{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:41:17Z","timestamp":1793727677161,"version":"4.6.1"},"reference-count":175,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Reproduction Science"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.anireprosci.2026.108123","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:29:57Z","timestamp":1770222597000},"page":"108123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Interferon tau and the immune blueprint of early ruminant pregnancy"],"prefix":"10.1016","volume":"288","author":[{"given":"Iqra","family":"Batool","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1-2","key":"10.1016\/j.anireprosci.2026.108123_bib1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jri.2011.05.005","article-title":"Regulation of non-classical major histocompatability complex class I mRNA expression in bovine embryos","volume":"91","author":"Al Naib","year":"2011","journal-title":"J. Reprod. Immunol."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3168\/jdsc.2022-0278","article-title":"Meta-analysis of the incidence of pregnancy losses in dairy cows at different stages to 90 days of gestation","volume":"4","author":"Albaaj","year":"2023","journal-title":"JDS Commun."},{"key":"10.1016\/j.anireprosci.2026.108123_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2021.103321","article-title":"JAK3 and PI3K mediates the suppressive effects of interferon tau on neutrophil extracellular traps formation during peri-implantation period","volume":"145","author":"Alhussien","year":"2021","journal-title":"J. Reprod. Immunol."},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib4","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3390\/dairy5030040","article-title":"Embryonic and fetal mortality in dairy cows: Incidence, relevance, and diagnosis approach in field conditions","volume":"5","author":"Andrade","year":"2024","journal-title":"Dairy"},{"issue":"6","key":"10.1016\/j.anireprosci.2026.108123_bib5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1095\/biolreprod.112.105684","article-title":"Endocrine delivery of interferon tau protects the corpus luteum from prostaglandin F2 alpha-induced luteolysis in ewes","volume":"88","author":"Antoniazzi","year":"2013","journal-title":"Biol. Reprod."},{"issue":"9","key":"10.1016\/j.anireprosci.2026.108123_bib6","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1210\/en.2010-0166","article-title":"Deletion of the Isg15 gene results in up-regulation of decidual cell survival genes and down-regulation of adhesion genes: implication for regulation by IL-1beta","volume":"151","author":"Ashley","year":"2010","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/1477-7827-9-148","article-title":"The chemokine receptor CXCR4 and its ligand CXCL12 are activated during implantation and placentation in sheep","volume":"9","author":"Ashley","year":"2011","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib8","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1210\/en.2003-1087","article-title":"Localization of ISG15 and conjugated proteins in bovine endometrium using immunohistochemistry and electron microscopy","volume":"145","author":"Austin","year":"2004","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s12522-011-0117-2","article-title":"Functions of interferon tau as an immunological regulator for establishment of pregnancy","volume":"11","author":"Bai","year":"2012","journal-title":"Reprod. Med. Biol."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib10","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1262\/jrd.2022-061","article-title":"Recent progress of interferon-tau research and potential direction beyond pregnancy recognition","volume":"68","author":"Bai","year":"2022","journal-title":"J. Reprod. Dev."},{"issue":"6","key":"10.1016\/j.anireprosci.2026.108123_bib11","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1530\/rep.0.1220907","article-title":"Increased expression of major histocompatibility complex (MHC) class I transplantation antigens in bovine trophoblast cells before fusion with maternal cells","volume":"122","author":"Bainbridge","year":"2001","journal-title":"Reproduction"},{"issue":"12","key":"10.1016\/j.anireprosci.2026.108123_bib12","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1210\/me.2010-0205","article-title":"Interferon tau regulates PGF2alpha release from the ovine endometrial epithelial cells via activation of novel JAK\/EGFR\/ERK\/EGR-1 pathways","volume":"24","author":"Banu","year":"2010","journal-title":"Mol. Endocrinol."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib13","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1530\/REP-17-0290","article-title":"Interferon-tau promotes luteal endothelial cell survival and inhibits specific luteolytic genes in bovine corpus luteum","volume":"154","author":"Basavaraja","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.anireprosci.2026.108123_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2025.157035","article-title":"Interferon tau in ruminant reproduction: mechanisms of maternal recognition of pregnancy and implications for fertility enhancement","volume":"196","author":"Batool","year":"2025","journal-title":"Cytokine"},{"key":"10.1016\/j.anireprosci.2026.108123_bib15","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-animal-022114-110639","article-title":"Uterine responses to the preattachment embryo in domestic ungulates: recognition of pregnancy and preparation for implantation","volume":"3","author":"Bauersachs","year":"2015","journal-title":"Annu. Rev. Anim. Biosci."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/2049-1891-4-23","article-title":"Pregnancy recognition signaling mechanisms in ruminants and pigs","volume":"4","author":"Bazer","year":"2013","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib17","doi-asserted-by":"crossref","first-page":"F11","DOI":"10.1530\/REP-17-0257","article-title":"Chronicling the discovery of interferon tau","volume":"154","author":"Bazer","year":"2017","journal-title":"Reproduction"},{"issue":"6","key":"10.1016\/j.anireprosci.2026.108123_bib18","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1600-0897.1997.tb00253.x","article-title":"Interferon tau: a novel pregnancy recognition signal","volume":"37","author":"Bazer","year":"1997","journal-title":"Am. J. Reprod. Immunol."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1530\/REP-09-0158","article-title":"Comparative aspects of implantation","volume":"138","author":"Bazer","year":"2009","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib20","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2741\/s184","article-title":"Uterine receptivity to implantation of blastocysts in mammals","volume":"3","author":"Bazer","year":"2011","journal-title":"Front Biosci. (Sch. Ed.)"},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib21","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1262\/jrd.2011-019","article-title":"Select nutrients in the uterine lumen of sheep and pigs affect conceptus development","volume":"58","author":"Bazer","year":"2012","journal-title":"J. Reprod. Dev."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib22","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1095\/biolreprod64.2.654","article-title":"Bovine interferon-\u03c4 stimulates the Janus kinase-signal transducer and activator of transcription pathway in bovine endometrial epithelial cells","volume":"64","author":"Binelli","year":"2001","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.anireprosci.2026.108123_bib23","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1095\/biolreprod.109.079467","article-title":"\"vein infusion of interferon tau (IFNT) extends luteal life span in ewes","volume":"82","author":"Bott","year":"2010","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib24","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.114.124156","article-title":"Biological roles of interferon tau (IFNT) and type I IFN receptors in elongation of the ovine conceptus","volume":"92","author":"Brooks","year":"2015","journal-title":"Biol. Reprod."},{"issue":"22","key":"10.1016\/j.anireprosci.2026.108123_bib25","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.3390\/ani12223068","article-title":"Interferon tau (IFNt) and interferon-stimulated genes (ISGs) expression in peripheral blood leukocytes and correlation with circulating pregnancy-associated glycoproteins (PAGs) during peri-implantation and early pregnancy in buffalo cows","volume":"12","author":"Casano","year":"2022","journal-title":"Animals"},{"issue":"4","key":"10.1016\/j.anireprosci.2026.108123_bib26","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1095\/biolreprod65.4.1038","article-title":"Interferon regulatory factor-two restricts expression of interferon-stimulated genes to the endometrial stroma and glandular epithelium of the ovine uterus","volume":"65","author":"Choi","year":"2001","journal-title":"Biol. Reprod."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib27","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1095\/biolreprod.102.012708","article-title":"Pregnancy and interferon tau regulate major histocompatibility complex class I and \u03b22-microglobulin expression in the ovine uterus","volume":"68","author":"Choi","year":"2003","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib28","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/1043-4666(90)90008-H","article-title":"Leukocyte inhibitory factor activates human neutrophils and macrophages to release leukotriene B4 and thromboxanes","volume":"2","author":"Conti","year":"1990","journal-title":"Cytokine"},{"key":"10.1016\/j.anireprosci.2026.108123_bib29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.anireprosci.2004.05.016","article-title":"Major histocompatibility antigen expression on the bovine placenta: its relationship to abnormal pregnancies and retained placenta","volume":"82","author":"Davies","year":"2004","journal-title":"Anim. Reprod. Sci."},{"issue":"4","key":"10.1016\/j.anireprosci.2026.108123_bib30","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ni.1854","article-title":"Regulation of leukocyte recruitment by the long pentraxin PTX3","volume":"11","author":"Deban","year":"2010","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1530\/rep.0.1210041","article-title":"Trophoblast interferon and pregnancy","volume":"121","author":"Demmers","year":"2001","journal-title":"Reproduction"},{"issue":"4-5","key":"10.1016\/j.anireprosci.2026.108123_bib32","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.placenta.2005.05.001","article-title":"Natural killer cells and dendritic cells at the human feto-maternal interface: an effective cooperation?","volume":"27","author":"Dietl","year":"2006","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib33","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/biolre\/ioad164","article-title":"Profiles of interferon-stimulated genes in multiple tissues and circulating pregnancy-associated glycoproteins and their association with pregnancy loss in dairy cows","volume":"110","author":"Domingues","year":"2023","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib34","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1210\/en.2012-1909","article-title":"Cortisol and interferon tau regulation of endometrial function and conceptus development in female sheep","volume":"154","author":"Dorniak","year":"2013","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jri.2009.06.125","article-title":"Classical and non-classical major histocompatibility complex class I gene expression in in vitro derived bovine embryos","volume":"82","author":"Doyle","year":"2009","journal-title":"J. Reprod. Immunol."},{"issue":"10","key":"10.1016\/j.anireprosci.2026.108123_bib36","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1210\/en.2004-0606","article-title":"Regulation of interferon-tau (IFN-tau) gene promoters by growth factors that target the Ets-2 composite enhancer: a possible model for maternal control of IFN-tau production by the conceptus during early pregnancy","volume":"145","author":"Ezashi","year":"2004","journal-title":"Endocrinology"},{"issue":"14","key":"10.1016\/j.anireprosci.2026.108123_bib37","doi-asserted-by":"crossref","first-page":"7882","DOI":"10.1073\/pnas.95.14.7882","article-title":"Control of interferon-tau gene expression by Ets-2","volume":"95","author":"Ezashi","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib38","doi-asserted-by":"crossref","first-page":"346","DOI":"10.21451\/1984-3143-AR877","article-title":"Embryo maternal immune interactions in cattle","volume":"13","author":"Fair","year":"2018","journal-title":"Anim. Reprod. (AR)"},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib39","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1095\/biolreprod.103.022137","article-title":"Search for the bovine homolog of the murine ped gene and characterization of its messenger RNA expression during bovine preimplantation development","volume":"70","author":"Fair","year":"2004","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/cells14020087","article-title":"IFN-\u03c4 maintains immune tolerance by promoting M2 macrophage polarization via modulation of Bta-miR-30b-5p in early uterine pregnancy in dairy cows","volume":"14","author":"Feng","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.anireprosci.2026.108123_bib41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbrc.2021.03.037","article-title":"Neutrophils recognize and amplify IFNT signals derived from day 7 bovine embryo for stimulation of ISGs expression in vitro: a possible implication for the early maternal recognition of pregnancy","volume":"553","author":"Fiorenza","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib42","doi-asserted-by":"crossref","DOI":"10.1590\/1984-3143-ar2021-0048","article-title":"Possible impact of neutrophils on immune responses during early pregnancy in ruminants","volume":"18","author":"Fiorenza","year":"2021","journal-title":"Anim. Reprod."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib43","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1095\/biolreprod.110.090019","article-title":"Conceptus-induced changes in the endometrial transcriptome: how soon does the cow know she is pregnant?","volume":"85","author":"Forde","year":"2011","journal-title":"Biol. Reprod."},{"issue":"16","key":"10.1016\/j.anireprosci.2026.108123_bib44","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1152\/physiolgenomics.00067.2012","article-title":"Evidence for an early endometrial response to pregnancy in cattle: both dependent upon and independent of interferon tau","volume":"44","author":"Forde","year":"2012","journal-title":"Physiol. Genom."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib45","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jri.2009.10.003","article-title":"GammadeltaTCR+ cells of the pregnant ovine uterus express variable T cell receptors and contain granulysin","volume":"84","author":"Fox","year":"2010","journal-title":"J. Reprod. Immunol."},{"issue":"6912","key":"10.1016\/j.anireprosci.2026.108123_bib46","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature01195","article-title":"Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response","volume":"420","author":"Garlanda","year":"2002","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib47","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3168\/jds.S0022-0302(07)72628-0","article-title":"Regulation of interferon-stimulated genes in peripheral blood leukocytes in pregnant and bred, nonpregnant dairy cows","volume":"90","author":"Gifford","year":"2007","journal-title":"J. Dairy Sci."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib48","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1071\/RD11915","article-title":"The effects of endometritis on the establishment of pregnancy in cattle","volume":"24","author":"Gilbert","year":"2011","journal-title":"Reprod. Fertil. Dev."},{"issue":"10","key":"10.1016\/j.anireprosci.2026.108123_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/life12101512","article-title":"The role of neutrophils in pregnancy, term and preterm labour","volume":"12","author":"Gimeno-Molina","year":"2022","journal-title":"Life"},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib50","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1530\/jrf.0.0650141","article-title":"Purification and properties of a major, low molecular weight protein released by the trophoblast of sheep blastocysts at day 13\u201321","volume":"65","author":"Godkin","year":"1982","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib51","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/jcp.1041480207","article-title":"Mechanism of control of trophoblast invasion in situ","volume":"148","author":"Graham","year":"1991","journal-title":"J. Cell Physiol."},{"issue":"1-2","key":"10.1016\/j.anireprosci.2026.108123_bib52","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.anireprosci.2010.05.010","article-title":"Measurement of interferon-tau (IFN-tau) stimulated gene expression in blood leukocytes for pregnancy diagnosis within 18\u201320 d after insemination in dairy cattle","volume":"121","author":"Green","year":"2010","journal-title":"Anim. Reprod. Sci."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib53","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1071\/RD10230","article-title":"Immunological mechanisms to establish embryo tolerance in early bovine pregnancy","volume":"23","author":"Groebner","year":"2011","journal-title":"Reprod. Fertil. Dev."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib54","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jlb.62.5.577","article-title":"In vivo properties of monocyte chemoattractant protein-1","volume":"62","author":"Gu","year":"1997","journal-title":"J. Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib55","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1677\/joe.1.07015","article-title":"Low blood ISG15 mRNA and progesterone levels are predictive of non-pregnant dairy cows","volume":"191","author":"Han","year":"2006","journal-title":"J. Endocrinol."},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib56","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/GCO.0b013e328133885f","article-title":"Role of chemokines in the endometrium and in embryo implantation","volume":"19","author":"Hannan","year":"2007","journal-title":"Curr. Opin. Obstet. Gynecol."},{"issue":"13","key":"10.1016\/j.anireprosci.2026.108123_bib57","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2527\/jas.2006-487","article-title":"Regulation of immune cells in the uterus during pregnancy in ruminants","volume":"85","author":"Hansen","year":"2007","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.anireprosci.2026.108123_bib58","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-3-319-43238-0_11","article-title":"Corpus luteum and early pregnancy in ruminants","author":"Hansen","year":"2017","journal-title":"Life Cycle Corpus Luteum"},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib59","doi-asserted-by":"crossref","first-page":"F45","DOI":"10.1530\/REP-17-0315","article-title":"Paracrine and endocrine actions of interferon tau (IFNT)","volume":"154","author":"Hansen","year":"2017","journal-title":"Reproduction"},{"issue":"7","key":"10.1016\/j.anireprosci.2026.108123_bib60","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.1016\/S0021-9258(18)53504-3","article-title":"Differential regulation of human indoleamine 2,3-dioxygenase gene expression by interferons-gamma and -alpha. Analysis of the regulatory region of the gene and identification of an interferon-gamma-inducible DNA-binding factor","volume":"268","author":"Hassanain","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.anireprosci.2026.108123_bib61","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1210\/mend-3-1-127","article-title":"Molecular cloning and characterization of DNAs corresponding to bovine trophoblast protein-1: a comparison with ovine trophoblast protein-1 and bovine interferon-\u03b1","volume":"3","author":"Imakawa","year":"1989","journal-title":"Mol. Endocrinol."},{"issue":"6146","key":"10.1016\/j.anireprosci.2026.108123_bib62","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/330377a0","article-title":"Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm","volume":"330","author":"Imakawa","year":"1987","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib63","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1600-0897.2004.00243.x","article-title":"Changes in immune cell distribution and IL-10 production are regulated through endometrial IP-10 expression in the goat uterus","volume":"53","author":"Imakawa","year":"2005","journal-title":"Am. J. Reprod. Immunol."},{"issue":"7","key":"10.1016\/j.anireprosci.2026.108123_bib64","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/asj.12807","article-title":"Thirty years of interferon-tau research; Past, present and future perspective","volume":"88","author":"Imakawa","year":"2017","journal-title":"Anim. Sci. J."},{"issue":"7","key":"10.1016\/j.anireprosci.2026.108123_bib65","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1093\/jas\/sky103","article-title":"Integration of molecules to construct the processes of conceptus implantation to the maternal endometrium","volume":"96","author":"Imakawa","year":"2018","journal-title":"J. Anim. Sci."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib66","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3168\/jds.2022-22983","article-title":"Interferon-tau protects bovine endometrial epithelial cells against inflammatory injury by regulating the PI3K\/AKT\/x3b2;-catenin\/FoxO1 signaling axis","volume":"107","author":"Jiang","year":"2024","journal-title":"J. Dairy Sci."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib67","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1095\/biolreprod61.1.312","article-title":"Expression of the interferon tau inducible ubiquitin cross-reactive protein in the ovine uterus","volume":"61","author":"Johnson","year":"1999","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib68","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF02738623","article-title":"Endometrial ISG17 mRNA and a related mRNA are induced by interferon-tau and localized to glandular epithelial and stromal cells from pregnant cows","volume":"10","author":"Johnson","year":"1999","journal-title":"Endocrine"},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib69","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1095\/biolreprod62.3.622","article-title":"Interferon-tau and progesterone regulate ubiquitin cross-reactive protein expression in the ovine uterus","volume":"62","author":"Johnson","year":"2000","journal-title":"Biol. Reprod."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib70","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1095\/biolreprod64.5.1392","article-title":"Effects of the estrous cycle, pregnancy, and interferon tau on 2\u2032, 5\u2032-oligoadenylate synthetase expression in the ovine uterus","volume":"64","author":"Johnson","year":"2001","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib71","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1210\/en.2004-1224","article-title":"Interferon stimulated gene 15 conjugates to endometrial cytosolic proteins and is expressed at the uterine-placental interface throughout pregnancy in sheep","volume":"146","author":"Joyce","year":"2005","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib72","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1095\/biolreprod.116.141069","article-title":"Changes in myeloid lineage cells in the uterus and peripheral blood of dairy heifers during early pregnancy","volume":"95","author":"Kamat","year":"2016","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib73","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1477-7827-11-6","article-title":"Differential neutrophil gene expression in early bovine pregnancy","volume":"11","author":"Kizaki","year":"2013","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"9","key":"10.1016\/j.anireprosci.2026.108123_bib74","doi-asserted-by":"crossref","first-page":"8396","DOI":"10.3168\/jds.2017-14251","article-title":"Hot topic: pregnancy-induced expression of interferon-stimulated genes in the cervical and vaginal mucosal membranes","volume":"101","author":"Kunii","year":"2018","journal-title":"J. Dairy Sci."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib75","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.4049\/jimmunol.180.5.3028","article-title":"Alternatively activated macrophages regulate extracellular levels of the hormone placental lactogen via receptor-mediated uptake and transcytosis","volume":"180","author":"Kzhyshkowska","year":"2008","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib76","first-page":"157","article-title":"Identification of a unique lymphocyte subpopulation in the sheep uterus","volume":"63","author":"Lee","year":"1988","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib77","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1530\/reprod\/119.1.25","article-title":"Uterine lymphocyte distribution and interleukin expression during early pregnancy in cows","volume":"119","author":"Leung","year":"2000","journal-title":"J. Reprod. Fertil."},{"issue":"6","key":"10.1016\/j.anireprosci.2026.108123_bib78","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1095\/biolreprod.107.063594","article-title":"Galectin 15 (LGALS15): a gene uniquely expressed in the uteri of sheep and goats that functions in trophoblast attachment","volume":"77","author":"Lewis","year":"2007","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib79","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1530\/JOE-13-0429","article-title":"Differential expression and regulation of Tdo2 during mouse decidualization","volume":"220","author":"Li","year":"2014","journal-title":"J. Endocrinol."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib80","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1152\/physrev.00012.2018","article-title":"The neutrophil's role during health and disease","volume":"99","author":"Liew","year":"2019","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib81","article-title":"Expression of ISG15 in bone marrow during early pregnancy in ewes","volume":"23","author":"Ling","year":"2017","journal-title":"Kafkas \u00dcniv. Vet. Fak. Derg."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib82","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1530\/jrf.0.0900235","article-title":"Expression of major histocompatibility complex antigens on the bovine placenta","volume":"90","author":"Low","year":"1990","journal-title":"Reproduction"},{"issue":"4","key":"10.1016\/j.anireprosci.2026.108123_bib83","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1262\/jrd.2011-049","article-title":"Gene expressions in the persistent corpus luteum of postpartum dairy cows: distinct profiles from the corpora lutea of the estrous cycle and pregnancy","volume":"58","author":"Magata","year":"2012","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.anireprosci.2026.108123_bib84","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.vetimm.2016.03.017","article-title":"Neutrophil gene dynamics and plasma cytokine levels in dairy cattle during peri-implantation period","volume":"173","author":"Manjari","year":"2016","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib85","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1007\/s11033-019-04865-w","article-title":"Implantation associated divergence in neutrophil glucocorticoid and cysteine-X-cysteine receptor genes in cattle","volume":"46","author":"Manjari","year":"2019","journal-title":"Mol. Biol. Rep."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib86","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1095\/biolreprod.112.101121","article-title":"Pivotal role for monocytes\/macrophages and dendritic cells in maternal immune response to the developing embryo in cattle","volume":"87","author":"Mansouri-Attia","year":"2012","journal-title":"Biol. Reprod."},{"issue":"8","key":"10.1016\/j.anireprosci.2026.108123_bib87","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nri3024","article-title":"Neutrophils in the activation and regulation of innate and adaptive immunity","volume":"11","author":"Mantovani","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.anireprosci.2026.108123_bib88","doi-asserted-by":"crossref","DOI":"10.1093\/jas\/skac123","article-title":"Ruminant conceptus-maternal interactions: interferon-tau and beyond","volume":"100","author":"Mathew","year":"2022","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.anireprosci.2026.108123_bib89","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1477-7827-10-21","article-title":"Relationship between quantity of IFNT estimated by IFN-stimulated gene expression in peripheral blood mononuclear cells and bovine embryonic mortality after AI or ET","volume":"10","author":"Matsuyama","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"11","key":"10.1016\/j.anireprosci.2026.108123_bib90","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1017\/S175173111600077X","article-title":"Interferon stimulated genes as peripheral diagnostic markers of early pregnancy in sheep: a critical assessment","volume":"10","author":"Mauffr\u00e9","year":"2016","journal-title":"Animal"},{"issue":"1-2","key":"10.1016\/j.anireprosci.2026.108123_bib91","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0165-0378(01)00118-8","article-title":"Tryptophan catabolism prevents maternal T cells from activating lethal anti-fetal immune responses","volume":"52","author":"Mellor","year":"2001","journal-title":"J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib92","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/rda.12638","article-title":"Pregnancy-induced ISG-15 and MX-1 gene expression is detected in the liver of Holstein-Friesian heifers during late peri-implantation period","volume":"51","author":"Meyerholz","year":"2016","journal-title":"Reprod. Domest. Anim."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib93","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.2527\/jas.2013-7332","article-title":"Cell biology symposium: perspectives: possible roles of polymorphonuclear neutrophils in angiogenesis and lymphangiogenesis in the corpus luteum during development and early pregnancy in ruminants","volume":"92","author":"Miyamoto","year":"2014","journal-title":"J. Anim. Sci."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib94","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1172\/JCI68107","article-title":"Uterine NK cells: active regulators at the maternal-fetal interface","volume":"124","author":"Moffett","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.anireprosci.2026.108123_bib95","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1080\/09291016.2017.1311984","article-title":"Fluctuation in the number, type and activity of blood neutrophils in cows exhibiting successful and unsuccessful completion of gestation cycle","volume":"48","author":"Mohammed","year":"2017","journal-title":"Biol. Rhythm Res."},{"key":"10.1016\/j.anireprosci.2026.108123_bib96","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.theriogenology.2022.08.020","article-title":"Pregnancy stage-dependent modulation of neutrophil function may impact embryo survivability and pregnancy outcome in crossbred cows","volume":"191","author":"Mohammed","year":"2022","journal-title":"Theriogenology"},{"issue":"8","key":"10.1016\/j.anireprosci.2026.108123_bib97","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.3168\/jds.2013-7802","article-title":"Effects of supplemental progesterone after artificial insemination on expression of interferon-stimulated genes and fertility in dairy cows","volume":"97","author":"Monteiro","year":"2014","journal-title":"J. Dairy Sci."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib98","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1749-6632.2010.05938.x","article-title":"Inflammation and pregnancy: the role of the immune system at the implantation site","volume":"1221","author":"Mor","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1\u20132","key":"10.1016\/j.anireprosci.2026.108123_bib99","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0165-5728(96)00231-7","article-title":"CD4 T suppressor cells mediate interferon tau protection against experimental allergic encephalomyelitis","volume":"75","author":"Mujtaba","year":"1997","journal-title":"J. Neuroimmunol."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib100","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1021\/pr200969a","article-title":"\"Proteome of the early embryo-maternal dialogue in the cattle uterus","volume":"11","author":"Mu\u00f1oz","year":"2012","journal-title":"J. Proteome Res"},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib101","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-065X.2011.01002.x","article-title":"Gimme shelter: the immune system during pregnancy","volume":"241","author":"Munoz-Suano","year":"2011","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.anireprosci.2026.108123_bib102","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1095\/biolreprod55.4.748","article-title":"Transforming growth factor beta in bovine placentas","volume":"55","author":"Munson","year":"1996","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.anireprosci.2026.108123_bib103","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/(SICI)1098-2795(199708)47:4<390::AID-MRD5>3.0.CO;2-F","article-title":"Repression of MHC class II gene transcription in trophoblast cells by novel single-stranded DNA binding proteins","volume":"47","author":"Murphy","year":"1997","journal-title":"Mol. Reprod. Dev."},{"issue":"52","key":"10.1016\/j.anireprosci.2026.108123_bib104","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1611944114","article-title":"Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy","volume":"113","author":"Nadkarni","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib105","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/1933719109349962","article-title":"The immunomodulatory roles of macrophages at the maternal-fetal interface","volume":"17","author":"Nagamatsu","year":"2010","journal-title":"Reprod. Sci."},{"issue":"4","key":"10.1016\/j.anireprosci.2026.108123_bib106","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1095\/biolreprod.102.008912","article-title":"A chemokine, interferon (IFN)-gamma-inducible protein 10 kDa, is stimulated by IFN-tau and recruits immune cells in the ovine endometrium","volume":"68","author":"Nagaoka","year":"2003","journal-title":"Biol. Reprod."},{"issue":"31","key":"10.1016\/j.anireprosci.2026.108123_bib107","doi-asserted-by":"crossref","first-page":"29048","DOI":"10.1074\/jbc.M300470200","article-title":"Regulation of blastocyst migration, apposition, and initial adhesion by a chemokine, interferon gamma-inducible protein 10 kDa (IP-10), during early gestation","volume":"278","author":"Nagaoka","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.anireprosci.2026.108123_bib108","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1530\/REP-11-0157","article-title":"Possible involvement of IFNT in lymphangiogenesis in the corpus luteum during the maternal recognition period in the cow","volume":"142","author":"Nitta","year":"2011","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib109","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9581350","article-title":"Comparison of immunomodulation properties of porcine mesenchymal stromal\/stem cells derived from the bone marrow, adipose tissue, and dermal skin tissue","volume":"2016","author":"Ock","year":"2016","journal-title":"Stem Cells Int."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib110","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1095\/biolreprod.109.082560","article-title":"Regulation of a bovine nonclassical major histocompatibility complex class I gene promoter","volume":"83","author":"O'Gorman","year":"2010","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib111","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1210\/en.2007-0863","article-title":"Expression of interferon (IFN)-stimulated genes in extrauterine tissues during early pregnancy in sheep is the consequence of endocrine IFN-tau release from the uterine vein","volume":"149","author":"Oliveira","year":"2008","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/j.anireprosci.2026.108123_bib112","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013213","article-title":"Differentiation of the endometrial macrophage during pregnancy in the cow","volume":"5","author":"Oliveira","year":"2010","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.anireprosci.2026.108123_bib113","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075571","article-title":"Characterization of the Th profile of the bovine endometrium during the oestrous cycle and early pregnancy","volume":"8","author":"Oliveira","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib114","first-page":"237","article-title":"Maternal immune responses to conceptus signals during early pregnancy in ruminants","volume":"11","author":"Ott","year":"2018","journal-title":"Anim. Reprod. (AR)"},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib115","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1530\/REP-18-0188","article-title":"Blastocyst-induced changes in the bovine endometrial transcriptome","volume":"156","author":"Passaro","year":"2018","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib116","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/imr.13090","article-title":"Fetal-placental antigens and the maternal immune system: Reproductive immunology comes of age","volume":"308","author":"Petroff","year":"2022","journal-title":"Immunol. Rev."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib117","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I-and type-II-interferon-mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.anireprosci.2026.108123_bib118","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1095\/biolreprod.114.121525","article-title":"Conceptus-induced changes in the gene expression of blood immune cells and the ultrasound-accessed luteal function in beef cattle: how early can we detect pregnancy?","volume":"91","author":"Pugliesi","year":"2014","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.anireprosci.2026.108123_bib119","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.bbrc.2018.04.178","article-title":"Evidence that interferon-tau secreted from Day-7 embryo in vivo generates anti-inflammatory immune response in the bovine uterus","volume":"500","author":"Rashid","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.anireprosci.2026.108123_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.anireprosci.2019.106251","article-title":"Pregnancy loss in beef cattle: a meta-analysis","volume":"212","author":"Reese","year":"2020","journal-title":"Anim. Reprod. Sci."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib121","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1095\/biolreprod.113.114694","article-title":"Low doses of bovine somatotropin enhance conceptus development and fertility in lactating dairy cows","volume":"90","author":"Ribeiro","year":"2014","journal-title":"Biol. Reprod."},{"issue":"5-6","key":"10.1016\/j.anireprosci.2026.108123_bib122","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cytogfr.2007.06.010","article-title":"Interferon-tau, a Type 1 interferon involved in maternal recognition of pregnancy","volume":"18","author":"Roberts","year":"2007","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.anireprosci.2026.108123_bib123","series-title":"Seminars in Cell & Developmental Biology","article-title":"Interferons and the maternal\u2013conceptus dialog in mammals","author":"Roberts","year":"2008"},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib124","doi-asserted-by":"crossref","first-page":"13733","DOI":"10.1038\/s41598-020-70616-8","article-title":"Early pregnancy-induced transcripts in peripheral blood immune cells in Bos indicus heifers","volume":"10","author":"Rocha","year":"2020","journal-title":"Sci. Rep."},{"issue":"22","key":"10.1016\/j.anireprosci.2026.108123_bib125","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1152\/physiolgenomics.00082.2013","article-title":"Pregnancy-associated genes contribute to antiluteolytic mechanisms in ovine corpus luteum","volume":"45","author":"Romero","year":"2013","journal-title":"Physiol. Genom."},{"issue":"6","key":"10.1016\/j.anireprosci.2026.108123_bib126","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1095\/biolreprod.115.132860","article-title":"Temporal release, paracrine and endocrine actions of ovine conceptus-derived interferon-tau during early pregnancy","volume":"93","author":"Romero","year":"2015","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib127","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1095\/biolreprod.102.004267","article-title":"Expression of interferon receptor subunits, IFNAR1 and IFNAR2, in the ovine uterus","volume":"67","author":"Rosenfeld","year":"2002","journal-title":"Biol. Reprod."},{"issue":"13","key":"10.1016\/j.anireprosci.2026.108123_bib128","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1182\/blood.V96.13.4300","article-title":"The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells","volume":"96","author":"Rovere","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.anireprosci.2026.108123_bib129","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.theriogenology.2017.07.051","article-title":"Interferon-\u03c4 induced gene expression in bovine hepatocytes during early pregnancy","volume":"104","author":"Ruhmann","year":"2017","journal-title":"Theriogenology"},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib130","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1530\/REP-14-0538","article-title":"Exosomes, endogenous retroviruses and toll-like receptors: pregnancy recognition in ewes","volume":"149","author":"Ruiz-Gonz\u00e1lez","year":"2015","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib131","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1095\/biolreprod.115.136523","article-title":"Trophoblast major histocompatibility complex class I expression is associated with immune-mediated rejection of bovine fetuses produced by cloning","volume":"95","author":"Rutigliano","year":"2016","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.anireprosci.2026.108123_bib132","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3390\/ijms18040742","article-title":"Possible roles of CC-and CXC-chemokines in regulating bovine endometrial function during early pregnancy","volume":"18","author":"Sakumoto","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib133","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/mrd.22171","article-title":"Down-regulation of interferon tau gene transcription with a transcription factor, EOMES","volume":"80","author":"Sakurai","year":"2013","journal-title":"Mol. Reprod. Dev."},{"issue":"11","key":"10.1016\/j.anireprosci.2026.108123_bib134","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080427","article-title":"Transcriptional regulation of two conceptus interferon tau genes expressed in Japanese black cattle during peri-implantation period","volume":"8","author":"Sakurai","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.anireprosci.2026.108123_bib135","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1242\/dev.01056","article-title":"PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization","volume":"131","author":"Salustri","year":"2004","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib136","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1095\/biolreprod.106.052944","article-title":"Progesterone regulation of preimplantation conceptus growth and galectin 15 (LGALS15) in the ovine uterus","volume":"75","author":"Satterfield","year":"2006","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib137","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/09291016.2018.1440777","article-title":"Interferon tau stimulated gene expression and proinflammatory cytokine profile relative to insemination in dairy cows","volume":"50","author":"Sheikh","year":"2019","journal-title":"Biol. Rhythm Res."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib138","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1262\/jrd.11-094K","article-title":"Upregulation of interferon-stimulated genes and interleukin-10 in peripheral blood immune cells during early pregnancy in dairy cows","volume":"58","author":"Shirasuna","year":"2012","journal-title":"J. Reprod. Dev."},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib139","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1530\/REP-15-0085","article-title":"Possible role of interferon tau on the bovine corpus luteum and neutrophils during the early pregnancy","volume":"150","author":"Shirasuna","year":"2015","journal-title":"Reproduction"},{"issue":"5","key":"10.1016\/j.anireprosci.2026.108123_bib140","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1530\/REP-16-0642","article-title":"Effects of supplementation with docosahexaenoic acid on reproduction of dairy cows","volume":"153","author":"Sinedino","year":"2017","journal-title":"Reproduction"},{"issue":"1-2","key":"10.1016\/j.anireprosci.2026.108123_bib141","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0165-2427(92)90153-H","article-title":"Inhibition of lymphocyte proliferation by bovine trophoblast protein-1 (type I trophoblast interferon) and bovine interferon-alpha I1","volume":"34","author":"Skopets","year":"1992","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.anireprosci.2026.108123_bib142","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1477-7827-2-49","article-title":"Conceptus signals for establishment and maintenance of pregnancy","volume":"2","author":"Spencer","year":"2004","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"11","key":"10.1016\/j.anireprosci.2026.108123_bib143","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1210\/endo.136.11.7588227","article-title":"Ovine interferon-tau inhibits estrogen receptor up-regulation and estrogen-induced luteolysis in cyclic ewes","volume":"136","author":"Spencer","year":"1995","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.anireprosci.2026.108123_bib144","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3181\/00379727-213-44053","article-title":"tau-Interferon: pregnancy recognition signal in ruminants","volume":"213","author":"Spencer","year":"1996","journal-title":"Proc. Soc. Exp. Biol. Med."},{"issue":"6","key":"10.1016\/j.anireprosci.2026.108123_bib145","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1095\/biolreprod61.6.1409","article-title":"Effects of recombinant ovine interferon tau, placental lactogen, and growth hormone on the ovine uterus","volume":"61","author":"Spencer","year":"1999","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2026.108123_bib146","first-page":"379","article-title":"Fetal-maternal interactions during the establishment of pregnancy in ruminants","volume":"64","author":"Spencer","year":"2007","journal-title":"Soc. Reprod. Fertil. Suppl."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib147","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1530\/REP-07-0327","article-title":"Genes involved in conceptus-endometrial interactions in ruminants: insights from reductionism and thoughts on holistic approaches","volume":"135","author":"Spencer","year":"2008","journal-title":"Reproduction"},{"issue":"7","key":"10.1016\/j.anireprosci.2026.108123_bib148","doi-asserted-by":"crossref","first-page":"5941","DOI":"10.3168\/jds.2015-10070","article-title":"The role of progesterone and conceptus-derived factors in uterine biology during early pregnancy in ruminants","volume":"99","author":"Spencer","year":"2016","journal-title":"J. Dairy Sci."},{"issue":"4","key":"10.1016\/j.anireprosci.2026.108123_bib149","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175954","article-title":"Pre-hatching embryo-dependent and-independent programming of endometrial function in cattle","volume":"12","author":"Sponchiado","year":"2017","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.anireprosci.2026.108123_bib150","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1210\/er.2005-0003","article-title":"The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy","volume":"26","author":"Straszewski-Chavez","year":"2005","journal-title":"Endocr. Rev."},{"issue":"7","key":"10.1016\/j.anireprosci.2026.108123_bib151","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.4049\/jimmunol.1100130","article-title":"Macrophages at the fetal-maternal interface express markers of alternative activation and are induced by M-CSF and IL-10","volume":"187","author":"Svensson","year":"2011","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.anireprosci.2026.108123_bib152","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1262\/jrd.2017-056","article-title":"Bovine embryo induces an anti-inflammatory response in uterine epithelial cells and immune cells in vitro: possible involvement of interferon tau as an intermediator","volume":"63","author":"Talukder","year":"2017","journal-title":"J. Reprod. Dev."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib153","doi-asserted-by":"crossref","first-page":"7850","DOI":"10.1038\/s41598-018-26224-8","article-title":"Oviduct epithelium induces interferon-tau in bovine Day-4 embryos, which generates an anti-inflammatory response in immune cells","volume":"8","author":"Talukder","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib154","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13069","article-title":"Day-7 embryos generate an anti-inflammatory immune response in peripheral blood immune cells in superovulated cows","volume":"81","author":"Talukder","year":"2019","journal-title":"Am. J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib155","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1146\/annurev.immunol.19.1.623","article-title":"IRF family of transcription factors as regulators of host defense","volume":"19","author":"Taniguchi","year":"2001","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib156","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1046\/j.8755-8920.2003.00125.x","article-title":"Regulation of numbers of macrophages in the endometrium of the sheep by systemic effects of pregnancy, local presence of the conceptus, and progesterone","volume":"51","author":"Tekin","year":"2004","journal-title":"Am. J. Reprod. Immunol."},{"issue":"4","key":"10.1016\/j.anireprosci.2026.108123_bib157","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-2052.1987.tb00775.x","article-title":"Expression and genetic segregation of parental BoLA serotypes in bovine embryos","volume":"18","author":"Templeton","year":"1987","journal-title":"Anim. Genet."},{"key":"10.1016\/j.anireprosci.2026.108123_bib158","first-page":"91","article-title":"Antiluteolytic effects of bovine trophoblast protein-1","volume":"37","author":"Thatcher","year":"1989","journal-title":"J. Reprod. Fertil. Suppl."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib159","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1600-0897.2006.00439.x","article-title":"Cellular localization and function of the antiviral protein, ovine Mx1 (oMx1): II. The oMx1 protein is a regulator of secretion in an ovine glandular epithelial cell line","volume":"57","author":"Toyokawa","year":"2007","journal-title":"Am. J. Reprod. Immunol."},{"issue":"9","key":"10.1016\/j.anireprosci.2026.108123_bib160","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1089\/jir.1998.18.731","article-title":"Trophoblast IFN-\u03c4 differentially induces lymphopenia and neutropenia in lambs","volume":"18","author":"Tuo","year":"1998","journal-title":"J. Interferon Cytokine Res."},{"issue":"26","key":"10.1016\/j.anireprosci.2026.108123_bib161","doi-asserted-by":"crossref","first-page":"11918","DOI":"10.1073\/pnas.1001749107","article-title":"Crosstalk between decidual NK and CD14+ myelomonocytic cells results in induction of Tregs and immunosuppression","volume":"107","author":"Vacca","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib162","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/biolre\/iox061","article-title":"Effects of early pregnancy on uterine lymphocytes and endometrial expression of immune-regulatory molecules in dairy heifers","volume":"97","author":"Vasudevan","year":"2017","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.anireprosci.2026.108123_bib163","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anireprosci.2019.05.010","article-title":"Immune status during postpartum, peri-implantation and early pregnancy in cattle: an updated view","volume":"206","author":"Vel\u00e1zquez","year":"2019","journal-title":"Anim. Reprod. Sci."},{"issue":"16","key":"10.1016\/j.anireprosci.2026.108123_bib164","doi-asserted-by":"crossref","first-page":"5788","DOI":"10.1073\/pnas.84.16.5788","article-title":"Transforming growth factor type beta induces monocyte chemotaxis and growth factor production","volume":"84","author":"Wahl","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.anireprosci.2026.108123_bib165","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1186\/1471-2164-11-474","article-title":"Modulation of the maternal immune system by the pre-implantation embryo","volume":"11","author":"Walker","year":"2010","journal-title":"BMC Genom."},{"key":"10.1016\/j.anireprosci.2026.108123_bib166","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.3389\/fimmu.2018.03025","article-title":"Immunological homeostasis at the ovine placenta may reflect the degree of maternal fetal interaction","volume":"9","author":"Wattegedera","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.anireprosci.2026.108123_bib167","first-page":"11","article-title":"Proteins of ovine blastocyst origin","author":"Wilson","year":"1979","journal-title":"Proc. Soc. Study Reprod."},{"key":"10.1016\/j.anireprosci.2026.108123_bib168","doi-asserted-by":"crossref","unstructured":"Wolf, E., Ali, A., Zakhartchenko, V., et al., 2026. Pregnancy establishment in cattle without embryonic interferon tau. Preprint, \u3008https:\/\/doi.org\/10.21203\/rs.3.rs-8509201\/v1\u3009.","DOI":"10.21203\/rs.3.rs-8509201\/v1"},{"issue":"11","key":"10.1016\/j.anireprosci.2026.108123_bib169","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1111\/asj.13101","article-title":"Expression of interferon-stimulated gene 15-kDa protein, cyclooxygenase (COX) 1, COX-2, aldo-keto reductase family 1, member B1, and prostaglandin E synthase in the spleen during early pregnancy in sheep","volume":"89","author":"Yang","year":"2018","journal-title":"Anim. Sci. J."},{"issue":"1","key":"10.1016\/j.anireprosci.2026.108123_bib170","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/mrd.23085","article-title":"Expression profiles of interferon-stimulated gene 15 and prostaglandin synthases in the ovine lymph nodes during early pregnancy","volume":"86","author":"Yang","year":"2019","journal-title":"Mol. Reprod. Dev."},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib171","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1677\/joe.0.170r007","article-title":"Expression of the antiviral protein Mx in peripheral blood mononuclear cells of pregnant and bred, non-pregnant ewes","volume":"170","author":"Yankey","year":"2001","journal-title":"J. Endocrinol."},{"issue":"7","key":"10.1016\/j.anireprosci.2026.108123_bib172","article-title":"Interferon-stimulated gene expression in peripheral blood leucocytes as a convenient prediction marker for embryo status in embryo-transferred japanese black cows during the peri-implantation period","volume":"10","author":"Yoshino","year":"2023","journal-title":"Vet. Sci."},{"key":"10.1016\/j.anireprosci.2026.108123_bib173","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2024.1344259","article-title":"Transcriptomic analysis of bovine endometrial epithelial cells in response to interferon tau and hormone stimulation","volume":"11","author":"Yu","year":"2024","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.anireprosci.2026.108123_bib174","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.theriogenology.2018.08.018","article-title":"Changes in expression of ISG15, progesterone receptor and progesterone-induced blocking factor in ovine thymus during early pregnancy","volume":"121","author":"Zhang","year":"2018","journal-title":"Theriogenology"},{"issue":"2","key":"10.1016\/j.anireprosci.2026.108123_bib175","doi-asserted-by":"crossref","DOI":"10.1590\/1984-3143-ar2019-0134","article-title":"Changes in expression of interferon-stimulated genes and ubiquitin activating enzyme E1-like in ovine thymus during early pregnancy","volume":"17","author":"Zhang","year":"2020","journal-title":"Anim. Reprod."}],"container-title":["Animal Reproduction Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432026000266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432026000266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T22:06:05Z","timestamp":1775945165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378432026000266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":175,"alternative-id":["S0378432026000266"],"URL":"https:\/\/doi.org\/10.1016\/j.anireprosci.2026.108123","relation":{},"ISSN":["0378-4320"],"issn-type":[{"value":"0378-4320","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interferon tau and the immune blueprint of early ruminant pregnancy","name":"articletitle","label":"Article Title"},{"value":"Animal Reproduction Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anireprosci.2026.108123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108123"}}