{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:41:51Z","timestamp":1790102511837,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Nutrition"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.aninu.2021.06.005","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T20:14:43Z","timestamp":1632341683000},"page":"277-288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Interaction between xylanase and a proton pump inhibitor on broiler chicken performance and gut function"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4181-5524","authenticated-orcid":false,"given":"Gemma","family":"Gonz\u00e1lez-Ortiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4096-398X","authenticated-orcid":false,"given":"Sophie A.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsi","family":"Vienola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Raatikainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"German","family":"Jurgens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Apajalahti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-4290","authenticated-orcid":false,"given":"Michael R.","family":"Bedford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.aninu.2021.06.005_bib1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1017\/S0043933918000272","article-title":"The use of NSP enzymes in poultry nutrition: myths and realities","volume":"74","author":"Aftab","year":"2018","journal-title":"World\u2019s Poult Sci J"},{"key":"10.1016\/j.aninu.2021.06.005_bib2","series-title":"Official methods of analysis of AOAC international","first-page":"2005","author":"Aoac","year":"2005"},{"key":"10.1016\/j.aninu.2021.06.005_bib3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.anifeedsci.2016.05.004","article-title":"Interaction between chicken intestinal microbiota and protein digestion","volume":"221","author":"Apajalahti","year":"2016","journal-title":"Anim Feed Sci Technol"},{"key":"10.1016\/j.aninu.2021.06.005_bib4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fvets.2019.00311","article-title":"Conversion of branched-chain amino acids to corresponding isoacids - an in\u00a0vitro tool for estimating ruminal protein degradability","volume":"6","author":"Apajalahti","year":"2019","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.aninu.2021.06.005_bib5","first-page":"1","article-title":"Age-related arabinoxylan hydrolysis and fermentation in the gastrointestinal tract of broilers fed wheat-based diets","author":"Bautil","year":"2019","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2021.06.005_bib6","series-title":"Poultry feedstuffs: supply, composition and nutritive value","first-page":"319","article-title":"The role of carbohydrases in feedstuff digestion","author":"Bedford","year":"2002"},{"issue":"5","key":"10.1016\/j.aninu.2021.06.005_bib7","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1080\/00071668.2018.1484074","article-title":"The evolution and application of enzymes in the animal feed industry: the role of data interpretation","volume":"59","author":"Bedford","year":"2018","journal-title":"Br Poultry Sci"},{"key":"10.1016\/j.aninu.2021.06.005_bib8","first-page":"27","article-title":"Clinical utility of esomeprazole for treatment of gastroesophageal reflux disease in pediatric and adolescent patients","volume":"3","author":"Cardile","year":"2012","journal-title":"Adolesc Health Med Therapeut"},{"issue":"11","key":"10.1016\/j.aninu.2021.06.005_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0240264","article-title":"Stimbiotic supplementation improved performance and reduced inflammatory response via stimulating fiber fermenting microbiome in weaner pigs housed in a poor sanitary environment and fed an antibiotic-free low zinc oxide diet","volume":"15","author":"Cho","year":"2020","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.aninu.2021.06.005_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1079\/BJN20041166","article-title":"A\u00a0comparison of three xylanases on the nutritive value of two wheats for broiler chickens","volume":"92","author":"Choct","year":"2004","journal-title":"Br J Nutr"},{"key":"10.1016\/j.aninu.2021.06.005_bib11","series-title":"Book Differential effects of fibrolytic enzymes on the in\u00a0vitro release of xylobiose from different cereal types","first-page":"20","article-title":"Differential effects of fibrolytic enzymes on the in\u00a0vitro release of xylobiose from different cereal types","author":"Dale","year":"2019"},{"issue":"17","key":"10.1016\/j.aninu.2021.06.005_bib12","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.1128\/AEM.01616-15","article-title":"Effects of xylo-oligosaccharides on broiler chicken performance and microbiota","volume":"81","author":"De Maesschalck","year":"2015","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.aninu.2021.06.005_bib13","series-title":"The value of fibre. Engaging the second brain for animal nutrition","first-page":"313","article-title":"Cross-feeding during human colon fermentation","author":"De Vuyst","year":"2019"},{"issue":"9","key":"10.1016\/j.aninu.2021.06.005_bib14","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.3382\/ps.2010-01264","article-title":"Effects of xylanase and citric acid on the performance, nutrient retention, and characteristics of gastrointestinal tract of broilers fed low-phosphorus wheat-based diets","volume":"90","author":"Esmaeilipour","year":"2011","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2021.06.005_bib15","series-title":"Book Directive 2010\/63\/EU of the European Parliament and of the Council of 22 of September 2010 on the protection of animals used for scientific purposes","article-title":"Directive 2010\/63\/EU of the European Parliament and of the Council of 22 of September 2010 on the protection of animals used for scientific purposes","year":"2010"},{"key":"10.1016\/j.aninu.2021.06.005_bib16","series-title":"Necesidades nutricionales para avicultura: pollos de carne y aves de puesta","author":"Fedna","year":"2008"},{"issue":"2","key":"10.1016\/j.aninu.2021.06.005_bib17","doi-asserted-by":"crossref","first-page":"G159","DOI":"10.1152\/ajpgi.00319.2017","article-title":"Protein fermentation in the gut; implications for intestinal dysfunction in humans, pigs, and poultry","volume":"315","author":"Gilbert","year":"2018","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.aninu.2021.06.005_bib18","first-page":"54","article-title":"Development of near infrared calibrations for determination of non-starch polysaccharide content in feedstuff","author":"Gomes","year":"2020","journal-title":"31st Annual Australian Poultry Science Symposium"},{"issue":"9","key":"10.1016\/j.aninu.2021.06.005_bib19","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.3382\/ps\/pez113","article-title":"Response of broiler chickens to xylanase and butyrate supplementation","volume":"89","author":"Gonz\u00e1lez-Ortiz","year":"2019","journal-title":"Poultry Sci"},{"issue":"3","key":"10.1016\/j.aninu.2021.06.005_bib20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.aninu.2016.06.005","article-title":"Evaluation of the effect of different wheats and xylanase supplementation on performance, nutrient and energy utilisation in broiler chicks","volume":"2","author":"Gonz\u00e1lez-Ortiz","year":"2016","journal-title":"Animal Nutr"},{"key":"10.1016\/j.aninu.2021.06.005_bib21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1079\/BJN19950014","article-title":"Calcium solubilization and retention in the gastrointestinal tract in chicks (Gallus domesticus) as a function of gastric acid secretion inhibition and of calcium carbonate particle size","volume":"73","author":"Guinotte","year":"1995","journal-title":"Br J Nutr"},{"issue":"6","key":"10.1016\/j.aninu.2021.06.005_bib22","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1017\/S0007114507868462","article-title":"Addition of oat hulls to an extruded rice-based diet for weaner pigs ameliorates the incidence of diarrhoea and reduces indices of protein fermentation in the gastrointestinal tract","volume":"99","author":"Kim","year":"2008","journal-title":"Br J Nutr"},{"issue":"4","key":"10.1016\/j.aninu.2021.06.005_bib23","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0377-8401(97)00009-6","article-title":"Carbohydrate and lignin contents of plant materials used in animal feeding","volume":"67","author":"Knudsen","year":"1997","journal-title":"Anim Feed Sci Technol"},{"key":"10.1016\/j.aninu.2021.06.005_bib24","volume":"vol. 238","author":"Kuhn","year":"2017"},{"key":"10.1016\/j.aninu.2021.06.005_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.anifeedsci.2017.07.017","article-title":"Age and dietary xylanase supplementation affects ileal sugar residues and short chain fatty acid concentration in the ileum and caecum of broiler chickens","volume":"234","author":"Lee","year":"2017","journal-title":"Anim Feed Sci Technol"},{"issue":"6","key":"10.1016\/j.aninu.2021.06.005_bib26","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.3382\/ps\/pey042","article-title":"Meta-analysis: explicit value of mono-component proteases in monogastric diets","volume":"97","author":"Lee","year":"2018","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2021.06.005_bib27","first-page":"1","article-title":"Exogenous phytase and xylanase exhibit opposing effects on real-time gizzard pH in broiler chickens","author":"Lee","year":"2018","journal-title":"Br Poultry Sci"},{"issue":"1","key":"10.1016\/j.aninu.2021.06.005_bib28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1757-4749-5-23","article-title":"Commensal Clostridia: leading players in the maintenance of gut homeostasis","volume":"5","author":"Lopetuso","year":"2013","journal-title":"Gut Pathog"},{"issue":"1","key":"10.1016\/j.aninu.2021.06.005_bib29","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.livsci.2007.01.081","article-title":"Microbial activity in the gut of piglets: I. Effect of prebiotic and probiotic supplementation","volume":"108","author":"Marinho","year":"2007","journal-title":"Livest Sci"},{"issue":"8","key":"10.1016\/j.aninu.2021.06.005_bib30","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3382\/ps.0631617","article-title":"The roles of protein level and diet form in water consumption and abdominal fat pad deposition of broilers","volume":"63","author":"Marks","year":"1984","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2021.06.005_bib31","doi-asserted-by":"crossref","first-page":"103155","DOI":"10.1016\/j.jcs.2020.103155","article-title":"Maize nutrient composition and the influence of xylanase addition","volume":"97","author":"Melo-Dur\u00e1n","year":"2021","journal-title":"J\u00a0Cereal Sci"},{"key":"10.1016\/j.aninu.2021.06.005_bib32","series-title":"Book in\u00a0vitro evaluation of xylo-oligosaccharide production from different batches of wheat with and without xylanase","first-page":"59","article-title":"In\u00a0vitro evaluation of xylo-oligosaccharide production from different batches of wheat with and without xylanase","author":"Morgan","year":"2019"},{"key":"10.1016\/j.aninu.2021.06.005_bib33","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.carbpol.2017.03.063","article-title":"Efficiency of xylanases from families 10 and 11 in production of xylo-oligosaccharides from wheat arabinoxylans","volume":"167","author":"Morgan","year":"2017","journal-title":"Carbohydr Polym"},{"issue":"11","key":"10.1016\/j.aninu.2021.06.005_bib34","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.3382\/ps.2007-00499","article-title":"Effects of fortifying low crude protein diet with crystalline amino acids on performance, blood ammonia level, and excreta characteristics of broiler chicks","volume":"87","author":"Namroud","year":"2008","journal-title":"Poultry Sci"},{"issue":"12","key":"10.1016\/j.aninu.2021.06.005_bib35","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.3382\/ps.2014-04091","article-title":"Protein source and dietary structure influence growth performance, gut morphology, and hindgut fermentation characteristics in broilers","volume":"93","author":"Qaisrani","year":"2014","journal-title":"Poultry Sci"},{"issue":"6","key":"10.1016\/j.aninu.2021.06.005_bib36","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.3382\/ps\/pew444","article-title":"Exploring the in\u00a0vivo digestion of plant proteins in broiler chickens","volume":"96","author":"Recoules","year":"2017","journal-title":"Poultry Sci"},{"issue":"11 Suppl","key":"10.1016\/j.aninu.2021.06.005_bib37","article-title":"Inulin-type fructans: functional food ingredients","volume":"137","author":"Roberfroid","year":"2007","journal-title":"J\u00a0Nutr"},{"issue":"4","key":"10.1016\/j.aninu.2021.06.005_bib38","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0377-8401(95)00916-7","article-title":"Determination of titanium dioxide added as an inert marker in chicken digestibility studies","volume":"59","author":"Short","year":"1996","journal-title":"Anim Feed Sci Technol"},{"issue":"2","key":"10.1016\/j.aninu.2021.06.005_bib39","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/00071660120121508","article-title":"Effect of enzyme supplementation of a rye-based diet on xylanase activity in the small intestine of broilers, on intestinal crypt cell proliferation and on nutrient digestibility and growth performance of the birds","volume":"43","author":"Silva","year":"2002","journal-title":"Br Poultry Sci"},{"issue":"6","key":"10.1016\/j.aninu.2021.06.005_bib40","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.3382\/ps\/pey038","article-title":"Interactions between the concentration of non-starch polysaccharides in wheat and the addition of an enzyme mixture in a broiler digestibility and performance trial","volume":"97","author":"Smeets","year":"2018","journal-title":"Poultry Sci"},{"issue":"9","key":"10.1016\/j.aninu.2021.06.005_bib41","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.3382\/ps.2014-03905","article-title":"Starch digestion capacity of poultry","volume":"93","author":"Svihus","year":"2014","journal-title":"Poultry Sci"},{"issue":"11","key":"10.1016\/j.aninu.2021.06.005_bib42","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.3382\/ps.0731663","article-title":"Effects of dietary supplementation with lactosucrose (4G-beta-D-galactosylsucrose) on cecal flora, cecal metabolites, and performance in broiler chickens","volume":"73","author":"Terada","year":"1994","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2021.06.005_bib43","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1051\/animres:19980402","article-title":"Growth promotants in feeding pigs and poultry. III. Alternatives to antibiotic growth promotants","volume":"47","author":"Thomke","year":"1998","journal-title":"Annales de zootechnie, INRA\/EDP Sciences"},{"issue":"12","key":"10.1016\/j.aninu.2021.06.005_bib44","first-page":"2348","article-title":"Structurally different wheat-derived arabinoxylooligosaccharides have different prebiotic and fermentation properties in rats","volume":"138","author":"Van Craeyveld","year":"2008","journal-title":"J\u00a0Nutr"},{"issue":"8","key":"10.1016\/j.aninu.2021.06.005_bib45","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1021\/ac60252a045","article-title":"Phenol-hypochlorite reaction for determination of ammonia","volume":"39","author":"Weatherburn","year":"1967","journal-title":"Anal Chem"},{"issue":"1","key":"10.1016\/j.aninu.2021.06.005_bib46","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/mnfr.201100542","article-title":"Relevance of protein fermentation to gut health","volume":"56","author":"Windey","year":"2012","journal-title":"Mol Nutr Food Res"},{"issue":"6","key":"10.1016\/j.aninu.2021.06.005_bib47","doi-asserted-by":"crossref","first-page":"855","DOI":"10.5713\/ajas.2014.14006","article-title":"Effects of xylanase supplementation on growth performance, nutrient digestibility and non-starch polysaccharide degradation in different sections of the gastrointestinal tract of broilers fed wheat-based diets","volume":"27","author":"Zhang","year":"2014","journal-title":"Asian-Australas J Anim Sci"},{"issue":"1","key":"10.1016\/j.aninu.2021.06.005_bib48","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/jsfa.8444","article-title":"Changes in monosaccharides, organic acids and amino acids during Cabernet Sauvignon wine ageing based on a simultaneous analysis using gas chromatography\u2013mass spectrometry","volume":"98","author":"Zhang","year":"2018","journal-title":"J\u00a0Sci Food Agric"}],"container-title":["Animal Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240565452100144X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240565452100144X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:24:47Z","timestamp":1762503887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240565452100144X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":48,"alternative-id":["S240565452100144X"],"URL":"https:\/\/doi.org\/10.1016\/j.aninu.2021.06.005","relation":{},"ISSN":["2405-6545"],"issn-type":[{"value":"2405-6545","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interaction between xylanase and a proton pump inhibitor on broiler chicken performance and gut function","name":"articletitle","label":"Article Title"},{"value":"Animal Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aninu.2021.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Chinese Association of Animal Science and Veterinary Medicine. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}