{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:55:47Z","timestamp":1791330947472,"version":"4.3.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100014996","name":"Health Commission of Zhejiang Province","doi-asserted-by":"publisher","award":["2021KY1186"],"award-info":[{"award-number":["2021KY1186"]}],"id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Auris Nasus Larynx"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.anl.2020.11.013","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T09:05:20Z","timestamp":1606467920000},"page":"601-608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Full-thickness cartilage graft myringoplasty combined with topical application of bFGF for repair of perforations with extensive epithelialization"],"prefix":"10.1016","volume":"48","author":[{"given":"Zhengcai","family":"Lou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anl.2020.11.013_bib0001","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1046\/j.1365-2273.1997.00006.x","article-title":"Histology of the perforated tympanic membrane and its muco-epithelial junction","volume":"22","author":"Somers","year":"1997","journal-title":"Clin Otolaryngol Allied Sci"},{"issue":"3 Pt 1","key":"10.1016\/j.anl.2020.11.013_bib0002","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/00005537-199603000-00020","article-title":"Structural characterization of persistent tympanic membrane perforations in man","volume":"106","author":"Spandow","year":"1996","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anl.2020.11.013_bib0003","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1017\/S0022215100084346","article-title":"Repair of large experimental perforations of the tympanic membrane","volume":"91","author":"Reeve","year":"1977","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.anl.2020.11.013_bib0004","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0030-6665(20)30467-9","article-title":"Tympanic membrane wound healing. An overview","volume":"28","author":"Gladstone","year":"1995","journal-title":"Otolaryngol Clin North Am"},{"key":"10.1016\/j.anl.2020.11.013_bib0005","doi-asserted-by":"crossref","first-page":"47Y55","DOI":"10.1177\/019459989210600127","article-title":"An animal model of chronic tympanic membrane perforation","volume":"106","author":"Amoils","year":"1992","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2020.11.013_bib0006","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1177\/0194599812456813","article-title":"Spontaneous healing of traumatic eardrum perforation: outward epithelial cell migration and clinical outcome","volume":"147","author":"Lou","year":"2012","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2020.11.013_bib0007","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1002\/lary.20998","article-title":"Histology of the healing tympanic membrane following perforation in rats","volume":"120","author":"Santa Maria","year":"2010","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anl.2020.11.013_bib0008","first-page":"428","article-title":"Growth factors in tympanic membrane perforations","volume":"19","author":"Somers","year":"1998","journal-title":"Am J Otol"},{"key":"10.1016\/j.anl.2020.11.013_bib0009","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3109\/00016488509108589","article-title":"Histology of the tympanic perforation and the replacement membrane","volume":"100","author":"Yamashita","year":"1985","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.anl.2020.11.013_bib0010","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/MAO.0b013e31823dbc26","article-title":"Myringoplasty in simple chronic otitis media: critical analysis of long-term results in a 1000-adult patient series","volume":"33","author":"Nardone","year":"2012","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.anl.2020.11.013_bib0011","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00405-008-0908-1","article-title":"Tympanoplasty in children","volume":"266","author":"Sarkar","year":"2009","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.anl.2020.11.013_bib0012","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.anl.2015.02.016","article-title":"Topical use of autologous platelet rich plasma in myringoplasty","volume":"42","author":"El-Anwar","year":"2015","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.anl.2020.11.013_bib0013","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1097\/MAO.0b013e31822e0e53","article-title":"Regenerative treatment for tympanic membrane perforation","volume":"32","author":"Kanemaru","year":"2011","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.anl.2020.11.013_bib0014","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/MAO.0b013e3181c34f01","article-title":"Basic fibroblast growth factor combined with atelocollagen for closing chronic tympanic membrane perforations in 87 patients","volume":"31","author":"Hakuba","year":"2010","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.anl.2020.11.013_bib0015","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0194-59989670008-6","article-title":"Repair of chronic tympanic membrane perforations with fibroblast growth factor","volume":"115","author":"Kato","year":"1996","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2020.11.013_bib0016","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1017\/S002221511800083X","article-title":"Regeneration of the tympanic membrane using fibroblast growth factor-2","volume":"132","author":"Lou","year":"2018","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.anl.2020.11.013_bib0017","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4081\/audiores.2015.117","article-title":"Outlook for tissue engineering of the tympanic membrane","volume":"5","author":"Villar-Fernandez","year":"2015","journal-title":"Audiol Res"},{"key":"10.1016\/j.anl.2020.11.013_bib0018","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1097\/MAO.0000000000000795","article-title":"Heparin binding epidermal growth factor-like growth factor heals chronic tympanic membrane perforations with advantage over fibroblast growth factor 2 and epidermal growth factor in an animal model","volume":"36","author":"Santa Maria","year":"2015","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.anl.2020.11.013_bib0019","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1017\/S0022215100138423","article-title":"Temporalis fascia grafts shrink","volume":"111","author":"England","year":"1997","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.anl.2020.11.013_bib0020","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1007\/s00405-018-5120-3","article-title":"Anatomical and functional long-term results of endoscopic butterfly inlay myringoplasty","volume":"275","author":"Karabulut","year":"2018","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.anl.2020.11.013_bib0021","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.anl.2018.07.001","article-title":"Comparison of clinical outcomes between butterfly inlay cartilage tympanoplasty and conventional underlay cartilage tympanoplasty","volume":"46","author":"Kim","year":"2019","journal-title":"Auris Nasus Larynx"},{"issue":"11","key":"10.1016\/j.anl.2020.11.013_bib0022","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1007\/s00405-012-2329-4","article-title":"Is cartilage better than temporalis muscle fascia in type I tympanoplasty? Implications for current surgical practice","volume":"270","author":"Iacovou","year":"2013","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.anl.2020.11.013_bib0023","series-title":"Otolaryngology","first-page":"1","article-title":"Surgery of chronic otitis media","author":"Sheehy","year":"1985"},{"key":"10.1016\/j.anl.2020.11.013_bib0024","first-page":"126","article-title":"Effect of the use of dry (rigid) or wet (soft) temporal fascia graft on tympanoplasty","volume":"38","author":"Alkan","year":"2009","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2020.11.013_bib0025","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1177\/019459988809800602","article-title":"Histologic study of homograft cartilages implanted in the middle ear","volume":"98","author":"Yamamoto","year":"1988","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2020.11.013_bib0026","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0385-8146(99)00012-7","article-title":"Fate of cartilage material used in middle ear surgery light and electron microscopy study","volume":"26","author":"Hamed","year":"1999","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.anl.2020.11.013_bib0027","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1523\/JNEUROSCI.17-15-05820.1997","article-title":"Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain","volume":"17","author":"Kuhn","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.anl.2020.11.013_bib0028","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000343775","article-title":"Comparative study of the effects of recombinant human epidermal growth factor and basic fibroblast growth factor on corneal epithelial wound healing and neovascularization in vivo and in vitro","volume":"49","author":"Yan","year":"2013","journal-title":"Ophthalmic Res"},{"key":"10.1016\/j.anl.2020.11.013_bib0029","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0194-5998(99)70122-1","article-title":"Healing large tympanic membrane perforations using hyaluronic acid, basic fibroblast growth factor, and epidermal growth factor","volume":"121","author":"Chauvin","year":"1999","journal-title":"Otolaryngol Head Neck Surg"}],"container-title":["Auris Nasus Larynx"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S038581462030314X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S038581462030314X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:26:01Z","timestamp":1778545561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S038581462030314X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S038581462030314X"],"URL":"https:\/\/doi.org\/10.1016\/j.anl.2020.11.013","relation":{},"ISSN":["0385-8146"],"issn-type":[{"value":"0385-8146","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Full-thickness cartilage graft myringoplasty combined with topical application of bFGF for repair of perforations with extensive epithelialization","name":"articletitle","label":"Article Title"},{"value":"Auris Nasus Larynx","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anl.2020.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Oto-Rhino-Laryngological Society of Japan Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}