{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:13:34Z","timestamp":1783952014063,"version":"3.55.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["120O543"],"award-info":[{"award-number":["120O543"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Reproduction Science"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.anireprosci.2023.107276","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T15:34:09Z","timestamp":1686152049000},"page":"107276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The role of nutritional-immunological indices in estimating serum LPS and antioxidant enzyme activity and sepsis status in female dogs with pyometra caused by E. coli"],"prefix":"10.1016","volume":"255","author":[{"given":"Murat Onur","family":"Yazl\u0131k","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130pek","family":"Mutluer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"\u00d6zkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130nci Ba\u015fak","family":"M\u00fc\u015ftak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice Esra","family":"\u00c7olako\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunus Furkan","family":"Alt\u0131nba\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet R\u0131fat","family":"Vural","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.anireprosci.2023.107276_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109691","article-title":"Metabolic endotoxemia is dictated by the type of lipopolysaccharide","volume":"36","author":"Anh\u00ea","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.anireprosci.2023.107276_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/03630260802625709","article-title":"Newer aspects of the pathophysiology of sickle cell disease vaso-occlusion","volume":"33","author":"Conran","year":"2009","journal-title":"Hemoglobin"},{"key":"10.1016\/j.anireprosci.2023.107276_bib3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1939-1676.2007.0021.x","article-title":"Serial evaluation of protein C and antithrombin in dogs with sepsis","volume":"22","author":"De Laforcade","year":"2008","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.anireprosci.2023.107276_bib4","unstructured":"De S\u00e1 Santos, C.A., 2016. Molecular markers of the healthy canine endometrial cycle (Doctoral dissertation, Universidade de Tras-os-Montes e Alto Douro (Portugal))."},{"key":"10.1016\/j.anireprosci.2023.107276_bib5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2460\/ajvr.69.2.228","article-title":"Effects of subanesthetic doses of ketamine on hemodynamic and immunologic variables in dogs with experimentally induced endotoxemia","volume":"69","author":"Declue","year":"2008","journal-title":"Am. J. Vet. Res."},{"issue":"1","key":"10.1016\/j.anireprosci.2023.107276_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.tvjl.2010.04.009","article-title":"Acute phase proteins: biomarkers of infection and inflammation in veterinary medicine","volume":"185","author":"Eckersall","year":"2010","journal-title":"Vet. J."},{"issue":"6","key":"10.1016\/j.anireprosci.2023.107276_bib7","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1939-1676.2001.tb01587.x","article-title":"Breed risk of pyometra in insured dogs in Sweden","volume":"15","author":"Egenvall","year":"2001","journal-title":"J. Vet. Intern. Med."},{"issue":"12","key":"10.1016\/j.anireprosci.2023.107276_bib8","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/0955-2863(90)90020-L","article-title":"Hepatic mechanisms for clearance and detoxification of bacterial endotoxins","volume":"1","author":"Fox","year":"1990","journal-title":"J. Nutr. Biochem."},{"issue":"7","key":"10.1016\/j.anireprosci.2023.107276_bib9","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1439-0442.1997.tb01127.x","article-title":"Bacteriological findings, blood chemistry profile and plasma endotoxin levels in bitches with pyometra or other uterine diseases","volume":"44","author":"Fransson","year":"1997","journal-title":"J. Vet. Med."},{"key":"10.1016\/j.anireprosci.2023.107276_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1681\/ASN.2009020213","article-title":"Reassessment of albumin as a nutritional marker in kidney disease","volume":"21","author":"Friedman","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.anireprosci.2023.107276_bib11","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0195-5616(89)50137-2","article-title":"Septic shock","volume":"19","author":"Goodwin","year":"1989","journal-title":"Vet. Clin. North Am: Small Anim. Pr."},{"issue":"24","key":"10.1016\/j.anireprosci.2023.107276_bib12","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.ehj.2003.10.015","article-title":"Oxidative stress in heart failure: more than just damage","volume":"24","author":"Grieve","year":"2003","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.anireprosci.2023.107276_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7150\/jca.27210","article-title":"The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score is a novel significant prognostic factor for patients with metastatic prostate cancer undergoing cytoreductive radical prostatectomy","volume":"10","author":"Guo","year":"2019","journal-title":"J. Cancer"},{"issue":"Suppl. 2","key":"10.1016\/j.anireprosci.2023.107276_bib14","first-page":"288","article-title":"Canine pyometra. what is new? reprod domest anim","volume":"52","author":"Hagman","year":"2017"},{"key":"10.1016\/j.anireprosci.2023.107276_bib15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1751-0147-47-55","article-title":"Pyometra in bitches induces elevated plasma endotoxin and prostaglandin F2\u03b1 metabolite levels","volume":"47","author":"Hagman","year":"2006","journal-title":"Acta Vet. Scand."},{"key":"10.1016\/j.anireprosci.2023.107276_bib16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1104\/pp.106.077073","article-title":"Reactive species and antioxidants. redox biology is a fundamental theme of aerobic life","volume":"141","author":"Halliwell","year":"2006","journal-title":"Plant Physiol."},{"issue":"2","key":"10.1016\/j.anireprosci.2023.107276_bib17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/sj.bjp.0705776","article-title":"Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean","volume":"142","author":"Halliwell","year":"2004","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.anireprosci.2023.107276_bib18","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.freeradbiomed.2005.08.047","article-title":"Nitric oxide as a cellular antioxidant: a little goes a long way","volume":"40","author":"Hummel","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.anireprosci.2023.107276_bib19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.tvjl.2005.11.009","article-title":"Reduction of mucin-1 gene expression associated with increased Escherichia coli adherence in the canine uterus in the early stage of dioestrus","volume":"173","author":"Ishiguro","year":"2007","journal-title":"Vet. J."},{"issue":"1","key":"10.1016\/j.anireprosci.2023.107276_bib20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/mr\/roac001","article-title":"Potential of the prognostic nutritional index to determine the risk factor for severe infection in elderly patients with rheumatoid arthritis","volume":"33","author":"Isoda","year":"2023","journal-title":"Mod. Rheuma"},{"key":"10.1016\/j.anireprosci.2023.107276_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.vetimm.2016.08.010","article-title":"Comparison of cytokine responses between dogs with sepsis and dogs with immune-mediated hemolytic anemia","volume":"180","author":"Johnson","year":"2016","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.anireprosci.2023.107276_bib22","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1476-4431.1999.tb00055.x","article-title":"Nitric oxide response in critically ill dogs","volume":"9","author":"Jones","year":"1999","journal-title":"J. Vet. Emerg. Crit. Care"},{"key":"10.1016\/j.anireprosci.2023.107276_bib23","first-page":"837","article-title":"Effects of pyometra on some oxidative stress parameters, inflammatory mediators and neutrophil segmentation in bitches","volume":"22","author":"Karabulut","year":"2016","journal-title":"Kafkas Univ. Vet. Fak. Derg."},{"key":"10.1016\/j.anireprosci.2023.107276_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.vetimm.2016.01.005","article-title":"Multiplex cytokine analyses in dogs with pyometra suggest involvement of KC-like chemokine in canine bacterial sepsis","volume":"170","author":"Karlsson","year":"2016","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"1","key":"10.1016\/j.anireprosci.2023.107276_bib25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/abbi.1999.1386","article-title":"Nitric oxide inhibits iron\u2013induced lipid peroxidation in HL-60 Cells","volume":"370","author":"Kelley","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.anireprosci.2023.107276_bib26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1034\/j.1399-6576.1999.430307.x","article-title":"The role of nitric oxide in sepsis-an overview","volume":"43","author":"Kirkeb\u00f8en","year":"1999","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.anireprosci.2023.107276_bib27","first-page":"787","article-title":"Lectin binding patterns in normal canine endometrium and in bitches with pyometra and cystic endometrial hyperplasia","volume":"18","author":"Leitner","year":"2003","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.anireprosci.2023.107276_bib28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.rvsc.2020.09.005","article-title":"Effects of different doses lipopolysaccharides on the mucosal barrier in mouse intestine","volume":"133","author":"Li","year":"2020","journal-title":"Res. Vet. Sci."},{"issue":"14","key":"10.1016\/j.anireprosci.2023.107276_bib29","first-page":"3927","article-title":"The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase","volume":"60","author":"Li","year":"2020","journal-title":"Cancer Res."},{"issue":"16","key":"10.1016\/j.anireprosci.2023.107276_bib30","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1016\/j.cell.2022.06.010","article-title":"Nitric oxide signaling in health and disease","volume":"185","author":"Lundberg","year":"2022","journal-title":"Cell"},{"issue":"e31256","key":"10.1016\/j.anireprosci.2023.107276_bib31","article-title":"Prognostic nutritional index as outcome predictor in patients with iliopsoas abscess","volume":"101","author":"Matsuo","year":"2022","journal-title":"Medicine"},{"key":"10.1016\/j.anireprosci.2023.107276_bib32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00024382-200304000-00002","article-title":"Relationships of circulating nitrite\/nitrate levels to severity and multiple organ dysfunction syndrome in systemic inflammatory response syndrome","volume":"19","author":"Mitaka","year":"2003","journal-title":"Shock"},{"issue":"3","key":"10.1016\/j.anireprosci.2023.107276_bib33","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2144\/04373ST06","article-title":"Detection of bacterial endotoxin in human tissues","volume":"37","author":"Nalepka","year":"2004","journal-title":"Biotechniques"},{"issue":"8","key":"10.1016\/j.anireprosci.2023.107276_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0272232","article-title":"Impact of pre-treatment prognostic nutritional index and the haemoglobin, albumin, lymphocyte and platelet (HALP) score on endometrial cancer survival: a prospective database analysis","volume":"17","author":"Njoku","year":"2022","journal-title":"Plos One"},{"issue":"11","key":"10.1016\/j.anireprosci.2023.107276_bib35","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0891-5849(01)00724-9","article-title":"Reactive oxygen species, antioxidants, and the mammalian thioredoxin system","volume":"31","author":"Nordberg","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.anireprosci.2023.107276_bib36","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1292\/jvms.55.607","article-title":"Changes in reticuloendothelial function in dogs with endotoxin induced shock","volume":"55","author":"Okano","year":"1993","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.anireprosci.2023.107276_bib37","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1292\/jvms.60.1265","article-title":"Relationship of the blood endotoxin concentration and prognosis in dogs with pyometra","volume":"60","author":"Okano","year":"1998","journal-title":"J. Vet. Med. Sci."},{"issue":"21","key":"10.1016\/j.anireprosci.2023.107276_bib38","doi-asserted-by":"crossref","DOI":"10.1136\/vr.d5137","article-title":"Plasma nitrate\/nitrite concentrations in dogs with naturally developing sepsis and non\u2010infectious forms of the systemic inflammatory response syndrome","volume":"169","author":"Osterbur","year":"2011","journal-title":"Vet. Rec."},{"key":"10.1016\/j.anireprosci.2023.107276_bib39","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1476-4431.2007.00249.x","article-title":"Clinical trials in spontaneous disease in dogs: a new paradigm for investigations of sepsis","volume":"17","author":"Otto","year":"2007","journal-title":"J. Vet. Emerg. Crit. Care"},{"issue":"1","key":"10.1016\/j.anireprosci.2023.107276_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-19146-y","article-title":"Prognostic Significance of HALP (Hemoglo- bin, Albumin, Lymphocyte and Platelet) in Patients with Bladder Cancer after Radical Cystectomy","volume":"8","author":"Peng","year":"2018","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.anireprosci.2023.107276_bib41","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.tips.2017.04.005","article-title":"Targeting free radicals in oxidative stress-related human diseases","volume":"38","author":"Poprac","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.anireprosci.2023.107276_bib42","series-title":"Clinical veterinary microbiology","first-page":"209","author":"Quinn","year":"1994"},{"issue":"11","key":"10.1016\/j.anireprosci.2023.107276_bib43","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.bcp.2006.07.004","article-title":"Regulation of inflammation and redox signaling by dietary polyphenols","volume":"72","author":"Rahman","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.anireprosci.2023.107276_bib44","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signalling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell Signal"},{"key":"10.1016\/j.anireprosci.2023.107276_bib45","first-page":"251","article-title":"Acute effect of ovariohysterectomy on lipid peroxidation and some antioxidant levels in dogs","volume":"52","author":"Serin","year":"2008","journal-title":"Bull. Vet. Inst. Pulawy"},{"issue":"2","key":"10.1016\/j.anireprosci.2023.107276_bib46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4103\/ajps.AJPS_4_21","article-title":"Albumin haemoglobin index: a novel pre-operative marker for predicting mortality and hospital stay in patients under one-year undergoing gastrointestinal surgeries","volume":"19","author":"Silahli","year":"2022","journal-title":"Afr. J. Paediatr. Surg."},{"issue":"1","key":"10.1016\/j.anireprosci.2023.107276_bib47","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jri.2009.10.004","article-title":"Gene transcription of TLR2, TLR4, LPS ligands and prostaglandin synthesis enzymes are up-regulated in canine uteri with cystic endometrial hyperplasia\u2013pyometra complex","volume":"84","author":"Silva","year":"2010","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.anireprosci.2023.107276_bib48","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.theriogenology.2006.04.023","article-title":"Canine pyometra","volume":"66","author":"Smith","year":"2006","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2023.107276_bib49","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.imbio.2004.09.003","article-title":"Effect of ovarian hormones on periodical changes in immune resistance associated with estrous cycle in the beagle bitch","volume":"209","author":"Sugiura","year":"2004","journal-title":"Immunobiology"},{"key":"10.1016\/j.anireprosci.2023.107276_bib50","first-page":"673","article-title":"Activity of antioxidant enzymes in uterine tissues of bitches with pyometra","volume":"53","author":"Szczubia\u0142","year":"2009","journal-title":"Bull. Vet. Inst. Pulawy"},{"key":"10.1016\/j.anireprosci.2023.107276_bib51","series-title":"Lumb & Jones' veterinary anesthesia","author":"Thurmon","year":"1996"},{"issue":"4","key":"10.1016\/j.anireprosci.2023.107276_bib52","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1515\/acve-2016-0046","article-title":"Plasma total antioxidant capacity and activities of blood glutathione peroxidase and superoxide dismutase determined in healthy dogs by using commercially available kits","volume":"66","author":"Tomsi\u010d","year":"2016","journal-title":"Acta Vet."},{"issue":"1","key":"10.1016\/j.anireprosci.2023.107276_bib53","first-page":"35","article-title":"Optimum timing for operation in bitches with pyometra related to endotoxemia","volume":"36","author":"Ucmak","year":"2012","journal-title":"Turk. J. Vet. Anim. Sci."},{"key":"10.1016\/j.anireprosci.2023.107276_bib54","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/01.SLA.0000055547.93484.87","article-title":"Hypoalbuminemia in acute illness: is there a rationale for intervention? a metaanalysis of cohort studies and controlled trials","volume":"237","author":"Vincent","year":"2003","journal-title":"Ann. Surg."},{"issue":"2","key":"10.1016\/j.anireprosci.2023.107276_bib55","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11605-019-04492-7","article-title":"Prognostic nutritional index and systemic immune-inflammation index predict the prognosis of patients with HCC","volume":"25","author":"Wang","year":"2021","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.anireprosci.2023.107276_bib56","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ijsu.2019.05.018","article-title":"The prognostic nutritional index is prognostic factor of gynecological cancer: a systematic review and meta-analysis","volume":"67","author":"Wang","year":"2019","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.anireprosci.2023.107276_bib57","unstructured":"Wei, T.,Simko, V. R package \u201ccorrplot\u201d: Visualization of a Correlation Matrix.[WWW document]. URL https:\/\/github. com\/taiyun\/corrplot.2021."},{"key":"10.1016\/j.anireprosci.2023.107276_bib58","first-page":"455","article-title":"Antiendotoxin immunotherapy for canine pyometra endotoxemia","volume":"25","author":"Wessels","year":"1989","journal-title":"Jour Am. Anim. Hosp. Assoc."},{"key":"10.1016\/j.anireprosci.2023.107276_bib59","article-title":"Circulating plasma endotoxin concentrations in healthy and hemorrhagic enteric dogs: antiendotoxin immunotherapy in hemorrhagic enteric endotoxemia","volume":"23","author":"Wessels","year":"1987","journal-title":"Jour Am. Anim. Hosp. Assoc."},{"issue":"1","key":"10.1016\/j.anireprosci.2023.107276_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2022.100710","article-title":"Lipopolysaccharide (LPS) suppresses follicle development marker expression and enhances cytokine expressions, which results in fail to granulosa cell proliferation in developing follicle in cows","volume":"23","author":"Yamamoto","year":"2023","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.anireprosci.2023.107276_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.824170","article-title":"The effect of endotoxin on the intestinal mucus layer in non-and post-pregnancy mice","volume":"8","author":"Yan","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.anireprosci.2023.107276_bib62","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.theriogenology.2022.09.015","article-title":"The evaluation of SIRS status with hemato-biochemical indices in bitches affected from pyometra and the Usefulness of these indices as a potential diagnostic tool","volume":"193","author":"Yazl\u0131k","year":"2022","journal-title":"Theriogenology"}],"container-title":["Animal Reproduction Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432023000908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432023000908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:49:32Z","timestamp":1759906172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378432023000908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":62,"alternative-id":["S0378432023000908"],"URL":"https:\/\/doi.org\/10.1016\/j.anireprosci.2023.107276","relation":{},"ISSN":["0378-4320"],"issn-type":[{"value":"0378-4320","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of nutritional-immunological indices in estimating serum LPS and antioxidant enzyme activity and sepsis status in female dogs with pyometra caused by E. coli","name":"articletitle","label":"Article Title"},{"value":"Animal Reproduction Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anireprosci.2023.107276","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107276"}}