{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:48:32Z","timestamp":1776185312203,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Auris Nasus Larynx"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.anl.2010.09.001","type":"journal-article","created":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T04:17:04Z","timestamp":1288239424000},"page":"220-227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Sinonasal inhalation of dornase alfa in CF: A double-blind placebo-controlled cross-over pilot trial"],"prefix":"10.1016","volume":"38","author":[{"given":"Jochen G.","family":"Mainz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Schiller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Ritschel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Joachim","family":"Mentzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Riethm\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assen","family":"Koitschev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerlind","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Beck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baerbel","family":"Wiedemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anl.2010.09.001_bib0005","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0091-6749(92)90183-3","article-title":"Impact of sinusitis in cystic fibrosis","volume":"90","author":"Ramsey","year":"1992","journal-title":"Allergy Clin Immunol J"},{"key":"10.1016\/j.anl.2010.09.001_bib0010","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/1099-0496(200012)30:6<481::AID-PPUL8>3.0.CO;2-N","article-title":"Sinonasal disease in cystic fibrosis: clinical characteristics, diagnosis, and management","volume":"30","author":"Gysin","year":"2000","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.anl.2010.09.001_bib0015","first-page":"152","article-title":"Endoscopic and CT-scan evaluation of rhinosinusitis in cystic fibrosis","volume":"33","author":"Coste","year":"1995","journal-title":"Rhinology"},{"key":"10.1016\/j.anl.2010.09.001_bib0020","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1080\/028418501127346639","article-title":"Complementary role of MR imaging of ethmomaxillary sinus disease depicted at CT in cystic fibrosis","volume":"42","author":"Eggesb\u00f8","year":"2001","journal-title":"Acta Radiol"},{"key":"10.1016\/j.anl.2010.09.001_bib0025","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1080\/028418501127347214","article-title":"CT characterization of developmental variations of the paranasal sinuses in cystic fibrosis","volume":"42","author":"Eggesbo","year":"2001","journal-title":"Acta Radiol"},{"key":"10.1016\/j.anl.2010.09.001_bib0030","doi-asserted-by":"crossref","first-page":"9188","DOI":"10.1073\/pnas.87.23.9188","article-title":"Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum","volume":"87","author":"Shak","year":"1990","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.anl.2010.09.001_bib0035","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1056\/NEJM199409083311003","article-title":"Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with Cystic Fibrosis","volume":"331","author":"Pulmozyme Study Group","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.anl.2010.09.001_bib0040","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1067\/mpd.2001.118570","article-title":"A two-year randomized, placebo-controlled trial of dornase alfa in young patients with cystic fibrosis with mild lung function abnormalities","volume":"139","author":"Quan","year":"2001","journal-title":"J Pediatr"},{"key":"10.1016\/j.anl.2010.09.001_bib0045","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/(SICI)1099-0496(199809)26:3<155::AID-PPUL1>3.0.CO;2-K","article-title":"Multicenter, open-label study of recombinant human DNase in cystic fibrosis patients with moderate lung disease. DNase International Study Group","volume":"26","author":"Harms","year":"1998","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.anl.2010.09.001_bib0050","first-page":"95","article-title":"Ability of aerosols to penetrate into adjoining rooms [Article in German]","volume":"190","author":"Kauf H","year":"1967","journal-title":"Exper Ohren-Nasen- und Kehlkopfheilkunde"},{"key":"10.1016\/j.anl.2010.09.001_bib0055","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1164\/rccm.200202-138BC","article-title":"Humming greatly increases nasal nitric oxide","volume":"166","author":"Weitzberg","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anl.2010.09.001_bib0060","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2362.2006.01654.x","article-title":"Sounding airflow enhances aerosol delivery into the paranasal sinuses","volume":"36","author":"Maniscalco","year":"2006","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.anl.2010.09.001_bib0065","first-page":"213","article-title":"Ventilation and drug delivery to the paranasal sinuses: studies in a nasal cast using pulsating airflow","volume":"46","author":"M\u00f6ller","year":"2008","journal-title":"Rhinology"},{"key":"10.1016\/j.anl.2010.09.001_bib0070","series-title":"Proceedings of the respiratory drug delivery (RDD) X","first-page":"737","article-title":"Deposition of Pulmozyme\u00ae into the sinus cavities of a human nasal cast model using PARI SINUS\u2122","author":"Schuschnig","year":"2006"},{"key":"10.1016\/j.anl.2010.09.001_bib0075","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.otohns.2009.12.028","article-title":"Pulsating aerosols for drug delivery to the sinuses in healthy volunteers","volume":"142","author":"M\u00f6ller","year":"2010","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2010.09.001_bib0080","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1001\/archotol.133.11.1115","article-title":"Nasal saline for chronic sinonasal symptoms: a randomized controlled trial","volume":"133","author":"Pynnonen","year":"2007","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2010.09.001_bib0085","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1067\/mhn.2002.121022","article-title":"Psychometric and clinimetric validity of the 20 Item Sino-Nasal Outcome Test (SNOT-20)","volume":"126","author":"Piccirillo","year":"2002","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2010.09.001_bib0090","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1177\/194589240501900312","article-title":"Impact of gender on general Quality of Life in patients with chronic sinusitis","volume":"19","author":"Baumann","year":"2005","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.anl.2010.09.001_bib0095","first-page":"268","article-title":"Impact of gender, age, and comorbidities on quality of life in patients with chronic rhinosinusitis","volume":"45","author":"Baumann","year":"2007","journal-title":"Rhinology"},{"key":"10.1016\/j.anl.2010.09.001_bib0100","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.anl.2009.11.016","article-title":"Reliability and validity assessments of a Japanese version of QOL 20-Item Sino-Nasal Outcome Test for chronic rhinosinusitis","volume":"37","author":"Majima","year":"2010","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.anl.2010.09.001_bib0105","series-title":"Design and analysis of cross-over trials","year":"2003"},{"key":"10.1016\/j.anl.2010.09.001_bib0110","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0022-3476(05)82653-8","article-title":"Pulmonary function and clinical course in patients with cystic fibrosis after pulmonary colonisation with Pseudomonas aeruginosa","volume":"116","author":"Kerem","year":"1990","journal-title":"J Pediatr"},{"key":"10.1016\/j.anl.2010.09.001_bib0115","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1001\/archpedi.1958.02060060008002","article-title":"Long-term study of one hundred five patients with cystic fibrosis; studies made over a five- to fourteen-year period","volume":"96","author":"Shwachman","year":"1958","journal-title":"AMA J Dis Child"},{"key":"10.1016\/j.anl.2010.09.001_bib0120","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF02914539","article-title":"Upper respiratory disease, sinusitis, and polyposis","volume":"9","author":"King","year":"1991","journal-title":"Clin Rev Allergy"},{"key":"10.1016\/j.anl.2010.09.001_bib0125","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S1569-1993(09)60005-9","article-title":"Management of chronic rhinosinusitis in CF","volume":"8S","author":"Mainz","year":"2009","journal-title":"J Cystic Fibrosis"},{"key":"10.1016\/j.anl.2010.09.001_bib0130","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1136\/thx.2008.104711","article-title":"Concordant genotype of upper and lower airways P. aeruginosa and S. aureus isolates in cystic fibrosis","volume":"64","author":"Mainz","year":"2009","journal-title":"Thorax"},{"key":"10.1016\/j.anl.2010.09.001_bib0135","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1097\/00005537-199612000-00019","article-title":"Endoscopic sinus surgery in the treatment of cystic fibrosis with nasal polyposis","volume":"106","author":"Rowe-Jones","year":"1996","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anl.2010.09.001_bib0140","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2500\/ajr.2007.21.2963","article-title":"Deposition of aerosolized particles in the maxillary sinuses before and after endoscopic sinus surgery","volume":"21","author":"St Martin","year":"2007","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.anl.2010.09.001_bib0145","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1001\/archotol.131.12.1097","article-title":"Dornase alfa as postoperative therapy in cystic fibrosis sinonasal disease","volume":"131","author":"Cimmino","year":"2005","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2010.09.001_bib0150","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1288\/00005537-199202000-00002","article-title":"The relationship between the nasal cycle and mucociliary clearance","volume":"102","author":"Littlejohn","year":"1992","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anl.2010.09.001_bib0155","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1177\/194589240501900411","article-title":"Lack of significant correlation between rhinosinusitis symptoms and specific regions of sinus computer tomography scans","volume":"19","author":"Holbrook","year":"2005","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.anl.2010.09.001_bib0160","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/01.mlg.0000198338.05826.18","article-title":"Health-related quality of life after polypectomy with and without additional surgery","volume":"116","author":"Browne","year":"2006","journal-title":"Laryngoscope"}],"container-title":["Auris Nasus Larynx"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814610001781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814610001781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:26:46Z","timestamp":1759951606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0385814610001781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0385814610001781"],"URL":"https:\/\/doi.org\/10.1016\/j.anl.2010.09.001","relation":{},"ISSN":["0385-8146"],"issn-type":[{"value":"0385-8146","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sinonasal inhalation of dornase alfa in CF: A double-blind placebo-controlled cross-over pilot trial","name":"articletitle","label":"Article Title"},{"value":"Auris Nasus Larynx","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anl.2010.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}