{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:27:42Z","timestamp":1792783662593,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014472","name":"Scientific Research Foundation of Hunan Provincial Education Department","doi-asserted-by":"publisher","award":["22A0154"],"award-info":[{"award-number":["22A0154"]}],"id":[{"id":"10.13039\/100014472","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Fund of Hunan Provincial Education Departent"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772642"],"award-info":[{"award-number":["31772642"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472930"],"award-info":[{"award-number":["32472930"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2019TP2004"],"award-info":[{"award-number":["2019TP2004"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Nutrition"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.aninu.2025.04.005","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T02:52:16Z","timestamp":1750387936000},"page":"165-178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Lactobacillus plantarum and Lactobacillus brevis alleviate enterotoxigenic Escherichia coli-induced intestinal inflammation and stabilize intestinal microorganisms and serum metabolites in piglets"],"prefix":"10.1016","volume":"22","author":[{"given":"Xuebing","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9475-5134","authenticated-orcid":false,"given":"Gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aninu.2025.04.005_bib1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.aninu.2025.04.005_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111619","article-title":"Biodegradation of fluorene by the newly isolated marine-derived fungus, mucor irregularis strain bpo1 using response surface methodology","volume":"208","author":"Bankole","year":"2021","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.aninu.2025.04.005_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-3-030-21162-2_5","article-title":"The role of ceramide 1-phosphate in inflammation, cellular proliferation, and wound healing","volume":"1159","author":"Berwick","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.aninu.2025.04.005_bib4","article-title":"Association between fusobacterium nucleatum and patient prognosis in metastatic colon cancer","volume":"11","author":"Bum","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.aninu.2025.04.005_bib5","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1080\/14760584.2023.2295015","article-title":"Combatting infectious diarrhea: innovations in treatment and vaccination strategies","volume":"23","author":"Chavda","year":"2024","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.aninu.2025.04.005_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/nu12010132","article-title":"Gastroesophageal reflux disease and probiotics: a systematic review","volume":"12","author":"Cheng","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.aninu.2025.04.005_bib15","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.chom.2022.09.014","article-title":"Gut colonization by Proteobacteria alters host metabolism and modulates cocaine neurobehavioral responses","volume":"30","author":"Cuesta","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.aninu.2025.04.005_bib16","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1515\/biol-2019-0049","article-title":"Study of lbhd1 expression with invasion and migration of bladder cancer","volume":"14","author":"Dong","year":"2019","journal-title":"Open Life Sci"},{"key":"10.1016\/j.aninu.2025.04.005_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.12938\/bmfh.16-030","article-title":"Enterotoxigenic escherichia coli and probiotics in swine: what the bleep do we know?","volume":"36","author":"Dubreuil","year":"2017","journal-title":"Biosci Microbiota Food Health"},{"key":"10.1016\/j.aninu.2025.04.005_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/ecosalplus.esp-0006-2016","article-title":"Animal enterotoxigenic escherichia coli","volume":"7","author":"Dubreuil","year":"2016","journal-title":"EcoSal Plus"},{"key":"10.1016\/j.aninu.2025.04.005_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11112264","article-title":"Inhibition of tumor growth and modulation of antioxidant activity of rhodoxanthin isolated from taxus baccata aril against b16f10 murine malignant melanoma","volume":"11","author":"Dumitra\u015f","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.aninu.2025.04.005_bib20","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.3748\/wjg.v30.i15.2096","article-title":"Shaping the gut immunological responses","volume":"30","author":"Filidou","year":"2024","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.aninu.2025.04.005_bib21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/ibd\/izx003","article-title":"Lactobacillus brevis kb290 with vitamin a ameliorates murine intestinal inflammation associated with the increase of cd11c+ macrophage\/cd103- dendritic cell ratio","volume":"24","author":"Fuke","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.aninu.2025.04.005_bib22","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.semcancer.2021.12.013","article-title":"Anticancer activity of lactic acid bacteria","volume":"86","author":"Garbacz","year":"2022","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.aninu.2025.04.005_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6867962","article-title":"Lactobacillus plantarum and lactobacillus brevis alleviate intestinal inflammation and microbial disorder induced by etec in a murine model","volume":"2021","author":"Han","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.aninu.2025.04.005_bib24","doi-asserted-by":"crossref","first-page":"10564","DOI":"10.1039\/D3FO03233G","article-title":"Epigallocatechin gallate alleviates osteoporosis by regulating the gut microbiota and serum metabolites in rats","volume":"14","author":"Han","year":"2023","journal-title":"Food Funct"},{"key":"10.1016\/j.aninu.2025.04.005_bib25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.17925\/EE.2022.18.2.82","article-title":"Apoc3 interference for familial chylomicronaemia syndrome","volume":"18","author":"Hegele","year":"2022","journal-title":"touchREV Endocrinol"},{"key":"10.1016\/j.aninu.2025.04.005_bib26","article-title":"Sdr16c5 promotes proliferation and migration and inhibits apoptosis in pancreatic cancer","volume":"18","author":"Hong","year":"2023","journal-title":"Open Life Sci"},{"key":"10.1016\/j.aninu.2025.04.005_bib27","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s41590-023-01498-x","article-title":"St3gal1 and \u03b2ii-spectrin pathways control car t cell migration to target tumors","volume":"24","author":"Hong","year":"2023","journal-title":"Nat Immunol"},{"key":"10.1016\/j.aninu.2025.04.005_bib28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejphar.2012.11.030","article-title":"Linoleoyl ethanolamide reduces lipopolysaccharide-induced inflammation in macrophages and ameliorates 2,4-dinitrofluorobenzene-induced contact dermatitis in mice","volume":"699","author":"Ishida","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.aninu.2025.04.005_bib29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainresbull.2021.01.010","article-title":"\u0392-1, 3-galactosyltransferase 2 deficiency exacerbates brain injury after transient focal cerebral ischemia in mice","volume":"169","author":"Jia","year":"2021","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.aninu.2025.04.005_bib30","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.ijmm.2016.05.016","article-title":"Sj\u00f6ling \u00c5 Identification of new heat-stable (sta) enterotoxin allele variants produced by human enterotoxigenic escherichia coli (etec)","volume":"306","author":"Joffr\u00e9","year":"2016","journal-title":"Int J Med Microbiol"},{"key":"10.1016\/j.aninu.2025.04.005_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrmicro818","article-title":"L pathogenic escherichia coli","volume":"2","author":"Kaper","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.aninu.2025.04.005_bib32","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.4014\/jmb.1906.06064","article-title":"Role of probiotics in human gut microbiome-associated diseases","volume":"29","author":"Kim","year":"2019","journal-title":"J Microbiol Biotechnol"},{"key":"10.1016\/j.aninu.2025.04.005_bib33","article-title":"Phosphatidylserine (ps) and phosphatidylglycerol (pg) nanodispersions as potential anti-inflammatory therapeutics: comparison of in vitro activity and impact of pegylation","volume":"23","author":"Klein","year":"2020","journal-title":"Nanomedicine"},{"key":"10.1016\/j.aninu.2025.04.005_bib34","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1038\/s41467-023-36910-5","article-title":"Overcoming adaptive resistance to anti-vegf therapy by targeting cd5l","volume":"14","author":"LaFargue","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.aninu.2025.04.005_bib35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.vetimm.2013.09.002","article-title":"Effect of lactobacillus brevis atcc 8287 as a feeding supplement on the performance and immune function of piglets","volume":"158","author":"L\u00e4hteinen","year":"2014","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.aninu.2025.04.005_bib36","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/lipd.12152","article-title":"The furan fatty acid 9m5 acts as a partial ligand to peroxisome proliferator-activated receptor gamma and enhances adipogenesis in 3t3-l1 preadipocytes","volume":"54","author":"Lauvai","year":"2019","journal-title":"Lipids"},{"key":"10.1016\/j.aninu.2025.04.005_bib37","article-title":"Gut microbiota and diarrhea: an updated review","volume":"11","author":"Li","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.aninu.2025.04.005_bib38","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.2527\/jas.2009-2771","article-title":"Chito-oligosaccharide reduces diarrhea incidence and attenuates the immune response of weaned pigs challenged with escherichia coli k88","volume":"88","author":"Liu","year":"2010","journal-title":"J Anim Sci"},{"key":"10.1016\/j.aninu.2025.04.005_bib39","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for rna-seq data with deseq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.aninu.2025.04.005_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.591408","article-title":"Lactobacillus pentosus increases the abundance of akkermansia and affects the serum metabolome to alleviate dss-induced colitis in a murine model","volume":"8","author":"Ma","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.aninu.2025.04.005_bib41","article-title":"Epigallocatechin gallate can protect mice from acute stress induced by lps while stabilizing gut microbes and serum metabolites levels","volume":"12","author":"Ma","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.aninu.2025.04.005_bib42","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.plipres.2013.12.001","article-title":"Regulation of energy metabolism by long-chain fatty acids","volume":"53","author":"Nakamura","year":"2014","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.aninu.2025.04.005_bib43","series-title":"Nutrient requirements of swine","year":"2012"},{"key":"10.1016\/j.aninu.2025.04.005_bib44","doi-asserted-by":"crossref","first-page":"5865","DOI":"10.1038\/s41467-020-19575-2","article-title":"St3gal1 is a target of the sox2-gli1 transcriptional complex and promotes melanoma metastasis through axl","volume":"11","author":"Pietrobono","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.aninu.2025.04.005_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24244545","article-title":"The role of phosphatidylethanolamine adducts in modification of the activity of membrane proteins under oxidative stress","volume":"24","author":"Pohl","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.aninu.2025.04.005_bib46","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/14787210.2022.2128765","article-title":"Lactic acid bacteria: prominent player in the fight against human pathogens","volume":"20","author":"Saha","year":"2022","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.aninu.2025.04.005_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104555","article-title":"Macrophage cd5l is a target for cancer immunotherapy","volume":"91","author":"Sanchez-Moral","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.aninu.2025.04.005_bib48","doi-asserted-by":"crossref","first-page":"359","DOI":"10.5551\/jat.7013","article-title":"The role of neutral cholesterol ester hydrolysis in macrophage foam cells","volume":"18","author":"Sekiya","year":"2011","journal-title":"J Atherosclerosis Thromb"},{"key":"10.1016\/j.aninu.2025.04.005_bib49","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1248\/cpb.37.3247","article-title":"Fasciculic acids a, b and c as calmodulin antagonists from the mushroom naematoloma fasciculare","volume":"37","author":"Takahashi","year":"1989","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1016\/j.aninu.2025.04.005_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18122730","article-title":"Lysophospholipid-related diseases and ppar\u03b3 signaling pathway","volume":"18","author":"Tsukahara","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.aninu.2025.04.005_bib51","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1097\/INF.0b013e3182975047","article-title":"The role of epsilonproteobacteria in children with gastroenteritis","volume":"32","author":"Vandenberg","year":"2013","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.aninu.2025.04.005_bib52","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.tim.2023.11.001","article-title":"Colonization factors of human and animal-specific enterotoxigenic escherichia coli (etec)","volume":"32","author":"von Mentzer","year":"2024","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.aninu.2025.04.005_bib53","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.3389\/fmicb.2018.01953","article-title":"Probiotic lactobacillus plantarum promotes intestinal barrier function by strengthening the epithelium and modulating gut microbiota","volume":"9","author":"Wang","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.aninu.2025.04.005_bib54","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1158\/2326-6066.CIR-21-0691","article-title":"P2rx7 enhances tumor control by cd8+ t cells in adoptive cell therapy","volume":"10","author":"Wanhainen","year":"2022","journal-title":"Cancer Immunol Res"},{"key":"10.1016\/j.aninu.2025.04.005_bib55","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.2527\/jas.2013-6619","article-title":"Effect of lactobacillus plantarum on diarrhea and intestinal barrier function of young piglets challenged with enterotoxigenic escherichia coli k88","volume":"92","author":"Yang","year":"2014","journal-title":"J Anim Sci"},{"key":"10.1016\/j.aninu.2025.04.005_bib56","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s00540-010-0912-7","article-title":"Colforsin-induced vasodilation in chronic hypoxic pulmonary hypertension in rats","volume":"24","author":"Yokochi","year":"2010","journal-title":"J Anesth"},{"key":"10.1016\/j.aninu.2025.04.005_bib57","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1017\/S0007114509289033","article-title":"Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (zo-1) expression in weaning piglets","volume":"102","author":"Zhang","year":"2009","journal-title":"Br J Nutr"},{"key":"10.1016\/j.aninu.2025.04.005_bib58","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/bib\/bby008","article-title":"Inferring and analyzing module-specific lncrna-mrna causal regulatory networks in human cancer","volume":"20","author":"Zhang","year":"2019","journal-title":"Briefings Bioinf"}],"container-title":["Animal Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405654525000794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405654525000794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:49:13Z","timestamp":1778881753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405654525000794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":50,"alternative-id":["S2405654525000794"],"URL":"https:\/\/doi.org\/10.1016\/j.aninu.2025.04.005","relation":{},"ISSN":["2405-6545"],"issn-type":[{"value":"2405-6545","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactobacillus plantarum and Lactobacillus brevis alleviate enterotoxigenic Escherichia coli-induced intestinal inflammation and stabilize intestinal microorganisms and serum metabolites in piglets","name":"articletitle","label":"Article Title"},{"value":"Animal Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aninu.2025.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}