{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T21:10:22Z","timestamp":1794258622297,"version":"4.9.0"},"reference-count":118,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Nutrition"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.aninu.2023.03.005","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T02:14:33Z","timestamp":1680574473000},"page":"240-248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":146,"special_numbering":"C","title":["Poultry gut health and beyond"],"prefix":"10.1016","volume":"13","author":[{"given":"Richard","family":"Ducatelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6476-5932","authenticated-orcid":false,"given":"Evy","family":"Goossens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venessa","family":"Eeckhaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Van Immerseel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aninu.2023.03.005_bib1","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.3390\/ani12172297","article-title":"Influence of heat stress on poultry growth performance, intestinal inflammation, and immune function and potential mitigation by probiotics","volume":"12","author":"Ahmad","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.aninu.2023.03.005_bib2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fimmu.2016.00231","article-title":"Unique transcompartmental bridge: antigen-presenting cells sampling across endothelial and mucosal barriers","volume":"7","author":"Allen","year":"2016","journal-title":"Front Immunol"},{"key":"10.1016\/j.aninu.2023.03.005_bib3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.anifeedsci.2016.05.004","article-title":"Interaction between chicken intestinal microbiota and protein digestion","volume":"221","author":"Apajalathi","year":"2016","journal-title":"Anim Feed Sci Technol"},{"key":"10.1016\/j.aninu.2023.03.005_bib4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1126\/science.1198469","article-title":"Induction of colonic regulatory T cells by indigenous Clostridium species","volume":"331","author":"Atarashi","year":"2010","journal-title":"Science (Wash D C)"},{"key":"10.1016\/j.aninu.2023.03.005_bib5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.aninu.2020.08.001","article-title":"Opportunities of prebiotics for the intestinal health of monogastric animals","volume":"6","author":"Azad","year":"2020","journal-title":"Anim Nutr"},{"key":"10.1016\/j.aninu.2023.03.005_bib6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1073\/pnas.0906112107","article-title":"The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation","volume":"107","author":"Bansal","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.aninu.2023.03.005_bib7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S1095-6433(01)00389-0","article-title":"Expression of P-glycoprotein in the chicken","volume":"130","author":"Barnes","year":"2001","journal-title":"Comp Biochem Physiol A"},{"key":"10.1016\/j.aninu.2023.03.005_bib8","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3389\/fgene.2019.00480","article-title":"Evaluation of intestinal permeability and liver bacterial translocation in two modern broilers and their jungle fowl ancestors","volume":"10","author":"Baxter","year":"2019","journal-title":"Front Genet"},{"key":"10.1016\/j.aninu.2023.03.005_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101612","article-title":"Factors affecting chicken gastrointestinal microbial composition and their association with gut health and productive performance","volume":"101","author":"Bindari","year":"2022","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib10","doi-asserted-by":"crossref","first-page":"8368","DOI":"10.3390\/ijms21218368","article-title":"Dietary carbohydrates and lipids in the pathogenesis of leaky gut syndrome: an overview","volume":"21","author":"Binienda","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib11","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1097\/CCM.0b013e31823dae05","article-title":"The anti-inflammatory effects of methane","volume":"40","author":"Boros","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.aninu.2023.03.005_bib12","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1074\/jbc.M211609200","article-title":"The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids","volume":"278","author":"Brown","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.aninu.2023.03.005_bib13","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2046452","article-title":"Acids produced by lactobacilli inhibit the growth of commensal Lachnospiraceae and S24-7 bacteria","volume":"14","author":"Brownlie","year":"2022","journal-title":"Gut Microb"},{"key":"10.1016\/j.aninu.2023.03.005_bib14","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1126\/science.aam9949","article-title":"Microbiota-activated PPAR-\u03b3-signaling inhibits dysbiotic Enterobacteriaceae expansion","volume":"357","author":"Byndloss","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.aninu.2023.03.005_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.752265","article-title":"The microbiota-gut-brain axis during heat stress in chickens: a review","volume":"12","author":"Cao","year":"2021","journal-title":"Front Physiol"},{"key":"10.1016\/j.aninu.2023.03.005_bib16","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.3390\/metabo12101000","article-title":"Effects of probiotics and gut microbiota on bone metabolism in chickens: a review","volume":"12","author":"Chen","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.aninu.2023.03.005_bib17","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1017\/S004393391600026X","article-title":"The role of the crop in poultry production","volume":"72","author":"Classen","year":"2016","journal-title":"World Poult Sci J"},{"key":"10.1016\/j.aninu.2023.03.005_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027949","article-title":"Modulations of the chicken cecal microbiome and metagenome in response to anticoccidial and growth promoter treatment","volume":"6","author":"Danzeisen","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.aninu.2023.03.005_bib19","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3382\/ps\/pez525","article-title":"Dietary zinc source impacts intestinal morphology and oxidative stress in young broilers","volume":"99","author":"De Grande","year":"2020","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib20","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1080\/03079457.2022.2086447","article-title":"Omics technologies in poultry health and productivity \u2013 part 1: current use in poultry research","volume":"51","author":"Dehau","year":"2022","journal-title":"Avian Pathol"},{"key":"10.1016\/j.aninu.2023.03.005_bib21","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.1128\/AEM.01616-15","article-title":"The effects of xylo-oligosaccharides on performance and microbiota in broiler chickens","volume":"81","author":"De Maesschalck","year":"2015","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.aninu.2023.03.005_bib22","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.3382\/ps\/pez090","article-title":"Amorphous cellulose feed supplement alters broiler caecal microbiome","volume":"98","author":"De Maesschalck","year":"2019","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13567-019-0663-x","article-title":"Host intestinal biomarker identification in a gut leakage model in broilers","volume":"50","author":"De Meyer","year":"2019","journal-title":"Vet Res"},{"key":"10.1016\/j.aninu.2023.03.005_bib24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/ps\/77.1.73","article-title":"Immunohistochemical observations in the ceca of chickens infected with Salmonella Enteritidis phage type four","volume":"77","author":"Desmidt","year":"1998","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cmet.2016.06.013","article-title":"Microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis","volume":"24","author":"De Vadder","year":"2016","journal-title":"Cell Metabol"},{"key":"10.1016\/j.aninu.2023.03.005_bib26","doi-asserted-by":"crossref","DOI":"10.1590\/S1517-83822012000400001","article-title":"Production of GABA (\u03b3 \u2013 aminobutyric acid) by microorganisms: a review","volume":"43","author":"Dhakal","year":"2012","journal-title":"Braz J Microbiol"},{"key":"10.1016\/j.aninu.2023.03.005_bib27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-015-2318-1","article-title":"Expression and localization of GPR91 and GPR99 in murine organs","volume":"364","author":"Diehl","year":"2016","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.aninu.2023.03.005_bib28","first-page":"43","article-title":"A\u00a0review of prebiotics and probiotics for the control of dysbiosis: present status and future perspectives","volume":"9","author":"Ducatelle","year":"2015","journal-title":"Animals"},{"key":"10.1016\/j.aninu.2023.03.005_bib29","series-title":"Enzymes in farm animal nutrition. 3rd ed. CAB Int","first-page":"254","article-title":"Enzymes and the microbiome in the post-antibiotic era. [Chapter 15]","author":"Ducatelle","year":"2022"},{"key":"10.1016\/j.aninu.2023.03.005_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2022.100543","article-title":"Implication of redox balance in animal health and performance at critical periods, insights from different animal species","volume":"16","author":"Durand","year":"2022","journal-title":"Animal"},{"key":"10.1016\/j.aninu.2023.03.005_bib31","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3390\/foods11071005","article-title":"Metabolic conversions by lactic acid bacteria during plant protein fermentations","volume":"11","author":"Engels","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.aninu.2023.03.005_bib32","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1053\/j.gastro.2014.04.041","article-title":"Carbon dioxide, hydrogen sulfide, and nitric oxide as signaling molecules in the gastrointestinal tract","volume":"147","author":"Farrugia","year":"2014","journal-title":"Gastroenterol"},{"key":"10.1016\/j.aninu.2023.03.005_bib33","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1177\/0148607188012004325","article-title":"Effect of a glutamine-supplemented enteral diet on methotrexate-induced enterocolitis","volume":"12","author":"Fox","year":"1988","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.aninu.2023.03.005_bib34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fcimb.2018.00013","article-title":"Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism","volume":"8","author":"Gao","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.aninu.2023.03.005_bib35","doi-asserted-by":"crossref","first-page":"G159","DOI":"10.1152\/ajpgi.00319.2017","article-title":"Protein fermentation in the gut: implications for intestinal dysfunction in humans, pigs, and poultry","volume":"315","author":"Gilbert","year":"2018","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.aninu.2023.03.005_bib36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.chom.2017.11.006","article-title":"Dysbiosis-associated change in host metabolism generates lactate to support Salmonella growth","volume":"23","author":"Gillis","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.aninu.2023.03.005_bib37","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13567-018-0548-4","article-title":"Elevated faecal ovotransferrin concentrations are indicative for intestinal barrier failure in broiler chickens","volume":"49","author":"Goossens","year":"2018","journal-title":"Vet Res"},{"key":"10.1016\/j.aninu.2023.03.005_bib38","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1080\/03079457.2022.2085545","article-title":"Omics technologies in poultry health and productivity \u2013 part 2: future applications in the poultry industry","volume":"51","author":"Goossens","year":"2022","journal-title":"Avian Pathol"},{"key":"10.1016\/j.aninu.2023.03.005_bib39","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1017\/S0954422410000247","article-title":"From the gut to the peripheral tissues: the multiple effects of butyrate","volume":"23","author":"Guilloteau","year":"2010","journal-title":"Nutr Res Rev"},{"key":"10.1016\/j.aninu.2023.03.005_bib40","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1007\/s00484-017-1414-1","article-title":"Effect of heat stress on protein utilization and nutrient transporters in meat-type chickens","volume":"61","author":"Habashy","year":"2017","journal-title":"Int J Biometeorol"},{"key":"10.1016\/j.aninu.2023.03.005_bib41","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.rvsc.2010.01.005","article-title":"Expression of drug efflux transporters in poultry tissues","volume":"89","author":"Haritova","year":"2010","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib42","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1017\/S0950268802007380","article-title":"Routes for Salmonella contamination of poultry meat: epidemiological study from hatchery to slaughterhouse","volume":"129","author":"Heyndrickx","year":"2002","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.aninu.2023.03.005_bib43","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.3390\/nu13124259","article-title":"Gut microbial metabolite-mediated regulation of the intestinal barrier in: the pathogenesis of inflammatory bowel disease","volume":"13","author":"Iyer","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.aninu.2023.03.005_bib44","first-page":"391","article-title":"Metabolism of vitamin A in inflammatory bowel disease","volume":"38","author":"Janczewska","year":"1991","journal-title":"H\u00e9pato-Gastro"},{"key":"10.1016\/j.aninu.2023.03.005_bib45","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1084\/jem.20122490","article-title":"Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes","volume":"210","author":"Jiang","year":"2013","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.aninu.2023.03.005_bib46","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nri.2016.88","article-title":"Immunological aspects of intestinal mucus and mucins","volume":"16","author":"Johansson","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.aninu.2023.03.005_bib47","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1017\/S0043933918000259","article-title":"Roles of dietary fibre and ingredient particle size in broiler nutrition","volume":"74","author":"Kheravii","year":"2018","journal-title":"World Poult Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib48","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.3382\/ps\/pex123","article-title":"Coarse particle inclusion and lignocellulose-rich fiber addition in feed benefit performance and health of broiler chickens","volume":"96","author":"Kheravii","year":"2017","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib49","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.aninu.2021.09.011","article-title":"Characterisation of undigested components throughout the gastrointestinal tract of broiler chickens fed either a wheat- or maize-based diet","volume":"8","author":"Kim","year":"2022","journal-title":"Anim Nutr"},{"key":"10.1016\/j.aninu.2023.03.005_bib50","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.aninu.2021.11.004","article-title":"The flow of non-starch polysaccharides along the gastrointestinal tract of broiler chickens fed either a wheat- or maize-based diet","volume":"9","author":"Kim","year":"2022","journal-title":"Anim Nutr"},{"key":"10.1016\/j.aninu.2023.03.005_bib51","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.3389\/fimmu.2019.02732","article-title":"Involvement of T-cell immunity in avian coccidiosis","volume":"10","author":"Kim","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.aninu.2023.03.005_bib52","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3389\/fimmu.2019.00560","article-title":"Indole treatment alleviates intestinal tissue damage induced by chicken coccidiosis through activation of the aryl hydrocarbon receptor","volume":"10","author":"Kim","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.aninu.2023.03.005_bib53","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.anifeedsci.2018.10.008","article-title":"The effect of microbiome modulation on the intestinal health of poultry","volume":"250","author":"Kogut","year":"2019","journal-title":"Anim Feed Sci Technol"},{"key":"10.1016\/j.aninu.2023.03.005_bib54","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.3382\/ps\/pey087","article-title":"Inflammatory phenotypes in the intestine of poultry: not all inflammation is created equal","volume":"97","author":"Kogut","year":"2018","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib55","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/j.psj.2019.12.011","article-title":"Microbiome and pathogen interaction with the immune system","volume":"99","author":"Kogut","year":"2020","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212446","article-title":"Contact with adult hen affects development of caecal microbiota in newly hatched chicks","volume":"14","author":"Kubasova","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.aninu.2023.03.005_bib57","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1007\/s002680010269","volume":"24","author":"Labow","year":"2000","journal-title":"Glutamine. World J Surg"},{"key":"10.1016\/j.aninu.2023.03.005_bib58","doi-asserted-by":"crossref","first-page":"E101","DOI":"10.2527\/jas.2008-1339","article-title":"Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects","volume":"87","author":"Lambert","year":"2009","journal-title":"J\u00a0Anim Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib59","first-page":"922","article-title":"Microbiota-derived lactate activates production of reactive oxygen species by the intestinal NADPH oxidase Nox and shortens Drosphila lifespan","volume":"49","author":"Latenko","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.aninu.2023.03.005_bib60","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.tim.2015.08.001","article-title":"Roles of indole as an interspecies and interkingdom signaling molecule","volume":"23","author":"Lee","year":"2015","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.aninu.2023.03.005_bib61","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1111\/mmi.14893","article-title":"Glutathione catabolism by Enterobacteriaceae species to hydrogen sulphide adversely affects the viability of host systems in the presence of 5\u2019fluoro-deoxyuridine","volume":"117","author":"Lim","year":"2022","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.aninu.2023.03.005_bib62","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fmicb.2014.00033","article-title":"Antibiotic growth promoters enhance animal production by targeting intestinal bile acid hydrolase and its producers","volume":"5","author":"Lin","year":"2014","journal-title":"Front Microbiol"},{"key":"10.1016\/j.aninu.2023.03.005_bib63","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat9076","article-title":"Colonocyte metabolism shapes the gut microbiota","volume":"362","author":"Litvak","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.aninu.2023.03.005_bib64","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/03079450903447404","article-title":"Exogenous lysozyme influences Clostridium perfringens colonization and intestinal barrier function in broiler chickens","volume":"39","author":"Liu","year":"2010","journal-title":"Avian Pathol"},{"key":"10.1016\/j.aninu.2023.03.005_bib65","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1093\/glycob\/cwt040","article-title":"A\u00a0refined palate: bacterial consumption of host glycans in the gut","volume":"23","author":"Marcobal","year":"2013","journal-title":"Glycobiology"},{"key":"10.1016\/j.aninu.2023.03.005_bib66","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1574-6968.2009.01750.x","article-title":"Lactate has the potential to promote hydrogen sulphide formation in the human colon","volume":"299","author":"Marquet","year":"2009","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.aninu.2023.03.005_bib67","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3382\/japr.2011-00477","article-title":"Poultry response to high levels of dietary fiber sources varying in physical and chemical charcteristics","volume":"21","author":"Mateos","year":"2012","journal-title":"J\u00a0Appl Poultry Res"},{"key":"10.1016\/j.aninu.2023.03.005_bib68","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/00071668.2021.1975260","article-title":"Effect of protease supplementation and diet type on jejunal and ileal digestibility and total tract metabolisability of nitrogen, starch, and energy in broilers","volume":"63","author":"McCafferty","year":"2022","journal-title":"Br Poultry Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib69","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1186\/s12864-018-4959-4","article-title":"Whole genome sequencing and function prediction of 133 gut anaerobes isolated from chicken caecum in pure cultures","volume":"19","author":"Medvecky","year":"2018","journal-title":"BMC Genom"},{"key":"10.1016\/j.aninu.2023.03.005_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/srep43199","article-title":"Commensal gut bacteria modulate phosphorylation-dependent PPAR-g transcriptional activity in human intestinal epithelial cells","volume":"7","author":"Nepelska","year":"2017","journal-title":"Sci Rep"},{"issue":"suppl 2","key":"10.1016\/j.aninu.2023.03.005_bib71","first-page":"7","article-title":"Oral tolerance is a state of active non responsiveness to ingested soluble antigens mediated by gut-associated intestinal lymphoid tissue","volume":"70","author":"Nowak-Wegrzyn","year":"2017","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.aninu.2023.03.005_bib72","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s40168-019-0704-8","article-title":"Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health","volume":"7","author":"Oliphant","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.aninu.2023.03.005_bib73","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.it.2017.11.003","article-title":"Intestinal intraepithelial lymphocytes: sentinels of the mucosal barrier","volume":"39","author":"Olivares-Villagomez","year":"2018","journal-title":"Trends Immunol"},{"key":"10.1016\/j.aninu.2023.03.005_bib74","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fvets.2015.00075","article-title":"Steering endogenous butyrate production in the intestinal tract of broilers as a tool to improve gut health","volume":"2","author":"Onrust","year":"2015","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib75","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1017\/S0043933914000038","article-title":"Acute phase proteins: a review of their function, behavior and measurement in chickens","volume":"70","author":"O'Reilly","year":"2014","journal-title":"World Poultrymeat J"},{"key":"10.1016\/j.aninu.2023.03.005_bib76","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri3565","article-title":"NOD proteins: regulators of inflammation in health and disease","volume":"14","author":"Philpott","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.aninu.2023.03.005_bib77","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12026-012-8315-5","article-title":"Working out mechanisms of controlled\/physiologic inflammation in the GI tract","volume":"54","author":"Rabinowitz","year":"2012","journal-title":"Immunol Res"},{"key":"10.1016\/j.aninu.2023.03.005_bib78","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.4049\/jimmunol.1700604","article-title":"GPR81, a cell surface receptor for lactate, regulates intestinal homeostasis and protects mice from experimental colitis","volume":"200","author":"Ranganathan","year":"2018","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.aninu.2023.03.005_bib79","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.anifeedsci.2017.02.011","article-title":"GH11 xylanase increases prebiotic oligosaccharides from wheat bran favouring butyrate-producing bacteria in\u00a0vitro","volume":"226","author":"Ravn","year":"2017","journal-title":"Anim Feed Sci Technol"},{"key":"10.1016\/j.aninu.2023.03.005_bib80","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3389\/fvets.2020.00629","article-title":"Oral treatment with ileal spores triggers immunometabolic shifts in chicken gut","volume":"7","author":"Redweik","year":"2020","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib81","unstructured":"Regulation N\u00b0 1831\/2003\/EC of the European union; https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=CELEX%3A32003R1831."},{"key":"10.1016\/j.aninu.2023.03.005_bib82","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/ismej.2014.14","article-title":"Phylogenetic distribution of three pathways for propionate production within the human gut microbiota","volume":"8","author":"Reichardt","year":"2014","journal-title":"ISME J"},{"key":"10.1016\/j.aninu.2023.03.005_bib83","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.aninu.2021.06.010","article-title":"Nutritional stimulation by in ovo feeding modulates cellular proliferation and differentiation in the small intestinal epithelium of chicks","volume":"8","author":"Reicher","year":"2022","journal-title":"Anim Nutr"},{"key":"10.1016\/j.aninu.2023.03.005_bib84","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.freeradbiomed.2016.09.022","article-title":"Oxygen as a driver of dysbiosis","volume":"105","author":"Rivera-Chavez","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.aninu.2023.03.005_bib85","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.chom.2016.03.004","article-title":"Depletion of butyrate-producing Clostridia from the gut microbiota drives an aerobic luminal expansion of Salmonella","volume":"19","author":"Rivera-Chavez","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.aninu.2023.03.005_bib86","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.3382\/ps\/pey191","article-title":"The foregut and its manipulation via feeding practices in the chicken","volume":"97","author":"Rodrigues","year":"2018","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib87","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3390\/ani10010103","article-title":"Composition and function of chicken gut microbiota","volume":"10","author":"Rychlik","year":"2020","journal-title":"Animals"},{"key":"10.1016\/j.aninu.2023.03.005_bib88","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3382\/ps.2011-01790","article-title":"The effect of insoluble fiber and intermittent feeding on gizzard development, gut motility and performance of broiler chickens","volume":"91","author":"Sacranie","year":"2012","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101490","article-title":"Effects of vitamin A on carcass and meat quality in broilers","volume":"100","author":"Savaris","year":"2021","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib90","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/gastro\/goy052","article-title":"Fight them or feed them: how the intestinal mucus layer manages the gut microbiota","volume":"7","author":"Schroeder","year":"2019","journal-title":"Gastroenterol Rep"},{"key":"10.1016\/j.aninu.2023.03.005_bib91","doi-asserted-by":"crossref","first-page":"10361","DOI":"10.1523\/JNEUROSCI.0441-14.2014","article-title":"Molecular and function diversity of GABA-A receptors in the enteric nervous system of the mouse colon","volume":"34","author":"Seifi","year":"2014","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.aninu.2023.03.005_bib92","article-title":"Distribution, organization and expression of genes concerned with anaerobic lactate utilization in human intestinal bacteria","volume":"8","author":"Sheridan","year":"2022","journal-title":"Microb Genom"},{"key":"10.1016\/j.aninu.2023.03.005_bib93","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","article-title":"Proteobacteria: microbial signature of dysbiosis in gut microbiota","volume":"33","author":"Shin","year":"2015","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.aninu.2023.03.005_bib94","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.anifeedsci.2018.04.027","article-title":"Broiler production without antibiotics: United States field perspectives","volume":"250","author":"Smith","year":"2019","journal-title":"Anim Feed Sci Technol"},{"key":"10.1016\/j.aninu.2023.03.005_bib95","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3389\/fmicb.2016.00187","article-title":"Bacteria within the gastrointestinal tract microbiota correlated with improved growth and feed conversion: challenges presented for the identification of performance enhancing probiotic bacteria","volume":"7","author":"Stanley","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.aninu.2023.03.005_bib96","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3382\/japr.2014-00937","article-title":"Function of the digestive system","volume":"23","author":"Svihus","year":"2014","journal-title":"J\u00a0Appl Poultry Res"},{"key":"10.1016\/j.aninu.2023.03.005_bib97","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1017\/S0043933911000249","article-title":"The gizzard: function, influence of diet structure and effects on nutrient availability","volume":"67","author":"Svihus","year":"2011","journal-title":"World Poult Sci J"},{"key":"10.1016\/j.aninu.2023.03.005_bib98","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1017\/S0043933913000287","article-title":"Function and nutritional roles of the avian caeca: a review","volume":"69","author":"Svihus","year":"2013","journal-title":"World Poult Sci J"},{"key":"10.1016\/j.aninu.2023.03.005_bib99","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-36226-1","article-title":"Avian Toll-like receptor allelic diversity far exceeds human polymorphism: an insight from domestic chicken breeds","volume":"8","author":"Swiderska","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.aninu.2023.03.005_bib100","first-page":"3717","article-title":"Glucagon-like peptide-2 and short chain fatty acids: a new twist to an old story","volume":"133","author":"Tappenden","year":"2003","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.aninu.2023.03.005_bib101","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12016-018-8680-5","article-title":"Mechanisms of oral tolerance","volume":"55","author":"Tordesillas","year":"2018","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.aninu.2023.03.005_bib102","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1080\/17474124.2017.1343143","article-title":"The intestinal barrier: a fundamental role in health and disease","volume":"11","author":"Van Camelbeke","year":"2017","journal-title":"Exp Rev Gastroenterol Hepathol"},{"key":"10.1016\/j.aninu.2023.03.005_bib103","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061964","article-title":"Chicken cathelicidins display antimicrobial activity against multiresistant bacteria without inducing strong resistance","volume":"8","author":"Veldhuizen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.aninu.2023.03.005_bib104","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1093\/molbev\/msy119","article-title":"Toll-like receptor evolution in birds: gene duplication, pseudogenization, and diversifying selection","volume":"35","author":"Velova","year":"2018","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.aninu.2023.03.005_bib105","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01343-18","article-title":"Reduced-particle-size wheat bran is efficiently colonized by a lactic acid producing community and reduces levels of Enterobacteriaceae in the cecal microbiota of broilers","volume":"84","author":"Vermeulen","year":"2018","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.aninu.2023.03.005_bib106","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.vetmic.2016.12.009","article-title":"Reduced particle size wheat bran is butyrogenic and lowers Salmonella colonization, when added to poultry feed","volume":"198","author":"Vermeulen","year":"2017","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.aninu.2023.03.005_bib107","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115142","article-title":"Succession and replacement of bacterial populations in the caecum of egg laying hens over their whole life","volume":"9","author":"Videnska","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.aninu.2023.03.005_bib108","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1080\/1828051X.2020.1845576","article-title":"Effect of dietary orange and grapefruit peel on growth performance, health status, meat quality and intestinal microflora of broiler chickens","volume":"19","author":"Vlaicu","year":"2020","journal-title":"Ital J Anim Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105509","article-title":"Paracellular intestinal permeability of chickens induced by DON and\/or C.\u00a0jejuni is associated with alterations in tight junction mRNA expression","volume":"168","author":"Von Bucholz","year":"2022","journal-title":"Microb Pathog"},{"key":"10.1016\/j.aninu.2023.03.005_bib110","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1017\/S0007114520004493","article-title":"Dietary muramidase degrades bacterial peptidoglycan to NOD-activating muramyl dipeptides and reduces duodenal inflammation in broiler chickens","volume":"126","author":"Wang","year":"2021","journal-title":"Br J Nutr"},{"key":"10.1016\/j.aninu.2023.03.005_bib111","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1038\/mi.2014.19","article-title":"NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6","volume":"7","author":"Watanabe","year":"2014","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.aninu.2023.03.005_bib112","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.3382\/ps\/pex444","article-title":"Dietary L-glutamine supplementation improves growth performance, gut orphology, and serum biochemical indices of broiler chickens during necrotic enteritis challenge","volume":"97","author":"Xue","year":"2018","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib113","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.5713\/ab.21.0485","article-title":"An updated review on probiotics as an alternative to antibiotics in poultry \u2013 a review","volume":"35","author":"Yacoob","year":"2022","journal-title":"Anim Biosci"},{"key":"10.1016\/j.aninu.2023.03.005_bib114","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fcimb.2015.00036","article-title":"Antimicrobial activities of chicken \u03b2-defensins (4 and 10) peptides against pathogenic bacteria and fungi","volume":"5","author":"Yacoub","year":"2015","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.aninu.2023.03.005_bib115","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3382\/ps\/pex297","article-title":"Short chain arabinoxylans prepared from enzymatically treated wheat grain exert prebiotic effects during the broiler starter period","volume":"97","author":"Yacoubi","year":"2018","journal-title":"Poultry Sci"},{"key":"10.1016\/j.aninu.2023.03.005_bib116","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.3389\/fimmu.2018.01434","article-title":"Implication of G protein-coupled receptor 43 in intestinal inflammation: a mini-review","volume":"9","author":"Yang","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.aninu.2023.03.005_bib117","first-page":"115","article-title":"A\u00a0review of probiotic applications in poultry: improving immunity and having beneficial effects on production and health","volume":"61","author":"Yousaf","year":"2022","journal-title":"Adv Microbiol"},{"key":"10.1016\/j.aninu.2023.03.005_bib118","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.3382\/ps\/pez279","article-title":"Effects of sodium butyrate on intestinal health and gut microbiota composition during intestinal inflammation progression in broilers","volume":"98","author":"Zou","year":"2019","journal-title":"Poultry Sci"}],"container-title":["Animal Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405654523000355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405654523000355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:31:36Z","timestamp":1762504296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405654523000355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":118,"alternative-id":["S2405654523000355"],"URL":"https:\/\/doi.org\/10.1016\/j.aninu.2023.03.005","relation":{},"ISSN":["2405-6545"],"issn-type":[{"value":"2405-6545","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Poultry gut health and beyond","name":"articletitle","label":"Article Title"},{"value":"Animal Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aninu.2023.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}