{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:17:14Z","timestamp":1791328634516,"version":"4.3.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Reproduction Science"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.anireprosci.2015.05.011","type":"journal-article","created":{"date-parts":[[2015,5,16]],"date-time":"2015-05-16T12:16:50Z","timestamp":1431778610000},"page":"46-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["l-Arginine supplementation 0.5% of diet during the last 90 days of gestation and 14 days postpartum reduced uterine fluid accumulation in the broodmare"],"prefix":"10.1016","volume":"159","author":[{"given":"A.M.","family":"Mesa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.K.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Sheehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.E.","family":"Kelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6839-071X","authenticated-orcid":false,"given":"C.J.","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anireprosci.2015.05.011_bib0005","series-title":"Equine Reproduction","first-page":"517","article-title":"Embryonic death in mares","author":"Ball","year":"1993"},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0010","first-page":"428","article-title":"Maternal amino acid supplementation for intrauterine growth restriction","volume":"3","author":"Brown","year":"2011","journal-title":"Front. Biosci. (Schol. Ed.)"},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0015","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0026-0495(94)90166-X","article-title":"Plasma arginine kinetics in adult man: response to an arginine-free diet","volume":"43","author":"Castillo","year":"1994","journal-title":"Metabolism"},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0160","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1095\/biolreprod59.4.933","article-title":"Regulation of inducible nitric oxide synthase messenger ribonucleic acid expression in pregnant rat uterus","volume":"59","author":"Dong","year":"1998","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0020","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2527\/jas1987.651179x","article-title":"Effect of excess levels of methionine, tryptophan, arginine, lysine or threonine on growth and dietary choice in the pig","volume":"65","author":"Edmonds","year":"1987","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0165","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0002-9378(99)70499-0","article-title":"Localized increase in nitric oxide production and the expression of nitric oxide synthase isoforms in rat uterus with experimental intrauterine infection","volume":"181","author":"Fang","year":"1999","journal-title":"Am. J. Obstet. General."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0025","first-page":"89","article-title":"The role of nitric oxide in l-arginine-stimulated growth hormone release","volume":"22","author":"Fisker","year":"1999","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0030","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1073\/pnas.91.2.539","article-title":"Role of nitric oxide in eicosanoid synthesis and uterine motility in estrogen-treated rat uteri","volume":"91","author":"Franchi","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0035","series-title":"Ultrasonic Imaging and Animal Reproduction: Color-Doppler Ultrasonography","author":"Ginther","year":"2007"},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0040","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2527\/jas1983.57199x","article-title":"Effects of excess arginine on swine growth and plasma amino acid levels","volume":"57","author":"Hagemeier","year":"1983","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0045","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.anireprosci.2013.03.001","article-title":"Oral l-arginine supplementation impacts several reproductive parameters during the postpartum period in mares","volume":"138","author":"Kelley","year":"2013","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0050","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.theriogenology.2013.12.012","article-title":"Influence of l-arginine supplementation on reproductive blood flow and embryo recovery rates in mares","volume":"81","author":"Kelley","year":"2014","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0055","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.2527\/jas.2014-7690","article-title":"Orally supplemented l-arginine impairs amino acid absorption depending on dose in horses","volume":"92","author":"Kelley","year":"2014","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0060","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.placenta.2005.04.011","article-title":"Reduced l-arginine level and decreased placental eNOS activity in preeclampsia","volume":"27","author":"Kim","year":"2006","journal-title":"Placenta"},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0065","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1056\/NEJM197109092851105","article-title":"Human maternal and fetal insulin response to arginine","volume":"285","author":"King","year":"1971","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0070","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.jnutbio.2011.06.012","article-title":"l-Arginine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells","volume":"23","author":"Kong","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0075","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1242\/jcs.051011","article-title":"mTOR signaling at a glance","volume":"122","author":"Laplante","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0080","doi-asserted-by":"crossref","first-page":"849","DOI":"10.3945\/jn.111.138172","article-title":"Parenteral administration of l-arginine enhances fetal survival and growth in sheep carrying multiple fetuses","volume":"141","author":"Lassala","year":"2011","journal-title":"J. Nutr."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0085","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.2042-3292.2005.tb00335.x","article-title":"Breeding mares on foal heat","volume":"17","author":"Macpherson","year":"2005","journal-title":"Equine Vet. Educ."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0090","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0093-691X(02)00829-4","article-title":"Effect of intra-uterine fluid accumulation during and after foal-heat and of different management techniques of postpartum fertility of thoroughbred mares","volume":"58","author":"Malschitzky","year":"2002","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0095","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/jn\/137.3.652","article-title":"Dietary l-arginine supplementation enhances the reproductive performance of gilts","volume":"137","author":"Mateo","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0100","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jevs.2011.01.004","article-title":"Supplemental l-arginine shortens gestation length and increases mare uterine blood flow before and after parturition","volume":"514\u2013520","author":"Mortensen","year":"2011","journal-title":"J. Equine Vet. Sci."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0105","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1172\/JCI1560","article-title":"Nitric oxide synthase modulates angiogenesis in response to tissue ischemia","volume":"101","author":"Murohara","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0110","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0272-6386(96)90265-6","article-title":"Salt-sensitive hypertension: lessons from animal models","volume":"28","author":"Sanders","year":"1996","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0115","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0895-7061(99)00233-2","article-title":"Blood pressure and metabolic changes during dietary l-arginine supplementation in humans","volume":"13","author":"Siani","year":"2000","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0170","first-page":"339","article-title":"Relationship between vascularity of the preovulatory follicle and establishment of pregnancy in mares","volume":"3","author":"Silva","year":"2006","journal-title":"Anim. Reprod."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0120","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1095\/biolreprod61.1.8","article-title":"Endogenous nitric oxide suppresses rat myometrial connexin 43 gap junction protein expression during pregnancy","volume":"61","author":"Sladek","year":"1999","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0125","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.2527\/jas.2011-4713","article-title":"Impact of moderate exercise on ovarian blood flow and early embryonic outcomes in mares","volume":"90","author":"Smith","year":"2012","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0130","series-title":"Biology and Mechanics of Blood Flows Part I: Biology","author":"Thiriet","year":"2008"},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0135","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0002-9378(98)80007-0","article-title":"Dietary l-arginine prevents fetal growth restriction in rats","volume":"178","author":"Vosatka","year":"1998","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0140","doi-asserted-by":"crossref","first-page":"E195","DOI":"10.2527\/jas.2009-2446","article-title":"Impacts of amino acid nutrition on pregnancy outcome in pigs: mechanisms and implications for swine production","volume":"88","author":"Wu","year":"2010","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0145","doi-asserted-by":"crossref","first-page":"1673S","DOI":"10.1093\/jn\/137.6.1673S","article-title":"Pharmacokinetics and safety of arginine supplementation in animals","volume":"137","author":"Wu","year":"2007","journal-title":"J. Nutr."},{"issue":"Pt 1","key":"10.1016\/j.anireprosci.2015.05.011_bib0150","first-page":"1","article-title":"Arginine metabolism: nitric oxide and beyond","volume":"336","author":"Wu","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.anireprosci.2015.05.011_bib0155","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1084\/jem.20040224","article-title":"Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events","volume":"200","author":"Yost","year":"2004","journal-title":"J. Exp. Med."}],"container-title":["Animal Reproduction Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432015001165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432015001165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:31:31Z","timestamp":1759905091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378432015001165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":34,"alternative-id":["S0378432015001165"],"URL":"https:\/\/doi.org\/10.1016\/j.anireprosci.2015.05.011","relation":{},"ISSN":["0378-4320"],"issn-type":[{"value":"0378-4320","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"l-Arginine supplementation 0.5% of diet during the last 90 days of gestation and 14 days postpartum reduced uterine fluid accumulation in the broodmare","name":"articletitle","label":"Article Title"},{"value":"Animal Reproduction Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anireprosci.2015.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}