{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:28:20Z","timestamp":1773034100574,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Auris Nasus Larynx"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.anl.2015.11.005","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T06:01:35Z","timestamp":1451368895000},"page":"440-445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["The value of insulin-like growth factor-1 receptor for predicting early glottic carcinoma response to radiotherapy"],"prefix":"10.1016","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-8011","authenticated-orcid":false,"given":"Fumihiko","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Ohba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhisa","family":"Fujimaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhisa","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anl.2015.11.005_bib0180","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/(SICI)1520-6823(1999)7:3<125::AID-ROI1>3.0.CO;2-W","article-title":"Molecular markers as prognostic factors for local recurrence and radioresistance in head and neck squamous cell carcinoma","volume":"7","author":"Smith","year":"1999","journal-title":"Radiat Oncol Investig"},{"key":"10.1016\/j.anl.2015.11.005_bib0185","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.anl.2004.05.003","article-title":"Prognostic significance of EGF receptor expression in early glottic cancer","volume":"31","author":"Demiral","year":"2004","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.anl.2015.11.005_bib0190","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1097\/00005537-199607000-00019","article-title":"Prognostic value of EGFR and TGF-alpha in early laryngeal cancer treated with radiotherapy","volume":"106","author":"Wen","year":"1996","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anl.2015.11.005_bib0195","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.rpor.2010.06.001","article-title":"Prognostic and predictive significance of p53, EGFr, Ki-67 in larynx preservation treatment","volume":"15","author":"Malecki","year":"2010","journal-title":"Rep Pract Oncol Radiother"},{"key":"10.1016\/j.anl.2015.11.005_bib0200","first-page":"408","article-title":"Overexpression of p53 predicts organ preservation using induction chemotherapy and radiation in patients with advanced laryngeal cancer. Department of Veterans Affairs Laryngeal Cancer Study Group","volume":"113","author":"Bradford","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2015.11.005_bib0205","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1093\/jnci\/93.24.1852","article-title":"Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)","volume":"93","author":"Lu","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.anl.2015.11.005_bib0210","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/JTO.0b013e31818180f5","article-title":"The insulin-like growth factor pathway in lung cancer","volume":"3","author":"Dziadziuszko","year":"2008","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.anl.2015.11.005_bib0215","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1083\/jcb.200703044","article-title":"A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop","volume":"178","author":"Xiong","year":"2007","journal-title":"J Cell Biol"},{"key":"10.1016\/j.anl.2015.11.005_bib0220","first-page":"875","article-title":"Upregulation of IGF-2 and IGF-1 receptor expression in oral cancer cell lines","volume":"31","author":"Brady","year":"2007","journal-title":"Int J Oncol"},{"key":"10.1016\/j.anl.2015.11.005_bib0225","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1038\/sj.bjc.6602627","article-title":"Role of insulin-like growth factor 1 receptor signalling in cancer","volume":"92","author":"Larsson","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1016\/j.anl.2015.11.005_bib0230","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3835(03)00159-9","article-title":"The insulin-like growth factor system and cancer","volume":"195","author":"LeRoith","year":"2003","journal-title":"Cancer Lett"},{"key":"10.1016\/j.anl.2015.11.005_bib0235","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1210\/er.2006-0001","article-title":"The role of the IGF system in cancer growth and metastasis: overview and recent insights","volume":"28","author":"Samani","year":"2007","journal-title":"Endocr Rev"},{"key":"10.1016\/j.anl.2015.11.005_bib0240","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1158\/1078-0432.CCR-06-2040","article-title":"Insulin-like growth factor receptor as a therapeutic target in head and neck cancer","volume":"13","author":"Barnes","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.anl.2015.11.005_bib0245","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.canlet.2006.08.004","article-title":"Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma","volume":"248","author":"Slomiany","year":"2007","journal-title":"Cancer Lett"},{"key":"10.1016\/j.anl.2015.11.005_bib0250","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.canlet.2005.08.009","article-title":"The prognostic role of loss of insulin-like growth factor-binding protein-3 expression in head and neck carcinogenesis","volume":"239","author":"Papadimitrakopoulou","year":"2006","journal-title":"Cancer Lett"},{"key":"10.1016\/j.anl.2015.11.005_bib0255","doi-asserted-by":"crossref","first-page":"8434","DOI":"10.1158\/1078-0432.CCR-04-0430","article-title":"Low levels of insulin-like growth factor type 1 receptor expression at cancer cell membrane predict liver metastasis in Dukes\u2019 C human colorectal cancers","volume":"10","author":"Nakamura","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.anl.2015.11.005_bib0260","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00428-003-0856-5","article-title":"IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer","volume":"443","author":"Peters","year":"2003","journal-title":"Virchows Arch"},{"key":"10.1016\/j.anl.2015.11.005_bib0265","first-page":"187","article-title":"Clinical implications of insulin-like growth factors through the presence of their binding proteins and receptors expressed in gynecological cancers","volume":"25","author":"Hirano","year":"2004","journal-title":"Eur J Gynaecol Oncol"},{"key":"10.1016\/j.anl.2015.11.005_bib0270","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ygyno.2007.04.004","article-title":"IGF-1R expression in localized cervical carcinoma patients treated by radiochemotherapy","volume":"106","author":"Lloret","year":"2007","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.anl.2015.11.005_bib0275","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3904\/kjim.2008.23.3.116","article-title":"Clinical significance of insulin-like growth factor-1 receptor expression in stage I non-small-cell lung cancer: immunohistochemical analysis","volume":"23","author":"Lee","year":"2008","journal-title":"Korean J Intern Med"},{"key":"10.1016\/j.anl.2015.11.005_bib0280","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.oraloncology.2011.06.007","article-title":"Insulin-like growth factor binding protein-3, in association with IGF-1 receptor, can predict prognosis in squamous cell carcinoma of the head and neck","volume":"47","author":"Sun","year":"2011","journal-title":"Oral Oncol"},{"key":"10.1016\/j.anl.2015.11.005_bib0285","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/000348940811700306","article-title":"Expression and clinical significance of epidermal growth factor receptor and type 1 insulin-like growth factor receptor in nasopharyngeal carcinoma","volume":"117","author":"Yuan","year":"2008","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"Suppl. 1","key":"10.1016\/j.anl.2015.11.005_bib0290","first-page":"58","article-title":"Insulin-like growth factor-I receptor in human oral cancer","volume":"49","author":"Reszec","year":"2004","journal-title":"Rocz Akad Med Bialymst"},{"key":"10.1016\/j.anl.2015.11.005_bib0295","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.oraloncology.2011.05.005","article-title":"IGF-1R expression predicts clinical outcome in patients with locally advanced oral squamous cell carcinoma","volume":"47","author":"Lara","year":"2011","journal-title":"Oral Oncol"},{"key":"10.1016\/j.anl.2015.11.005_bib0300","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/hed.23702","article-title":"Relationship between insulin-like growth factor-1 receptor and human papillomavirus in patients with oropharyngeal cancer","volume":"37","author":"Matsumoto","year":"2015","journal-title":"Head Neck"},{"key":"10.1016\/j.anl.2015.11.005_bib0305","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/ijc.11487","article-title":"The IGF-1 receptor in cancer biology","volume":"107","author":"Baserga","year":"2003","journal-title":"Int J Cancer"},{"key":"10.1016\/j.anl.2015.11.005_bib0310","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.bbrc.2004.06.175","article-title":"Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis","volume":"321","author":"Steinbach","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.anl.2015.11.005_bib0315","doi-asserted-by":"crossref","first-page":"19665","DOI":"10.1074\/jbc.M500815200","article-title":"A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity","volume":"280","author":"Lu","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.anl.2015.11.005_bib0320","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/sj.bjc.6600182","article-title":"ZD1839 (\u2018Iressa\u2019), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model","volume":"86","author":"Williams","year":"2002","journal-title":"Br J Cancer"},{"key":"10.1016\/j.anl.2015.11.005_bib0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1593\/tlo.11265","article-title":"Role of IGF-1 receptor in radiation response","volume":"5","author":"Valenciano","year":"2012","journal-title":"Transl Oncol"},{"key":"10.1016\/j.anl.2015.11.005_bib0330","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.radonc.2010.03.009","article-title":"Prognostic significance of IGF-1R expression in patients treated with breast-conserving surgery and radiation therapy","volume":"96","author":"Taunk","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.anl.2015.11.005_bib0335","first-page":"3079","article-title":"Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation","volume":"57","author":"Turner","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.anl.2015.11.005_bib0340","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1001\/archotol.1991.01870150065008","article-title":"Radiotherapy. The mainstay in the treatment of early glottic carcinoma","volume":"117","author":"Pellitteri","year":"1991","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2015.11.005_bib0345","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/hed.2880130505","article-title":"Glottic cancer involving anterior commissure: surgery vs radiotherapy","volume":"13","author":"Rucci","year":"1991","journal-title":"Head Neck"},{"key":"10.1016\/j.anl.2015.11.005_bib0350","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/0360-3016(93)90005-G","article-title":"T1\u2013T2 squamous cell carcinoma of the glottic larynx treated with radiotherapy: a multivariate analysis of variables potentially influencing local control","volume":"25","author":"Fein","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Auris Nasus Larynx"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S038581461500245X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S038581461500245X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:31:59Z","timestamp":1759951919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S038581461500245X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S038581461500245X"],"URL":"https:\/\/doi.org\/10.1016\/j.anl.2015.11.005","relation":{},"ISSN":["0385-8146"],"issn-type":[{"value":"0385-8146","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The value of insulin-like growth factor-1 receptor for predicting early glottic carcinoma response to radiotherapy","name":"articletitle","label":"Article Title"},{"value":"Auris Nasus Larynx","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anl.2015.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}