{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:26:48Z","timestamp":1759969608473,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Reproduction Science"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.anireprosci.2020.106347","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T11:10:20Z","timestamp":1585825820000},"page":"106347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Relative abundance and localization of interferon-stimulated gene 15 mRNA transcript in intra- and extra-uterine tissues during the early stages of pregnancy in sheep"],"prefix":"10.1016","volume":"216","author":[{"given":"Ilyas","family":"Alak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Hitit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Kose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Salih","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyyup Hakan","family":"Ucar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra","family":"Atli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet O.","family":"Atli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anireprosci.2020.106347_bib0005","article-title":"A high throughput in situ hybridization method to characterize mRNA expression patterns in the fetal mouse lower urogenital tract","volume":"54","author":"Abler","year":"2011","journal-title":"J. Vis. Exp."},{"issue":"144","key":"10.1016\/j.anireprosci.2020.106347_bib0010","first-page":"1","article-title":"Endocrine delivery of interferon tau protects the corpus luteum from prostaglandin F2 alpha-induced luteolysis in ewes","volume":"88","author":"Antoniazzi","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0015","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1210\/en.2010-0166","article-title":"Deletion of the Isg15 gene results in up-regulation of decidual cell survival genes and down-regulation of adhesion genes: implication for regulation by IL-1beta","volume":"151","author":"Ashley","year":"2010","journal-title":"Endocrinology"},{"issue":"130","key":"10.1016\/j.anireprosci.2020.106347_bib0020","first-page":"1","article-title":"Patterns of gene expression in the bovine corpus luteum following repeated intrauterine infusions of low doses of prostaglandin F2alpha","volume":"86","author":"Atli","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0025","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1210\/en.2002-0031","article-title":"Interferon-stimulated gene-15 (Isg15) expression is up-regulated in the mouse uterus in response to the implanting conceptus","volume":"144","author":"Austin","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2020.106347_bib0030","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1530\/REP-17-0290","article-title":"Interferon-tau promotes luteal endothelial cell survival and inhibits specific luteolytic genes in bovine corpus luteum","volume":"154","author":"Basavaraja","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.anireprosci.2020.106347_bib0035","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1095\/biolreprod60.4.920","article-title":"Localization of ubiquitin and ubiquitin cross-reactive protein in human and baboon endometrium and decidua during the menstrual cycle and early pregnancy","volume":"60","author":"Bebington","year":"1999","journal-title":"Biol. Reprod."},{"issue":"104468","key":"10.1016\/j.anireprosci.2020.106347_bib0040","first-page":"1","article-title":"The brain-placental axis: therapeutic and pharmacological relevancy to pregnancy","volume":"149","author":"Behura","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0045","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1095\/biolreprod65.4.1038","article-title":"Interferon regulatory factor-two restricts expression of interferon-stimulated genes to the endometrial stroma and glandular epithelium of the ovine uterus","volume":"65","author":"Choi","year":"2001","journal-title":"Biol. Reprod."},{"issue":"12704","key":"10.1016\/j.anireprosci.2020.106347_bib0050","first-page":"1","article-title":"Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis","volume":"5","author":"Fan","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0055","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1530\/jrf.0.0710057","article-title":"Proteins released by cultured Day 15-16 conceptuses prolong luteal maintenance when introduced into the uterine lumen of cyclic ewes","volume":"71","author":"Godkin","year":"1984","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0060","doi-asserted-by":"crossref","first-page":"11315","DOI":"10.1016\/S0021-9258(18)60961-5","article-title":"Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin","volume":"262","author":"Haas","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0065","doi-asserted-by":"crossref","first-page":"12801","DOI":"10.1016\/S0021-9258(18)37627-0","article-title":"Interferon RNA of embryonic origin is expressed transiently during early pregnancy in the ewe","volume":"263","author":"Hansen","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0070","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1210\/en.2004-1224","article-title":"Interferon stimulated gene 15 conjugates to endometrial cytosolic proteins and is expressed at the uterine-placental interface throughout pregnancy in sheep","volume":"146","author":"Joyce","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2020.106347_bib0075","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0006-291X(03)01216-6","article-title":"ISG15, not just another ubiquitin-like protein","volume":"307","author":"Kim","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.smallrumres.2016.05.007","article-title":"Investigation of interferon-tau stimulated genes (ISGs) simultaneously in the endometrium, corpus luteum (CL) and peripheral blood leukocytes (PBLs) in the preluteolytic stage of early pregnancy in ewes","volume":"140","author":"Kiyma","year":"2016","journal-title":"Small Rumin. Res."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0085","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1439-0531.2010.01731.x","article-title":"The expression of interferon-stimulated gene 15 in equine endometrium","volume":"46","author":"Klein","year":"2011","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0090","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.theriogenology.2015.11.032","article-title":"Expression profile of interferon tau-stimulated genes in ovine peripheral blood leukocytes during embryonic death","volume":"85","author":"Kose","year":"2016","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2020.106347_bib0095","doi-asserted-by":"crossref","first-page":"8396","DOI":"10.3168\/jds.2017-14251","article-title":"Hot topic: pregnancy-induced expression of interferon-stimulated genes in the cervical and vaginal mucosal membranes","volume":"101","author":"Kunii","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0100","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.anireprosci.2020.106347_bib0105","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1038\/jcbfm.2011.103","article-title":"Increased cerebral protein ISGylation after focal ischemia is neuroprotective","volume":"31","author":"Nakka","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0110","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1210\/en.2007-0863","article-title":"Expression of interferon (IFN)-stimulated genes in extrauterine tissues during early pregnancy in sheep is the consequence of endocrine IFN-tau release from the uterine vein","volume":"149","author":"Oliveira","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2020.106347_bib0115","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1534\/g3.115.020982","article-title":"An examination of dynamic gene expression changes in the mouse brain during pregnancy and the postpartum period","volume":"6","author":"Ray","year":"2015","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.anireprosci.2020.106347_bib0120","first-page":"432","article-title":"Interferons as hormones of pregnancy","volume":"13","author":"Roberts","year":"1992","journal-title":"Endo. Rev."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0125","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.theriogenology.2017.07.051","article-title":"Interferon-tau induced gene expression in bovine hepatocytes during early pregnancy","volume":"104","author":"Ruhmann","year":"2017","journal-title":"Theriogenology"},{"issue":"3887","key":"10.1016\/j.anireprosci.2020.106347_bib0130","first-page":"1","article-title":"Expression of chemerin and its receptors in the porcine hypothalamus and plasma chemerin levels during the oestrous cycle and early pregnancy","volume":"20","author":"Smolinska","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0135","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1530\/rep.1.00398","article-title":"Implantation mechanisms: insights from the sheep","volume":"128","author":"Spencer","year":"2004","journal-title":"Reproduction"},{"key":"10.1016\/j.anireprosci.2020.106347_bib0140","first-page":"15","article-title":"Maternal recognition of pregnancy","volume":"49","author":"Thatcher","year":"1995","journal-title":"J. Reprod. Fertil. Suppl."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0145","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/rda.12169","article-title":"A potential autocrine role for interferon tau in ovine trophectoderm","volume":"48","author":"Wang","year":"2013","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0150","first-page":"767","article-title":"Expression of ISG15 in bone marrow during early pregnancy in Ewes","volume":"23","author":"Yang","year":"2017","journal-title":"Kafkas Univ. Vet. Fak. Derg."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0155","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1111\/asj.13101","article-title":"Expression of interferon-stimulated gene 15-kDa protein, cyclooxygenase (COX) 1, COX-2, aldo-keto reductase family 1, member B1, and prostaglandin E synthase in the spleen during early pregnancy in sheep","volume":"89","author":"Yang","year":"2018","journal-title":"Anim. Sci. J."},{"key":"10.1016\/j.anireprosci.2020.106347_bib0160","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.theriogenology.2018.10.004","article-title":"Comparison of Th1 and Th2 cytokines production in ovine lymph nodes during early pregnancy","volume":"123","author":"Yang","year":"2019","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2020.106347_bib0165","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1677\/joe.0.170r007","article-title":"Expression of the antiviral protein Mx in peripheral blood mononuclear cells of pregnant and bred, non-pregnant ewes","volume":"170","author":"Yankey","year":"2001","journal-title":"J. Endo."},{"issue":"245","key":"10.1016\/j.anireprosci.2020.106347_bib0170","first-page":"1","article-title":"Modulation of helper t cytokines in Thymus during early pregnancy in ewes","volume":"9","author":"Zhang","year":"2019","journal-title":"Animals"},{"key":"10.1016\/j.anireprosci.2020.106347_bib0175","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1071\/RD15209","article-title":"Roles of interferon-stimulated gene 15 protein in bovine embryo development","volume":"29","author":"Zhao","year":"2017","journal-title":"Reprod. Fert. Develop."}],"container-title":["Animal Reproduction Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432020302190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432020302190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:43:06Z","timestamp":1759905786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378432020302190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":35,"alternative-id":["S0378432020302190"],"URL":"https:\/\/doi.org\/10.1016\/j.anireprosci.2020.106347","relation":{},"ISSN":["0378-4320"],"issn-type":[{"type":"print","value":"0378-4320"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relative abundance and localization of interferon-stimulated gene 15 mRNA transcript in intra- and extra-uterine tissues during the early stages of pregnancy in sheep","name":"articletitle","label":"Article Title"},{"value":"Animal Reproduction Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anireprosci.2020.106347","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106347"}}