{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:26:11Z","timestamp":1759969571217,"version":"build-2065373602"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["18\/04106-1"],"award-info":[{"award-number":["18\/04106-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Reproduction Science"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.anireprosci.2023.107407","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T11:50:26Z","timestamp":1704196226000},"page":"107407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Steroidogenic activity and morphological characterization of prenatal testes and epididymis of guinea pig (Cavia porcellus)"],"prefix":"10.1016","volume":"261","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7517-174X","authenticated-orcid":false,"given":"G.A.A.","family":"Lemos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.C.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.C.C.","family":"Brito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.S.","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.C.","family":"Assis Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anireprosci.2023.107407_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1439-0531.2012.02056.x","article-title":"Domestic animal models for biomedical research","volume":"47","author":"B\u00e4hr","year":"2012","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.anireprosci.2023.107407_bib2","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1046\/j.1432-1327.1999.00245.x","article-title":"Expression of 3beta-hydroxysteroid dehydrogenase type I and type VI isoforms in the mouse testis during development","volume":"260","author":"Baker","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.anireprosci.2023.107407_bib3","first-page":"1561","article-title":"Expression and regulation of steroid 5 alpha-reductase in the urogenital tract of the fetal rat","volume":"9","author":"Berman","year":"1995","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.anireprosci.2023.107407_bib4","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1210\/endo.135.3.8070367","article-title":"Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens","volume":"135","author":"Bremner","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2023.107407_bib5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diff.2013.12.003","article-title":"Development of the external genitalia: perspectives from the spotted hyena (Crocuta crocuta)","volume":"87","author":"Cunha","year":"2014","journal-title":"Differentiation"},{"key":"10.1016\/j.anireprosci.2023.107407_bib6","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1210\/endo-96-4-879","article-title":"Cellular localization of 5\u03b1-reductase and 3\u03b1-hydroxysteroid dehydrogenase in the seminiferous tubule of the rat testis","volume":"96","author":"Dorrington","year":"1975","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2023.107407_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080861","article-title":"Importance of the androgen receptor signaling in gene transactivation and transrepression for pubertal maturation of the testis","volume":"8","author":"Edelsztein","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.anireprosci.2023.107407_bib8","doi-asserted-by":"crossref","DOI":"10.1186\/s13633-016-0038-2","article-title":"Anti-M\u00fcllerian hormone as a marker of steroid and gonadotropin action in the testis of children and adolescents with disorders of the gonadal axis","volume":"2016","author":"Edelsztein","year":"2016","journal-title":"Int. J. Pediatr. Endocrinol."},{"key":"10.1016\/j.anireprosci.2023.107407_bib9","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1210\/endo-102-4-999","article-title":"Developmental pattern of testosterone synthesis by fetal rat testes in response to luteinizing hormone*","volume":"102","author":"Feldman","year":"1978","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2023.107407_bib10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ydbio.2008.10.012","article-title":"Development and morphogenesis of the Wolffian\/epididymal duct, more twists and turns","volume":"325","author":"Joseph","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.anireprosci.2023.107407_bib11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1055\/s-0032-1324719","article-title":"Testicular anti-m\u00fcllerian hormone: clinical applications in DSD","volume":"30","author":"Josso","year":"2012","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.anireprosci.2023.107407_bib12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1210\/endo-77-2-273","article-title":"Testosterone synthesis by the fetal rabbit gonad","volume":"77","author":"Lipsett","year":"1965","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2023.107407_bib13","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1210\/endo.142.11.8510","article-title":"Unexpected virilization in male mice lacking steroid 5\u03b1-reductase enzymes","volume":"142","author":"Mahendroo","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2023.107407_bib14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1677\/joe.0.1470285","article-title":"Immunolocalisation of androgen receptor to interstitial cells in fetal rat testes and to mesenchymal and epithelial cells of associated ducts","volume":"147","author":"Majdic","year":"1995","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.anireprosci.2023.107407_bib15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/15476278.2016.1145318","article-title":"Studies of gonadal sex differentiation","volume":"12","author":"Makiyan","year":"2016","journal-title":"Organogenesis"},{"key":"10.1016\/j.anireprosci.2023.107407_bib16","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jsbmb.2010.12.013","article-title":"17\u03b2-Hydroxysteroid dehydrogenases (17\u03b2-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development","volume":"125","author":"Marchais-Oberwinkler","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.anireprosci.2023.107407_bib17","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4067\/S0717-95022018000200677","article-title":"Sexual determination and differentiation during embryonic and fetal development of New Zealand rabbit females","volume":"36","author":"Mario","year":"2018","journal-title":"Int. J. Morphol."},{"key":"10.1016\/j.anireprosci.2023.107407_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/j.1939-4640.2002.tb02607.x","article-title":"Hormonal regulation of spermatogenesis in primates and man: insights for development of the male hormonal contraceptive","volume":"23","author":"McLachlan","year":"2002","journal-title":"J. Androl."},{"key":"10.1016\/j.anireprosci.2023.107407_bib19","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.4067\/S0717-95022021000501253","article-title":"Gonadal differentiation during embryonic and fetal development of Male New Zealand Rabbits (Oryctolagus cuniculus)","volume":"39","author":"Miranda","year":"2021","journal-title":"Int. J. Morphol."},{"key":"10.1016\/j.anireprosci.2023.107407_bib20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cmet.2016.07.017","article-title":"Sex and gender: critical variables in pre-clinical and clinical medical research","volume":"24","author":"Morselli","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.anireprosci.2023.107407_bib21","doi-asserted-by":"crossref","first-page":"749","DOI":"10.4103\/1008-682X.155540","article-title":"Understanding normal and abnormal development of the Wolffian\/epididymal duct by using transgenic mice","volume":"17","author":"Murashima","year":"2015","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.anireprosci.2023.107407_bib22","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jez.616","article-title":"The mechanism of sex determination in vertebrates-are sex steroids the key-factor?","volume":"313A","author":"Nakamura","year":"2010","journal-title":"J. Exp. Zool. Part A Ecol. Gen. Physiol."},{"key":"10.1016\/j.anireprosci.2023.107407_bib23","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4322\/jms.107816","article-title":"Morphological development of the testicles and spermatogenesis in guinea pigs (Cavia porcellus Linnaeus, 1758)","volume":"34","author":"Nunes","year":"2017","journal-title":"J. Morphol. Sci."},{"key":"10.1016\/j.anireprosci.2023.107407_bib24","first-page":"2","article-title":"Sertoli cells as key drivers of testis function. Seminars in cell & development","volume":"121","author":"O\u2019Donnell","year":"2022","journal-title":"Biol"},{"key":"10.1016\/j.anireprosci.2023.107407_bib25","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1210\/endo.141.7.7545","article-title":"Localization of 17\u03b2-hydroxysteroid dehydrogenase\/17-ketosteroid reductase isoform expression in the developing mouse testis\u2014androstenedione is the major androgen secreted by fetal\/neonatal leydig cells*","volume":"141","author":"O\u2019Shaughnessy","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2023.107407_bib26","doi-asserted-by":"crossref","DOI":"10.1071\/RDv28n2Ab70","article-title":"70 gonadal development in guinea pig males (Cavia porcellus)","volume":"28","author":"Oliveira","year":"2016","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.anireprosci.2023.107407_bib27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1530\/jrf.0.0910357","article-title":"Effect of temperature and the role of testicular descent on post-natal testicular androgen production in the mouse","volume":"91","author":"O'Shaughnessy","year":"1991","journal-title":"Reproduction"},{"key":"10.1016\/j.anireprosci.2023.107407_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.583477","article-title":"Sex differences in the development of the rodent corticolimbic system","volume":"14","author":"Premachandran","year":"2020","journal-title":"Front Neurosci."},{"key":"10.1016\/j.anireprosci.2023.107407_bib29","first-page":"629","article-title":"The role of fetal androgen in sex differentiation in mammals","author":"Price","year":"1965","journal-title":"Inter. Anim. King"},{"key":"10.1016\/j.anireprosci.2023.107407_bib30","series-title":"Endotext","article-title":"Sexual Differentiation","author":"Rey","year":"2000"},{"key":"10.1016\/j.anireprosci.2023.107407_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/wdev.310","article-title":"The cell biology and molecular genetics of M\u00fcllerian duct development","volume":"7","author":"Roly","year":"2018","journal-title":"WIREs Dev. Biol."},{"issue":"2","key":"10.1016\/j.anireprosci.2023.107407_bib32","first-page":"389","article-title":"Intrauterine development of female genital organs in Cavia porcellus (Rodentia: Caviidae). Pakistan","volume":"46","author":"Santos","year":"2016","journal-title":"J. Zool."},{"key":"10.1016\/j.anireprosci.2023.107407_bib33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.diff.2018.04.001","article-title":"Development of urogenital system in the Spix cavy: a model for studies on sexual differentiation","volume":"101","author":"Santos","year":"2018","journal-title":"Differentiation"},{"key":"10.1016\/j.anireprosci.2023.107407_bib34","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1071\/RD20293","article-title":"Steroidogenesis during prenatal testicular development in Spix's cavy Galea spixii","volume":"33","author":"Santos","year":"2021","journal-title":"Rep. Fertil. Dev."},{"key":"10.1016\/j.anireprosci.2023.107407_bib35","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1530\/REP-17-0075","article-title":"Steroidogenesis during postnatal testicular development of Galea spixii","volume":"154","author":"Santos","year":"2017","journal-title":"Reproduction"},{"issue":"4 0","key":"10.1016\/j.anireprosci.2023.107407_bib36","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.juro.2013.02.3198","article-title":"Sexual differentiation in the male and female mouse from days 0 to 21: a detailed and novel morphometric description","volume":"190","author":"Schlomer","year":"2013","journal-title":"J. Urol. Oct."},{"key":"10.1016\/j.anireprosci.2023.107407_bib37","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1530\/JME-14-0018","article-title":"Molecular mechanisms involved in mammalian primary sex determination","volume":"53","author":"She","year":"2014","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.anireprosci.2023.107407_bib38","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1002\/dvdy.22378","article-title":"Gene expression in the efferent ducts, epididymis, and vas deferens during embryonic development of the mouse","volume":"239","author":"Snyder","year":"2010","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.anireprosci.2023.107407_bib39","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bbrc.2012.04.161","article-title":"Testicular steroidogenesis is locally regulated by androgen via suppression of Nur77","volume":"422","author":"Song","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.anireprosci.2023.107407_bib40","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/humupd\/7.3.314","article-title":"Disorders linked to insufficient androgen action in male children","volume":"7","author":"Sultan","year":"2001","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.anireprosci.2023.107407_bib41","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/dgd.12247","article-title":"Systematic analyses of murine masculinization processes based on genital sex differentiation parameters","volume":"57","author":"Suzuki","year":"2015","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.anireprosci.2023.107407_bib42","article-title":"What does androgen receptor signaling pathway in sertoli cells during normal spermatogenesis tell us?","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.anireprosci.2023.107407_bib43","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.semcdb.2016.03.003","article-title":"Development, function and fate of fetal Leydig cells","volume":"59","author":"Wen","year":"2016","journal-title":"Sem. Cell Dev. Biol."},{"key":"10.1016\/j.anireprosci.2023.107407_bib44","first-page":"1431","article-title":"Early secretion of testosterone by embryonic mouse testis. Comptes rendus hebdomadaires des seances de l\u2032Academie des sciences","volume":"275","author":"Weniger","year":"1972","journal-title":"Ser. D: Sci. Nat."},{"key":"10.1016\/j.anireprosci.2023.107407_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.00430","article-title":"Insights into the development of the adult leydig cell lineage from stem leydig cells","volume":"8","author":"Ye","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.anireprosci.2023.107407_bib46","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1530\/REP-21-0106","article-title":"Differentiation of fetal sertoli cells in the adult testis","volume":"162","author":"Yokonishi","year":"2021","journal-title":"Reproduction"},{"key":"10.1016\/j.anireprosci.2023.107407_bib47","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1385\/ENDO:9:3:253","article-title":"Androgen receptor expression in the testes and epididymides of prenatal and postnatal Sprague-Dawley Rats","volume":"9","author":"You","year":"1998","journal-title":"Endocrine"},{"key":"10.1016\/j.anireprosci.2023.107407_bib48","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1095\/biolreprod63.2.368","article-title":"Effects of androgen on androgen receptor expression in rat testicular and epididymal cells: a quantitative immunohistochemical study1","volume":"63","author":"Zhu","year":"2000","journal-title":"Biol. Rep."}],"container-title":["Animal Reproduction Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037843202300221X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037843202300221X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:51:16Z","timestamp":1759906276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037843202300221X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":48,"alternative-id":["S037843202300221X"],"URL":"https:\/\/doi.org\/10.1016\/j.anireprosci.2023.107407","relation":{},"ISSN":["0378-4320"],"issn-type":[{"type":"print","value":"0378-4320"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Steroidogenic activity and morphological characterization of prenatal testes and epididymis of guinea pig (Cavia porcellus)","name":"articletitle","label":"Article Title"},{"value":"Animal Reproduction Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anireprosci.2023.107407","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107407"}}