{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:27:19Z","timestamp":1777519639820,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Fondecyt","award":["11130206"],"award-info":[{"award-number":["11130206"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Reproduction Science"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.anireprosci.2017.04.006","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T19:01:43Z","timestamp":1493838103000},"page":"28-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Effects of leptin administration on development, vascularization and function of Corpus luteum in alpacas submitted to pre-ovulatory fasting"],"prefix":"10.1016","volume":"182","author":[{"given":"Mar\u00eda Cecilia","family":"Norambuena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Maureira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Rubilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Alfaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"Ulloa-Leal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anireprosci.2017.04.006_bib0005","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1095\/biolreprod63.1.127","article-title":"Leptin gene expression, circulating leptin, and luteinizing hormone pulsatility are acutely responsive to short-term fasting in prepubertal heifers: relationships to circulating insulin and insulin-like growth factor I","volume":"63","author":"Amstalden","year":"2000","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0010","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1095\/biolreprod66.5.1555","article-title":"Central infusion of recombinant ovine leptin normalize plasma insulin and stimulates a novel hypersecretion of luteinizing hormone after short-term fasting in mature beef cows","volume":"66","author":"Amstalden","year":"2002","journal-title":"Biol. Reprod."},{"issue":"83","key":"10.1016\/j.anireprosci.2017.04.006_bib0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.anireprosci.2004.04.022","article-title":"Vascular control of ovarian function: ovulation, Corpus luteum formation and regression","volume":"82","author":"Acosta","year":"2004","journal-title":"Anim. Reprod. Sci."},{"issue":"6","key":"10.1016\/j.anireprosci.2017.04.006_bib0020","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/hep.20965","article-title":"Upregulation of pro-inflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells","volume":"42","author":"Allefi","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0025","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1177\/002215540305101003","article-title":"Leptin expression in the rat ovary depends on estrous cycle","volume":"51","author":"Archanco","year":"2003","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0030","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1210\/endo.137.7.8770941","article-title":"Leptin is a metabolic signal to the reproductive system","volume":"137","author":"Barash","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0035","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1096\/fj.04-2271fje","article-title":"Leptin induces ovulation in GnRH deficient mice","volume":"19","author":"Barkan","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0040","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1095\/biolreprod45.4.553","article-title":"The effect of ovarian follicle size on pituitary and ovarian responses to copulation in domesticated South American camelid","volume":"45","author":"Bravo","year":"1991","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.anireprosci.2017.04.006_bib0045","first-page":"371","article-title":"Angiogenic factors and ovarian follicle development","volume":"6","author":"Bruno","year":"2009","journal-title":"Anim. Reprod."},{"issue":"6","key":"10.1016\/j.anireprosci.2017.04.006_bib0050","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/rda.12762","article-title":"Hormonal changes and follicular activity after treatment with intravaginal progesterone-releasing devices in llamas","volume":"51","author":"Cavilla","year":"2016","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0055","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0378-4320(01)00173-7","article-title":"Ovarian follicular wave pattern and the effect of exogenous progesterone on follicular activity in non-mated llamas","author":"Chavez","year":"2002","journal-title":"Anim. Reprod. Sci."},{"issue":"1","key":"10.1016\/j.anireprosci.2017.04.006_bib0060","doi-asserted-by":"crossref","first-page":"T37","DOI":"10.1530\/JOE-14-0413","article-title":"20 years of leptin: leptin and reproduction: past milestones, present undertakings, and future endeavors","volume":"223","author":"Chehab","year":"2014","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.domaniend.2005.02.026","article-title":"Leptin expression in ruminants: nutritional and physiological regulation in relation with energy metabolism","volume":"29","author":"Chilliard","year":"2005","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0070","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.smallrumres.2004.10.004","article-title":"Carcass characteristics of Peruvian llama (Lama glama) and alpaca (Lama pacos) reared in the Andean highlands","volume":"58","author":"Cristofanelli","year":"2005","journal-title":"Small Rumin. Res."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0075","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1017\/S0007114507704968","article-title":"Body fat content and feeding level interact strongly in the short- and medium-term regulation of plasma leptin during underfeeding and re-feeding in adult sheep","volume":"98","author":"Delavaud","year":"2007","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0080","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1677\/JOE-07-0622","article-title":"Leptin modulates the expression of its receptors in the hypothalamic\u2013pituitary\u2013ovarian axis in a differential way","volume":"198","author":"Di Yorio","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0085","first-page":"115","article-title":"Leptin determination and serum levels in adult alpacas with different body condition","volume":"18","author":"Enciso","year":"2007","journal-title":"Rev. Inv. Vet."},{"issue":"12","key":"10.1016\/j.anireprosci.2017.04.006_bib0090","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1056\/NEJM199909163411204","article-title":"Effects of recombinant leptin therapy in a child with congenital leptin deficiency","volume":"341","author":"Farooqi","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0095","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.anireprosci.2014.08.001","article-title":"The effect of repeated administrations of llama ovulation-inducing factor (OIF\/NGF) during the peri-ovulatory period on Corpus luteum development and function in llamas","volume":"159","author":"Fern\u00e1ndez","year":"2014","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0100","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/biolreprod\/3.2.252","article-title":"Corpus luteum function in the alpaca","volume":"3","author":"Fern\u00e1ndez-Baca","year":"1970","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.anireprosci.2017.04.006_bib0105","doi-asserted-by":"crossref","first-page":"T1","DOI":"10.1530\/JOE-14-0405","article-title":"20 years of leptin: leptin at 20: an overview","volume":"223","author":"Friedman","year":"2014","journal-title":"J. Endocrinol."},{"issue":"6","key":"10.1016\/j.anireprosci.2017.04.006_bib0110","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1530\/rep.1.00256","article-title":"Direct in vivo effects of leptin on ovarian steroidogenesis in sheep","volume":"128","author":"Kendall","year":"2004","journal-title":"Reproduction"},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0115","series-title":"Proceedings of ICAR 2012. Satellite Meeting on Camelid Reproduction","article-title":"Identification of the ovulation-inducing factor in alpaca seminal plasma","author":"Kershaw-Young","year":"2012"},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0120","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.anireprosci.2012.08.030","article-title":"Expression of leptin and its receptor in Corpus luteum during estrous cycle in buffalo (Bubalus bubalis)","volume":"135","author":"Kumar","year":"2012","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0125","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1095\/biolreprod.103.021345","article-title":"Leptin prevents fasting-mediated reductions in pulsatile secretion of luteinizing hormone and enhances its gonadotropin-releasing hormone-mediated release in heifers","volume":"70","author":"Maciel","year":"2004","journal-title":"Biol. Reprod."},{"issue":"9","key":"10.1016\/j.anireprosci.2017.04.006_bib0130","doi-asserted-by":"crossref","first-page":"412","DOI":"10.17221\/77\/2009-VETMED","article-title":"Altered plasma triglyceride-rich lipoproteins and triglyceride secretion in feed-restricted pregnant ewes","volume":"54","author":"Mazuri","year":"2009","journal-title":"Vet. Med."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0135","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1530\/rep.1.00557","article-title":"The ovarian expression of mRNAs for aromatase, IGF-I receptor, IGF-binding protein-2, -4 and -5, leptin and leptin receptor in cycling ewes after three days of leptin infusion","volume":"130","author":"Mu\u00f1oz-Gutierrez","year":"2005","journal-title":"Reproduction"},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0140","first-page":"11","article-title":"Leptin regulates pulsatile luteinizing hormone and growth hormone secretion in sheep","volume":"141","author":"Nagatani","year":"2000","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.anireprosci.2017.04.006_bib0145","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/1745039X.2014.912039","article-title":"Energy metabolism and methane production in llamas, sheep and goats fed high- and low-quality grass-based diets","volume":"68","author":"Nielsen","year":"2014","journal-title":"Arch. Anim. Nutr."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0150","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.anireprosci.2013.01.019","article-title":"Effects of nutritional restriction on metabolic and ovarian function in llamas (Lama glama)","volume":"138","author":"Norambuena","year":"2013","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0155","first-page":"74","article-title":"Luteinizing hormone pulse frequency is increased by arginine infusion in prepubertal sheep","volume":"104","author":"Recabarren","year":"1996","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0160","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mce.2005.07.007","article-title":"Leptin enhances ovulation and attenuates the effects produced by food restriction","volume":"242","author":"Roman","year":"2005","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0165","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1095\/biolreprod65.3.879","article-title":"Evidence for a role of capillary pericytes in vascular growth of the developing ovine Corpus luteum","volume":"65","author":"Redmer","year":"2001","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0170","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/mrd.21129","article-title":"The expresion of leptin and its receptor during different physiological stages in the bovine ovary","volume":"77","author":"Sarkar","year":"2010","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0175","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1095\/biolreprod.102.006734","article-title":"Changes of messenger RNA expression of angiogenic factors and related receptors during follicular development in gilts","volume":"67","author":"Shimizu","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0180","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1477-7827-9-74","article-title":"Cetrorelix suppress the preovulatory LH surge and ovulation induced by ovulation-inducing factor (OIF) present in llama seminal plasma","volume":"9","author":"Silva","year":"2011","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0185","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0378-4320(96)01538-2","article-title":"Reproduction in llamas and alpacas","volume":"42","author":"Summar","year":"1996","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0190","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.theriogenology.2014.01.038","article-title":"Luteotrophic effect of ovulation-inducing factor\/nerve growth factor present in the seminal plasma of llamas","volume":"81","author":"Ulloa-Leal","year":"2014","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0195","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cvfa.2009.03.003","article-title":"Nutritional requirements and assessing nutritional status in camelids","volume":"25","author":"Van Saun","year":"2009","journal-title":"Vet. Clin. Anim. Food"},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0200","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.anireprosci.2010.08.031","article-title":"Ovarian function in South American camelids (alpacas, llamas, vicu\u00f1as, guanacos)","volume":"124","author":"Vaughan","year":"2011","journal-title":"Anim. Reprod. Sci."},{"issue":"1","key":"10.1016\/j.anireprosci.2017.04.006_bib0205","doi-asserted-by":"crossref","first-page":"45","DOI":"10.7557\/2.21.1.1527","article-title":"Biochemical adaptation of camelids during periods when food is withheld","volume":"21","author":"Wensvoort","year":"2001","journal-title":"Rangifer"},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0210","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.anireprosci.2014.05.002","article-title":"The effect of leptin on luteal angiogenic factors during the luteal phase of the estrous cycle in goats","volume":"148","author":"Wiles","year":"2014","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2017.04.006_bib0215","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1177\/153537020322800312","article-title":"Divergent effects of leptin on luteinizing hormone and insulin secretion are dose dependent","volume":"228","author":"Zieba","year":"2003","journal-title":"Exp. Biol. Med."}],"container-title":["Animal Reproduction Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037843201630598X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037843201630598X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:35:14Z","timestamp":1759905314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037843201630598X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":43,"alternative-id":["S037843201630598X"],"URL":"https:\/\/doi.org\/10.1016\/j.anireprosci.2017.04.006","relation":{},"ISSN":["0378-4320"],"issn-type":[{"value":"0378-4320","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of leptin administration on development, vascularization and function of Corpus luteum in alpacas submitted to pre-ovulatory fasting","name":"articletitle","label":"Article Title"},{"value":"Animal Reproduction Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anireprosci.2017.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}