{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:48:44Z","timestamp":1761709724447,"version":"build-2065373602"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Science without Borders-CNPq-GDE-USA","award":["208518\/2014-2"],"award-info":[{"award-number":["208518\/2014-2"]}]},{"name":"USDA-ARS National","award":["5042-21000-003-00D"],"award-info":[{"award-number":["5042-21000-003-00D"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Reproduction Science"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.anireprosci.2020.106464","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T02:06:36Z","timestamp":1587175596000},"page":"106464","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Effect of oral urea supplementation on the endometrial transcriptome of mares"],"prefix":"10.1016","volume":"216","author":[{"given":"Yatta","family":"Linhares Boakari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossam","family":"El-Sheikh Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pouya","family":"Dini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shavahn","family":"Loux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Barbosa Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Esteller-Vico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Scoggin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Ball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anireprosci.2020.106464_bib0005","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.placenta.2009.09.007","article-title":"A review of implantation and early placentation in the mare","volume":"30","author":"Allen","year":"2009","journal-title":"Placenta"},{"year":"2010","series-title":"FastQC: a quality control tool for high throughput sequence data","author":"Andrews","key":"10.1016\/j.anireprosci.2020.106464_bib0010"},{"key":"10.1016\/j.anireprosci.2020.106464_bib0015","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.2042-3306.1997.tb05102.x","article-title":"Success rates when attempting to nonsurgically collect equine embryos at 144, 156 or 168 hours after ovulation","volume":"25","author":"Battut","year":"1997","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0020","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1530\/rep.1.00996","article-title":"Embryo-induced transcriptome changes in bovine endometrium reveal species-specific and common molecular markers of uterine receptivity","volume":"132","author":"Bauersachs","year":"2006","journal-title":"Reproduction"},{"key":"10.1016\/j.anireprosci.2020.106464_bib0025","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3390\/genes10080576","article-title":"A high protein model alters the endometrial transcriptome of mares","volume":"10","author":"Boakari","year":"2019","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.anireprosci.2020.106464_bib0030","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0378-4320(00)00076-2","article-title":"Nutritional interactions with reproductive performance in dairy cattle","volume":"60","author":"Butler","year":"2000","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0035","doi-asserted-by":"crossref","first-page":"858","DOI":"10.2527\/1996.744858x","article-title":"Plasma and milk urea nitrogen in relation to pregnancy rate in lactating dairy cattle","volume":"74","author":"Butler","year":"1996","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0040","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/1471-2105-10-421","article-title":"BLAST+: architecture and applications","volume":"10","author":"Camacho","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.anireprosci.2020.106464_bib0045","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.2042-3306.2006.tb05620.x","article-title":"Effects on exercise response, fluid and acid-base balance of protein intake from forage-only diets in Standardbred horses","volume":"38","author":"Connysson","year":"2006","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122515","article-title":"Reference gene validation for RT-qPCR, a note on different available software packages","volume":"10","author":"De Spiegelaere","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.anireprosci.2020.106464_bib0055","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.anireprosci.2020.106464_bib0060","doi-asserted-by":"crossref","first-page":"702","DOI":"10.2527\/1993.713702x","article-title":"Alterations of pH in response to increased dietary protein in cattle are unique to the uterus","volume":"71","author":"Elrod","year":"1993","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0065","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1017\/S1357729800055892","article-title":"The effects of dietary urea on embryo development in superovulated donor ewes and on early embryo survival and development in recipient ewes","volume":"72","author":"Fahey","year":"2001","journal-title":"Anim. Sci."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0070","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.theriogenology.2018.03.017","article-title":"The anti-inflammatory effect of exogenous lactoferrin on breeding-induced endometritis when administered post-breeding in susceptible mares","volume":"114","author":"Fedorka","year":"2018","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2020.106464_bib0075","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0093-691X(91)90348-H","article-title":"Time of embryo transport through the mare oviduct","volume":"36","author":"Freeman","year":"1991","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2020.106464_bib0080","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1095\/biolreprod.112.103226","article-title":"Exploration of global gene expression changes during the estrous cycle in equine endometrium","volume":"87","author":"Gebhardt","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0085","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tibs.2006.11.001","article-title":"Cell death by necrosis: towards a molecular definition","volume":"32","author":"Golstein","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0090","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/ahe.12335","article-title":"Comparative histomorphological study of endometrium in mares","volume":"47","author":"Herrera","year":"2018","journal-title":"Anat. Histol. Embryol."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0095","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0100","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s42003-018-0199-z","article-title":"Improved reference genome for the domestic horse increases assembly contiguity and composition","volume":"1","author":"Kalbfleisch","year":"2018","journal-title":"Commun. Biol."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0105","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2017.113","article-title":"The FANTOM5 collection, a data series underpinning mammalian transcriptome atlases in diverse cell types","volume":"4","author":"Kawaji","year":"2017","journal-title":"Sci. Data"},{"key":"10.1016\/j.anireprosci.2020.106464_bib0110","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1095\/biolreprod.109.081612","article-title":"Transcriptional profiling of equine endometrium during the time of maternal recognition of pregnancy","volume":"83","author":"Klein","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0115","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/rda.12116","article-title":"Expression of aquaporin water channels in equine endometrium is differentially regulated during the oestrous cycle and early pregnancy","volume":"48","author":"Klein","year":"2013","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0120","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in Ingenuity Pathway Analysis","volume":"30","author":"Kramer","year":"2014","journal-title":"Bioinformatics"},{"year":"2012","series-title":"Trim Galore: a wrapper tool around Cutadapt and FastQC to consistently apply quality and adapter trimming to FastQ files, with some extra functionality for MspI-digested RRBS-type (Reduced Representation Bisufite-Seq) libraries","author":"Krueger","key":"10.1016\/j.anireprosci.2020.106464_bib0125"},{"key":"10.1016\/j.anireprosci.2020.106464_bib0130","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.anireprosci.2020.106464_bib0135","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1530\/REP-16-0396","article-title":"Characterization of the cervical mucus plug in mares","volume":"153","author":"Loux","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.anireprosci.2020.106464_bib0140","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/rmb2.12030","article-title":"Thin endometrium transcriptome analysis reveals a potential mechanism of implantation failure","volume":"16","author":"Maekawa","year":"2017","journal-title":"Reprod. Med. Biol."},{"issue":"6","key":"10.1016\/j.anireprosci.2020.106464_bib0145","first-page":"1","article-title":"Conceptus-endometrium crosstalk during maternal recognition of pregnancy in cattle","volume":"87","author":"Mamo","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0150","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1079\/BJN19960043","article-title":"Utilization of endogenous and dietary urea in the large intestine of the mature horse","volume":"76","author":"Martin","year":"1996","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0155","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0378-4320(96)01627-2","article-title":"Dietary excesses of urea influence the viability and metabolism of preimplantation sheep embryos and may affect fetal growth among survivors","volume":"47","author":"McEvoy","year":"1997","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0160","first-page":"101","article-title":"Lactoferrin in the mouse uterus: analyses of the preimplantation period and regulation by ovarian steroids","volume":"6","author":"McMaster","year":"1992","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0165","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/jpn.12927","article-title":"Using the indicator amino acid oxidation technique to study threonine requirements in horses receiving a predominantly forage diet","volume":"102","author":"Mok","year":"2018","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"key":"10.1016\/j.anireprosci.2020.106464_bib0170","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/mp.55.3.186","article-title":"Temporal and spatial expression of connective tissue growth factor (CCN2; CTGF) and transforming growth factor beta type 1 (TGF-beta1) at the utero-placental interface during early pregnancy in the pig","volume":"55","author":"Moussad","year":"2002","journal-title":"Mol. Pathol."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anireprosci.2005.02.009","article-title":"Detrimental effects of high plasma urea nitrogen levels on viability of embryos from lactating dairy cows","volume":"91","author":"Rhoads","year":"2006","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0180","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/gkp045","article-title":"Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data","volume":"37","author":"Ruijter","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0185","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0378-4320(00)00138-X","article-title":"The early fetal life of the equine conceptus","volume":"60","author":"Sharp","year":"2000","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0190","doi-asserted-by":"crossref","first-page":"34254","DOI":"10.1074\/jbc.M201659200","article-title":"A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid","volume":"277","author":"Sonoda","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0195","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0200","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0205","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1152\/physiolgenomics.00065.2011","article-title":"Dietary n-3 polyunsaturated fatty acid supplementation alters the expression of genes involved in the control of fertility in the bovine uterine endometrium","volume":"44","author":"Waters","year":"2012","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.anireprosci.2020.106464_bib0210","first-page":"786","article-title":"Urea-associated oxidative stress and Gadd153\/CHOP induction","volume":"276","author":"Zhang","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.anireprosci.2020.106464_bib0215","doi-asserted-by":"crossref","first-page":"8815","DOI":"10.1038\/s41598-017-09307-w","article-title":"Extracting intercellular signaling network of cancer tissues using ligand-receptor expression patterns from whole-tumor and single-cell transcriptomes","volume":"7","author":"Zhou","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Animal Reproduction Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432020303365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432020303365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:43:26Z","timestamp":1759905806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378432020303365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":43,"alternative-id":["S0378432020303365"],"URL":"https:\/\/doi.org\/10.1016\/j.anireprosci.2020.106464","relation":{},"ISSN":["0378-4320"],"issn-type":[{"type":"print","value":"0378-4320"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of oral urea supplementation on the endometrial transcriptome of mares","name":"articletitle","label":"Article Title"},{"value":"Animal Reproduction Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anireprosci.2020.106464","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106464"}}