{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:29:49Z","timestamp":1793478589699,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302795"],"award-info":[{"award-number":["32302795"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472955"],"award-info":[{"award-number":["32472955"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal Reproduction Science"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.anireprosci.2026.108334","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:35:54Z","timestamp":1789054554000},"page":"108334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effects of dietary supplementation with taxifolin on reproductive performance in aging layer breeder roosters"],"prefix":"10.1016","volume":"294","author":[{"given":"Wenyan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8804-4730","authenticated-orcid":false,"given":"Xiangsen","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yikun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zili","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihui","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anireprosci.2026.108334_bib1","first-page":"1","article-title":"Investigation of the effects of rutin on valproic acid induced testicular damage in rats","volume":"16","author":"Akarsu","year":"2023","journal-title":"Kocatepe Vet. J."},{"key":"10.1016\/j.anireprosci.2026.108334_bib2","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.3390\/molecules24183333","article-title":"The thioredoxin system is regulated by the ASK-1\/JNK\/p38\/Survivin pathway during germ cell apoptosis","volume":"24","author":"Al-Kandari","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.anireprosci.2026.108334_bib3","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1071\/RD17072","article-title":"d-Aspartate amends reproductive performance of aged roosters by changing gene expression and testicular histology","volume":"30","author":"Ansari","year":"2018","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.anireprosci.2026.108334_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.theriogenology.2017.01.014","article-title":"Improvement of post-thawed sperm quality and fertility of Arian rooster by oral administration of d-aspartic acid","volume":"92","author":"Ansari","year":"2017","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2026.108334_bib5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0093-691X(01)00590-8","article-title":"Effect of antioxidants on preservation of motility, viability and acrosomal integrity of equine spermatozoa during storage at 5\u00b0C","volume":"56","author":"Ball","year":"2001","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2026.108334_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4061\/2011\/686137","article-title":"Impacts of oxidative stress and antioxidants on semen functions","volume":"2011","author":"Bansal","year":"2011","journal-title":"Vet. Med. Int."},{"key":"10.1016\/j.anireprosci.2026.108334_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.theriogenology.2017.06.018","article-title":"Feeding rosemary leaves powder ameliorates rooster age-related subfertility","volume":"101","author":"Borghei-Rad","year":"2017","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2026.108334_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2025.1686381","article-title":"Taxifolin for prevention of COGnitive impairment (T-COG trial): a study protocol for a randomized, double-blind, placebo-controlled trial","volume":"12","author":"Chiba","year":"2025","journal-title":"Front. Nutr."},{"key":"10.1016\/j.anireprosci.2026.108334_bib9","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.3390\/ijms17121986","article-title":"Pro- and antioxidant activity of three selected flavan type flavonoids: catechin, eriodictyol and taxifolin","volume":"17","author":"Chobot","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.anireprosci.2026.108334_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejphar.2017.04.003","article-title":"L-carnitine preserves cardiac function by activating p38 MAPK\/Nrf2 signalling in hearts exposed to irradiation","volume":"804","author":"Fan","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.anireprosci.2026.108334_bib11","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s40104-021-00633-8","article-title":"Natural astaxanthin enhanced antioxidant capacity and improved semen quality through the MAPK\/Nrf2 pathway in aging layer breeder roosters","volume":"12","author":"Gao","year":"2021","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.anireprosci.2026.108334_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101045","article-title":"Dietary supplementation with natural astaxanthin from Haematococcus pluvialis improves antioxidant enzyme activity, free radical scavenging ability, and gene expression of antioxidant enzymes in laying hens","volume":"100","author":"Heng","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.anireprosci.2026.108334_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12894-018-0421-9","article-title":"Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats","volume":"18","author":"Jahan","year":"2018","journal-title":"BMC Urol."},{"key":"10.1016\/j.anireprosci.2026.108334_bib14","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.3382\/ps\/pev123","article-title":"Review of rearing-related factors affecting the welfare of laying hens","volume":"94","author":"Janczak","year":"2015","journal-title":"Poult. Sci."},{"key":"10.1016\/j.anireprosci.2026.108334_bib15","doi-asserted-by":"crossref","first-page":"581","DOI":"10.4062\/biomolther.2016.141","article-title":"Lonchocarpine increases Nrf2\/ARE-mediated antioxidant enzyme expression by modulating AMPK and MAPK signaling in brain astrocytes","volume":"24","author":"Jeong","year":"2016","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.anireprosci.2026.108334_bib16","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1080\/1828051X.2024.2366956","article-title":"Dietary Aronia melanocarpa supplementation inhibit the oxidative stress caused by aging in ovary of late laying hens from 59 to 67 weeks of age","volume":"23","author":"Jing","year":"2024","journal-title":"Ital. J. Anim. Sci."},{"key":"10.1016\/j.anireprosci.2026.108334_bib17","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/00071668.2019.1571165","article-title":"Effects of dietary curcumin supplementation on seminal quality indices and fertility rate in broiler breeder roosters","volume":"60","author":"Kazemizadeh","year":"2019","journal-title":"Br. Poult. Sci."},{"key":"10.1016\/j.anireprosci.2026.108334_bib18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1017\/S0043933911000316","article-title":"Antioxidants and poultry semen quality","volume":"67","author":"Khan","year":"2011","journal-title":"Worlds Poult. Sci. J."},{"key":"10.1016\/j.anireprosci.2026.108334_bib19","first-page":"233","article-title":"Enzymatic polymerization of dihydroquercetin using bilirubin oxidase","volume":"80","author":"Khlupova","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.anireprosci.2026.108334_bib20","article-title":"Dietary supplementation with lycopene improves semen quality and antioxidant status in breeder roosters","volume":"104","author":"Long","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.anireprosci.2026.108334_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.101812","article-title":"Research note: Dietary supplementation with pyrroloquinoline quinone disodium (PQQ.Na2) improves oxidative status and semen quality in aging layer breeder roosters","volume":"101","author":"Long","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.anireprosci.2026.108334_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104252","article-title":"Dietary alpha-linolenic acid supplementation enhances semen quality, antioxidant capacity, and sperm survival in aging breeder roosters","volume":"103","author":"Long","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.anireprosci.2026.108334_bib23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/00071660903401540","article-title":"Effect of lycopene on semen quality, fertility and native immunity of broiler breeder","volume":"51","author":"Mangiagalli","year":"2010","journal-title":"Br. Poult. Sci."},{"key":"10.1016\/j.anireprosci.2026.108334_bib24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tox.2013.09.003","article-title":"Tributyltin chloride induced testicular toxicity by JNK and p38 activation, redox imbalance and cell death in sertoli-germ cell co-culture","volume":"314","author":"Mitra","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.anireprosci.2026.108334_bib25","doi-asserted-by":"crossref","first-page":"11802","DOI":"10.3390\/ijms252111802","article-title":"Impact of reductive stress on human infertility: underlying mechanisms and perspectives","volume":"25","author":"Moustakli","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.anireprosci.2026.108334_bib26","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s11745-004-1333-0","article-title":"Mechanisms of regulation of gene expression by fatty acids","volume":"39","author":"Nakamura","year":"2004","journal-title":"Lipids"},{"key":"10.1016\/j.anireprosci.2026.108334_bib27","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.3724\/abbs.2025139","article-title":"Angelicin attenuates sepsis-associated acute liver injury via p38 MAPK inhibition and NF-\u03baB-mediated Nrf2\/Keap1 activation to suppress inflammation and oxidative stress","volume":"58","author":"Pan","year":"2026","journal-title":"ABBS"},{"key":"10.1016\/j.anireprosci.2026.108334_bib28","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1074\/jbc.RA118.004253","article-title":"Antioxidant treatment induces reductive stress associated with mitochondrial dysfunction in adipocytes","volume":"294","author":"Peris","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.anireprosci.2026.108334_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.132531","article-title":"Plant flavonoids: classification, distribution, biosynthesis, and antioxidant activity","volume":"383","author":"Shen","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.anireprosci.2026.108334_bib30","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2174\/0929867013373039","article-title":"Relative impact of oxidative stress on male reproductive function","volume":"8","author":"Sikka","year":"2001","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.anireprosci.2026.108334_bib31","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.fct.2013.11.013","article-title":"Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis","volume":"63","author":"Sun","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.anireprosci.2026.108334_bib32","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0093-691X(00)00249-1","article-title":"Phospholipid fatty acid composition, vitamin E content and susceptibility to lipid peroxidation of duck spermatozoa","volume":"53","author":"Surai","year":"2000","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2026.108334_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2024.1506029","article-title":"Improving fertilization rates in IVF using rutin and quercetin in preculture medium or through oral administration","volume":"11","author":"Tanaka","year":"2025","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.anireprosci.2026.108334_bib34","first-page":"621","article-title":"Antioxidant properties of dihydroquercetin","volume":"41","author":"Teselkin","year":"1996","journal-title":"Biofizika"},{"key":"10.1016\/j.anireprosci.2026.108334_bib35","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.2337\/diab.46.11.1733","article-title":"Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells","volume":"46","author":"Tiedge","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.anireprosci.2026.108334_bib36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.antiviral.2017.09.010","article-title":"Celastrol inhibits hepatitis C virus replication by upregulating heme oxygenase-1 via the JNK MAPK\/Nrf2 pathway in human hepatoma cells","volume":"146","author":"Tseng","year":"2017","journal-title":"Antivir. Res."},{"key":"10.1016\/j.anireprosci.2026.108334_bib37","article-title":"The impact of oxidative stress on male reproductive function: exploring the role of antioxidant supplementation","volume":"15","author":"Walke","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.anireprosci.2026.108334_bib38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/gcen.1999.7276","article-title":"Fertility decline in aging roosters is related to increased testicular and plasma levels of estradiol","volume":"115","author":"Weil","year":"1999","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.anireprosci.2026.108334_bib39","first-page":"520","article-title":"Taxifolin protects RPE cells against oxidative stress-induced apoptosis","volume":"23","author":"Xie","year":"2017","journal-title":"Mol. Vision."},{"key":"10.1016\/j.anireprosci.2026.108334_bib40","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.theriogenology.2021.12.032","article-title":"Dietary folic acid supplementation improves semen quality and spermatogenesis through altering autophagy and histone methylation in the testis of aged broiler breeder roosters","volume":"181","author":"Ye","year":"2022","journal-title":"Theriogenology"},{"key":"10.1016\/j.anireprosci.2026.108334_bib41","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.3390\/ijms21072346","article-title":"Understanding MAPK signaling pathways in apoptosis","volume":"21","author":"Yue","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.anireprosci.2026.108334_bib42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.theriogenology.2019.02.030","article-title":"Dietary supplementation with flaxseed oil as source of omega-3 fatty acids improves seminal quality and reproductive performance in aged broiler breeder roosters","volume":"130","author":"Zanussi","year":"2019","journal-title":"Theriogenology"}],"container-title":["Animal Reproduction Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037843202600237X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037843202600237X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:43:58Z","timestamp":1793475838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037843202600237X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":42,"alternative-id":["S037843202600237X"],"URL":"https:\/\/doi.org\/10.1016\/j.anireprosci.2026.108334","relation":{},"ISSN":["0378-4320"],"issn-type":[{"value":"0378-4320","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of dietary supplementation with taxifolin on reproductive performance in aging layer breeder roosters","name":"articletitle","label":"Article Title"},{"value":"Animal Reproduction Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anireprosci.2026.108334","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108334"}}