{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T01:17:45Z","timestamp":1768526265065,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371076"],"award-info":[{"award-number":["81371076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Suburb Tertiary Hospital Clinical Capacity Building Project","award":["SHDC12015905"],"award-info":[{"award-number":["SHDC12015905"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Auris Nasus Larynx"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.anl.2018.12.004","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T19:10:26Z","timestamp":1544728226000},"page":"533-541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["CD4+ T cells induce productions of IL-5 and IL-13 through MHCII on ILC2s in a murine model of allergic rhinitis"],"prefix":"10.1016","volume":"46","author":[{"given":"Lin","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Jin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Yue","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Bin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anl.2018.12.004_bib0005","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1056\/NEJMcp1412282","article-title":"Clinical practice. Allergic rhinitis","volume":"372","author":"Wheatley","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.anl.2018.12.004_bib0010","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nri2735","article-title":"How are T(H)2-type immune responses initiated and amplified?","volume":"10","author":"Paul","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.anl.2018.12.004_bib0015","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2012.08.015","article-title":"The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells","volume":"37","author":"Mj\u0151sberg","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.anl.2018.12.004_bib0020","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4193\/Rhin17.065","article-title":"Allergic inflammation is exacerbated by allergen-induced type 2 innate lymphoid cells in a murine model of allergic rhinitis","volume":"55","author":"Lin","year":"2017","journal-title":"Rhinology"},{"key":"10.1016\/j.anl.2018.12.004_bib0025","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.coi.2011.12.007","article-title":"Replenishing B lymphocytes in health and disease","volume":"24","author":"Zhang","year":"2012","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.anl.2018.12.004_bib0030","doi-asserted-by":"crossref","first-page":"370","DOI":"10.2500\/aap.2010.31.3388","article-title":"Allergic rhinitis: pathophysiology","volume":"31","author":"Broide","year":"2010","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.anl.2018.12.004_bib0035","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nature08900","article-title":"ILC2s represent a new innate effector leukocyte that mediates type-2 immunity","volume":"464","author":"Neill","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.anl.2018.12.004_bib0040","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pt.2011.01.001","article-title":"ILC2s and beyond: new insights into helminth expulsion","volume":"27","author":"Neill","year":"2011","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.anl.2018.12.004_bib0045","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.immuni.2014.06.016","article-title":"MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion","volume":"41","author":"Oliphant","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.anl.2018.12.004_bib0050","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.immuni.2014.01.011","article-title":"Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation","volume":"40","author":"Halim","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.anl.2018.12.004_bib0055","doi-asserted-by":"crossref","first-page":"7157","DOI":"10.4049\/jimmunol.179.10.7157","article-title":"IL-21 administration into the nostril alleviates murine allergic rhinitis","volume":"179","author":"Hiromura","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.anl.2018.12.004_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2011.09.041","article-title":"Innate IL-13-producing ILC2s arise during allergic lung inflammation and contribute to airways hyperreactivity","volume":"129","author":"Barlow","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anl.2018.12.004_bib0065","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1002\/eji.201142021","article-title":"CCL25 induces \u03b1\u2084\u03b2\u2087 integrin-dependent migration of IL-17\u207a \u03b3\u03b4 T lymphocytes during an allergic reaction","volume":"42","author":"Costa","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.anl.2018.12.004_bib0070","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/MOO.0b013e3283533632","article-title":"Role of innate immunity in the pathogenesis of allergic rhinitis","volume":"20","author":"Melvin","year":"2012","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2018.12.004_bib0075","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1073\/pnas.1003988107","article-title":"Systemically dispersed innate IL-13-expressing cells in type 2 immunity","volume":"107","author":"Price","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.anl.2018.12.004_bib0080","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(1)Sca-1(1) lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.anl.2018.12.004_bib0085","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/mi.2013.121","article-title":"Conventional CD4+ T cells regulate IL-22-producing intestinal innate lymphoid cells","volume":"7","author":"Korn","year":"2014","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.anl.2018.12.004_bib0090","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature12240","article-title":"Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria","volume":"498","author":"Hepworth","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.anl.2018.12.004_bib0095","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"Schmitz","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.anl.2018.12.004_bib0100","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1084\/jem.20061675","article-title":"Interleukin 25 promotes the initiation of proallergic type 2 responses","volume":"204","author":"Angkasekwinai","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.anl.2018.12.004_bib0105","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1164\/rccm.201212-2227OC","article-title":"IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps","volume":"188","author":"Shaw","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anl.2018.12.004_bib0110","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/all.12440","article-title":"Association between group 2 innate lymphoid cells enrichment, nasal polyps and allergy in chronic rhinosinusitis","volume":"69","author":"Miljkovic","year":"2014","journal-title":"Allerg"},{"key":"10.1016\/j.anl.2018.12.004_bib0115","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.clim.2014.09.007","article-title":"Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness","volume":"155","author":"Walford","year":"2014","journal-title":"Clin Immunol"},{"key":"10.1016\/j.anl.2018.12.004_bib0120","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/alr.21417","article-title":"Cellular comparison of sinus mucosa vs polyp tissue from a single sinus cavity in chronic rhinosinusitis","volume":"5","author":"Ho","year":"2014","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.anl.2018.12.004_bib0125","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/cea.12462","article-title":"Group 2 innate lymphoid cells (ILC2s) are increased in chronic rhinosinusitis with nasal polyps or eosinophilia","volume":"45","author":"Ho","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.anl.2018.12.004_bib0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103540","article-title":"Nasal sensitization with ragweed pollen induces local-allergic-rhinitis-like symptoms in mice","volume":"9","author":"Kato","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.anl.2018.12.004_bib0135","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1073\/pnas.1201042109","article-title":"Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice","volume":"109","author":"Yasuda","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.anl.2018.12.004_bib0140","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000024029","article-title":"Role of CD4-positive T cells in the pathogenesis of nasal allergy in the murine model","volume":"118","author":"Ogasawara","year":"1999","journal-title":"Int Arch Allergy Immunol"}],"container-title":["Auris Nasus Larynx"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814618308344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814618308344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:35:48Z","timestamp":1759952148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0385814618308344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0385814618308344"],"URL":"https:\/\/doi.org\/10.1016\/j.anl.2018.12.004","relation":{},"ISSN":["0385-8146"],"issn-type":[{"value":"0385-8146","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD4+ T cells induce productions of IL-5 and IL-13 through MHCII on ILC2s in a murine model of allergic rhinitis","name":"articletitle","label":"Article Title"},{"value":"Auris Nasus Larynx","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anl.2018.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}