{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:57:22Z","timestamp":1783475842614,"version":"3.55.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Reproduction Science"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.anireprosci.2023.107306","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T17:45:54Z","timestamp":1690566354000},"page":"107306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Study on the changes of LHR, FSHR and AR with the development of testis cells in Hu sheep"],"prefix":"10.1016","volume":"256","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-8613","authenticated-orcid":false,"given":"Jie","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anireprosci.2023.107306_bib1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1530\/rep.0.1220227","article-title":"Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice","volume":"122","author":"Baker","year":"2001","journal-title":"Reproduction"},{"key":"10.1016\/j.anireprosci.2023.107306_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygcen.2019.113276","article-title":"Characterization of gonadotropin receptors Fshr and Lhr in Japanese medaka, Oryzias latipes","volume":"285","author":"Burow","year":"2020","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.anireprosci.2023.107306_bib3","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1038\/sj.onc.1204632","article-title":"The ERK-dependent signalling is stage-specifically modulated by FSH, during primary Sertoli cell maturation","volume":"20","author":"Cr\u00e9pieux","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.anireprosci.2023.107306_bib4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1146\/annurev.physiol.60.1.461","article-title":"The luteinizing hormone receptor","volume":"60","author":"Dufau","year":"1998","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.anireprosci.2023.107306_bib5","series-title":"The Testis in Childhood Between Birth and Puberty","author":"Rajpert-DeMeyts","year":"2013"},{"key":"10.1016\/j.anireprosci.2023.107306_bib6","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.2527\/jas.2014-7903","article-title":"Temporal changes in histomorphology and gene expression in goat testes during postnatal development","volume":"92","author":"Faucette","year":"2014","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.anireprosci.2023.107306_bib7","article-title":"Flow cytometry of murine spermatocytes","volume":"72","author":"Gaysinskaya","year":"2015","journal-title":"Curr. Protoc. Cytom"},{"key":"10.1016\/j.anireprosci.2023.107306_bib8","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1530\/REP-09-0531","article-title":"Kr\u00fcppel-like factor 4 is widely expressed in the mouse male and female reproductive tract and responds as an immediate early gene to activation of the protein kinase A in TM4 Sertoli cells","volume":"139","author":"Godmann","year":"2010","journal-title":"Reproduction"},{"key":"10.1016\/j.anireprosci.2023.107306_bib9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/(SICI)1097-0185(199709)249:1<54::AID-AR7>3.0.CO;2-F","article-title":"Immunolocalization of androgen receptor and estrogen receptor in the developing testis and excurrent ducts of goats","volume":"249","author":"Goyal","year":"1997","journal-title":"Anat. Rec."},{"key":"10.1016\/j.anireprosci.2023.107306_bib10","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.devcel.2018.07.025","article-title":"A comprehensive roadmap of murine spermatogenesis defined by single-cell RNA-Seq","volume":"46","author":"Green","year":"2018","journal-title":"Dev. Cell."},{"key":"10.1016\/j.anireprosci.2023.107306_bib11","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41422-018-0099-2","article-title":"The adult human testis transcriptional cell atlas","volume":"28","author":"Guo","year":"2018","journal-title":"Cell. Res."},{"key":"10.1016\/j.anireprosci.2023.107306_bib12","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.stem.2019.12.005","article-title":"The dynamic transcriptional cell atlas of testis development during human puberty","volume":"26","author":"Guo","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.anireprosci.2023.107306_bib13","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.theriogenology.2007.01.020","article-title":"Stereological study of postnatal testicular development in Blackbelly sheep","volume":"68","author":"Herrera-Alarc\u00f3n","year":"2007","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2023.107306_bib14","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1477-7827-1-52","article-title":"Estrogen in the adult male reproductive tract: a review","volume":"1","author":"Hess","year":"2003","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.anireprosci.2023.107306_bib15","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1210\/en.2003-1055","article-title":"Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse","volume":"145","author":"Johnston","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2023.107306_bib16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/MED.0000000000000339","article-title":"Testicular growth and development in puberty","volume":"24","author":"Koskenniemi","year":"2017","journal-title":"Curr. Endocrinol. Diabetes. Obes."},{"key":"10.1016\/j.anireprosci.2023.107306_bib17","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.devcel.2020.07.018","article-title":"Single-Cell RNA sequencing of the cynomolgus macaque testis reveals conserved transcriptional profiles during mammalian spermatogenesis","volume":"54","author":"Lau","year":"2020","journal-title":"Dev. Cell."},{"key":"10.1016\/j.anireprosci.2023.107306_bib18","doi-asserted-by":"crossref","first-page":"8084","DOI":"10.1038\/srep08084","article-title":"Fractionation of human spermatogenic cells using STA-PUT gravity sedimentation and their miRNA profiling","volume":"5","author":"Liu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.anireprosci.2023.107306_bib19","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1095\/biolreprod64.2.689","article-title":"Specific staining of Sertoli cell nuclei and evaluation of Sertoli cell number and proliferative activity in Meishan and White Composite boars during the neonatal period","volume":"64","author":"McCoard","year":"2001","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2023.107306_bib20","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1126\/science.2502842","article-title":"Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family","volume":"245","author":"McFarland","year":"1989","journal-title":"Science"},{"issue":"141","key":"10.1016\/j.anireprosci.2023.107306_bib21","first-page":"70","article-title":"Postnatal testicular development and testosterone changes in Ghezel ram lambs","volume":"2016","author":"Moghaddam","year":"2016","journal-title":"Small Rumin. Res."},{"key":"10.1016\/j.anireprosci.2023.107306_bib22","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1365-2605.2010.01084.x","article-title":"Non-linear association between androgen receptor CAG repeat length and risk of male subfertility--a meta-analysis","volume":"34","author":"Nenonen","year":"2011","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.anireprosci.2023.107306_bib23","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/aja.1000990303","article-title":"A description of spermiogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewal","volume":"99","author":"Oakberg","year":"1956","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.anireprosci.2023.107306_bib24","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1210\/endo-103-5-1944","article-title":"Autoradiographic localization of specifically bound 125I-labeled follicle-stimulating hormone on spermatogonia of the rat testis","volume":"103","author":"Orth","year":"1978","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2023.107306_bib25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.semcdb.2014.02.010","article-title":"Hormonal control of germ cell development and spermatogenesis","volume":"29","author":"O'Shaughnessy","year":"2014","journal-title":"Semin. Cell. Dev. Biol."},{"key":"10.1016\/j.anireprosci.2023.107306_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1677\/joe.0.1510029","article-title":"Stage-specific expression of the FSH receptor gene in the prepubertal and adult rat seminiferous epithelium","volume":"151","author":"Rannikko","year":"1996","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.anireprosci.2023.107306_bib27","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/jemt.20754","article-title":"Ontogeny of the androgen receptor expression in the fetal and postnatal testis: its relevance on Sertoli cell maturation and the onset of adult spermatogenesis","volume":"72","author":"Rey","year":"2009","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.anireprosci.2023.107306_bib28","unstructured":"RM, S., 1994. Regulation of spermatogenesis. Raven, New York."},{"key":"10.1016\/j.anireprosci.2023.107306_bib29","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1242\/dev.146571","article-title":"The nature and dynamics of spermatogonial stem cells","volume":"144","author":"de Rooij","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.anireprosci.2023.107306_bib30","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1210\/endo-127-6-3180","article-title":"Immunohistochemical localization of the androgen receptor in rat and human tissues","volume":"127","author":"Sar","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2023.107306_bib31","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S1096-4959(01)00339-6","article-title":"Gonadotropins, their receptors, and the regulation of testicular functions in fish","volume":"129","author":"Schulz","year":"2001","journal-title":"Comp. Biochem. Physiol. B. Biochem. Mol. Biol."},{"key":"10.1016\/j.anireprosci.2023.107306_bib32","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1210\/endo.136.9.7649092","article-title":"Quantitative analysis of androgen receptor messenger ribonucleic acid in developing Leydig cells and Sertoli cells by in situ hybridization","volume":"136","author":"Shan","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2023.107306_bib33","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1097\/01.ju.0000179540.28209.de","article-title":"Immunolocalization of androgen receptor and estrogen receptors alpha and beta in human fetal testis and epididymis","volume":"174","author":"Shapiro","year":"2005","journal-title":"J. Urol."},{"key":"10.1016\/j.anireprosci.2023.107306_bib34","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1530\/rep.0.1250769","article-title":"Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood","volume":"125","author":"Sharpe","year":"2003","journal-title":"Reproduction"},{"key":"10.1016\/j.anireprosci.2023.107306_bib35","first-page":"479","article-title":"Developmental changes of testicular gonadotropin receptors and serum gonadotropin levels in two strains of mice","volume":"10","author":"Shiraishi K","year":"1993","journal-title":"Zool. Sci."},{"key":"10.1016\/j.anireprosci.2023.107306_bib36","unstructured":"Skandalakis, J., Gray, S., Rowe, J.J., 1983. Testis and epididymis."},{"key":"10.1016\/j.anireprosci.2023.107306_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2014.02.012","article-title":"The regulation of spermatogenesis by androgens","volume":"30","author":"Smith","year":"2014","journal-title":"Semin. Cell. Dev. Biol."},{"key":"10.1016\/j.anireprosci.2023.107306_bib38","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1210\/mend-4-4-525","article-title":"The testicular receptor for follicle stimulating hormone: structure and functional expression of cloned cDNA","volume":"4","author":"Sprengel","year":"1990","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.anireprosci.2023.107306_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(25)06715-8","article-title":"Human growth hormone","volume":"46","author":"Strobl","year":"1994","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.anireprosci.2023.107306_bib40","first-page":"350","article-title":"Androgen receptor distribution in adult human testis","volume":"84","author":"Su\u00e1rez-Quian","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.anireprosci.2023.107306_bib41","doi-asserted-by":"crossref","first-page":"18975","DOI":"10.1073\/pnas.0608565103","article-title":"Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cells","volume":"103","author":"Tsai","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.anireprosci.2023.107306_bib42","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-genet-112414-055145","article-title":"Meiotic silencing in mammals","volume":"49","author":"Turner","year":"2015","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.anireprosci.2023.107306_bib43","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1210\/endo.134.5.8156934","article-title":"Androgen receptor distribution in rat testis: new implications for androgen regulation of spermatogenesis","volume":"134","author":"Vornberger","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2023.107306_bib44","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.stem.2018.08.007","article-title":"Single-cell RNA sequencing analysis reveals sequential cell fate transition during human spermatogenesis","volume":"23","author":"Wang","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"7","key":"10.1016\/j.anireprosci.2023.107306_bib45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1477-7827-7-39","article-title":"Luteinizing hormone induces expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat Leydig cells","volume":"2009","author":"Wang","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.anireprosci.2023.107306_bib46","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1365-2605.1989.tb01285.x","article-title":"Determination of Sertoli cell numbers in the developing rat testis by stereological methods","volume":"12","author":"Wang","year":"1989","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.anireprosci.2023.107306_bib47","article-title":"Characterization of sheep spermatogenesis through single-cell RNA sequencing","volume":"35","author":"Yang","year":"2021","journal-title":"Faseb. J."},{"key":"10.1016\/j.anireprosci.2023.107306_bib48","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1385\/ENDO:9:3:253","article-title":"Androgen receptor expression in the testes and epididymides of prenatal and postnatal Sprague-Dawley rats","volume":"9","author":"You","year":"1998","journal-title":"Endocrine"},{"key":"10.1016\/j.anireprosci.2023.107306_bib49","doi-asserted-by":"crossref","first-page":"401","DOI":"10.24272\/j.issn.2095-8137.2020.373","article-title":"Single-cell RNA sequencing reveals atlas of dairy goat testis cells","volume":"42","author":"Yu","year":"2021","journal-title":"Zool. Res."}],"container-title":["Animal Reproduction Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432023001203?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432023001203?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:50:06Z","timestamp":1759906206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378432023001203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":49,"alternative-id":["S0378432023001203"],"URL":"https:\/\/doi.org\/10.1016\/j.anireprosci.2023.107306","relation":{},"ISSN":["0378-4320"],"issn-type":[{"value":"0378-4320","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study on the changes of LHR, FSHR and AR with the development of testis cells in Hu sheep","name":"articletitle","label":"Article Title"},{"value":"Animal Reproduction Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anireprosci.2023.107306","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107306"}}