{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:25:11Z","timestamp":1790727911997,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T00:00:00Z","timestamp":1577750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31560640"],"award-info":[{"award-number":["31560640"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31672433"],"award-info":[{"award-number":["31672433"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Nutrition"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.aninu.2019.12.001","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T06:45:38Z","timestamp":1578379538000},"page":"98-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Amino acids regulate energy utilization through mammalian target of rapamycin complex 1 and adenosine monophosphate activated protein kinase pathway in porcine enterocytes"],"prefix":"10.1016","volume":"6","author":[{"given":"Hao","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuifang","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi'e","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aninu.2019.12.001_bib1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.tcb.2014.03.003","article-title":"Regulation of mTORC1 by amino acids","volume":"24","author":"Bar-Peled","year":"2014","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.aninu.2019.12.001_bib2","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.cmet.2013.03.003","article-title":"Molecular and genetic crosstalks between mTOR and ERRalpha are key determinants of rapamycin-induced nonalcoholic fatty liver","volume":"17","author":"Chaveroux","year":"2013","journal-title":"Cell Metabol"},{"key":"10.1016\/j.aninu.2019.12.001_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2337\/db09-0929","article-title":"Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue","volume":"59","author":"Cheng","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.aninu.2019.12.001_bib4","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nature06322","article-title":"mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex","volume":"450","author":"Cunningham","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.aninu.2019.12.001_bib5","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.cmet.2010.08.016","article-title":"Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice","volume":"12","author":"D'Antona","year":"2010","journal-title":"Cell Metabol"},{"key":"10.1016\/j.aninu.2019.12.001_bib6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.nut.2016.10.016","article-title":"Effect of branched-chain amino acid ratio on the proliferation, differentiation, and expression levels of key regulators involved in protein metabolism of myocytes","volume":"36","author":"Duan","year":"2017","journal-title":"Nutrition"},{"key":"10.1016\/j.aninu.2019.12.001_bib7","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/emboj.2011.12","article-title":"AMPK and autophagy get connected","volume":"30","author":"Hardie","year":"2011","journal-title":"EMBO J"},{"key":"10.1016\/j.aninu.2019.12.001_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093597","article-title":"Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis","volume":"9","author":"Johnson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.aninu.2019.12.001_bib9","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.aninu.2019.12.001_bib10","doi-asserted-by":"crossref","first-page":"6225","DOI":"10.1128\/MCB.25.14.6225-6234.2005","article-title":"Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis","volume":"25","author":"Li","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.aninu.2019.12.001_bib11","article-title":"Characterization and regulation of the amino acid transporter SNAT2 in the small intestine of piglets","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.aninu.2019.12.001_bib12","article-title":"Leucine modulates mitochondrial biogenesis and SIRT1-AMPK signaling in C2C12 myotubes","volume":"2014","author":"Liang","year":"2014","journal-title":"J\u00a0Nutr Metab"},{"key":"10.1016\/j.aninu.2019.12.001_bib13","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.cmet.2013.10.001","article-title":"mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation","volume":"18","author":"Morita","year":"2013","journal-title":"Cell Metabol"},{"key":"10.1016\/j.aninu.2019.12.001_bib14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.4161\/15384101.2014.991572","article-title":"mTOR coordinates protein synthesis, mitochondrial activity and proliferation","volume":"14","author":"Morita","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.aninu.2019.12.001_bib15","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.cell.2011.10.021","article-title":"Feedback on fat: p62-mTORC1-autophagy connections","volume":"147","author":"Moscat","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.aninu.2019.12.001_bib16","doi-asserted-by":"crossref","first-page":"22E","DOI":"10.1016\/j.amjcard.2008.02.077","article-title":"Amino acids and mitochondrial biogenesis","volume":"101","author":"Nisoli","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.aninu.2019.12.001_bib17","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nrc3106","article-title":"RAS oncogenes: weaving a tumorigenic web","volume":"11","author":"Pylayeva-Gupta","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.aninu.2019.12.001_bib18","doi-asserted-by":"crossref","first-page":"22229","DOI":"10.1073\/pnas.0912074106","article-title":"Direct control of mitochondrial function by mTOR","volume":"106","author":"Ramanathan","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.aninu.2019.12.001_bib19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/2049-1891-4-7","article-title":"Biochemical and physiological bases for utilization of dietary amino acids by young pigs","volume":"4","author":"Rezaei","year":"2013","journal-title":"J\u00a0Anim Sci Biotechnol"},{"key":"10.1016\/j.aninu.2019.12.001_bib20","doi-asserted-by":"crossref","first-page":"27643","DOI":"10.1074\/jbc.M603536200","article-title":"The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity","volume":"281","author":"Schieke","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.aninu.2019.12.001_bib21","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2741\/4352","article-title":"L-arginine improves DNA synthesis in LPS-challenged enterocytes","volume":"20","author":"Tan","year":"2015","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10.1016\/j.aninu.2019.12.001_bib22","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41467-017-00369-y","article-title":"Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation","volume":"8","author":"Tan","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.aninu.2019.12.001_bib23","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1158\/1535-7163.MCT-15-0621","article-title":"The role of PGC1alpha in cancer metabolism and its therapeutic implications","volume":"15","author":"Tan","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.aninu.2019.12.001_bib24","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2016.07.002","article-title":"Mitochondria and cancer","volume":"166","author":"Vyas","year":"2016","journal-title":"Cell"},{"issue":"Pt 1","key":"10.1016\/j.aninu.2019.12.001_bib25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1042\/bj2990115","article-title":"Synthesis of citrulline from glutamine in pig enterocytes","volume":"299","author":"Wu","year":"1994","journal-title":"Biochem J"},{"key":"10.1016\/j.aninu.2019.12.001_bib26","first-page":"R334","article-title":"Glutamine and glucose metabolism in enterocytes of the neonatal pig","volume":"268","author":"Wu","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.aninu.2019.12.001_bib27","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.2527\/jas.2013-6427","article-title":"Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol: II. Intestinal morphology and function","volume":"91","author":"Xiao","year":"2013","journal-title":"J\u00a0Anim Sci"},{"key":"10.1016\/j.aninu.2019.12.001_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8364279","article-title":"N-Acetyl-L-cysteine protects the enterocyte against oxidative damage by modulation of mitochondrial function","volume":"2016","author":"Xiao","year":"2016","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.aninu.2019.12.001_bib29","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.cmet.2014.06.014","article-title":"The lysosomal v-ATPase-ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism","volume":"20","author":"Zhang","year":"2014","journal-title":"Cell Metabol"},{"key":"10.1016\/j.aninu.2019.12.001_bib30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","article-title":"mTOR: from growth signal integration to cancer, diabetes and ageing","volume":"12","author":"Zoncu","year":"2011","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["Animal Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405654519301970?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405654519301970?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:20:01Z","timestamp":1762503601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405654519301970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S2405654519301970"],"URL":"https:\/\/doi.org\/10.1016\/j.aninu.2019.12.001","relation":{},"ISSN":["2405-6545"],"issn-type":[{"value":"2405-6545","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amino acids regulate energy utilization through mammalian target of rapamycin complex 1 and adenosine monophosphate activated protein kinase pathway in porcine enterocytes","name":"articletitle","label":"Article Title"},{"value":"Animal Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aninu.2019.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Chinese Association of Animal Science and Veterinary Medicine. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.","name":"copyright","label":"Copyright"}]}}