{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:14:01Z","timestamp":1792095241659,"version":"4.4.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["303544\/2022\\u201388"],"award-info":[{"award-number":["303544\/2022\\u201388"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["406866\/2022-8\/INCT"],"award-info":[{"award-number":["406866\/2022-8\/INCT"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["408696\/2024\\u20139\/INCT"],"award-info":[{"award-number":["408696\/2024\\u20139\/INCT"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Reproduction Science"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.anireprosci.2026.108178","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T01:53:38Z","timestamp":1775181218000},"page":"108178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Uterine inflammation did not compromise fertility in young primiparous Bos indicus cows enrolled in postpartum timed AI programs"],"prefix":"10.1016","volume":"290","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2069-951X","authenticated-orcid":false,"given":"Luiz Francisco Machado","family":"Pfeifer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Lauanne Silva","family":"Lacouth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica de Souza","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid Pedra\u00e7a","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira Alves de Souza","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Reis","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7931-455X","authenticated-orcid":false,"given":"\u00c9riklis","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-9663","authenticated-orcid":false,"given":"Fabiana","family":"Sterza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos Louzada","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anireprosci.2026.108178_bib1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.theriogenology.2024.04.018","article-title":"Timed-artificial insemination protocols for Bos indicus beef heifers: Evaluation of protocol length and variations in prostaglandin F2\u03b1 treatments","volume":"223","author":"Alves","year":"2024","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2026.108178_bib2","first-page":"1","article-title":"Exploring uterine inflammation in postpartum primiparous precocious and conventional and multiparous Bos indicus beef cows","author":"Andrade","year":"2023","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.anireprosci.2026.108178_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.livsci.2021.104528","article-title":"Uterine health and fertility of timed AI postpartum Nelore beef cows raised in the Amazon biome","volume":"249","author":"Andrade","year":"2021","journal-title":"Liv Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.livsci.2008.11.004","article-title":"Validation of body condiction score as a predictor of subcutaneous fat in Nelore (Bos indicus) cows","volume":"123","author":"Ayres","year":"2009","journal-title":"Liv Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib5","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3168\/jds.2016-11529","article-title":"Cytological endometritis at artificial insemination in dairy cows: prevalence and effect on pregnancy outcome","volume":"100","author":"Bogado Pascottini","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib6","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/rda.13037","article-title":"Cytobrush: a tool for sequential evaluation of gene expression in bovine endometrium","volume":"52","author":"Cardoso","year":"2017","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.anireprosci.2026.108178_bib7","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.3168\/jds.2020-19181","article-title":"Effect of protein level and methionine supplementation on dairy cows during the transition period","volume":"104","author":"Cardoso","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib8","doi-asserted-by":"crossref","first-page":"S175","DOI":"10.1093\/jas\/skaa138","article-title":"Amino acids and the regulation of oxidative stress and immune function in dairy cattle","volume":"98","author":"Coleman","year":"2020","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib9","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.theriogenology.2011.08.033","article-title":"Effects of polymorphonuclear neutrophile infiltration into the endometrial environment on embryonic development in superovulated cows","volume":"77","author":"Drillich","year":"2012","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2026.108178_bib10","doi-asserted-by":"crossref","first-page":"951","DOI":"10.2527\/2002.804951x","article-title":"Genetic evaluation of the probability of pregnancy at 14 months for Nellore heifers 1","volume":"80","author":"Eler","year":"2002","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib11","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1017\/S1751731117002464","article-title":"A combination of nutrition and genetics is able to reduce age at puberty in Nelore heifers to below 18 months","volume":"12","author":"Ferraz Junior","year":"2018","journal-title":"Anim. Int. J. Anim. Biosci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7827-7-55","article-title":"Expression of genes associated with immunity in the endometrium of cattle with disparate postpartum uterine disease and fertility","volume":"7","author":"Herath","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.anireprosci.2026.108178_bib13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1017\/S175173111200170X","article-title":"Nutrition, immune function and health of dairy cattle","volume":"7","author":"Ingvartsen","year":"2013","journal-title":"Animal"},{"key":"10.1016\/j.anireprosci.2026.108178_bib14","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.3168\/jds.2018-15687","article-title":"Glutathione metabolism and nuclear factor erythroid 2-like 2 (NFE2L2)-related proteins in adipose tissue are altered by supply of ethyl-cellulose rumen-protected methionine in peripartal Holstein cows","volume":"102","author":"Liang","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.theriogenology.2021.11.002","article-title":"Quantitative and functional dynamics of circulating and endometrial polymorphonuclear leukocytes in healthy peripartum dairy cows","volume":"178","author":"Lietaer","year":"2022","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2026.108178_bib16","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.anireprosci.2026.108178_bib17","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/gerona\/60.11.1394","article-title":"Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor\/binding protein knockout mice","volume":"60","author":"Masternak","year":"2005","journal-title":"J. Gerontol. - Ser. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.livsci.2016.11.008","article-title":"E ff ect of pre-partum dam supplementation, creep-feeding and post- weaning feedlot on age at puberty in Nellore heifers","volume":"195","author":"Nepomuceno","year":"2017","journal-title":"Liv Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1751731119000442","article-title":"Timed artificial insemination plus heat I: effect of estrus expression scores on pregnancy of cows subjected to progesterone-estradiol-based protocols","volume":"13","author":"Nogueira","year":"2019","journal-title":"Animal"},{"key":"10.1016\/j.anireprosci.2026.108178_bib20","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.anireprosci.2004.04.007","article-title":"Puberty in South American Bos indicus (Zebu) cattle","author":"Nogueira","year":"2004","journal-title":"Animal Reproduction Science"},{"key":"10.1016\/j.anireprosci.2026.108178_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.anireprosci.2022.106928","article-title":"The effect of subclinical endometritis on reproductive performance in postpartum Bos indicus multiparous beef cows","volume":"237","author":"Oliveira Filho","year":"2022","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib22","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.theriogenology.2013.11.016","article-title":"The use of PGF2alpha as ovulatory stimulus for timed artificial insemination in cattle","volume":"81","author":"Pfeifer","year":"2014","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2026.108178_bib23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.anireprosci.2018.08.039","article-title":"Uterine inflammation and fertility of beef cows subjected to timed AI at different days postpartum","volume":"197","author":"Pfeifer","year":"2018","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.livsci.2019.103886","article-title":"Effect of estradiol cypionate on estrus expression and pregnancy in timed artificially inseminated beef cows","volume":"231","author":"Pfeifer","year":"2020","journal-title":"Liv Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib25","doi-asserted-by":"crossref","DOI":"10.11606\/issn.1678-4456.bjvras.2025.223638","article-title":"Impact of sperm hyperactivation and estrus on pregnancy in timed AI Bos indicus beef cows","volume":"62","author":"Pfeifer","year":"2025","journal-title":"Braz. J. Vet. Res Anim. Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib26","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.3168\/jds.2009-2117","article-title":"Evaluation of the Metricheck device and the gloved hand for the diagnosis of clinical endometritis in dairy cows","volume":"92","author":"Pleticha","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib27","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/rda.12465","article-title":"Evaluation of subclinical endometritis and consequences on fertility in piedmontese beef cows","volume":"50","author":"Ricci","year":"2015","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.anireprosci.2026.108178_bib28","doi-asserted-by":"crossref","DOI":"10.1017\/S1751731119000454","article-title":"Timed artificial insemination plus heat II: gonadorelin injection in cows with low estrus expression scores increased pregnancy in progesterone\/estradiol-based protocol","author":"Rodrigues","year":"2019","journal-title":"Animal 16"},{"key":"10.1016\/j.anireprosci.2026.108178_bib29","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.theriogenology.2011.02.022","article-title":"Importance of estrus on pregnancy per insemination in suckled Bos indicus cows submitted to estradiol\/progesterone-based timed insemination protocols","volume":"76","author":"Sa Filho","year":"2011","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2026.108178_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.anireprosci.2008.04.006","article-title":"Effect of progesterone and\/or estradiol treatments prior to induction of ovulation on subsequent luteal lifespan in anestrous Nelore cows","volume":"112","author":"Sa Filho","year":"2009","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.anireprosci.2011.02.007","article-title":"Fixed-time AI protocols replacing eCG with a single dose of FSH were less effective in stimulating follicular growth, ovulation, and fertility in suckled-anestrus Nelore beef cows","volume":"124","author":"Sales","year":"2011","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib32","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.theriogenology.2008.09.043","article-title":"Postpartum endometrial cytology in beef cows","volume":"71","author":"Santos","year":"2009","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2026.108178_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1439-0531.2009.01465.x","article-title":"Mechanisms of infertility associated with clinical and subclinical endometritis in high producing dairy cattle","volume":"44","author":"Sheldon","year":"2009","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.anireprosci.2026.108178_bib34","doi-asserted-by":"crossref","first-page":"622","DOI":"10.21451\/1984-3143-AR1006","article-title":"Postpartum uterine infection and endometritis in dairy cattle","volume":"14","author":"Sheldon","year":"2017","journal-title":"Anim. Reprod."},{"key":"10.1016\/j.anireprosci.2026.108178_bib35","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.theriogenology.2005.08.021","article-title":"Defining postpartum uterine disease in cattle","volume":"65","author":"Sheldon","year":"2006","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2026.108178_bib36","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0093-691X(97)00038-1","article-title":"Neutrophil migration into the uterine lumen of the cow: The influence of endogenous and exogenous sex steroid hormones using two intrauterine chemoattractants","author":"Subandrio","year":"1997","journal-title":"Theriogenology 45"},{"key":"10.1016\/j.anireprosci.2026.108178_bib37","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.anireprosci.2008.03.012","article-title":"Intravaginal progesterone device and\/or temporary weaning on reproductive performance of anestrous crossbred Angus x Nelore cows","volume":"111","author":"Vasconcelos","year":"2009","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.anireprosci.2026.108178_bib38","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.theriogenology.2004.03.017","article-title":"Clinical evaluation of postpartum vaginal mucus reflects uterine bacterial infection and the immune response in cattle","volume":"63","author":"Williams","year":"2005","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2026.108178_bib39","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.aninu.2015.09.002","article-title":"Epigenetic modulation of DNA methylation by nutrition and its mechanisms in animals","volume":"1","author":"Zhang","year":"2015","journal-title":"Anim. Nutr."}],"container-title":["Animal Reproduction Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432026000813?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378432026000813?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T14:32:57Z","timestamp":1779460377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378432026000813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":39,"alternative-id":["S0378432026000813"],"URL":"https:\/\/doi.org\/10.1016\/j.anireprosci.2026.108178","relation":{},"ISSN":["0378-4320"],"issn-type":[{"value":"0378-4320","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uterine inflammation did not compromise fertility in young primiparous Bos indicus cows enrolled in postpartum timed AI programs","name":"articletitle","label":"Article Title"},{"value":"Animal Reproduction Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anireprosci.2026.108178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108178"}}