{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:49:22Z","timestamp":1789775362148,"version":"4.0.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["86037-293205"],"award-info":[{"award-number":["86037-293205"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PID2023\\u2013150622OA-100"],"award-info":[{"award-number":["PID2023\\u2013150622OA-100"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PID2022\\u2013137645OB-100"],"award-info":[{"award-number":["PID2022\\u2013137645OB-100"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"State Agency of Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Reproduction Science"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.anireprosci.2025.107988","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T23:00:54Z","timestamp":1757026854000},"page":"107988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Gene dysregulation impairs placental angiogenesis in allogeneic pig pregnancies"],"prefix":"10.1016","volume":"281","author":[{"given":"Cristina A.","family":"Martinez-Serrano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2010-5849","authenticated-orcid":false,"given":"Josep M.","family":"Cambra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0120-354X","authenticated-orcid":false,"given":"Manuel","family":"Alvarez-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Parrilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6202-5946","authenticated-orcid":false,"given":"Cristina","family":"Cuello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6955-7750","authenticated-orcid":false,"given":"Maria A.","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio A.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5194-2124","authenticated-orcid":false,"given":"Heriberto","family":"Rodriguez-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anireprosci.2025.107988_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/jcp.30529","article-title":"TGF-\u03b2 signaling: a recap of SMAD-independent and SMAD-dependent pathways","volume":"237","author":"Aashaq","year":"2022","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"Bolstad","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.anireprosci.2025.107988_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21197034","article-title":"Redox regulation of STAT1 and STAT3 signaling","volume":"21","author":"Butturini","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.anireprosci.2025.107988_bib4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1439-0531.2004.00530.x","article-title":"Comparative effects of autologous and homologous seminal plasma on the viability of largely extended boar spermatozoa","volume":"39","author":"Caballero","year":"2004","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.anireprosci.2025.107988_bib5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/micc.12093","article-title":"Regulation of placental angiogenesis","volume":"21","author":"Chen","year":"2014","journal-title":"Microcirculation"},{"key":"10.1016\/j.anireprosci.2025.107988_bib6","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.devcel.2011.12.022","article-title":"Developmental cell trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling","volume":"22","author":"Chhabra","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.anireprosci.2025.107988_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep33915","article-title":"Effective vitrification and warming of porcine embryos using a pH-stable, chemically defined medium","volume":"6","author":"Cuello","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.anireprosci.2025.107988_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.anireprosci.2025.107988_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7827-9-5","article-title":"Expression of angiogenic basic fibroblast growth factor, platelet derived growth factor, thrombospondin-1 and their receptors at the porcine maternal-fetal interface","volume":"9","author":"Edwards","year":"2011","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib10","first-page":"57","article-title":"Placental vascularization in middle and late gestation in the pig","volume":"3","author":"Fiorimanti","year":"2022","journal-title":"Reprod. Fertil."},{"key":"10.1016\/j.anireprosci.2025.107988_bib11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/biolre\/ioaa178","article-title":"Altered expression of ADM and ADM2 by hypoxia regulates migration of trophoblast and HLA-G expression","volume":"104","author":"Gu","year":"2021","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2025.107988_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygeno.2025.111014","article-title":"Navigating gene editing in porcine embryos: methods, challenges, and future perspectives","volume":"117","author":"Hamze","year":"2025","journal-title":"Genomics"},{"key":"10.1016\/j.anireprosci.2025.107988_bib13","doi-asserted-by":"crossref","first-page":"13706","DOI":"10.3390\/ijms241813706","article-title":"The TGF-\u03b2\/UCHL5\/Smad2 axis contributes to the pathogenesis of placenta accreta","volume":"24","author":"Hashimoto","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.anireprosci.2025.107988_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241813706","article-title":"The TGF-\u03b2\/UCHL5\/Smad2 axis contributes to the pathogenesis of placenta accreta","volume":"24","author":"Hashimoto","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.anireprosci.2025.107988_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7827-11-62","article-title":"Temporo-spatial expression of adrenomedullin and its receptors in the bovine placenta","volume":"11","author":"Hayashi","year":"2013","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib16","first-page":"4941","article-title":"MicroRNA expression profiling in placenta and maternal plasma in early pregnancy loss","volume":"17","author":"Hosseini","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.anireprosci.2025.107988_bib17","first-page":"1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.anireprosci.2025.107988_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102051","article-title":"Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway","volume":"45","author":"Hu","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102051","article-title":"Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway","volume":"45","author":"Hu","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib20","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/biolre\/ioac163","article-title":"STAT3 in porcine endometrium during early pregnancy induces changes in extracellular matrix components and promotes angiogenesis","volume":"107","author":"Jalali","year":"2022","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2025.107988_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-3-030-77360-1_5","article-title":"The early stages of implantation and placentation in the pig","volume":"234","author":"Johnson","year":"2021","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib22","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1210\/en.2007-0505","article-title":"Pig conceptuses secrete estrogen and interferons to differentially regulate uterine STAT1 in a temporal and cell Type-Specific manner","volume":"148","author":"Joyce","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.anireprosci.2025.107988_bib23","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1095\/biolreprod62.6.1772","article-title":"Keratinocyte growth factor: expression by endometrial epithelia of the porcine uterus","volume":"62","author":"Ka","year":"2000","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2025.107988_bib24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.theriogenology.2015.08.001","article-title":"Placentation, maternal-fetal interface, and conceptus loss in swine","volume":"85","author":"Kridli","year":"2016","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2025.107988_bib25","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.tem.2012.02.007","article-title":"Adrenomedullin and pregnancy: perspectives from animal models to humans","volume":"23","author":"Lenhart","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.anireprosci.2025.107988_bib26","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.114.118299","article-title":"Trophoblast-specific reduction of VEGFA alters placental gene expression and maternal cardiovascular function in mice","volume":"91","author":"Li","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2025.107988_bib27","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1172\/JCI67039","article-title":"Fetal-derived adrenomedullin mediates the innate immune milieu of the placenta","volume":"123","author":"Li","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.anireprosci.2025.107988_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1331964","article-title":"Research progress on the STAT signaling pathway in pregnancy and pregnancy-associated disorders","volume":"14","author":"Li","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib29","article-title":"Impaired bone morphogenetic protein signaling pathways disrupt decidualization in endometriosis","author":"Liao","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.anireprosci.2025.107988_bib30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s10020-024-00961-1","article-title":"Exploring Smad5: a review to pave the way for a deeper understanding of the pathobiology of common respiratory diseases","volume":"30","author":"Lin","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.anireprosci.2025.107988_bib31","first-page":"1","article-title":"Angiogenic signaling pathways and anti-angiogenic therapy for cancer","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.anireprosci.2025.107988_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2022.100590","article-title":"A decreased expression of interferon stimulated genes in peri-implantation endometrium of embryo transfer recipient sows could contribute to embryo death","volume":"16","author":"Martinez","year":"2022","journal-title":"Animal"},{"key":"10.1016\/j.anireprosci.2025.107988_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2022.100590","article-title":"A decreased expression of interferon stimulated genes in peri-implantation endometrium of embryo transfer recipient sows could contribute to embryo death","volume":"16","author":"Martinez","year":"2022","journal-title":"Animal"},{"key":"10.1016\/j.anireprosci.2025.107988_bib34","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.theriogenology.2015.06.002","article-title":"Recent advances toward the practical application of embryo transfer in pigs","volume":"85","author":"Martinez","year":"2016","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2025.107988_bib35","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/rda.13465","article-title":"Achievements and future perspectives of embryo transfer technology in pigs","volume":"54","author":"Martinez","year":"2019","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.anireprosci.2025.107988_bib36","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.repbio.2017.05.005","article-title":"Involvement of STAT1 in proliferation and invasiveness of trophoblastic cells","volume":"17","author":"Pereira de Sousa","year":"2017","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib37","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s10456-014-9423-8","article-title":"Angiopoietin-like protein 2 regulates endothelial colony forming cell vasculogenesis","volume":"17","author":"Richardson","year":"2014","journal-title":"Angiogenesis"},{"key":"10.1016\/j.anireprosci.2025.107988_bib38","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7827-1-23","article-title":"Analysis and characterization of differential gene expression during rapid trophoblastic elongation in the pig using suppression subtractive hybridization","volume":"1","author":"Ross","year":"2003","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0955-0674(00)00194-0","article-title":"HIF-1 and mechanisms of hypoxia sensing","volume":"13","author":"Semenza","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib40","doi-asserted-by":"crossref","first-page":"6678","DOI":"10.1002\/jcp.30330","article-title":"Human placenta-derived mesenchymal stem cells induce trophoblast invasion via dynamic effects on mitochondrial function","volume":"236","author":"Seok","year":"2021","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.837000","article-title":"A novel regulated network mediated by downregulation HIF1A-AS2 lncRNA impairs placental angiogenesis by promoting ANGPTL4 expression in preeclampsia","volume":"10","author":"Shu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib42","first-page":"241","article-title":"STAT1 as a central mediator of IFN\u03b3 and TLR4 signal integration in vascular dysfunction","volume":"1","author":"Sikorski","year":"2012","journal-title":"JAKSTAT"},{"key":"10.1016\/j.anireprosci.2025.107988_bib43","first-page":"455","article-title":"Vascular endothelial growth factor (VEGF)-key factor in normal and pathological angiogenesis","volume":"59","author":"Stanca Melincovici","year":"2018","journal-title":"Rom. J. Morphol. Embryol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib44","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-3-030-85686-1_2","article-title":"Insights into the regulation of implantation and placentation in humans, rodents, sheep, and pigs","volume":"1354","author":"Stenhouse","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib45","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.anireprosci.2025.107988_bib46","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.3390\/ijms25147569","article-title":"A narrative review on the pathophysiology of preeclampsia","volume":"25","author":"Torres-Torres","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.anireprosci.2025.107988_bib47","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.omtn.2020.09.019","article-title":"miR-18a contributes to preeclampsia by downregulating Smad2 (Full Length) and reducing TGF-\u03b2 signaling","volume":"22","author":"Xu","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.anireprosci.2025.107988_bib48","first-page":"11","article-title":"Cross-Species insights into trophoblast invasion during placentation governed by Immune-Featured trophoblast cells","author":"Zang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.anireprosci.2025.107988_bib49","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.3892\/mmr.2017.6903","article-title":"Peroxisome proliferator-activated receptor \u03b3 mediates porcine placental angiogenesis through hypoxia inducible factor-, vascular endothelial growth factor- and angiopoietin-mediated signaling","volume":"16","author":"Zhang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.anireprosci.2025.107988_bib50","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10735-018-9757-4","article-title":"The decreased expression of Stat3 and p-Stat3 in preeclampsia-like rat placenta","volume":"49","author":"Zhang","year":"2018","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.anireprosci.2025.107988_bib51","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jare.2020.09.002","article-title":"Decreased PIBF1\/IL6\/p-STAT3 during the mid-secretory phase inhibits human endometrial stromal cell proliferation and decidualization","volume":"30","author":"Zhou","year":"2021","journal-title":"J. Adv. Res."}],"container-title":["Animal Reproduction Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432025002271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432025002271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:11:36Z","timestamp":1772831496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378432025002271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":51,"alternative-id":["S0378432025002271"],"URL":"https:\/\/doi.org\/10.1016\/j.anireprosci.2025.107988","relation":{},"ISSN":["0378-4320"],"issn-type":[{"value":"0378-4320","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene dysregulation impairs placental angiogenesis in allogeneic pig pregnancies","name":"articletitle","label":"Article Title"},{"value":"Animal Reproduction Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anireprosci.2025.107988","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107988"}}