{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:47:11Z","timestamp":1792388831207,"version":"4.4.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K16908"],"award-info":[{"award-number":["17K16908"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K09754"],"award-info":[{"award-number":["20K09754"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011326","name":"Shiga University of Medical Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Auris Nasus Larynx"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.anl.2022.11.006","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T15:32:44Z","timestamp":1669995164000},"page":"540-549","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["A decreased prevalence of group 2 innate lymphoid cells in blood is associated with good postoperative outcomes in patients with chronic rhinosinusitis"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7687-9427","authenticated-orcid":false,"given":"Ichiro","family":"Tojima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Murao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kento","family":"Kawakita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shino","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Kouzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"S29","key":"10.1016\/j.anl.2022.11.006_bib0001","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"issue":"4","key":"10.1016\/j.anl.2022.11.006_bib0002","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.alit.2019.07.002","article-title":"Eosinophilic chronic rhinosinusitis","volume":"68","author":"Fujieda","year":"2019","journal-title":"Allergol Int"},{"issue":"5","key":"10.1016\/j.anl.2022.11.006_bib0003","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.jaci.2008.07.008","article-title":"Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease","volume":"122","author":"Zhang","year":"2008","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.anl.2022.11.006_bib0004","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/cea.12472","article-title":"Pathogenesis of nasal polyposis","volume":"45","author":"Hulse","year":"2015","journal-title":"Clin Exp Allergy"},{"issue":"8","key":"10.1016\/j.anl.2022.11.006_bib0005","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/all.12644","article-title":"Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study","volume":"70","author":"Tokunaga","year":"2015","journal-title":"Allergy"},{"issue":"4","key":"10.1016\/j.anl.2022.11.006_bib0006","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund","year":"1993","journal-title":"Rhinology"},{"issue":"2","key":"10.1016\/j.anl.2022.11.006_bib0007","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2500\/ajra.2015.29.4140","article-title":"Clustering of chronic rhinosinusitis symptomatology reveals novel associations with objective clinical and demographic characteristics","volume":"29","author":"Sedaghat","year":"2015","journal-title":"Am J Rhinol Allergy"},{"issue":"2","key":"10.1016\/j.anl.2022.11.006_bib0008","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.anl.2015.08.014","article-title":"Past, present and future of macrolide thrapy for chronic rhinosinusitis in Japan","volume":"43","author":"Shimizu","year":"2016","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.anl.2022.11.006_bib0009","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev-pathol-052016-100401","article-title":"Immunopathogenesis of chronic rhinosinusitis and nasal polyposis","volume":"12","author":"Schleimer","year":"2017","journal-title":"Annu Rev Pathol"},{"issue":"1","key":"10.1016\/j.anl.2022.11.006_bib0010","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/ACI.0000000000000496","article-title":"Group 2 innate lymphoid cells and eosinophilic chronic rhinosinusitis","volume":"19","author":"Tojima","year":"2019","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.anl.2022.11.006_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2016.07.010","article-title":"Group 2 innate lymphoid cells are increased in nasal polyps in patients with eosinophilic chronic rhinosinusitis","volume":"170","author":"Tojima","year":"2016","journal-title":"Clin Immunol"},{"issue":"12","key":"10.1016\/j.anl.2022.11.006_bib0012","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1111\/all.13974","article-title":"Evidence for the induction of Th2 inflammation by group 2 innate lymphoid cells in response to prostaglandin D2 and cysteinyl leukotrienes in allergic rhinisits","volume":"74","author":"Tojima","year":"2019","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.anl.2022.11.006_bib0013","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/cea.12462","article-title":"Group 2 innate lymphoid cells (ILC2s) are increased in chronic rhinosinusitis with nasal polyps or eosinophilia","volume":"45","author":"Ho","year":"2015","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"10.1016\/j.anl.2022.11.006_bib0014","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.clim.2014.09.007","article-title":"Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness","volume":"155","author":"Walford","year":"2014","journal-title":"Clin Immunol"},{"issue":"1","key":"10.1016\/j.anl.2022.11.006_bib0015","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jaci.2016.11.023","article-title":"Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin-exacerbated respiratory disease","volume":"140","author":"Eastman","year":"2017","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anl.2022.11.006_bib0016","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jaci.2019.01.027","article-title":"Activation of group 2 innate lymphoid cells after allergen challenge in asthmatic patients","volume":"144","author":"Winkler","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anl.2022.11.006_bib0017","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.clim.2017.09.008","article-title":"Increased innate type 2 immune response in house dust mite-allergic patients with allergic rhinitis","volume":"183","author":"Zhong","year":"2017","journal-title":"Clinical Immunol"},{"issue":"5","key":"10.1016\/j.anl.2022.11.006_bib0018","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.jaci.2014.07.029","article-title":"Seasonal increases in peripheral innate lymphoid type 2 cells are inhibited by subcutaneous grass pollen immunotherapy","volume":"134","author":"Lao-Araya","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.anl.2022.11.006_bib0019","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jaci.2014.06.024","article-title":"Enhanced innate type 2 immune response in peripheral blood from patients with asthma","volume":"134","author":"Bartemes","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.anl.2022.11.006_bib0020","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1165\/rcmb.2016-0099OC","article-title":"IL-13+ Type 2 Innate Lymphoid Cells Correlate with Asthma Control Status and Treatment Response","volume":"55","author":"Jia","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"11","key":"10.1016\/j.anl.2022.11.006_bib0021","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.rmed.2015.09.016","article-title":"Type 2 innate lymphoid cells: A novel biomarker of eosinophilic airway inflammation in patients with mild to moderate asthma","volume":"109","author":"Liu","year":"2015","journal-title":"Respir Med"},{"issue":"1","key":"10.1016\/j.anl.2022.11.006_bib0022","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jaci.2017.03.010","article-title":"\u03b22 integrins rather than \u03b21 integrins mediate Alternaria-induced group 2 innate lymphoid cell trafficking to the lung","volume":"141","author":"Karta","year":"2018","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.anl.2022.11.006_bib0023","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/iid3.161","article-title":"Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps","volume":"5","author":"Poposki","year":"2017","journal-title":"Immun Inflamm Dis"},{"issue":"1","key":"10.1016\/j.anl.2022.11.006_bib0024","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41572-020-00218-1","article-title":"Adult chronic rhinosinusitis","volume":"6","author":"Bachert","year":"2020","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"10.1016\/j.anl.2022.11.006_bib0025","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/all.14906","article-title":"Dupilumab efficacy in chronic rhinosinusitis with nasal polyps from SINUS-52 is unaffected by eosinophilic status","volume":"77","author":"Fujieda","year":"2022","journal-title":"Allergy"}],"container-title":["Auris Nasus Larynx"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814622002243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814622002243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:40:05Z","timestamp":1759952405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0385814622002243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0385814622002243"],"URL":"https:\/\/doi.org\/10.1016\/j.anl.2022.11.006","relation":{},"ISSN":["0385-8146"],"issn-type":[{"value":"0385-8146","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A decreased prevalence of group 2 innate lymphoid cells in blood is associated with good postoperative outcomes in patients with chronic rhinosinusitis","name":"articletitle","label":"Article Title"},{"value":"Auris Nasus Larynx","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anl.2022.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}