{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:08:21Z","timestamp":1759972101841,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"am","delay-in-days":215,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23592473"],"award-info":[{"award-number":["23592473"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Auris Nasus Larynx"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.anl.2022.03.009","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T17:20:14Z","timestamp":1647451214000},"page":"928-937","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of salicylate derivatives on localization of p.H723R allele product of SLC26A4"],"prefix":"10.1016","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2389-7995","authenticated-orcid":false,"given":"Michio","family":"Murakoshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhi","family":"Koike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Usami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazusaku","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhisa","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Haga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Tsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyasu","family":"Hirasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anl.2022.03.009_bib0001","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ng1297-411","article-title":"Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS)","volume":"17","author":"Everett","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.anl.2022.03.009_bib0002","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1210\/endo.141.2.7303","article-title":"Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells","volume":"141","author":"Royaux","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.anl.2022.03.009_bib0003","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.biochi.2016.10.002","article-title":"Mapping pathogenic mutations suggests an innovative structural model for the pendrin (SLC26A4) transmembrane domain","volume":"132","author":"Bassot","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/j.anl.2022.03.009_bib0004","doi-asserted-by":"crossref","first-page":"9970","DOI":"10.1074\/jbc.RA118.001831","article-title":"The extracellular loop of pendrin and prestin modulates their voltage-sensing property","volume":"293","author":"Kuwabara","year":"2018","journal-title":"J Biol Chem"},{"key":"10.1016\/j.anl.2022.03.009_bib0005","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/7783","article-title":"The Pendred syndrome gene encodes a chloride-iodide transport protein","volume":"21","author":"Scott","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.anl.2022.03.009_bib0006","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1073\/pnas.071516798","article-title":"Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion","volume":"98","author":"Royaux","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.anl.2022.03.009_bib0007","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1210\/jcem.87.7.8679","article-title":"Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells","volume":"87","author":"Yoshida","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.anl.2022.03.009_bib0008","doi-asserted-by":"crossref","first-page":"13004","DOI":"10.1074\/jbc.M313648200","article-title":"Functional characterization of pendrin in a polarized cell system. Evidence for pendrin-mediated apical iodide efflux","volume":"279","author":"Gillam","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.anl.2022.03.009_bib0009","doi-asserted-by":"crossref","first-page":"F1345","DOI":"10.1152\/ajprenal.00487.2006","article-title":"Loss of cochlear HCO3\u2212 secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model","volume":"292","author":"Wangemann","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.anl.2022.03.009_bib0010","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.tem.2008.07.001","article-title":"Pendred syndrome and iodide transport in the thyroid","volume":"19","author":"Kopp","year":"2008","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.anl.2022.03.009_bib0011","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/s00424-003-1090-3","article-title":"The SLC26 gene family of multifunctional anion exchangers","volume":"447","author":"Mount","year":"2004","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.anl.2022.03.009_bib0012","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s004390050933","article-title":"Non-syndromic hearing loss associated with enlarged vestibular aqueduct is caused by PDS mutations","volume":"104","author":"Usami","year":"1999","journal-title":"Hum Genet"},{"key":"10.1016\/j.anl.2022.03.009_bib0013","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00060793-199912000-00002","article-title":"Pendred syndrome: clinical characteristics and molecular basis","volume":"6","author":"Kopp","year":"1999","journal-title":"Curr Opin Endocrinol Diabetes"},{"key":"10.1016\/j.anl.2022.03.009_bib0014","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1677\/JME-08-0175","article-title":"Functional characterization of wild-type and mutated pendrin (SLC26A4), the anion transporter involved in Pendred syndrome","volume":"43","author":"Dossena","year":"2009","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.anl.2022.03.009_bib0015","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/sj.ejhg.5201073","article-title":"Distribution and frequencies of PDS (SLC26A4) mutations in Pendred syndrome and nonsyndromic hearing loss associated with enlarged vestibular aqueduct: a unique spectrum of mutations in Japanese","volume":"11","author":"Tsukamoto","year":"2003","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.anl.2022.03.009_bib0016","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/jhg.2014.12","article-title":"Mutation spectrum and genotype-phenotype correlation of hearing loss patients caused by SLC26A4 mutations in the Japanese: a large cohort study","volume":"59","author":"Miyagawa","year":"2014","journal-title":"J Hum Genet"},{"key":"10.1016\/j.anl.2022.03.009_bib0017","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.heares.2010.08.015","article-title":"Salicylate restores transport function and anion exchanger activity of missense pendrin mutations","volume":"270","author":"Ishihara","year":"2010","journal-title":"Hear Res"},{"key":"10.1016\/j.anl.2022.03.009_bib0018","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0196-0709(91)90071-M","article-title":"Salicylate ototoxicity: review and synthesis","volume":"12","author":"Boettcher","year":"1991","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.anl.2022.03.009_bib0019","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.anl.2022.03.009_bib0020","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.celrep.2016.12.020","article-title":"Cochlear cell modeling using disease-specific iPSCs unveils a degenerative phenotype and suggests treatments for congenital progressive hearing loss","volume":"18","author":"Hosoya","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.anl.2022.03.009_bib0021","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.reth.2018.11.001","article-title":"Estimating the concentration of therapeutic range using disease-specific iPS cells: low-dose rapamycin therapy for Pendred syndrome","volume":"10","author":"Hosoya","year":"2019","journal-title":"Regen Ther"},{"key":"10.1016\/j.anl.2022.03.009_bib0022","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1093\/hmg\/11.21.2625","article-title":"Retention of pendrin in the endoplasmic reticulum is a major mechanism for Pendred syndrome","volume":"11","author":"Rotman-Pikielny","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.anl.2022.03.009_bib0023","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/jmg.2007.054635","article-title":"Heterogeneity in the processing defect of SLC26A4 mutants","volume":"45","author":"Yoon","year":"2008","journal-title":"J Med Genet"},{"key":"10.1016\/j.anl.2022.03.009_bib0024","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/35012009","article-title":"Prestin is the motor protein of cochlear outer hair cells","volume":"405","author":"Zheng","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.anl.2022.03.009_bib0025","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nrm730","article-title":"Prestin, a new type of motor protein","volume":"3","author":"Dallos","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.anl.2022.03.009_bib0026","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/j.febslet.2010.04.010","article-title":"Salicylate-induced translocation of prestin having mutation in the GTSRH sequence to the plasma membrane","volume":"584","author":"Kumano","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1016\/j.anl.2022.03.009_bib0027","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000071059","article-title":"A cochlear cell line as an in vitro system for drug ototoxicity screening","volume":"8","author":"Kalinec","year":"2003","journal-title":"Audiol Neurootol"},{"key":"10.1016\/j.anl.2022.03.009_bib0028","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.heares.2016.02.019","article-title":"HEI-OC1 cells as a model for investigating drug cytotoxicity","volume":"335","author":"Kalinec","year":"2016","journal-title":"Hear Res"},{"key":"10.1016\/j.anl.2022.03.009_bib0029","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1126\/science.271.5255.1493","article-title":"Misfolding the way to disease","volume":"271","author":"Taubes","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.anl.2022.03.009_bib0030","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1379\/1466-1268(1996)001<0109:IOMACC>2.3.CO;2","article-title":"Influence of molecular and chemical chaperones on protein folding","volume":"1","author":"Welch","year":"1996","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.anl.2022.03.009_bib0031","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0014-5793(01)02486-3","article-title":"Protein misfolding and disease; protein refolding and therapy","volume":"498","author":"Soto","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/j.anl.2022.03.009_bib0032","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nature02265","article-title":"Therapeutic approaches to protein-misfolding diseases","volume":"426","author":"Cohen","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.anl.2022.03.009_bib0033","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1511\/2005.54.967","article-title":"A new understanding of protein mutation unfolds","volume":"93","author":"Conn","year":"2005","journal-title":"Am Sci"},{"key":"10.1016\/j.anl.2022.03.009_bib0034","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/B978-0-12-385952-5.00008-7","article-title":"Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptors","volume":"62","author":"Conn","year":"2011","journal-title":"Adv Pharmacol"},{"key":"10.1016\/j.anl.2022.03.009_bib0035","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1210\/jcem.87.7.8582","article-title":"Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target","volume":"87","author":"Janovick","year":"2002","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Auris Nasus Larynx"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S038581462200058X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S038581462200058X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:39:56Z","timestamp":1759952396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S038581462200058X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S038581462200058X"],"URL":"https:\/\/doi.org\/10.1016\/j.anl.2022.03.009","relation":{},"ISSN":["0385-8146"],"issn-type":[{"type":"print","value":"0385-8146"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of salicylate derivatives on localization of p.H723R allele product of SLC26A4","name":"articletitle","label":"Article Title"},{"value":"Auris Nasus Larynx","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anl.2022.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}