{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:55:26Z","timestamp":1777600526880,"version":"3.51.4"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Mississippi Agricultural Forestry"},{"name":"Experiment Station"},{"name":"Selcuk University"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Reproduction Science"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.anireprosci.2016.02.015","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T15:23:19Z","timestamp":1455981799000},"page":"88-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Sperm macromolecules associated with bull fertility"],"prefix":"10.1016","volume":"169","author":[{"given":"Abdullah","family":"Kaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdo\u011fan","family":"Memili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anireprosci.2016.02.015_bib0005","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1096\/fj.14-256495","article-title":"Sperm-derived WW domain-binding protein PAWP, elicits calcium oscillations and oocyte activation in humans and mice","volume":"28","author":"Aarabi","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0010","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.7150\/ijms.6395","article-title":"Mammalian sperm fertility related proteins","volume":"10","author":"Ashrafzadeh","year":"2013","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0015","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1470-8744.1987.tb00465.x","article-title":"Highperformance liquid chromatographic separation and partial characterization of human protamines 1, 2, and 3","volume":"9","author":"Balhorn","year":"1987","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0020","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/gb-2007-8-9-227","article-title":"The protamine family of sperm nuclear proteins","volume":"8","author":"Balhorn","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0025","series-title":"Abnormal Morphology of Bovine Spermatozoa","author":"Barth","year":"1989"},{"issue":"1","key":"10.1016\/j.anireprosci.2016.02.015_bib0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1530\/REP-08-0503","article-title":"Spermatozoal transcriptome profiling for bull sperm motility: a potential tool to evaluate semen quality","volume":"138","author":"Bissonnette","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0035","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.3168\/jds.2010-3728","article-title":"A whole-genome association analysis of noncompensatory fertility in Holstein bulls","volume":"94","author":"Blaschek","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0040","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/molehr\/5.5.433","article-title":"Evidence that a functional fertilin-like ADAM plays a role in human sperm\u2014oolemmal interactions","volume":"5","author":"Bronson","year":"1999","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0045","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1095\/biolreprod.112.103788","article-title":"Cryopreserved bovine spermatozoal transcript profile as revealed by high-throughput ribonucleic acid sequencing","volume":"88","author":"Card","year":"2013","journal-title":"J. Biol. Reprod."},{"issue":"4","key":"10.1016\/j.anireprosci.2016.02.015_bib0050","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.theriogenology.2014.10.015","article-title":"Comparative transcript profiling of gene expression of fresh and frozen-thawed bull sperm","volume":"83","author":"Chen","year":"2014","journal-title":"Theriogenology"},{"issue":"E. Suppl","key":"10.1016\/j.anireprosci.2016.02.015_bib0055","doi-asserted-by":"crossref","first-page":"E93","DOI":"10.3168\/jds.S0022-0302(04)70065-X","article-title":"Sustaining the fertility of artificially inseminated dairy cattle: the role of the artificial insemination industry","volume":"87","author":"DeJarnette","year":"2004","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0060","unstructured":"DeJarnette, J.M., 2010. Understanding estimates of sire fertility: from A to Z. In: Proc. 14th Tech. Conf. on Artif. Insem. and Reprod., Nat\u2019l Assoc. Animal Breeders, Milwaukee, WI."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0065","first-page":"92","article-title":"Sperm chromatin structure reflects fertility phenotypes in breeding bulls","volume":"92","author":"Dogan","year":"2015","journal-title":"J. Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0070","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.rbmo.2010.06.022","article-title":"Transcriptome analyses of bull spermatozoa: implications for male fertility","volume":"21","author":"Feugang","year":"2010","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0075","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1530\/REP-06-0292","article-title":"A molecular analysis of the population of mRNA in bovine spermatozoa","volume":"133","author":"Gilbert","year":"2007","journal-title":"Reproduction"},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0080","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.anireprosci.2006.12.010","article-title":"Assessment of in vitro sperm characteristics in relation to fertility in dairy bulls","volume":"103","author":"Gillan","year":"2008","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0085","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1477-7827-10-82","article-title":"Dynamics of microRNAs in bull spermatozoa","volume":"10","author":"Govindaraju","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0090","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s00441-012-1452-2","article-title":"Delivering value from sperm proteomics for fertility","volume":"349","author":"Govindaraju","year":"2012","journal-title":"J. Cell Tissue Res."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0095","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nature08162","article-title":"Distinctive chromatin in human sperm packages genes for embryo development","volume":"460","author":"Hammoud","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0100","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nature03362","article-title":"The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs","volume":"434","author":"Inoue","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0105","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/mrd.21359","article-title":"PLC\u03b6 and its role as a trigger of development in vertebrates","volume":"78","author":"Ito","year":"2011","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0110","first-page":"01930","article-title":"Decreased fecundity and sperm DNA methylation patterns","author":"Jenkins","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0115","unstructured":"Johnson, L.A., Wilker, C.E., Cerelli, J.S., 1994. Spermatogenesis in the bull. In: Proc. 15th Tech. Conf. on Artif. Insem. and Reprod., pp 9\u201327 NAAB. Columbia, Missouri."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0120","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1093\/humrep\/der329","article-title":"A survey of small RNAs in human sperm","volume":"26","author":"Krawetz","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0125","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jprot.2014.07.024","article-title":"Qualitative and quantitative peptidomic and proteomic approaches to phenotyping chicken semen","volume":"112","author":"Labas","year":"2015","journal-title":"J. Proteomics"},{"issue":"4","key":"10.1016\/j.anireprosci.2016.02.015_bib0130","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1095\/biolreprod.106.059030","article-title":"Transcriptome analysis of bull semen with extreme nonreturn rate: use of suppression-subtractive hybridization to identify functional markers for fertility","volume":"78","author":"Lalancette","year":"2008","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0135","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1073\/pnas.1110368109","article-title":"Sperm-borne microRNA-34c is required for the first cleavage division in mouse","volume":"109","author":"Liu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0140","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3168\/jds.S0022-0302(01)70158-0","article-title":"Reproductive loss in high-producing dairy cattle: where will it end?","volume":"84","author":"Lucy","year":"2001","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0145","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/nar\/18.5.1249","article-title":"The lack of protamine 2 (P2) in boar and bull spermatozoa is due to mutations within the P2 gene","volume":"18","author":"Maier","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0150","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/j.1939-4640.2003.tb02692.x","article-title":"Marked differences in protamine content and P1\/P2 ratios in sperm cells from percoll fractions between patients and controls","volume":"24","author":"Mengual","year":"2003","journal-title":"J. Androl."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0155","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.molmed.2005.02.006","article-title":"The controversy, potential and roles of spermatozoal RNA","volume":"11","author":"Miller","year":"2005","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0160","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/aja.2010.65","article-title":"Proteomics and the genetics of sperm chromatin condensation","volume":"13","author":"Oliva","year":"2011","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0165","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/humupd\/dml009","article-title":"Protamines and male infertility","volume":"12","author":"Oliva","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0170","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1530\/REP-12-0399","article-title":"Molecular morphology and function of bull spermatozoa linked to histones and associated with fertility","volume":"146","author":"Oliveira","year":"2013","journal-title":"J. Reprod."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0175","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/S0140-6736(02)09899-9","article-title":"Spermatozoal RNA profiles of normal fertile men","volume":"360","author":"Ostermeier","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0180","doi-asserted-by":"crossref","DOI":"10.3906\/vet-1404-76","article-title":"Molecular, cellular and physiological determinants of bull fertility","author":"Parisi","year":"2014","journal-title":"Turk. J. Vet. Anim. Sci."},{"issue":"8","key":"10.1016\/j.anireprosci.2016.02.015_bib0185","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1021\/pr300248s","article-title":"Fertility-related proteomic profiling bull spermatozoa separated by percoll","volume":"11","author":"Park","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0190","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1752-0509-2-19","article-title":"Comprehensive proteomic analysis of bovine spermatozoa of varying fertility rates and identification of biomarkers associated with fertility","volume":"2","author":"Peddinti","year":"2008","journal-title":"BMC Syst. Biol."},{"issue":"1","key":"10.1016\/j.anireprosci.2016.02.015_bib0195","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/rda.12215","article-title":"Percentage of ubiquitinated spermatozoa does not correlate with fertilizing capacity of thawed bovine semen","volume":"49","author":"Rodr\u00edguez-Lozano","year":"2014","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0200","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1046\/j.1439-0531.2003.00436.x","article-title":"Laboratory semen assessment and prediction of fertility: still utopia?","volume":"38","author":"Rodr\u00edguez-Mart\u00ednez","year":"2003","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0205","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1017\/S1357729800051845","article-title":"Declining fertility in dairy cattle: changes in traditional and endocrine parameters of fertility","volume":"70","author":"Royal","year":"2000","journal-title":"Anim. Sci."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0210","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.theriogenology.2008.04.012","article-title":"Sperm morphology: its relevance to compensable and uncompensable traits in semen","volume":"70","author":"Saacke","year":"2008","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0215","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1530\/rep.1.01021","article-title":"Developmental and molecular correlates of bovine preimplantation embryos","volume":"131","author":"Sagirkaya","year":"2006","journal-title":"J. Reprod."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0220","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.theriogenology.2015.07.035","article-title":"Use of combinations of in vitro quality assessments to predict fertility of bovine semen","volume":"84","author":"Sellem","year":"2015","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0225","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1186\/1471-2164-15-451","article-title":"An integrated platform for bovine DNA methylome analysis suitable for small samples","volume":"15","author":"Shojaei Saadi","year":"2014","journal-title":"BMC Genomics"},{"issue":"6261","key":"10.1016\/j.anireprosci.2016.02.015_bib0230","doi-asserted-by":"crossref","DOI":"10.1126\/science.aab2006","article-title":"Disruption of histone methylation in developing sperm impairs offspring health transgenerationally","volume":"350","author":"Siklenka","year":"2015","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.anireprosci.2016.02.015_bib0235","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1039\/c3mb25494a","article-title":"Unravelling the bull fertility proteome","volume":"9","author":"Soggiu","year":"2013","journal-title":"Mol. Biosyst."},{"issue":"4","key":"10.1016\/j.anireprosci.2016.02.015_bib0240","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4103\/1008-682X.153847","article-title":"Negative biomarker based male fertility evaluation: sperm phenotypes associated with molecular-level anomalies","volume":"17","author":"Sutovsky","year":"2015","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0245","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1471-213X-10-67","article-title":"Gene trap mutation of murine outer dense fiber protein-2 gene can result in sperm tail abnormalities in mice with high percentage chimaerism","volume":"10","author":"Tarnasky","year":"2010","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0250","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.theriogenology.2014.06.012","article-title":"Genome-wide profiling of sperm DNA methylation in relation to buffalo (Bubalus bubalis) bull fertility","volume":"82","author":"Verma","year":"2014","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0255","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1095\/biolreprod44.4.569","article-title":"DNA packaging and organization in mammalian spermatozoa: comparison with somatic cells","volume":"44","author":"Ward","year":"1991","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2016.02.015_bib0260","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.fertnstert.2006.06.057","article-title":"Identification of several proteins involved in regulation of sperm motility by proteomic analysis","volume":"87","author":"Zhao","year":"2007","journal-title":"Fertil. Steril."}],"container-title":["Animal Reproduction Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432016300550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432016300550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:32:43Z","timestamp":1759905163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378432016300550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":52,"alternative-id":["S0378432016300550"],"URL":"https:\/\/doi.org\/10.1016\/j.anireprosci.2016.02.015","relation":{},"ISSN":["0378-4320"],"issn-type":[{"value":"0378-4320","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sperm macromolecules associated with bull fertility","name":"articletitle","label":"Article Title"},{"value":"Animal Reproduction Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anireprosci.2016.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}