{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T23:49:13Z","timestamp":1781912953475,"version":"3.54.5"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Auris Nasus Larynx"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.anl.2022.09.010","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T08:36:41Z","timestamp":1665563801000},"page":"430-439","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Combining Epstein\u2013Barr virus antibodies for early detection of nasopharyngeal carcinoma: A meta-analysis"],"prefix":"10.1016","volume":"50","author":[{"given":"Mei","family":"Lian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10192","key":"10.1016\/j.anl.2022.09.010_bib0001","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","article-title":"Nasopharyngeal carcinoma","volume":"394","author":"Chen","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.anl.2022.09.010_bib0002","series-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay","year":"2020"},{"issue":"11","key":"10.1016\/j.anl.2022.09.010_bib0003","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/cac2.12218","article-title":"The Chinese Society of Clinical Oncology (CSCO) clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma","volume":"41","author":"Tang","year":"2021","journal-title":"Cancer Commun (Lond)"},{"issue":"10","key":"10.1016\/j.anl.2022.09.010_bib0004","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1093\/annonc\/mdz231","article-title":"Incidence and Mortality of Nasopharyngeal Carcinoma: Interim Analysis of a Cluster Randomized Controlled Screening Trial (PRO-NPC-001) in Southern China","volume":"30","author":"Ji","year":"2019","journal-title":"Ann Oncol"},{"issue":"1732","key":"10.1016\/j.anl.2022.09.010_bib0005","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2016.0270","article-title":"Epstein-Barr virus infection and nasopharyngeal carcinoma","volume":"372","author":"Tsao","year":"2017","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"5","key":"10.1016\/j.anl.2022.09.010_bib0006","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.7314\/APJCP.2014.15.5.2001","article-title":"Diagnostic significance of combined detection of Epstein-Barr virus antibodies, VCA\/IgA, EA\/IgA, Rta\/IgG and EBNA1\/IgA for nasopharyngeal carcinoma","volume":"15","author":"Cai","year":"2014","journal-title":"Asian Pac J Caner Prev"},{"issue":"2","key":"10.1016\/j.anl.2022.09.010_bib0007","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/ijc.26380","article-title":"Establishment of VCA and EBNA1 IgA-based combination by enzyme-linked immunosorbent assay as preferred screening method for nasopharyngeal carcinoma: a two-stage design with a preliminary performance study and a mass screening in southern China","volume":"131","author":"Liu","year":"2011","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.anl.2022.09.010_bib0008","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/sj.bjc.6603609","article-title":"Sustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinoma","volume":"96","author":"Ji","year":"2007","journal-title":"Br J Cancer"},{"issue":"26","key":"10.1016\/j.anl.2022.09.010_bib0009","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1056\/NEJMoa011610","article-title":"Serologic markers of Epstein-Barr Virus infection and nasopharyngeal carcinoma in taiwanese men","volume":"345","author":"Chien","year":"2001","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.anl.2022.09.010_bib0010","doi-asserted-by":"crossref","first-page":"e19100","DOI":"10.1371\/journal.pone.0019100","article-title":"Fluctuations of Epstein-barr virus serological antibodies and risk for nasopharyngeal carcinoma: a prospective screening study with a 20-year follow-up","volume":"6","author":"Cao","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.anl.2022.09.010_bib0011","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1001\/jama.2017.19163","article-title":"Preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies: the PRISMA-DTA statement","volume":"319","author":"McInnes","year":"2018","journal-title":"Jama"},{"issue":"8","key":"10.1016\/j.anl.2022.09.010_bib0012","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.anl.2022.09.010_bib0013","series-title":"Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy Version 1.0. ed","article-title":"Chapter 10: analysing and presenting results","author":"Macaskill","year":"2010"},{"issue":"5","key":"10.1016\/j.anl.2022.09.010_bib0014","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/ijc.11130","article-title":"EBV specific antibody-based and DNA-based assays in serologic diagnosis of nasopharyngeal carcinoma","volume":"105","author":"Chan","year":"2003","journal-title":"Int J Cancer"},{"issue":"14","key":"10.1016\/j.anl.2022.09.010_bib0015","first-page":"1949","article-title":"Clinical value of the combined detection of three EBV antibodies in the screening of nasopharyngeal carcinoma","volume":"38","author":"Chen","year":"2017","journal-title":"Int J Lab Med"},{"issue":"4","key":"10.1016\/j.anl.2022.09.010_bib0016","first-page":"62","article-title":"Clinical value of triple test (VCA-IGA, EA-IGG, NA1-IGA) in serological diagnosis of nasopharyngeal carcinoma","volume":"12","author":"Deng","year":"2012","journal-title":"Modern Hospital"},{"issue":"19","key":"10.1016\/j.anl.2022.09.010_bib0017","first-page":"108","article-title":"Relationship between EBV NAI-IgA and VCA-IgA antibodies with diagnosis and therapeutic effect of nasopharyngeal carcinoma","volume":"32","author":"Deng","year":"2011","journal-title":"J Med Forum"},{"issue":"13","key":"10.1016\/j.anl.2022.09.010_bib0018","first-page":"1856","article-title":"Diagnostic calue of combined detection of Rta-IgG,EBNA1-IgA and VCA-IgA antibodies in nasopharyngeal carcinoma in Zhongshan Area","volume":"36","author":"Du","year":"2015","journal-title":"Int J Lab Med"},{"issue":"11","key":"10.1016\/j.anl.2022.09.010_bib0019","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1128\/CVI.00135-08","article-title":"Evaluation of a multianalyte profiling assay and an enzyme-linked immunosorbent assay for serological examination of Epstein-Barr virus-specific antibody responses in diagnosis of nasopharyngeal carcinoma","volume":"15","author":"Gu","year":"2008","journal-title":"Clin Vaccine Immunol"},{"issue":"4","key":"10.1016\/j.anl.2022.09.010_bib0020","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1007\/s12253-020-00808-0","article-title":"Comparison of Epstein-Barr virus serological tools for the screening and risk assessment of nasopharyngeal carcinoma: a large population-based study","volume":"26","author":"Guo","year":"2020","journal-title":"Pathol Oncol Res"},{"issue":"22","key":"10.1016\/j.anl.2022.09.010_bib0021","first-page":"1271","article-title":"A diagnostic test of optimized combinations of EBV DNA and EBV antibodies for nasopharyngeal carcinoma","volume":"36","author":"Jiang","year":"2009","journal-title":"Chin J Clin Onco"},{"issue":"11","key":"10.1016\/j.anl.2022.09.010_bib0022","first-page":"1320","article-title":"The value of the combined assay of Rta-IgG, VCA-IgA and EA-IgA for screening populations at high risk of nasopharyngeal carcinoma in physical examination","volume":"52","author":"Li","year":"2020","journal-title":"Inner Mongolia Med J"},{"issue":"19","key":"10.1016\/j.anl.2022.09.010_bib0023","first-page":"225","article-title":"Clinical value of three kinds of EB virus antibody detection in screening of nasopharyngeal carcinoma","volume":"6","author":"Pan","year":"2016","journal-title":"Chin Med Pharm"},{"issue":"5","key":"10.1016\/j.anl.2022.09.010_bib0024","first-page":"736","article-title":"Study on the application of three EB virus related antibodies in the diagnosis of EB virus associated nasopharyngeal carcinoma","volume":"24","author":"Sun","year":"2017","journal-title":"Chin J Prim Med Pharm"},{"issue":"23","key":"10.1016\/j.anl.2022.09.010_bib0025","first-page":"3396","article-title":"Study on Diagnostic Value of Rta-IgG Combined with VCA-IgA and EA-IgA EB viral antibodies detection in nasopharyngeal carcinoma in hunan area","volume":"16","author":"Tang","year":"2019","journal-title":"Lab Med Clin"},{"issue":"74","key":"10.1016\/j.anl.2022.09.010_bib0026","first-page":"1","article-title":"Detection and Analysis of Three Antibodies of Eb Virus NA,ZTA and VCA","volume":"24","author":"Wang","year":"2021","journal-title":"Smart Healthcare"},{"issue":"1","key":"10.1016\/j.anl.2022.09.010_bib0027","first-page":"40","article-title":"Analysis of serum anti-Epstein-Barr virus antibody in patients with nasopharyngeal carcinoma in Shanghai","volume":"12","author":"Wang","year":"2012","journal-title":"Chin J Ophthalmol and Otorhinolaryngol"},{"issue":"8","key":"10.1016\/j.anl.2022.09.010_bib0028","first-page":"609","article-title":"VCA-IgA and Rta-IgG joint detection diagnosis and effectiveness of nasopharyngeal carcinoma","volume":"39","author":"Wu","year":"2016","journal-title":"Chin J Lab Med"},{"issue":"12","key":"10.1016\/j.anl.2022.09.010_bib0029","first-page":"16104","article-title":"Expression of EBV Antibody EA-IgA, Rta-IgG and VCA-IgA and SA in serum and the implication of combined assay in nasopharyngeal carcinoma diagnosis","volume":"8","author":"Xia","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"issue":"17","key":"10.1016\/j.anl.2022.09.010_bib0030","first-page":"2500","article-title":"Clinical value of rta protein antibody IgG of EB virus in diagnosis for nasopharynx cancer","volume":"36","author":"Xu","year":"2015","journal-title":"Int J Lab Med"},{"issue":"8","key":"10.1016\/j.anl.2022.09.010_bib0031","first-page":"98","article-title":"Correlation Study on Serum EA-IgA, VCA-IgA, Rta-IgG, EBV-DNA levels of nasopharyngeal carcinoma","volume":"52","author":"Yan","year":"2017","journal-title":"Chin J Med"},{"issue":"22","key":"10.1016\/j.anl.2022.09.010_bib0032","first-page":"1740","article-title":"The combined interpretation schemes including VCA-IgA, EA-IgA and Rta-IgG in the diagnosis of nasopharyngeal carcinoma","volume":"32","author":"Yi","year":"2018","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"issue":"12","key":"10.1016\/j.anl.2022.09.010_bib0033","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.7150\/jca.23755","article-title":"Assessment of the long-term diagnostic performance of a new serological screening scheme in large-scale nasopharyngeal carcinoma screening","volume":"9","author":"Yu","year":"2018","journal-title":"J Cancer"},{"issue":"01","key":"10.1016\/j.anl.2022.09.010_bib0034","first-page":"44","article-title":"Diagnostic significance of combined detection of Epstein-Barr virus antibodies,EA-IgA,VCA-IgA and Rta-IgG in serum for nasopharyngeal carcinoma","volume":"28","author":"Zhang","year":"2021","journal-title":"Prat Prev Med"},{"issue":"2","key":"10.1016\/j.anl.2022.09.010_bib0035","doi-asserted-by":"crossref","first-page":"114","DOI":"10.5732\/cjc.010.10377","article-title":"The prevalence and prevention of nasopharyngeal carcinoma in China","volume":"30","author":"Cao","year":"2011","journal-title":"Chin J Cancer"},{"issue":"10","key":"10.1016\/j.anl.2022.09.010_bib0036","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1002\/cncr.28001","article-title":"Early detection of nasopharyngeal carcinoma by plasma epstein-barr virus DNA analysis in a surveillance program","volume":"119","author":"Chan","year":"2013","journal-title":"Cancer"},{"key":"10.1016\/j.anl.2022.09.010_bib0037","series-title":"Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy Version 1.0. ed","article-title":"Chapter 11: interpreting results and drawing conclusions","author":"Macaskill","year":"2013"},{"key":"10.1016\/j.anl.2022.09.010_bib0038","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijid.2014.03.1373","article-title":"Evaluation of a semi-quantitative ELISA for IgA antibody against epstein-barr virus capsid antigen in the serological diagnosis of nasopharyngeal carcinoma","volume":"25","author":"Chen","year":"2014","journal-title":"Int J Infect Dis"},{"issue":"6","key":"10.1016\/j.anl.2022.09.010_bib0039","first-page":"1155","article-title":"Diagnostic value of serum Epstein-Barr virus capsid Antigen-IgA for nasopharyngeal carcinoma: a meta-analysis based on 21 studies","volume":"62","author":"Chen","year":"2016","journal-title":"Clin Lab"},{"issue":"8061","key":"10.1016\/j.anl.2022.09.010_bib0040","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0140-6736(78)91220-5","article-title":"Serum IgA Antibodies to Epstein-Barr virus capsid antigen preceding smptoms of nasopharyngeal Carcinoma","volume":"1","author":"Ho","year":"1978","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.anl.2022.09.010_bib0041","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12885-017-3718-2","article-title":"Chemokine CCL27 is a novel plasma biomarker for identification the nasopharyngeal carcinoma patients from the epstein-barr virus capsid antigen-specific IgA seropositive population","volume":"18","author":"Mao","year":"2018","journal-title":"BMC Cancer"},{"issue":"2","key":"10.1016\/j.anl.2022.09.010_bib0042","first-page":"113","article-title":"Significance of plasma IgA and IgG antibodies to epstein-barr virus early and viral capsid antigens in thai nasopharyngeal carcinoma","volume":"4","author":"Tiwawech","year":"2003","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.anl.2022.09.010_bib0043","article-title":"Anti-Epstein-Barr virus antibodies in beijing during 2013-2017: what we have found in the different patients","volume":"13","author":"Cui","year":"2018"},{"key":"10.1016\/j.anl.2022.09.010_bib0044","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.3389\/fonc.2020.01779","article-title":"Accuracy evaluation and comparison of 14 diagnostic markers for nasopharyngeal carcinoma: a meta-analysis","volume":"10","author":"Feng","year":"2020","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.anl.2022.09.010_bib0045","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s12935-021-01862-7","article-title":"The diagnostic value of EBV-DNA and EBV-related antibodies detection for nasopharyngeal carcinoma: a meta-analysis","volume":"21","author":"Liu","year":"2021","journal-title":"Cancer Cell Int"},{"issue":"10","key":"10.1016\/j.anl.2022.09.010_bib0046","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1007\/s12325-020-01461-4","article-title":"A randomized controlled trial on evaluation of plasma epstein-barr virus biomarker for early diagnosis in patients with nasopharyngeal carcinoma","volume":"37","author":"Liu","year":"2020","journal-title":"Adv Ther"},{"issue":"11","key":"10.1016\/j.anl.2022.09.010_bib0047","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/cac2.12100","article-title":"Clinical Utility of Epstein-Barr Virus DNA and other liquid biopsy markers in nasopharyngeal carcinoma","volume":"40","author":"Tan","year":"2020","journal-title":"Cancer Commun (Lond)"},{"issue":"7","key":"10.1016\/j.anl.2022.09.010_bib0048","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/1097-0142(20011001)92:7<1872::AID-CNCR1704>3.0.CO;2-N","article-title":"Antibody Response to Epstein-Barr virus rta protein in patients with nasopharyngeal carcinoma: a new serologic parameter for diagnosis","volume":"92","author":"Feng","year":"2001","journal-title":"Cancer."},{"issue":"3","key":"10.1016\/j.anl.2022.09.010_bib0049","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3233\/CBM-160586","article-title":"Rta-IgG as a biomarker for diagnosis and post treatment prognostic of nasopharyngeal carcinoma","volume":"16","author":"Xu","year":"2016","journal-title":"Cancer Biomark"},{"issue":"9","key":"10.1016\/j.anl.2022.09.010_bib0050","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.3389\/fonc.2019.01391","article-title":"Utility of serum EB virus Zta antibody in the diagnostic of nasopharyngeal carcinoma: evidences from 2,126 cases and 15,644","author":"Zhang","year":"2019","journal-title":"Controls. Front Oncol."}],"container-title":["Auris Nasus Larynx"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814622002140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814622002140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:39:34Z","timestamp":1759952374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0385814622002140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S0385814622002140"],"URL":"https:\/\/doi.org\/10.1016\/j.anl.2022.09.010","relation":{},"ISSN":["0385-8146"],"issn-type":[{"value":"0385-8146","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combining Epstein\u2013Barr virus antibodies for early detection of nasopharyngeal carcinoma: A meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Auris Nasus Larynx","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anl.2022.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}