{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:18:44Z","timestamp":1783682324533,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32002193"],"award-info":[{"award-number":["32002193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012453","name":"China Agricultural Research System","doi-asserted-by":"publisher","award":["CARS-42"],"award-info":[{"award-number":["CARS-42"]}],"id":[{"id":"10.13039\/501100012453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Nutrition"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.aninu.2022.09.013","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T04:48:51Z","timestamp":1666154931000},"page":"215-226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Effect of riboflavin deficiency on intestinal morphology, jejunum mucosa proteomics, and cecal microbiota of Pekin ducks"],"prefix":"10.1016","volume":"12","author":[{"given":"Yaxi","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanbao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengkui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7653-8438","authenticated-orcid":false,"given":"Jing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aninu.2022.09.013_bib1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1079\/BJN19860097","article-title":"The influence of riboflavin deficiency on absorption and liver storage of iron in the growing rat","volume":"56","author":"Adelekan","year":"1986","journal-title":"Br J Nutr"},{"key":"10.1016\/j.aninu.2022.09.013_bib2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0003-2697(90)90546-L","article-title":"Identification of FAD, FMN, and riboflavin in the retina by microextraction and high-performance liquid chromatography","volume":"188","author":"Batey","year":"1990","journal-title":"Anal Biochem"},{"key":"10.1016\/j.aninu.2022.09.013_bib3","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.3390\/microorganisms8081134","article-title":"Effects of vitamin B2 supplementation in broilers microbiota and metabolome","volume":"8","author":"Biagi","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.aninu.2022.09.013_bib4","first-page":"197","article-title":"Reversed-phase liquid chromatographic determination of riboflavin in feeds","volume":"86","author":"Britton","year":"2003","journal-title":"J\u00a0AOAC Int"},{"key":"10.1016\/j.aninu.2022.09.013_bib5","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.3382\/ps.0691357","article-title":"Riboflavin requirement of chicks fed purified amino acid and conventional corn-soybean meal diets","volume":"69","author":"Chung","year":"1990","journal-title":"Poult sci"},{"key":"10.1016\/j.aninu.2022.09.013_bib6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12864-018-4568-2","article-title":"Transcriptional profiling of liver in riboflavin-deficient chicken embryos explains impaired lipid utilization, energy depletion, massive hemorrhaging, and delayed feathering","volume":"19","author":"Cogburn","year":"2018","journal-title":"BMC Genom"},{"key":"10.1016\/j.aninu.2022.09.013_bib7","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/elps.200500687","article-title":"Coordinated and reversible reduction of enzymes involved in terminal oxidative metabolism in skeletal muscle mitochondria from a riboflavin-responsive, multiple acyl-CoA dehydrogenase deficiency patient","volume":"27","author":"Gianazza","year":"2016","journal-title":"Electrophoresis"},{"key":"10.1016\/j.aninu.2022.09.013_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.727200","article-title":"Effects of total dietary fiber on cecal microbial community and intestinal morphology of growing white Pekin duck","volume":"12","author":"Hao","year":"2021","journal-title":"Front Microbiol"},{"key":"10.1016\/j.aninu.2022.09.013_bib9","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3390\/microorganisms10030578","article-title":"Gut Microbiota dysbiosis: triggers, consequences, diagnostic and therapeutic options","volume":"10","author":"Hrncir","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.aninu.2022.09.013_bib10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1194\/jlr.R200014-JLR200","article-title":"Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly","volume":"44","author":"Hussain","year":"2003","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.aninu.2022.09.013_bib11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.copbio.2012.08.005","article-title":"Bacteria as vitamin suppliers to their host: a gut microbiota perspective","volume":"24","author":"LeBlanc","year":"2013","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.aninu.2022.09.013_bib12","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s00394-012-0458-6","article-title":"Riboflavin depletion of intestinal cells in\u00a0vitro leads to impaired energy generation and enhanced oxidative stress","volume":"52","author":"Lee","year":"2013","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.aninu.2022.09.013_bib13","series-title":"Nutrient requirements of meat-type duck","author":"Ministry of Agriculture of China","year":"2012"},{"key":"10.1016\/j.aninu.2022.09.013_bib14","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.molmet.2016.05.015","article-title":"The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512","volume":"5","author":"Mziaut","year":"2016","journal-title":"Mol Metabol"},{"key":"10.1016\/j.aninu.2022.09.013_bib15","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s10620-010-1374-3","article-title":"Riboflavin depletion impairs cell proliferation in adult human duodenum: identification of potential effectors","volume":"56","author":"Nakano","year":"2011","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.aninu.2022.09.013_bib16","series-title":"Nutrient requirements of poultry","year":"1994"},{"key":"10.1016\/j.aninu.2022.09.013_bib17","first-page":"1","article-title":"Riboflavin is an antioxidant: a review update","author":"Olfat","year":"2022","journal-title":"Br J Nutr"},{"key":"10.1016\/j.aninu.2022.09.013_bib18","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00394-020-02283-4","article-title":"Dietary riboflavin deficiency induces ariboflavinosis and esophageal epithelial atrophy in association with modification of gut microbiota in rats","volume":"60","author":"Pan","year":"2021","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.aninu.2022.09.013_bib19","article-title":"Dietary riboflavin deficiency induces genomic instability of esophageal squamous cells that is associated with gut microbiota dysbiosis in rats","volume":"11","author":"Pan","year":"2020","journal-title":"Food Funct"},{"key":"10.1016\/j.aninu.2022.09.013_bib20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cca.2010.08.037","article-title":"Rapid determination of vitamin B2 (riboflavin) in plasma by HPLC","volume":"412","author":"Petteys","year":"2011","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.aninu.2022.09.013_bib21","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1875774","article-title":"Effects of colon-targeted vitamins on the composition and metabolic activity of the human gut microbiome\u2013a pilot study","volume":"13","author":"Pham","year":"2021","journal-title":"Gut Microb"},{"key":"10.1016\/j.aninu.2022.09.013_bib22","first-page":"413","article-title":"The relative effectiveness of iron and iron with riboflavin in correcting a microcytic anaemia in men and children in rural Gambia","volume":"37","author":"Powers","year":"1983","journal-title":"Hum Nutr Clin Nutr"},{"key":"10.1016\/j.aninu.2022.09.013_bib23","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1079\/BJN19910107","article-title":"Riboflavin deficiency in the rat: effects on iron utilization and loss","volume":"65","author":"Powers","year":"1991","journal-title":"Br J Nutr"},{"key":"10.1016\/j.aninu.2022.09.013_bib24","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1079\/BJN19880047","article-title":"The effect of riboflavin deficiency in rats on the absorption and distribution of iron","volume":"59","author":"Powers","year":"1988","journal-title":"Br J Nutr"},{"key":"10.1016\/j.aninu.2022.09.013_bib25","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1079\/BJN19930055","article-title":"A\u00a0proposed intestinal mechanism for the effect of riboflavin deficiency on iron loss in the rat","volume":"69","author":"Powers","year":"1993","journal-title":"Br J Nutr"},{"key":"10.1016\/j.aninu.2022.09.013_bib26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3390\/ani10010103","article-title":"Composition and function of chicken gut microbiota","volume":"10","author":"Rychlik","year":"2020","journal-title":"Animals"},{"key":"10.1016\/j.aninu.2022.09.013_bib27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/bs.afnr.2017.11.002","article-title":"Riboflavin in human health: a review of current evidences","volume":"83","author":"Saedisomeolia","year":"2018","journal-title":"Adv Food Nutr Res"},{"key":"10.1016\/j.aninu.2022.09.013_bib28","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jmb.2008.11.051","article-title":"Properties of an ezrin mutant defective in F-actin binding","volume":"385","author":"Saleh","year":"2009","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.aninu.2022.09.013_bib29","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.devcel.2004.05.007","article-title":"Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine","volume":"6","author":"Saotome","year":"2004","journal-title":"Dev Cell"},{"key":"10.1016\/j.aninu.2022.09.013_bib30","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1097-2765(00)80332-9","article-title":"Identification of the major intestinal fatty acid transport protein","volume":"4","author":"Stahl","year":"1999","journal-title":"Mol Cell"},{"key":"10.1016\/j.aninu.2022.09.013_bib31","first-page":"28","article-title":"The fatty acid transport function of fatty acid-binding proteins","volume":"1486","author":"Storch","year":"2000","journal-title":"BBA-Mol Cell Biol"},{"key":"10.1016\/j.aninu.2022.09.013_bib32","doi-asserted-by":"crossref","first-page":"950","DOI":"10.3390\/ijms21030950","article-title":"Riboflavin: the health benefits of a forgotten natural vitamin","volume":"21","author":"Suwannasom","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.aninu.2022.09.013_bib33","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1017\/S0007114514001846","article-title":"Supplemental dietary L-arginine attenuates intestinal mucosal disruption during a coccidial vaccine challenge in broiler chickens","volume":"112","author":"Tan","year":"2014","journal-title":"Br J Nutr"},{"key":"10.1016\/j.aninu.2022.09.013_bib34","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1017\/S0007114517002641","article-title":"Severe riboflavin deficiency induces alterations in the hepatic proteome of starter Pekin ducks","volume":"118","author":"Tang","year":"2017","journal-title":"Br J Nutr"},{"key":"10.1016\/j.aninu.2022.09.013_bib35","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.anifeedsci.2015.07.023","article-title":"Effects of riboflavin supplementation on growth performance, carcass traits, and riboflavin status of growing male white Pekin ducks","volume":"209","author":"Tang","year":"2015","journal-title":"Anim Feed Sci Technol"},{"key":"10.1016\/j.aninu.2022.09.013_bib36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.livsci.2014.10.016","article-title":"Dietary riboflavin supplementation improve the growth performance and antioxidant status of starter white Pekin ducks fed a corn-soybean meal diets","volume":"170","author":"Tang","year":"2014","journal-title":"Livest Sci"},{"key":"10.1016\/j.aninu.2022.09.013_bib37","first-page":"407","article-title":"Riboflavin requirements of white Pekin ducks from hatch to 21 d of age","volume":"54","author":"Tang","year":"2013","journal-title":"Br Poultry Sci"},{"key":"10.1016\/j.aninu.2022.09.013_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12986-019-0345-8","article-title":"Maternal diet deficient in riboflavin induces embryonic death associated with alterations in the hepatic proteome of duck embryos","volume":"16","author":"Tang","year":"2019","journal-title":"Nutr Metab"},{"key":"10.1016\/j.aninu.2022.09.013_bib39","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1080\/10408398.2016.1145104","article-title":"Riboflavin and health: a review of recent human research","volume":"57","author":"Thakur","year":"2017","journal-title":"Crit Rev Food Sci"},{"key":"10.1016\/j.aninu.2022.09.013_bib40","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1079\/BJN19960133","article-title":"Cytokinetic and structural responses of the rat small intestine to riboflavin depletion","volume":"75","author":"Williams","year":"1996","journal-title":"Br J Nutr"},{"key":"10.1016\/j.aninu.2022.09.013_bib41","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/gut.39.2.220","article-title":"An investigation into the reversibility of the morphological and cytokinetic changes seen in the small intestine of riboflavin deficient rats","volume":"39","author":"Williams","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.aninu.2022.09.013_bib42","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1079\/BJN19950015","article-title":"Morphological changes in the rat small intestine in response to riboflavin depletion","volume":"73","author":"Williams","year":"1995","journal-title":"Br J Nutr"},{"key":"10.1016\/j.aninu.2022.09.013_bib43","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1023\/A:1023785200638","article-title":"Absence of luminal riboflavin disturbs early postnatal development of the gastrointestinal tract","volume":"48","author":"Yates","year":"2003","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.aninu.2022.09.013_bib44","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1079\/BJN2001420","article-title":"Riboflavin deficiency: early effects on post-weaning development of the duodenum in rats","volume":"86","author":"Yates","year":"2001","journal-title":"Br J Nutr"},{"key":"10.1016\/j.aninu.2022.09.013_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101342","article-title":"Effects of riboflavin deficiency on the lipid metabolism of duck breeders and duck embryos","volume":"100","author":"Zhang","year":"2021","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2022.09.013_bib46","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1021\/acs.jafc.2c00117","article-title":"Riboflavin bioenriched soymilk alleviates oxidative stress mediated liver injury, intestinal inflammation, and gut microbiota modification in B2 depletion-repletion mice","volume":"70","author":"Zhu","year":"2022","journal-title":"J\u00a0Agric Food Chem"}],"container-title":["Animal Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405654522001445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405654522001445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:26:43Z","timestamp":1762504003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405654522001445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":46,"alternative-id":["S2405654522001445"],"URL":"https:\/\/doi.org\/10.1016\/j.aninu.2022.09.013","relation":{},"ISSN":["2405-6545"],"issn-type":[{"value":"2405-6545","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of riboflavin deficiency on intestinal morphology, jejunum mucosa proteomics, and cecal microbiota of Pekin ducks","name":"articletitle","label":"Article Title"},{"value":"Animal Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aninu.2022.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}