{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:45:52Z","timestamp":1787240752889,"version":"build-2736575974"},"reference-count":48,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.animal.2020.100148","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T13:46:17Z","timestamp":1609422377000},"page":"100148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["The association of prepartum urine pH, plasma total calcium concentration at calving and postpartum diseases in Holstein dairy cattle"],"prefix":"10.1016","volume":"15","author":[{"given":"P.","family":"Melendez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bartolome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Roeschmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Arevalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Coarsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.animal.2020.100148_bb0005","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0034-5288(94)90147-3","article-title":"Effects of dietary acidity on calcium balance and mobilisation, bone morphology and 1,25- dihydroxyvitamin D in prepartal dairy cows","volume":"56","author":"Abu Damir","year":"1994","journal-title":"Research in Veterinary Science"},{"key":"10.1016\/j.animal.2020.100148_bb0010","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.2527\/jas.2012-5463","article-title":"BOARD INVITED REVIEW: The importance of the gestation period for welfare of calves: maternal stressors and difficult births","volume":"90","author":"Arnott","year":"2012","journal-title":"Journal of Animal Science"},{"key":"10.1016\/j.animal.2020.100148_bb0015","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1751-0147-44-111","article-title":"Causes of stillbirth and time of death in Swedish Holstein calves examined post mortem","volume":"44","author":"Berglund","year":"2003","journal-title":"Acta Veterinaria Scandinavica"},{"key":"10.1016\/j.animal.2020.100148_bb0020","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.3168\/jds.S0022-0302(84)81657-4","article-title":"Manipulating dietary anions and cations for prepartum dairy cows to reduce incidence of milk fever","volume":"67","author":"Block","year":"1984","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.theriogenology.2017.01.039","article-title":"Association between subclinical hypocalcemia in the first 3 days of lactation and reproductive performance of dairy cows","volume":"94","author":"Caixeta","year":"2017","journal-title":"Theriogenology"},{"key":"10.1016\/j.animal.2020.100148_bb0030","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.3168\/jds.2019-16991","article-title":"Effects of anionic supplement source in prepartum negative dietary cation-anion difference diets on serum calcium, feed intake, and lactational performance of multiparous dairy cows","volume":"103","author":"Caixeta","year":"2020","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0035","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.3168\/jds.2010-4075","article-title":"The association of serum metabolites with clinical disease during the transition period","volume":"94","author":"Chapinal","year":"2011","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0040","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3168\/jds.S0022-0302(06)72116-6","article-title":"Impact of lowering dietary cation-anion difference in nonlactating dairy cows: a meta-analysis","volume":"89","author":"Charbonneau","year":"2006","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0045","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.3109\/14767058.2015.1107903","article-title":"Ketoacidosis in diabetic pregnancy","volume":"29","author":"Dalfra","year":"2016","journal-title":"The Journal of Maternal-Fetal & Neonatal Medicine"},{"key":"10.1016\/j.animal.2020.100148_bb0050","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.3168\/jds.S0022-0302(94)77212-X","article-title":"Principal descriptors of body condition score in Holstein cows","volume":"77","author":"Ferguson","year":"1994","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0055","doi-asserted-by":"crossref","DOI":"10.3168\/jds.2019-18068","article-title":"Negative dietary cation-anion difference and amount of calcium in prepartum diets: Effects on milk production, blood calcium, and health","volume":"103","author":"Glosson","year":"2020","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0060","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.cvfa.2014.04.003","article-title":"Calcium and magnesium disorders","volume":"30","author":"Goff","year":"2014","journal-title":"The Veterinary Clinics of North America. Food Animal Practice"},{"key":"10.1016\/j.animal.2020.100148_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3168\/jds.2017-13112","article-title":"Invited review: Mineral absorption mechanisms, mineral interactions that affect acid-base and antioxidant status, and diet considerations to improve mineral status","volume":"101","author":"Goff","year":"2018","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0070","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.3168\/jds.S0022-0302(97)76055-7","article-title":"Physiological changes at parturitionand their relationship to metabolic disorders","volume":"80","author":"Goff","year":"1997","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0075","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.3168\/jds.S0022-0302(91)78579-2","article-title":"Addition of chloride to a prepartal diet high in cations increases 1,25-Dihydroxyvitamin D response to hypocalcemia preventing milk fever","volume":"74","author":"Goff","year":"1991","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0080","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3168\/jds.S0022-0302(04)73275-0","article-title":"Relative acidifying activity of anionic salts commonly used to prevent milk fever","volume":"87","author":"Goff","year":"2004","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0085","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1023\/A:1023340506782","article-title":"The effect of subclinical hypocalcaemia induced by Na2EDTA on the feed intake and chewing activity of dairy cows","volume":"27","author":"Hansen","year":"2003","journal-title":"Veterinary Research Communications"},{"key":"10.1016\/j.animal.2020.100148_bb0090","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1111\/asj.13300","article-title":"Insulin resistance: relationship between indices during late gestation in dairy cows and effects on newborn metabolism","volume":"90","author":"Hasegawa","year":"2019","journal-title":"Animal Science Journal"},{"key":"10.1016\/j.animal.2020.100148_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/8769714","article-title":"Euglycemic diabetic ketoacidosis in pregnancy: a case report and review of current literature","volume":"2019","author":"Jaber","year":"2019","journal-title":"Case Reports in Critical Care"},{"key":"10.1016\/j.animal.2020.100148_bb0100","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.3168\/jds.S0022-0302(98)70142-0","article-title":"Recommendations for recording and calculating the incidence of selected clinical diseases of dairy cattle","volume":"81","author":"Kelton","year":"1998","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0105","doi-asserted-by":"crossref","first-page":"7534","DOI":"10.3168\/jds.2017-12543","article-title":"Seasonal and maternal effects on acid-base, l-lactate, electrolyte, and hematological status of 205 dairy calves born to eutocic dams","volume":"100","author":"Kov\u00e1cs","year":"2017","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0110","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.3168\/jds.2018-14769","article-title":"Effects of prepartum dietary cation-anion difference intake on production and health of dairy cows: a meta-analysis","volume":"102","author":"Lean","year":"2019","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0115","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.3168\/jds.2016-11565","article-title":"Estimating US dairy clinical disease costs with a stochastic simulation model","volume":"100","author":"Liang","year":"2017","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0120","doi-asserted-by":"crossref","first-page":"6568","DOI":"10.3168\/jds.2017-14038","article-title":"Maternal late-gestation metabolic stress is associated with changes in immune and metabolic responses of dairy calves","volume":"101","author":"Ling","year":"2018","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0125","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.3168\/jds.2006-295","article-title":"Impacts of dystocia on health and survival of dairy calves","volume":"90","author":"Lombard","year":"2007","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0130","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.3168\/jds.2018-14580","article-title":"Effects of level of dietary cation-anion difference and duration of prepartum feeding on performance and metabolism of dairy cows","volume":"101","author":"Lopera","year":"2018","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0135","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3168\/jds.2019-17191","article-title":"Association of transient, persistent, or delayed subclinical hypocalcemia with early lactation disease, removal, and milk yield in Holstein cows","volume":"103","author":"McArt","year":"2020","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0140","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.3168\/jds.2012-5443","article-title":"Epidemiology of subclinical ketosis in early lactation dairy cattle","volume":"95","author":"McArt","year":"2012","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0145","first-page":"320","article-title":"Prepartum urine pH as a predictor of left displacement of abomasum","volume":"26","author":"Mecitoglu","year":"2016","journal-title":"The Journal of Animal & Plant Sciences"},{"key":"10.1016\/j.animal.2020.100148_bb0150","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fnut.2017.00026","article-title":"A dairy herd case investigation with very low dietary cation-anion difference in prepartum dairy cows","volume":"4","author":"Melendez","year":"2017","journal-title":"Frontiers in Nutrition"},{"key":"10.1016\/j.animal.2020.100148_bb0155","series-title":"Reproduction, events and management pregnancy: periparturient disorders","article-title":"Reference module in food sciences","author":"Melendez","year":"2016"},{"key":"10.1016\/j.animal.2020.100148_bb0160","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/00480169.2018.1556747","article-title":"Effect of diets containing sulfate or chloride-based anionic salts, fed to grazing prepartum dairy cows, on concentrations of Ca in plasma, disease incidence and milk yield","volume":"67","author":"Melendez","year":"2019","journal-title":"New Zealand Veterinary Journal"},{"key":"10.1016\/j.animal.2020.100148_bb0165","series-title":"Nutrient requirements of dairy cattle","author":"National Research Council (NRC)","year":"2001"},{"key":"10.1016\/j.animal.2020.100148_bb0170","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0009-8981(70)90288-3","article-title":"Serum inorganic phosphorus determination using p-phenylenediamine as a reducing agent","volume":"27","author":"Parekh","year":"1970","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.animal.2020.100148_bb0175","doi-asserted-by":"crossref","first-page":"640","DOI":"10.14202\/vetworld.2013.640-646","article-title":"Importance of urinalysis in veterinary practice \u2013 a review","volume":"6","author":"Parrah","year":"2013","journal-title":"Veterinary World"},{"key":"10.1016\/j.animal.2020.100148_bb0180","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cvsm.2018.10.005","article-title":"Importance of urinalysis","volume":"49","author":"Piech","year":"2019","journal-title":"Veterinary Clinic of Small Animal Practice"},{"key":"10.1016\/j.animal.2020.100148_bb0185","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.3168\/jds.2009-2378","article-title":"Effects of anion supplementation to low-potassium prepartum diets on macromineral status and performance of periparturient dairy cows","volume":"92","author":"Ramos-Nieves","year":"2009","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0190","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.tvjl.2010.03.025","article-title":"Prevalence of subclinical hypocalcemia in dairy herds","volume":"188","author":"Reinhardt","year":"2011","journal-title":"The Veterinary Journal"},{"key":"10.1016\/j.animal.2020.100148_bb0195","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.3168\/jds.2018-14628","article-title":"Meta-analysis of the effects of prepartum dietary cation-anion difference on performance and health of dairy cows","volume":"102","author":"Santos","year":"2019","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0200","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.theriogenology.2015.03.014","article-title":"Relationships among ketosis, serum metabolites, body condition, and reproductive outcomes in dairy cows","volume":"84","author":"Shin","year":"2015","journal-title":"Theriogenology"},{"key":"10.1016\/j.animal.2020.100148_bb0205","series-title":"Large animal internal medicine","first-page":"350","article-title":"Clinical chemistry tests","author":"St\u00e4mpfli","year":"2015"},{"key":"10.1016\/j.animal.2020.100148_bb0210","series-title":"SAS\/STAT software: change and enhancements through release 9.4 for windows","author":"Statistical Analysis Software (SAS)","year":"2017"},{"key":"10.1016\/j.animal.2020.100148_bb0215","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.prevetmed.2016.06.002","article-title":"A systematic review and meta-analysis of the diagnostic accuracy of point-of-care tests for the detection of hyperketonemia in dairy cows","volume":"130","author":"Tatone","year":"2016","journal-title":"Preventive Veterinary Medicine"},{"key":"10.1016\/j.animal.2020.100148_bb0220","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.3168\/jds.S0022-0302(98)75732-7","article-title":"Effects of dietary cation-anion difference on the acid-base status of dry cows","volume":"81","author":"Vagnoni","year":"1998","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0225","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.3168\/jds.2015-9378","article-title":"The cornell net carbohydrate and protein system: updates to the model and evaluation of version 6.5","volume":"98","author":"Van Amburgh","year":"2015","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0230","series-title":"Methods of enzymatic analysis","first-page":"1836","article-title":"D-3-hydroxybutyrate","author":"Williamson","year":"1974"},{"key":"10.1016\/j.animal.2020.100148_bb0235","doi-asserted-by":"crossref","first-page":"7133","DOI":"10.3168\/jds.2014-8273","article-title":"Effect of feeding a negative dietary cation-anion difference diet for an extended time prepartum on postpartum serum and urine metabolites and performance","volume":"97","author":"Wu","year":"2014","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100148_bb0240","doi-asserted-by":"crossref","first-page":"8461","DOI":"10.3168\/jds.2018-14748","article-title":"Effect of dietary cation-anion difference on acid-base status and dry matter intake in dry pregnant cows","volume":"101","author":"Zimpel","year":"2018","journal-title":"Journal of Dairy Science"}],"container-title":["Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751731120301506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751731120301506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:40:11Z","timestamp":1761694811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751731120301506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1751731120301506"],"URL":"https:\/\/doi.org\/10.1016\/j.animal.2020.100148","relation":{},"ISSN":["1751-7311"],"issn-type":[{"value":"1751-7311","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association of prepartum urine pH, plasma total calcium concentration at calving and postpartum diseases in Holstein dairy cattle","name":"articletitle","label":"Article Title"},{"value":"Animal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.animal.2020.100148","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V. on behalf of The Animal Consortium.","name":"copyright","label":"Copyright"}],"article-number":"100148"}}