{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:04:47Z","timestamp":1778875487085,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Auris Nasus Larynx"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.anl.2006.07.014","type":"journal-article","created":{"date-parts":[[2006,11,10]],"date-time":"2006-11-10T07:28:04Z","timestamp":1163143684000},"page":"267-271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["A case of squamous cell carcinoma of the head and neck producing granulocyte-colony stimulating factor with marked leukocytosis"],"prefix":"10.1016","volume":"34","author":[{"given":"Minoru","family":"Toyoda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Chikamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Sakakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumasa","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoaki","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Shimamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Furuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anl.2006.07.014_bib1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/0959-8049(94)00488-Q","article-title":"Value of granulocyte colony stimulating factor in radiotherapy induced neutropenia: clinical and laboratory studies","volume":"31","author":"MacManus","year":"1995","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.anl.2006.07.014_bib2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/(SICI)1097-0215(19990105)80:1<78::AID-IJC16>3.0.CO;2-S","article-title":"Granulocyte-colony-stimulating factor enhances invasive potential of human head-and-neck-carcinoma cell lines","volume":"80","author":"Noda","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1016\/j.anl.2006.07.014_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/ijc.1297","article-title":"Granulocyte colony-stimulating factor (G-CSF)-mediated signaling regulates type IV collagenase activity in head and neck cancer cells","volume":"93","author":"Sugimoto","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.anl.2006.07.014_bib4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2169\/internalmedicine.31.277","article-title":"Granulocyte colony-stimulating factor-producing large cell undifferentiated carcinoma of the lung","volume":"31","author":"Shijubo","year":"1992","journal-title":"Intern Med"},{"key":"10.1016\/j.anl.2006.07.014_bib5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1349-7006.1996.tb00245.x","article-title":"Establishment of a clonal cell line producing granulocyte colony-stimulating factor and parathyroid hormone-related protein from a lung cancer patient with leukocytosis and hypercalcemia","volume":"87","author":"Asahi","year":"1996","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/j.anl.2006.07.014_bib6","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1056\/NEJM199012133232418","article-title":"Bladder cancer producing granulocyte colony-stimulating factor","volume":"323","author":"Ito","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.anl.2006.07.014_bib7","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/1097-0142(19850815)56:4<782::AID-CNCR2820560414>3.0.CO;2-5","article-title":"A case of gastric carcinoma associated with excessive granulocytosis. Production of a colony stimulating factor by the tumor","volume":"56","author":"Obara","year":"1985","journal-title":"Cancer"},{"key":"10.1016\/j.anl.2006.07.014_bib8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/1097-0339(200010)23:4<269::AID-DC11>3.0.CO;2-A","article-title":"Granulocyte colony-stimulating factor-producing small-cell carcinoma of the uterine cervix: Report of a case","volume":"23","author":"Watanabe","year":"2000","journal-title":"Diagn Cytopathol"},{"key":"10.1016\/j.anl.2006.07.014_bib9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/gyno.2000.5904","article-title":"A case of cervical cancer with aggressive tumor growth: possible autocrine growth stimulation by G-CSF and IL-6","volume":"78","author":"Kyo","year":"2000","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.anl.2006.07.014_bib10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1177\/38.2.1688901","article-title":"Establishment of specific monoclonal antibodies against recombinant human granulocyte colony-stimulating factor (hG-CSF) and their application for immunoperoxidase staining of paraffin-embedded sections","volume":"38","author":"Shimamura","year":"1990","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.anl.2006.07.014_bib11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1749-6632.1974.tb14451.x","article-title":"Granulocytosis in neoplasia","volume":"230","author":"Robinson","year":"1974","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.anl.2006.07.014_bib12","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/j.1349-7006.1994.tb02938.x","article-title":"New human oral squamous carcinoma cell line and its tumorigenic subline producing granulocyte colony-stimulating factor","volume":"85","author":"Matsuo","year":"1994","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/j.anl.2006.07.014_bib13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/(SICI)1097-0347(199707)19:4<351::AID-HED15>3.0.CO;2-C","article-title":"Granulocyte colony stimulating factor-producing tongue carcinoma","volume":"19","author":"Horii","year":"1997","journal-title":"Head Neck"},{"key":"10.1016\/j.anl.2006.07.014_bib14","first-page":"794","article-title":"Expression of granulocyte colony-stimulating factor receptor correlates with prognosis in oral and mesopharyngeal carcinoma","volume":"58","author":"Tsuzuki","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.anl.2006.07.014_bib15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/ijc.11188","article-title":"Expression profiles of angiogenic growth factors in squamous cell carcinomas of the head and neck","volume":"106","author":"Ninck","year":"2003","journal-title":"Int J Cancer"},{"key":"10.1016\/j.anl.2006.07.014_bib16","first-page":"768","article-title":"Electron microscopic identification of the intracellular secretion pathway of human G-CSF in a human tumor cell line: a comparative study with a Chinese hamster ovary cell line (IA1-7) transfected with human G-CSF cDNA","volume":"19","author":"Akatsuka","year":"1991","journal-title":"Exp Hematol"},{"key":"10.1016\/j.anl.2006.07.014_bib17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF02592273","article-title":"Recent developments in the cell biology of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor: activities on endothelial cells","volume":"23","author":"Bussolino","year":"1993","journal-title":"Int J Clin Lab Res"},{"key":"10.1016\/j.anl.2006.07.014_bib18","first-page":"523","article-title":"Angiogenic factors are hematopoietic growth factors and vice versa","volume":"8","author":"Bikfalvi","year":"1994","journal-title":"Leukemia (Baltimore)"},{"key":"10.1016\/j.anl.2006.07.014_bib19","doi-asserted-by":"crossref","first-page":"7801","DOI":"10.1158\/0008-5472.CAN-03-3301","article-title":"Cooperative autocrine and paracrine functions of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in the progression of skin carcinoma cells","volume":"64","author":"Obermueller","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.anl.2006.07.014_bib20","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0301-472X(02)00785-3","article-title":"Peripheral blood stem cell harvests from G-CSF-stimulated donors contain a skewed Th2 CD4 phenotype and a predominance of type 2 dendritic cells","volume":"30","author":"Klangsinsirikul","year":"2002","journal-title":"Exp Hematol"},{"key":"10.1016\/j.anl.2006.07.014_bib21","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1084\/jem.188.12.2357","article-title":"The central role of CD4+ T cells in the antitumor immune response","volume":"188","author":"Hung","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.anl.2006.07.014_bib22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1084\/jem.189.5.753","article-title":"CD4 T cells and their role in antitumor immune responses","volume":"189","author":"Toes","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.anl.2006.07.014_bib23","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1182\/blood.V95.8.2484","article-title":"Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells","volume":"95","author":"Arpinati","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.anl.2006.07.014_bib24","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0301-472X(02)00785-3","article-title":"Peripheral blood stem cell harvests from G-CSF-stimulated donors contain a skewed Th2 CD4 phenotype and a predominance of type 2 dendritic cells","volume":"30","author":"Klangsinsirikul","year":"2002","journal-title":"Exp Hematol"},{"key":"10.1016\/j.anl.2006.07.014_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/(SICI)1097-0215(20000320)89:2<187::AID-IJC14>3.0.CO;2-V","article-title":"Clinical significance of p53 functional loss in squamous cell carcinoma of the oropharynx","volume":"89","author":"Obata","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1016\/j.anl.2006.07.014_bib26","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1002\/cncr.10388","article-title":"Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma","volume":"94","author":"Bandoh","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.anl.2006.07.014_bib27","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0959-437X(96)80091-8","article-title":"P-glycoprotein and multidrug resistance","volume":"6","author":"Gottesman","year":"1996","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.anl.2006.07.014_bib28","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/S0306-3623(96)00081-X","article-title":"The P-glycoprotein multidrug transporter","volume":"27","author":"Fardel","year":"1996","journal-title":"Gen Pharmacol"},{"key":"10.1016\/j.anl.2006.07.014_bib29","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2174\/1389450043345461","article-title":"Potential for predicting toxicity and response of fluoropyrimidines in patients","volume":"5","author":"Eliason","year":"2004","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.anl.2006.07.014_bib30","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s10147-003-0330-z","article-title":"Clinical implications of dihydropyrimidine dehydrogenase (DPD) activity in 5-FU-based chemotherapy: mutations in the DPD gene, and DPD inhibitory fluoropyrimidines","volume":"8","author":"Omura","year":"2003","journal-title":"Int J Clin Oncol"}],"container-title":["Auris Nasus Larynx"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814606001131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814606001131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:23:42Z","timestamp":1759951422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0385814606001131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0385814606001131"],"URL":"https:\/\/doi.org\/10.1016\/j.anl.2006.07.014","relation":{},"ISSN":["0385-8146"],"issn-type":[{"value":"0385-8146","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A case of squamous cell carcinoma of the head and neck producing granulocyte-colony stimulating factor with marked leukocytosis","name":"articletitle","label":"Article Title"},{"value":"Auris Nasus Larynx","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anl.2006.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}