{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T18:06:33Z","timestamp":1766599593193,"version":"3.40.3"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annales d'Endocrinologie"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.ando.2025.101706","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T16:03:23Z","timestamp":1737993803000},"page":"101706","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Co-existing autonomous cortisol secretion in primary aldosteronism"],"prefix":"10.1016","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0042-6928","authenticated-orcid":false,"given":"Tugba","family":"Barlas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-7761","authenticated-orcid":false,"given":"Alev","family":"Eroglu Altinova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6168-937X","authenticated-orcid":false,"given":"Fusun","family":"Balos Toruner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7518-388X","authenticated-orcid":false,"given":"Ethem Turgay","family":"Cerit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-6881","authenticated-orcid":false,"given":"Mehmet Muhittin","family":"Yalcin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0601-6893","authenticated-orcid":false,"given":"Ayhan","family":"Karakoc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0457-6560","authenticated-orcid":false,"given":"Mujde","family":"Akturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ando.2025.101706_bib0205","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1210\/jc.2016-1472","article-title":"Study heterogeneity and estimation of prevalence of primary aldosteronism: a systematic review and meta-regression analysis","volume":"101","author":"K\u00e4yser","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2025.101706_bib0210","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.jacc.2017.01.052","article-title":"Prevalence and clinical manifestations of primary aldosteronism encountered in primary care practice","volume":"69","author":"Monticone","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ando.2025.101706_bib0215","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S2213-8587(17)30319-4","article-title":"Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis","volume":"6","author":"Monticone","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.ando.2025.101706_bib0220","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1210\/jc.2008-2116","article-title":"Cardiovascular and cerebrovascular comorbidities of hypokalemic and normokalemic primary aldosteronism: results of the German Conn's Registry","volume":"94","author":"Born-Frontsberg","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2025.101706_bib0225","doi-asserted-by":"crossref","DOI":"10.1038\/s41574-024-00984-y","article-title":"Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches","author":"Prete","year":"2024","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.ando.2025.101706_bib0230","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.3390\/diagnostics12112772","article-title":"The entity of connshing syndrome: primary aldosteronism with autonomous cortisol secretion","volume":"12","author":"Carsote","year":"2022","journal-title":"Diagnostics"},{"key":"10.1016\/j.ando.2025.101706_bib0235","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93136","article-title":"Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism","volume":"2","author":"Arlt","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.ando.2025.101706_bib0240","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.12998\/wjcc.v9.i5.1119","article-title":"Primary aldosteronism due to bilateral micronodular hyperplasia and concomitant subclinical Cushing's syndrome: a case report","volume":"9","author":"Teragawa","year":"2021","journal-title":"World J Clin Cases"},{"key":"10.1016\/j.ando.2025.101706_bib0245","doi-asserted-by":"crossref","DOI":"10.1530\/EC-23-0043","article-title":"Autonomous cortisol secretion in patients with primary aldosteronism: prevalence and implications on cardiometabolic profile and on surgical outcomes","volume":"12","author":"Araujo-Castro","year":"2023","journal-title":"Endocr Connect"},{"key":"10.1016\/j.ando.2025.101706_bib0250","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/cen.15013","article-title":"Effect of mild cortisol cosecretion on body composition and metabolic parameters in patients with primary hyperaldosteronism","volume":"100","author":"Mansour","year":"2024","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.ando.2025.101706_bib0255","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1530\/EJE-21-1131","article-title":"Primary aldosteronism with mild autonomous cortisol secretion increases renal complication risk","volume":"186","author":"Katabami","year":"2022","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ando.2025.101706_bib0260","doi-asserted-by":"crossref","first-page":"1369582","DOI":"10.3389\/fendo.2024.1369582","article-title":"The influence of cortisol co-secretion on clinical characteristics and postoperative outcomes in unilateral primary aldosteronism","volume":"15","author":"Jiang","year":"2024","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.ando.2025.101706_bib0265","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1210\/jc.2019-00299","article-title":"Impaired glucose metabolism in primary aldosteronism is associated with cortisol cosecretion","volume":"104","author":"Gerards","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2025.101706_bib0270","doi-asserted-by":"crossref","DOI":"10.1093\/ejendo\/lvae119","article-title":"NTpro-BNP levels in patients with primary hyperaldosteronism and autonomous cortisol co-secretion","author":"Hirsch","year":"2024","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ando.2025.101706_bib0275","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/cen.14546","article-title":"Apparent failed and discordant adrenal vein sampling: a potential confounding role of cortisol cosecretion?","volume":"96","author":"Kline","year":"2022","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.ando.2025.101706_bib0280","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1210\/clinem\/dgab698","article-title":"Selective glucocorticoid replacement following unilateral adrenalectomy for hypercortisolism and primary aldosteronism","volume":"107","author":"DeLozier","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2025.101706_bib0285","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1093\/ejendo\/lvad066","article-title":"European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in claboration with the European Network for the Study of Adrenal Tumors","volume":"189","author":"Fassnacht","year":"2023","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ando.2025.101706_bib0290","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/cen.15109","article-title":"Beyond symptomatology: a comparative analysis of unilateral and bilateral macronodular mild autonomous cortisol secretion","volume":"101","author":"Barlas","year":"2024","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.ando.2025.101706_bib0295","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S2213-8587(21)00210-2","article-title":"Diagnosis and treatment of primary aldosteronism","volume":"9","author":"Reincke","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.ando.2025.101706_bib0300","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine Society Clinical Practice Guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ando.2025.101706_bib0305","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1210\/jc.2008-0125","article-title":"The diagnosis of Cushing's syndrome: an endocrine society clinical practice guideline","volume":"93","author":"Nieman","year":"2008","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.ando.2025.101706_bib0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12020-019-01888-y","article-title":"Autonomous cortisol secretion in adrenal incidentalomas","volume":"64","author":"Araujo-Castro","year":"2019","journal-title":"Endocrine"},{"key":"10.1016\/j.ando.2025.101706_bib0315","doi-asserted-by":"crossref","first-page":"e3706","DOI":"10.1210\/clinem\/dgaa379","article-title":"Development and validation of prediction models for subtype diagnosis of patients with primary aldosteronism","volume":"105","author":"Burrello","year":"2020","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.ando.2025.101706_bib0320","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1097\/HJH.0000000000001961","article-title":"2018 Practice Guidelines for the management of arterial hypertension of the European Society of Hypertension and the European Society of Cardiology: ESH\/ESC Task Force for the Management of Arterial Hypertension","volume":"36","author":"Williams","year":"2018","journal-title":"J Hypertens"},{"key":"10.1016\/j.ando.2025.101706_bib0325","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.2337\/dc24-S002","article-title":"Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2024","volume":"47","year":"2024","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ando.2025.101706_bib0330","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1258\/acb.2009.009007","article-title":"How should proteinuria be detected and measured?","volume":"46","author":"Lamb","year":"2009","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.ando.2025.101706_bib0335","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ando.2025.101706_bib0340","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1507\/endocrj.K10E-402","article-title":"Clinicopathological features of primary aldosteronism associated with subclinical Cushing's syndrome","volume":"58","author":"Hiraishi","year":"2011","journal-title":"Endocr J"},{"key":"10.1016\/j.ando.2025.101706_bib0345","doi-asserted-by":"crossref","DOI":"10.1530\/EC-23-0043","article-title":"Autonomous cortisol secretion in patients with primary aldosteronism: prevalence and implications on cardiometabolic profile and on surgical outcomes","volume":"12","author":"Araujo-Castro","year":"2023","journal-title":"Endocrine Connect"},{"key":"10.1016\/j.ando.2025.101706_bib0350","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1373\/clinchem.2015.251199","article-title":"Mass spectrometry-based adrenal and peripheral venous steroid profiling for subtyping primary aldosteronism","volume":"62","author":"Eisenhofer","year":"2016","journal-title":"Clin Chem"},{"key":"10.1016\/j.ando.2025.101706_bib0355","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1055\/s-0043-122602","article-title":"Subtyping of patients with primary aldosteronism: an update","volume":"49","author":"Lenders","year":"2017","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.ando.2025.101706_bib0360","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1097\/HJH.0000000000001488","article-title":"Identifying unilateral disease in Chinese patients with primary aldosteronism by using a modified prediction score","volume":"35","author":"Zhang","year":"2017","journal-title":"J Hypertens"},{"key":"10.1016\/j.ando.2025.101706_bib0365","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1530\/EJE-21-0541","article-title":"Influence of cortisol cosecretion on non-ACTH-stimulated adrenal venous sampling in primary aldosteronism: a retrospective cohort study","volume":"187","author":"Heinrich","year":"2022","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ando.2025.101706_bib0370","doi-asserted-by":"crossref","first-page":"e3776","DOI":"10.1210\/clinem\/dgaa519","article-title":"Low-grade cortisol cosecretion has limited impact on ACTH-stimulated AVS parameters in primary aldosteronism","volume":"105","author":"O\u2019Toole","year":"2020","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.ando.2025.101706_bib0375","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.3390\/biomedicines12112430","article-title":"Impact of cortisol-cosecretion on adrenal venous sampling results in primary aldosteronism: study of 225 cases","volume":"12","author":"Lamas","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.ando.2025.101706_bib0380","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1210\/jc.2018-00617","article-title":"Cortisol excess in patients with primary aldosteronism impacts left ventricular hypertrophy","volume":"103","author":"Adolf","year":"2018","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.ando.2025.101706_bib0385","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1530\/EJE-21-1157","article-title":"Autonomous cortisol secretion is associated with worse arterial stiffness and vascular fibrosis in primary aldosteronism: a cross-sectional study with follow-up data","volume":"187","author":"Tsai","year":"2022","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ando.2025.101706_bib0390","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1097\/HJH.0000000000001550","article-title":"The impact of Connshing's syndrome-mild cortisol excess in primary aldosteronism drives diabetes risk","volume":"35","author":"Beuschlein","year":"2017","journal-title":"J Hypertens"},{"key":"10.1016\/j.ando.2025.101706_bib0395","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1210\/jc.2019-00299","article-title":"Impaired glucose metabolism in primary aldosteronism is associated with cortisol cosecretion","volume":"104","author":"Gerards","year":"2019","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.ando.2025.101706_bib0400","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1097\/HJH.0000000000001361","article-title":"Risk of new-onset diabetes mellitus in primary aldosteronism: a population study over 5 years","volume":"35","author":"Wu","year":"2017","journal-title":"J Hypertens"}],"container-title":["Annales d'Endocrinologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003426625000253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003426625000253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T08:37:39Z","timestamp":1743928659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003426625000253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0003426625000253"],"URL":"https:\/\/doi.org\/10.1016\/j.ando.2025.101706","relation":{},"ISSN":["0003-4266"],"issn-type":[{"type":"print","value":"0003-4266"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Co-existing autonomous cortisol secretion in primary aldosteronism","name":"articletitle","label":"Article Title"},{"value":"Annales d'Endocrinologie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ando.2025.101706","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101706"}}