{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:35:53Z","timestamp":1789536953651,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000040","name":"Agriculture and Agri-Food Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005642","name":"Universit\u00e0 degli Studi di Sassari","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005595","name":"University of California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["animal"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.animal.2023.100894","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T16:04:56Z","timestamp":1687795496000},"page":"100894","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"S5","title":["Systematic review and meta-analysis of the methionine utilization efficiency in piglets receiving different methionine sources"],"prefix":"10.1016","volume":"17","author":[{"given":"V.C.","family":"Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Remus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.I.","family":"Batonon-Alavo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Rouffineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-0895","authenticated-orcid":false,"given":"C.","family":"Pomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0833-1352","authenticated-orcid":false,"given":"E.","family":"Kebreab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.animal.2023.100894_b0005","series-title":"An introduction to categorical data analysis","author":"Agresti","year":"2018"},{"key":"10.1016\/j.animal.2023.100894_b0010","doi-asserted-by":"crossref","first-page":"1670S","DOI":"10.1093\/jn\/136.6.1670S","article-title":"Comparative species utilization and toxicity of sulfur amino acids","volume":"136","author":"Baker","year":"2006","journal-title":"The Journal of Nutrition"},{"key":"10.1016\/j.animal.2023.100894_b0015","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.aninu.2023.01.009","article-title":"A systematic review of metabolism of methionine sources in animals: One parameter does not convey a comprehensive story","volume":"13","author":"Becquet","year":"2023","journal-title":"Animal Nutrition Journal"},{"key":"10.1016\/j.animal.2023.100894_b0020","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.aninu.2022.09.004","article-title":"Absorption of methionine sources in animals\u2014is there more to know?","volume":"12","author":"Becquet","year":"2023","journal-title":"Animal Nutrition Journal"},{"key":"10.1016\/j.animal.2023.100894_b0025","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1093\/jn\/122.9.1862","article-title":"Efficiency of dietary methionine utilization by young pigs","volume":"122","author":"Chung","year":"1992","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.animal.2023.100894_b0030","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4141\/cjas92-024","article-title":"Utilization of methionine isomers and analogs by the pig","volume":"72","author":"Chung","year":"1992","journal-title":"Canadian Journal of Animal Science"},{"key":"10.1016\/j.animal.2023.100894_b0035","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1017\/S1751731110000340","article-title":"A sulfur amino acid deficiency changes the amino acid composition of body protein in piglets","volume":"4","author":"Conde-Aguilera","year":"2010","journal-title":"Animal"},{"key":"10.1016\/j.animal.2023.100894_b0040","series-title":"Amino acids in animal nutrition","author":"D\u2019Mello","year":"2003"},{"key":"10.1016\/j.animal.2023.100894_b0045","first-page":"E159","article-title":"Modeling chemical and physical body composition of the growing pig","volume":"81","author":"De Lange","year":"2003","journal-title":"Journal of Animal Science"},{"key":"10.1016\/j.animal.2023.100894_b0050","series-title":"Applied Missing Data Analysis","author":"Enders","year":"2022"},{"key":"10.1016\/j.animal.2023.100894_b0055","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1017\/S0007114509992169","article-title":"Effects of dl-2-hydroxy-4-methylthiobutyrate on the first-pass intestinal metabolism of dietary methionine and its extra-intestinal availability","volume":"103","author":"Fang","year":"2010","journal-title":"British Journal of Nutrition"},{"key":"10.1016\/j.animal.2023.100894_b0060","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1021\/jf903317x","article-title":"Methionine metabolism in piglets fed DL-methionine or its hydroxy analogue was affected by distribution of enzymes oxidizing these sources to keto-methionine","volume":"58","author":"Fang","year":"2010","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.animal.2023.100894_b0065","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1093\/ps\/84.10.1584","article-title":"Growth, body composition, and marginal efficiency of methionine utilization are affected by nonessential amino acid nitrogen supplementation in male broiler chicken","volume":"84","author":"Fatufe","year":"2005","journal-title":"Poultry Science"},{"key":"10.1016\/j.animal.2023.100894_b0070","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1093\/ps\/83.8.1314","article-title":"Response to lysine intake in composition of body weight gain and efficiency of lysine utilization of growing male chickens from two genotypes","volume":"83","author":"Fatufe","year":"2004","journal-title":"Poultry Science"},{"key":"10.1016\/j.animal.2023.100894_b0075","first-page":"135","article-title":"Efficacy of Methionine Hydroxy Analog and Dl-Methionine as Methionine Sources for Growing Pigs","volume":"5","author":"Feng","year":"2006","journal-title":"Journal of Animal and Veterinary Advances"},{"key":"10.1016\/j.animal.2023.100894_b0080","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1079\/BJN19890028","article-title":"The optimum dietary amino acid pattern for growing pigs: 2. Requirements for maintenance and for tissue protein accretion","volume":"62","author":"Fuller","year":"1989","journal-title":"British Journal of Nutrition"},{"key":"10.1016\/j.animal.2023.100894_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2021.100268","article-title":"Flash dietary methionine supply over growth requirements in pigs: Multi-facetted effects on skeletal muscle metabolism","volume":"15","author":"Gondret","year":"2021","journal-title":"Animal"},{"key":"10.1016\/j.animal.2023.100894_b0090","doi-asserted-by":"crossref","first-page":"8685","DOI":"10.3168\/jds.2020-19672","article-title":"Predicting ruminally undegraded and microbial protein flows from the rumen","volume":"104","author":"Hanigan","year":"2021","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.animal.2023.100894_b0095","series-title":"Doing meta-analysis with R: A hands-on guide","author":"Harrer","year":"2021"},{"key":"10.1016\/j.animal.2023.100894_b0100","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.2527\/jas.2010-3235","article-title":"The site of intestinal disappearance of DL-methionine and methionine hydroxy analog differs in pigs","volume":"89","author":"Jendza","year":"2011","journal-title":"Journal of Animal Science"},{"key":"10.1016\/j.animal.2023.100894_b0105","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2527\/2006.841104x","article-title":"Efficacy of DL-methionine hydroxy analog free acid and DL-methionine as methionine sources for pigs","volume":"84","author":"Kim","year":"2006","journal-title":"Journal of Animal Science"},{"key":"10.1016\/j.animal.2023.100894_b0110","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2527\/1998.763781x","article-title":"The relative effectiveness of 2-hydroxy-4-(methylthio) butanoic acid and DL-methionine in young swine","volume":"76","author":"Knight","year":"1998","journal-title":"Journal of Animal Science"},{"key":"10.1016\/j.animal.2023.100894_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v082.i13","article-title":"lmerTest package: Tests in linear mixed effects models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"Journal of Statistical Software"},{"key":"10.1016\/j.animal.2023.100894_b0120","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.meatsci.2018.06.040","article-title":"Improving pork quality traits by a short-term dietary hydroxy methionine supplementation at levels above growth requirements in finisher pigs","volume":"145","author":"Lebret","year":"2018","journal-title":"Meat Science"},{"key":"10.1016\/j.animal.2023.100894_b0125","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5808\/GI.2016.14.4.173","article-title":"Comparison of two meta-analysis methods: Inverse-variance-weighted average and weighted sum of Z-scores","volume":"14","author":"Lee","year":"2016","journal-title":"Genomics & Informatics"},{"key":"10.1016\/j.animal.2023.100894_b0130","series-title":"Amino acids in animal nutrition","first-page":"143","article-title":"Methionine-cystine relationships in pig nutrition","author":"Lewis","year":"2003"},{"key":"10.1016\/j.animal.2023.100894_b0135","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.21105\/joss.03139","article-title":"performance: An R package for assessment, comparison and testing of statistical models","volume":"6","author":"L\u00fcdecke","year":"2021","journal-title":"Journal of Open Source Software"},{"key":"10.1016\/j.animal.2023.100894_b0140","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1093\/jn\/134.4.836","article-title":"Indicator amino acid oxidation responds rapidly to changes in lysine or protein intake in growing and adult pigs","volume":"134","author":"Moehn","year":"2004","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.animal.2023.100894_b0145","doi-asserted-by":"crossref","unstructured":"NRC, National Research Council, 2012. Nutrient Requirements of Swine: Eleventh Revised Edition. National Academies Press, Washington, DC, USA. doi: 10.17226\/13298.","DOI":"10.17226\/13298"},{"key":"10.1016\/j.animal.2023.100894_b0150","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.animal.2023.100894_b0155","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.742220","article-title":"Feeding strategies to reduce nutrient losses and improve the sustainability of growing pigs","volume":"8","author":"Pomar","year":"2021","journal-title":"Frontiers in Veterinary Science"},{"key":"10.1016\/j.animal.2023.100894_b0160","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/af\/vfz006","article-title":"Precision pig feeding: a breakthrough toward sustainability","volume":"9","author":"Pomar","year":"2019","journal-title":"Animal Frontiers"},{"key":"10.1016\/j.animal.2023.100894_b0165","series-title":"A language and environment for statistical computing","author":"R Core Team","year":"2021"},{"key":"10.1016\/j.animal.2023.100894_b0170","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/jn\/nxy296","article-title":"Substitution of dietary sulfur amino acids by DL-2-hydroxy-4-methylthiobutyric acid increases remethylation and decreases transsulfuration in weaned piglets","volume":"149","author":"Rasch","year":"2019","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.animal.2023.100894_b0175","doi-asserted-by":"crossref","first-page":"e0208488","DOI":"10.1371\/journal.pone.0208488","article-title":"Partitioning the efficiency of utilization of amino acids in growing broilers. Multiple linear regression and multivariate approaches","volume":"13","author":"Reis","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.animal.2023.100894_b0180","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.livsci.2015.10.006","article-title":"Exploratory study on the utilization of different dietary methionine sources and methionine to lysine ratio for growing\u2013finishing pigs","volume":"181","author":"Remus","year":"2015","journal-title":"Livestock Science"},{"key":"10.1016\/j.animal.2023.100894_b0185","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40104-019-0328-7","article-title":"Pigs receiving daily tailored diets using precision-feeding techniques have different threonine requirements than pigs fed in conventional phase-feeding systems","volume":"10","author":"Remus","year":"2019","journal-title":"Journal of Animal Science and Biotechnology"},{"key":"10.1016\/j.animal.2023.100894_b0190","doi-asserted-by":"crossref","first-page":"s360","DOI":"10.1017\/S1751731120001469","article-title":"Precision livestock farming: real-time estimation of daily protein deposition in growing\u2013finishing pigs","volume":"14","author":"Remus","year":"2020","journal-title":"Animal"},{"key":"10.1016\/j.animal.2023.100894_b0195","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/ps\/84.9.1397","article-title":"Comparative in vitro and in vivo absorption of 2-hydroxy-4(methylthio) butanoic acid and methionine in the broiler chicken","volume":"84","author":"Richards","year":"2005","journal-title":"Poultry Science"},{"key":"10.1016\/j.animal.2023.100894_b0200","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12263-021-00694-4","article-title":"Expression of proposed methionine transporters along the gastrointestinal tract of pigs and their regulation by dietary methionine sources","volume":"16","author":"Romanet","year":"2021","journal-title":"Genes & Nutrition"},{"key":"10.1016\/j.animal.2023.100894_b0205","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.3382\/ps.2007-00514","article-title":"Meta-analysis of the relative efficiency of methionine-hydroxy-analogue-free-acid compared with DL-methionine in broilers using nonlinear mixed models","volume":"87","author":"Sauer","year":"2008","journal-title":"Poultry Science"},{"key":"10.1016\/j.animal.2023.100894_b0210","doi-asserted-by":"crossref","first-page":"s207","DOI":"10.1017\/S1751731120001688","article-title":"Review: Use and misuse of meta-analysis in animal science","volume":"14","author":"Sauvant","year":"2020","journal-title":"Animal"},{"key":"10.1016\/j.animal.2023.100894_b0215","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1017\/S1751731109990917","article-title":"Methionine-hydroxy analogue was found to be significantly less bioavailable compared to dl-methionine for protein deposition in growing pigs","volume":"4","author":"Shoveller","year":"2010","journal-title":"Animal"},{"key":"10.1016\/j.animal.2023.100894_b0220","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.2527\/2004.8292610x","article-title":"Bioefficacy of L-lysine sulfate compared with feed-grade L-lysine\u2022HCl in young pigs","volume":"82","author":"Smiricky-Tjardes","year":"2004","journal-title":"Journal of Animal Science"},{"key":"10.1016\/j.animal.2023.100894_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.101762","article-title":"Evaluating growth response of broiler chickens fed diets supplemented with synthetic DL-methionine or DL-hydroxy methionine: a meta-analysis","volume":"101","author":"Uddin","year":"2022","journal-title":"Poultry Science"},{"key":"10.1016\/j.animal.2023.100894_b0230","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40104-015-0016-1","article-title":"Concept and application of ideal protein for pigs","volume":"6","author":"van Milgen","year":"2015","journal-title":"Journal of Animal Science and Biotechnology"},{"key":"10.1016\/j.animal.2023.100894_b0235","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.anifeedsci.2007.05.020","article-title":"InraPorc: A model and decision support tool for the nutrition of growing pigs","volume":"143","author":"van Milgen","year":"2008","journal-title":"Animal Feed Science and Technology"},{"key":"10.1016\/j.animal.2023.100894_b0240","series-title":"Energy and protein metabolism and nutrition (Ed. Chizzotti) \u2013 EAAP Scientific Series","first-page":"3195","article-title":"The cost of the conversion of L-methionine precursors in mammals and birds","author":"van Milgen","year":"2019"},{"key":"10.1016\/j.animal.2023.100894_b0245","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s40104-018-0276-7","article-title":"Advances in low-protein diets for swine","volume":"9","author":"Wang","year":"2018","journal-title":"Journal of Animal Science and Biotechnology"},{"key":"10.1016\/j.animal.2023.100894_b0250","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.exger.2015.03.004","article-title":"Dietary l-methionine restriction decreases oxidative stress in porcine liver mitochondria","volume":"65","author":"Ying","year":"2015","journal-title":"Experimental Gerontology"},{"key":"10.1016\/j.animal.2023.100894_b0255","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/jpn.13000","article-title":"Effects of L-methionine on performance, gut morphology and antioxidant status in gut and liver of piglets in relation to DL-methionine","volume":"103","author":"Zeitz","year":"2019","journal-title":"Journal of Animal Physiology and Animal Nutrition"},{"key":"10.1016\/j.animal.2023.100894_b0260","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3390\/ani9121048","article-title":"Increased consumption of sulfur amino acids by both sows and piglets enhances the ability of the progeny to adverse effects induced by lipopolysaccharide","volume":"9","author":"Zhang","year":"2019","journal-title":"Animals"},{"key":"10.1016\/j.animal.2023.100894_b0265","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.5713\/ajas.2005.1003","article-title":"Comparative studies on the relative efficacy of DL-methionine and liquid methionine hydroxy analogue in growing pigs","volume":"18","author":"Zimmermann","year":"2005","journal-title":"Asian-Australasian Journal of Animal Sciences"}],"container-title":["animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S175173112300191X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S175173112300191X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:50:58Z","timestamp":1761695458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S175173112300191X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":53,"alternative-id":["S175173112300191X"],"URL":"https:\/\/doi.org\/10.1016\/j.animal.2023.100894","relation":{},"ISSN":["1751-7311"],"issn-type":[{"value":"1751-7311","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic review and meta-analysis of the methionine utilization efficiency in piglets receiving different methionine sources","name":"articletitle","label":"Article Title"},{"value":"animal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.animal.2023.100894","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V. on behalf of The Animal Consortium.","name":"copyright","label":"Copyright"}],"article-number":"100894"}}