{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:12:24Z","timestamp":1787976744794,"version":"build-2784847793"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Auris Nasus Larynx"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.anl.2018.09.005","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T00:48:16Z","timestamp":1537577296000},"page":"424-430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Risk factors for cervical lymph node metastasis in endoscopically resected superficial hypopharyngeal cancers"],"prefix":"10.1016","volume":"46","author":[{"given":"Takayuki","family":"Imai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigemi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Oikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukinori","family":"Asada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takefumi","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuro","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anl.2018.09.005_bib0005","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/cncr.20482","article-title":"Squamous cell carcinoma in situ at oropharyngeal and hypopharyngeal mucosal sites","volume":"101","author":"Muto","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.anl.2018.09.005_bib0010","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hed.20943","article-title":"Prospective study of early detection of pharyngeal superficial carcinoma with the narrowband imaging laryngoscope","volume":"31","author":"Ugumori","year":"2009","journal-title":"Head Neck"},{"key":"10.1016\/j.anl.2018.09.005_bib0015","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/01.mlg.0000204304.38797.34","article-title":"Laryngoscopic detection of pharyngeal carcinoma in situ with narrowband imaging","volume":"116","author":"Watanabe","year":"2006","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anl.2018.09.005_bib0020","article-title":"The role of transoral robotic surgery in the management of oropharyngeal cancer: a review of the literature","volume":"2012","author":"Dowthwaite","year":"2012","journal-title":"ISRN Oncol"},{"key":"10.1016\/j.anl.2018.09.005_bib0025","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.gie.2011.04.027","article-title":"Long-term outcome of transoral organ-preserving pharyngeal endoscopic resection for superficial pharyngeal cancer","volume":"74","author":"Muto","year":"2011","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.anl.2018.09.005_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-0029-1243807","article-title":"Feasibility of endoscopic mucosal resection for superficial pharyngeal cancer: a minimally invasive treatment","volume":"42","author":"Suzuki","year":"2010","journal-title":"Endoscopy"},{"key":"10.1016\/j.anl.2018.09.005_bib0035","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1002\/lary.26953","article-title":"Complications after endoscopic laryngopharyngeal surgery","volume":"128","author":"Kishimoto","year":"2018","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anl.2018.09.005_bib0040","first-page":"19","article-title":"Risk factors for cervical lymph node metastasis in superficial head and neck squamous cell carcinoma","volume":"62","author":"Sasaki","year":"2015","journal-title":"J Med Dent Sci"},{"key":"10.1016\/j.anl.2018.09.005_bib0045","doi-asserted-by":"crossref","first-page":"E266","DOI":"10.1055\/s-0034-1392094","article-title":"The short-term and long-term outcomes of the endoscopic resection for the superficial pharyngeal squamous cell carcinoma","volume":"3","author":"Kinjo","year":"2015","journal-title":"Endosc Int Open"},{"key":"10.1016\/j.anl.2018.09.005_bib0050","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.anl.2011.01.001","article-title":"Predictors of cervical lymph node involvement in patients with pharyngeal carcinoma undergoing endoscopic mucosal resection","volume":"38","author":"Taniguchi","year":"2011","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.anl.2018.09.005_bib0055","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/den.12712","article-title":"Efficacy of double-scope endoscopic submucosal dissection and long-term outcomes of endoscopic resection for superficial pharyngeal cancer","volume":"29","author":"Yoshio","year":"2017","journal-title":"Dig Endosc"},{"key":"10.1016\/j.anl.2018.09.005_bib0060","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3109\/00016489.2015.1016186","article-title":"The potential risk of vessel infiltration and cervical lymph node metastasis in hypopharyngeal superficial squamous cell carcinoma: a retrospective observational study","volume":"135","author":"Ebisumoto","year":"2015","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.anl.2018.09.005_bib0065","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0039-6060(98)70165-5","article-title":"Treatment of superficial cancer of the esophagus: a summary of responses to a questionnaire on superficial cancer of the esophagus in Japan","volume":"123","author":"Kodama","year":"1998","journal-title":"Surgery"},{"key":"10.1016\/j.anl.2018.09.005_bib0070","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1053\/j.gastro.2004.04.022","article-title":"Risk factors for an adverse outcome in early invasive colorectal carcinoma","volume":"127","author":"Ueno","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.anl.2018.09.005_bib0075","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/modpathol.2015.36","article-title":"A three-tier classification system based on the depth of submucosal invasion and budding\/sprouting can improve the treatment strategy for T1 colorectal cancer: a retrospective multicenter study","volume":"28","author":"Kawachi","year":"2015","journal-title":"Mod Pathol"},{"key":"10.1016\/j.anl.2018.09.005_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.bjc.6603518","article-title":"The potential role of podoplanin in tumour invasion","volume":"96","author":"Wicki","year":"2007","journal-title":"Br J Cancer"},{"key":"10.1016\/j.anl.2018.09.005_bib0085","doi-asserted-by":"crossref","first-page":"6920","DOI":"10.1038\/onc.2008.343","article-title":"Cadherins and cancer: how does cadherin dysfunction promote tumor progression?","volume":"27","author":"Jeanes","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.anl.2018.09.005_bib0090","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.anl.2011.04.003","article-title":"Reduced E-cadherin expression is associated with lymph node metastases in laryngeal squamous cell carcinoma","volume":"39","author":"Li","year":"2012","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.anl.2018.09.005_bib0095","first-page":"6111","article-title":"Tumor budding, EMT and cancer stem cells in T1-2\/N0 oral squamous cell carcinomas","volume":"35","author":"Attramadal","year":"2015","journal-title":"Anticancer Res"},{"key":"10.1016\/j.anl.2018.09.005_bib0100","first-page":"5023","article-title":"Tumor budding and E-cadherin expression are useful predictors of nodal involvement in T1 esophageal squamous cell carcinoma","volume":"33","author":"Nakagawa","year":"2013","journal-title":"Anticancer Res"},{"key":"10.1016\/j.anl.2018.09.005_bib0105","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/PAT.0b013e3283425b7f","article-title":"Loss of E-cadherin independently predicts the lymph node status in colorectal cancer","volume":"43","author":"Karamitopoulou","year":"2011","journal-title":"Pathology"},{"key":"10.1016\/j.anl.2018.09.005_bib0110","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/jso.20937","article-title":"The significances of lymph node micrometastasis and its correlation with E-cadherin expression in pT1-T3N0 gastric adenocarcinoma","volume":"97","author":"Kim","year":"2008","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.anl.2018.09.005_bib0115","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s12105-017-0814-1","article-title":"Predictive significance of tumor depth and budding for late lymph node metastases in patients with clinical N0 early oral tongue carcinoma","volume":"11","author":"Hori","year":"2017","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.anl.2018.09.005_bib0120","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/his.12471","article-title":"Tumour budding in head and neck squamous cell carcinoma \u2014 a systematic review","volume":"65","author":"Almangush","year":"2014","journal-title":"Histopathology"},{"key":"10.1016\/j.anl.2018.09.005_bib0125","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.prp.2009.09.006","article-title":"Tumor budding as a prognostic marker in laryngeal carcinoma","volume":"206","author":"Sarioglu","year":"2010","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.anl.2018.09.005_bib0130","doi-asserted-by":"crossref","first-page":"651","DOI":"10.18632\/oncotarget.199","article-title":"Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget","volume":"1","author":"Zlobec","year":"2010","journal-title":"Oncotarget"},{"key":"10.1016\/j.anl.2018.09.005_bib0135","doi-asserted-by":"crossref","first-page":"e1510","DOI":"10.1097\/MD.0000000000001510","article-title":"Evaluation of lymphatic and vascular invasion in relation to clinicopathological factors and treatment outcome in oral cavity squamous cell carcinoma","volume":"94","author":"Adel","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.anl.2018.09.005_bib0140","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1245\/s10434-010-1219-5","article-title":"Tumor depth as a predictor of lymph node metastasis of supraglottic and hypopharyngeal cancers","volume":"18","author":"Tomifuji","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.anl.2018.09.005_bib0145","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.ejso.2006.05.004","article-title":"Depth of invasion is the most significant histological predictor of subclinical cervical lymph node metastasis in early squamous carcinomas of the oral cavity","volume":"32","author":"Kane","year":"2006","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.anl.2018.09.005_bib0150","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/jjco\/hyw172","article-title":"Retrospective observational study of occult cervical lymph-node metastasis in T1N0 tongue cancer","volume":"47","author":"Imai","year":"2017","journal-title":"Jpn J Clin Oncol"}],"container-title":["Auris Nasus Larynx"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814618304954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814618304954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:36:01Z","timestamp":1759952161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0385814618304954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0385814618304954"],"URL":"https:\/\/doi.org\/10.1016\/j.anl.2018.09.005","relation":{},"ISSN":["0385-8146"],"issn-type":[{"value":"0385-8146","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors for cervical lymph node metastasis in endoscopically resected superficial hypopharyngeal cancers","name":"articletitle","label":"Article Title"},{"value":"Auris Nasus Larynx","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anl.2018.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}