{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:49:29Z","timestamp":1778647769405,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:00:00Z","timestamp":1608336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.animal.2020.100170","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T20:49:39Z","timestamp":1611262179000},"page":"100170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increasing preweaning milk replacer supply affects postweaning energy metabolism of Holstein male calves"],"prefix":"10.1016","volume":"15","author":[{"given":"I.P.C.","family":"de Carvalho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.A.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.N.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mart\u00edn-Tereso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.animal.2020.100170_bb0005","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ejcb.2013.06.001","article-title":"Adipocyte and adipogenesis","volume":"92","author":"Ali","year":"2013","journal-title":"European Journal of Cell Biology"},{"key":"10.1016\/j.animal.2020.100170_bb0010","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.3168\/jds.2012-6196","article-title":"Insulin responsiveness is affected by the level of milk replacer offered to young calves","volume":"96","author":"Bach","year":"2013","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100170_bb0015","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0739-7240(99)00039-9","article-title":"Endocrine and metabolic aspects in milk-fed calves","volume":"17","author":"Blum","year":"1999","journal-title":"Domestic Animal Endocrinology"},{"key":"10.1016\/j.animal.2020.100170_bb0020","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1071\/EA05225","article-title":"Influences of nutrition during pregnancy and lactation on birth weights and growth to weaning of calves sired by Piedmontese or Wagyu bulls","volume":"46","author":"Cafe","year":"2006","journal-title":"Australian Journal of Experimental Agriculture"},{"key":"10.1016\/j.animal.2020.100170_bb0025","doi-asserted-by":"crossref","first-page":"R1195","DOI":"10.1152\/ajpregu.90851.2008","article-title":"Evaluation of different methods for assessment of insulin sensitivity in G\u00f6ttingen minipigs: introduction of a new, simpler method","volume":"297","author":"Christoffersen","year":"2009","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.animal.2020.100170_bb0030","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.physbeh.2007.11.017","article-title":"Early life programming of obesity and metabolic disease","volume":"94","author":"Cottrell","year":"2008","journal-title":"Physiology and Behavior"},{"key":"10.1016\/j.animal.2020.100170_bb0035","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3168\/jds.2017-13692","article-title":"Effect of milk replacer feeding rate, age at weaning, and method of reducing milk replacer to weaning on digestion, performance, rumination, and activity in dairy calves to 4 months of age","volume":"101","author":"Dennis","year":"2018","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100170_bb0040","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3168\/jds.S0022-0302(01)74541-9","article-title":"Composition of growth of Holstein calves fed milk replacer from birth to 105-kilogram body weight","volume":"84","author":"Diaz","year":"2001","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100170_bb0045","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.tem.2013.05.006","article-title":"Nutritional programming of insulin resistance: causes and consequences","volume":"24","author":"Duque-Guimar\u00e3es","year":"2013","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.animal.2020.100170_bb0050","doi-asserted-by":"crossref","first-page":"6206","DOI":"10.3168\/jds.2015-10744","article-title":"A meta-analysis of the effects of preweaned calf nutrition and growth on first-lactation performance","volume":"99","author":"Gelsinger","year":"2016","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100170_bb0055","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1051\/rnd:19910405","article-title":"Insulin and glucose in neonatal calves after peroral insulin and intravenous glucose administration","volume":"31","author":"Gr\u00fctter","year":"1991","journal-title":"Reproduction Nutrition Development"},{"key":"10.1016\/j.animal.2020.100170_bb0060","doi-asserted-by":"crossref","first-page":"8952","DOI":"10.3168\/jds.2015-9759","article-title":"Effects of human visitation on calf growth and performance of calves fed different milk replacer feeding levels","volume":"98","author":"Guindon","year":"2015","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100170_bb0065","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1017\/S1751731110001448","article-title":"Endocrine and metabolic regulation of muscle growth and body composition in cattle","volume":"4","author":"Hocquette","year":"2010","journal-title":"Animal"},{"key":"10.1016\/j.animal.2020.100170_bb0070","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2527\/1994.721160x","article-title":"Insulin resistance, hyperglycemia, and glucosuria in intensively milk-fed calves","volume":"72","author":"Hostettler-Allen","year":"1994","journal-title":"Journal of Animal Science"},{"key":"10.1016\/j.animal.2020.100170_bb0075","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1093\/jn\/128.6.1023","article-title":"Insulin-dependent glucose utilization in intensively milk-fed veal calves is modulated by supplemental lactose in an age-dependent manner","volume":"128","author":"Hugi","year":"1998","journal-title":"The Journal of Nutrition"},{"key":"10.1016\/j.animal.2020.100170_bb0080","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.3168\/jds.S0022-0302(02)74391-9","article-title":"Effects of ad libitum milk intake on dairy calves","volume":"85","author":"Jasper","year":"2002","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100170_bb0085","doi-asserted-by":"crossref","first-page":"8446","DOI":"10.3168\/jds.2018-14559","article-title":"Different milk feeding intensities during the first 4 weeks of rearing dairy calves: Part 3: Plasma metabolomics analysis reveals long-term metabolic imprinting in Holstein heifers","volume":"101","author":"Ken\u00e9z","year":"2018","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100170_bb0090","doi-asserted-by":"crossref","first-page":"8513","DOI":"10.3168\/jds.2019-16328","article-title":"Effects of ad libitum milk replacer feeding and butyrate supplementation on the epithelial growth and development of the gastrointestinal tract in Holstein calves","volume":"102","author":"Koch","year":"2019","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100170_bb0095","first-page":"2132","article-title":"Central insulin action regulates peripheral glucose and fat metabolism in mice","volume":"118","author":"Koch","year":"2008","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.animal.2020.100170_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0201929","article-title":"Nutrient supply alters transcriptome regulation in adipose tissue of pre-weaning Holstein calves","volume":"13","author":"Leal","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.animal.2020.100170_bb0105","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/jpn.12241","article-title":"Effects of two different rearing protocols for Holstein bull calves in the first 3 weeks of life on health status, metabolism and subsequent performance","volume":"99","author":"Maccari","year":"2015","journal-title":"Journal of Animal Physiology and Animal Nutrition"},{"key":"10.1016\/j.animal.2020.100170_bb0110","doi-asserted-by":"crossref","first-page":"8007","DOI":"10.3168\/jds.2015-10826","article-title":"Effect of plane of milk replacer intake and age on glucose and insulin kinetics and abomasal emptying in female Holstein Friesian dairy calves fed twice daily","volume":"99","author":"MacPherson","year":"2016","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100170_bb0115","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.animal.2020.100170_bb0120","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/bmb\/60.1.143","article-title":"Metabolic programming in animals: type 2 diabetes","volume":"60","author":"Ozanne","year":"2001","journal-title":"British Medical Bulletin"},{"key":"10.1016\/j.animal.2020.100170_bb0125","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.3168\/jds.2006-759","article-title":"Induction of hyperlipidemia by intravenous infusion of tallow emulsion causes insulin resistance in Holstein cows","volume":"90","author":"Pires","year":"2007","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100170_bb0130","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.beem.2012.03.008","article-title":"Early postnatal life as a critical time window for determination of long-term metabolic health","volume":"26","author":"Plagemann","year":"2012","journal-title":"Best Practice & Research. Clinical Endocrinology & Metabolism"},{"key":"10.1016\/j.animal.2020.100170_bb0135","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3168\/jds.2018-15074","article-title":"Relationships between protein and energy consumed from milk replacer and starter and calf growth and first-lactation production of Holstein dairy cows","volume":"102","author":"Rauba","year":"2019","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100170_bb0140","series-title":"Muscle development of livestock animals: physiology, genetics, and meat quality","first-page":"1","article-title":"Number and size of muscle fibres in relation to meat production","author":"Rehfeldt","year":"2004"},{"key":"10.1016\/j.animal.2020.100170_bb0145","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mce.2011.11.013","article-title":"Role of the pre-and post-natal environment in developmental programming of health and productivity","volume":"354","author":"Reynolds","year":"2012","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1016\/j.animal.2020.100170_bb0150","series-title":"Tables of composition and nutritional value of feed materials: pigs, poultry, cattle, sheep, goats, rabbits, horses and fish","author":"Sauvant","year":"2004"},{"key":"10.1016\/j.animal.2020.100170_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168974","article-title":"Effects of feeding milk replacer ad libitum or in restricted amounts for the first five weeks of life on the growth, metabolic adaptation, and immune status of newborn calves","volume":"11","author":"Sch\u00e4ff","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.animal.2020.100170_bb0160","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3168\/jds.2011-4391","article-title":"Preweaning milk replacer intake and effects on long-term productivity of dairy calves","volume":"95","author":"Soberon","year":"2012","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100170_bb0165","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tem.2007.12.001","article-title":"Metabolic programming in the immediate postnatal period","volume":"19","author":"Srinivasan","year":"2008","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.animal.2020.100170_bb0170","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3168\/jds.2006-612","article-title":"Design and analysis of pen studies in the animal sciences","volume":"90","author":"St-Pierre","year":"2007","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2020.100170_bb0175","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.livsci.2006.10.001","article-title":"Effect of level of milk replacer fed to Holstein calves on performance during the pre-weaning period and starter digestibility at weaning","volume":"110","author":"Terr\u00e9","year":"2007","journal-title":"Livestock Science"},{"key":"10.1016\/j.animal.2020.100170_bb0180","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1017\/S0022029909004142","article-title":"Long-term effects on heifer performance of an enhanced growth-feeding programme applied during the pre-weaning period","volume":"76","author":"Terr\u00e9","year":"2009","journal-title":"Journal of Dairy Research"},{"key":"10.1016\/j.animal.2020.100170_bb0185","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.domaniend.2006.11.002","article-title":"Postprandial blood hormone and metabolite concentrations influenced by feeding frequency and feeding level in veal calves","volume":"34","author":"Vicari","year":"2008","journal-title":"Domestic Animal Endocrinology"},{"key":"10.1016\/j.animal.2020.100170_bb0190","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.livsci.2015.09.008","article-title":"Short-and medium-term changes in performance and metabolism of dairy calves offered different amounts of milk replacers","volume":"181","author":"Yunta","year":"2015","journal-title":"Livestock Science"}],"container-title":["Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751731120301725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751731120301725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:40:23Z","timestamp":1761694823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751731120301725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1751731120301725"],"URL":"https:\/\/doi.org\/10.1016\/j.animal.2020.100170","relation":{},"ISSN":["1751-7311"],"issn-type":[{"value":"1751-7311","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increasing preweaning milk replacer supply affects postweaning energy metabolism of Holstein male calves","name":"articletitle","label":"Article Title"},{"value":"Animal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.animal.2020.100170","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V. on behalf of The Animal Consortium.","name":"copyright","label":"Copyright"}],"article-number":"100170"}}