodulatory effects of opioids","volume":"20","author":"Odunayo","year":"2010","journal-title":"J Vet Emerg Critical Care"},{"key":"10.1016\/j.ando.2018.06.001_bib0305","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1056\/NEJMoa1705835","article-title":"Adjunctive glucocorticoid therapy in patients with septic shock","volume":"378","author":"Venkatesh","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ando.2018.06.001_bib0310","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1001\/jama.288.7.862","article-title":"Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock","volume":"288","author":"Annane","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.ando.2018.06.001_bib0315","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa071366","article-title":"Hydrocortisone therapy for patients with septic shock","volume":"358","author":"Sprung","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ando.2018.06.001_bib0320","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/00003246-199303000-00018","article-title":"Hypercortisolism in septic shock is not suppressible by dexamethasone infusion","volume":"21","author":"Perrot","year":"1993","journal-title":"Crit Care Med"}],"container-title":["Annales d'Endocrinologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003426618300957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003426618300957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T22:51:35Z","timestamp":1757717495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003426618300957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0003426618300957"],"URL":"https:\/\/doi.org\/10.1016\/j.ando.2018.06.001","relation":{},"ISSN":["0003-4266"],"issn-type":[{"value":"0003-4266","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of \u03b2-endorphin in peripheral tissues after systemic administration of lipopolysaccharide as a model of endotoxic shock in mice","name":"articletitle","label":"Article Title"},{"value":"Annales d'Endocrinologie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ando.2018.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}